DNA replication licensing factor MCM4

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA replication licensing factor MCM4, putative

Species:

Leishmania braziliensis

UniProt:

A4H5K0_LEIBR

TriTrypDb:

LbrM.09.0250 , LBRM2903_090007500 , LBRM2903_090007600

Length:

922

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0032991	protein-containing complex	1	12
GO:0042555	MCM complex	2	12
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4H5K0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5K0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006270	DNA replication initiation	5	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0000727	double-strand break repair via break-induced replication	8	1
GO:0006268	DNA unwinding involved in DNA replication	9	1
GO:0006271	DNA strand elongation involved in DNA replication	6	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006310	DNA recombination	5	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0006996	organelle organization	4	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0022616	DNA strand elongation	5	1
GO:0032392	DNA geometric change	7	1
GO:0032508	DNA duplex unwinding	8	1
GO:0033554	cellular response to stress	3	1
GO:0050896	response to stimulus	1	1
GO:0051276	chromosome organization	5	1
GO:0051716	cellular response to stimulus	2	1
GO:0071103	DNA conformation change	6	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1902292	cell cycle DNA replication initiation	3	1
GO:1902315	nuclear cell cycle DNA replication initiation	4	1
GO:1902975	mitotic DNA replication initiation	4	1
GO:1903047	mitotic cell cycle process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003678	DNA helicase activity	3	12
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008094	ATP-dependent activity, acting on DNA	2	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0016887	ATP hydrolysis activity	7	12
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140097	catalytic activity, acting on DNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003697	single-stranded DNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	328	332	PF00656	0.300
CLV_C14_Caspase3-7	372	376	PF00656	0.633
CLV_C14_Caspase3-7	684	688	PF00656	0.626
CLV_C14_Caspase3-7	694	698	PF00656	0.582
CLV_NRD_NRD_1	33	35	PF00675	0.323
CLV_NRD_NRD_1	348	350	PF00675	0.609
CLV_NRD_NRD_1	618	620	PF00675	0.223
CLV_NRD_NRD_1	638	640	PF00675	0.435
CLV_NRD_NRD_1	844	846	PF00675	0.460
CLV_NRD_NRD_1	852	854	PF00675	0.383
CLV_NRD_NRD_1	859	861	PF00675	0.367
CLV_PCSK_KEX2_1	33	35	PF00082	0.323
CLV_PCSK_KEX2_1	422	424	PF00082	0.227
CLV_PCSK_KEX2_1	618	620	PF00082	0.223
CLV_PCSK_KEX2_1	638	640	PF00082	0.435
CLV_PCSK_KEX2_1	751	753	PF00082	0.172
CLV_PCSK_KEX2_1	805	807	PF00082	0.279
CLV_PCSK_KEX2_1	844	846	PF00082	0.460
CLV_PCSK_KEX2_1	851	853	PF00082	0.413
CLV_PCSK_KEX2_1	859	861	PF00082	0.367
CLV_PCSK_PC1ET2_1	422	424	PF00082	0.227
CLV_PCSK_PC1ET2_1	751	753	PF00082	0.148
CLV_PCSK_PC1ET2_1	805	807	PF00082	0.279
CLV_PCSK_PC1ET2_1	851	853	PF00082	0.476
CLV_PCSK_PC7_1	29	35	PF00082	0.321
CLV_PCSK_SKI1_1	103	107	PF00082	0.255
CLV_PCSK_SKI1_1	154	158	PF00082	0.256
CLV_PCSK_SKI1_1	320	324	PF00082	0.382
CLV_PCSK_SKI1_1	382	386	PF00082	0.418
CLV_PCSK_SKI1_1	423	427	PF00082	0.212
CLV_PCSK_SKI1_1	542	546	PF00082	0.212
CLV_PCSK_SKI1_1	619	623	PF00082	0.283
CLV_PCSK_SKI1_1	639	643	PF00082	0.611
CLV_PCSK_SKI1_1	814	818	PF00082	0.519
CLV_PCSK_SKI1_1	868	872	PF00082	0.360
CLV_Separin_Metazoa	336	340	PF03568	0.544
DEG_APCC_DBOX_1	422	430	PF00400	0.412
DEG_APCC_DBOX_1	458	466	PF00400	0.515
DEG_APCC_DBOX_1	541	549	PF00400	0.412
DEG_APCC_DBOX_1	600	608	PF00400	0.412
DEG_Kelch_Keap1_1	508	513	PF01344	0.412
DOC_MAPK_DCC_7	204	214	PF00069	0.412
DOC_MAPK_gen_1	204	214	PF00069	0.431
DOC_MAPK_gen_1	751	760	PF00069	0.348
DOC_MAPK_gen_1	789	798	PF00069	0.412
DOC_MAPK_gen_1	805	812	PF00069	0.412
DOC_MAPK_MEF2A_6	113	120	PF00069	0.424
DOC_MAPK_MEF2A_6	125	132	PF00069	0.426
DOC_MAPK_MEF2A_6	207	214	PF00069	0.412
DOC_MAPK_MEF2A_6	459	466	PF00069	0.412
DOC_MAPK_MEF2A_6	601	609	PF00069	0.412
DOC_MAPK_MEF2A_6	805	812	PF00069	0.501
DOC_MAPK_RevD_3	605	619	PF00069	0.479
DOC_PP2B_PxIxI_1	209	215	PF00149	0.423
DOC_USP7_MATH_1	363	367	PF00917	0.597
DOC_USP7_MATH_1	449	453	PF00917	0.515
DOC_USP7_MATH_1	540	544	PF00917	0.423
DOC_USP7_MATH_1	567	571	PF00917	0.412
DOC_USP7_MATH_1	577	581	PF00917	0.412
DOC_USP7_MATH_1	61	65	PF00917	0.537
DOC_USP7_MATH_1	73	77	PF00917	0.560
DOC_USP7_MATH_1	763	767	PF00917	0.437
DOC_USP7_UBL2_3	263	267	PF12436	0.515
DOC_USP7_UBL2_3	99	103	PF12436	0.515
DOC_WW_Pin1_4	185	190	PF00397	0.483
DOC_WW_Pin1_4	268	273	PF00397	0.479
DOC_WW_Pin1_4	277	282	PF00397	0.350
DOC_WW_Pin1_4	308	313	PF00397	0.515
DOC_WW_Pin1_4	359	364	PF00397	0.651
DOC_WW_Pin1_4	49	54	PF00397	0.514
LIG_14-3-3_CanoR_1	113	117	PF00244	0.484
LIG_14-3-3_CanoR_1	618	628	PF00244	0.356
LIG_14-3-3_CanoR_1	673	679	PF00244	0.699
LIG_14-3-3_CanoR_1	782	790	PF00244	0.478
LIG_14-3-3_CanoR_1	791	798	PF00244	0.428
LIG_14-3-3_CanoR_1	806	811	PF00244	0.408
LIG_Actin_WH2_2	145	162	PF00022	0.464
LIG_AP2alpha_1	28	32	PF02296	0.392
LIG_APCC_ABBA_1	25	30	PF00400	0.458
LIG_APCC_ABBA_1	257	262	PF00400	0.430
LIG_APCC_ABBA_1	625	630	PF00400	0.412
LIG_APCC_ABBAyCdc20_2	435	441	PF00400	0.515
LIG_BIR_II_1	1	5	PF00653	0.431
LIG_BIR_III_4	687	691	PF00653	0.754
LIG_BRCT_BRCA1_1	454	458	PF00533	0.515
LIG_CaM_IQ_9	219	235	PF13499	0.437
LIG_Clathr_ClatBox_1	823	827	PF01394	0.488
LIG_eIF4E_1	153	159	PF01652	0.464
LIG_eIF4E_1	260	266	PF01652	0.515
LIG_FHA_1	113	119	PF00498	0.528
LIG_FHA_1	137	143	PF00498	0.520
LIG_FHA_1	317	323	PF00498	0.372
LIG_FHA_1	36	42	PF00498	0.470
LIG_FHA_1	365	371	PF00498	0.671
LIG_FHA_1	386	392	PF00498	0.547
LIG_FHA_1	500	506	PF00498	0.412
LIG_FHA_1	509	515	PF00498	0.412
LIG_FHA_1	539	545	PF00498	0.412
LIG_FHA_1	551	557	PF00498	0.412
LIG_FHA_1	567	573	PF00498	0.412
LIG_FHA_1	620	626	PF00498	0.348
LIG_FHA_1	673	679	PF00498	0.569
LIG_FHA_1	77	83	PF00498	0.348
LIG_FHA_1	818	824	PF00498	0.462
LIG_FHA_1	90	96	PF00498	0.331
LIG_FHA_1	905	911	PF00498	0.437
LIG_FHA_2	326	332	PF00498	0.310
LIG_FHA_2	370	376	PF00498	0.552
LIG_FHA_2	692	698	PF00498	0.607
LIG_Integrin_isoDGR_2	56	58	PF01839	0.168
LIG_LIR_Gen_1	104	110	PF02991	0.514
LIG_LIR_Gen_1	117	128	PF02991	0.545
LIG_LIR_Gen_1	12	23	PF02991	0.531
LIG_LIR_Gen_1	392	401	PF02991	0.445
LIG_LIR_Gen_1	402	411	PF02991	0.381
LIG_LIR_Gen_1	532	540	PF02991	0.412
LIG_LIR_Gen_1	600	609	PF02991	0.412
LIG_LIR_Gen_1	731	741	PF02991	0.412
LIG_LIR_Nem_3	117	123	PF02991	0.473
LIG_LIR_Nem_3	12	18	PF02991	0.550
LIG_LIR_Nem_3	150	156	PF02991	0.479
LIG_LIR_Nem_3	30	35	PF02991	0.424
LIG_LIR_Nem_3	392	397	PF02991	0.417
LIG_LIR_Nem_3	402	407	PF02991	0.403
LIG_LIR_Nem_3	600	605	PF02991	0.412
LIG_LIR_Nem_3	731	736	PF02991	0.414
LIG_LIR_Nem_3	739	745	PF02991	0.415
LIG_NRBOX	461	467	PF00104	0.515
LIG_NRBOX	603	609	PF00104	0.412
LIG_NRBOX	845	851	PF00104	0.442
LIG_NRBOX	889	895	PF00104	0.367
LIG_Pex14_1	220	224	PF04695	0.515
LIG_Pex14_2	28	32	PF04695	0.248
LIG_Pex14_2	602	606	PF04695	0.412
LIG_RPA_C_Fungi	848	860	PF08784	0.394
LIG_SH2_PTP2	733	736	PF00017	0.283
LIG_SH2_PTP2	757	760	PF00017	0.342
LIG_SH2_STAP1	15	19	PF00017	0.521
LIG_SH2_STAP1	249	253	PF00017	0.248
LIG_SH2_STAP1	404	408	PF00017	0.283
LIG_SH2_STAP1	792	796	PF00017	0.184
LIG_SH2_STAT3	854	857	PF00017	0.430
LIG_SH2_STAT3	94	97	PF00017	0.357
LIG_SH2_STAT5	101	104	PF00017	0.280
LIG_SH2_STAT5	131	134	PF00017	0.392
LIG_SH2_STAT5	17	20	PF00017	0.380
LIG_SH2_STAT5	35	38	PF00017	0.392
LIG_SH2_STAT5	490	493	PF00017	0.248
LIG_SH2_STAT5	733	736	PF00017	0.262
LIG_SH2_STAT5	757	760	PF00017	0.248
LIG_SH2_STAT5	854	857	PF00017	0.441
LIG_SH2_STAT5	94	97	PF00017	0.286
LIG_SH3_3	132	138	PF00018	0.342
LIG_SH3_3	42	48	PF00018	0.430
LIG_SH3_3	512	518	PF00018	0.248
LIG_SH3_3	64	70	PF00018	0.373
LIG_SH3_3	717	723	PF00018	0.408
LIG_SH3_3	878	884	PF00018	0.526
LIG_SUMO_SIM_anti_2	155	160	PF11976	0.433
LIG_SUMO_SIM_anti_2	889	895	PF11976	0.357
LIG_SUMO_SIM_anti_2	906	913	PF11976	0.381
LIG_SUMO_SIM_par_1	114	119	PF11976	0.285
LIG_SUMO_SIM_par_1	889	895	PF11976	0.475
LIG_UBA3_1	195	199	PF00899	0.392
LIG_WRC_WIRS_1	36	41	PF05994	0.340
LIG_WRC_WIRS_1	408	413	PF05994	0.248
LIG_WRC_WIRS_1	900	905	PF05994	0.383
MOD_CDK_SPK_2	49	54	PF00069	0.159
MOD_CDK_SPxK_1	308	314	PF00069	0.392
MOD_CK1_1	180	186	PF00069	0.459
MOD_CK1_1	2	8	PF00069	0.475
MOD_CK1_1	440	446	PF00069	0.295
MOD_CK1_1	452	458	PF00069	0.358
MOD_CK1_1	49	55	PF00069	0.423
MOD_CK1_1	634	640	PF00069	0.587
MOD_CK1_1	674	680	PF00069	0.672
MOD_CK1_1	681	687	PF00069	0.670
MOD_CK1_1	75	81	PF00069	0.389
MOD_CK1_1	766	772	PF00069	0.283
MOD_CK1_1	794	800	PF00069	0.392
MOD_CK2_1	111	117	PF00069	0.283
MOD_CK2_1	255	261	PF00069	0.283
MOD_Cter_Amidation	857	860	PF01082	0.373
MOD_GlcNHglycan	1	4	PF01048	0.632
MOD_GlcNHglycan	145	148	PF01048	0.410
MOD_GlcNHglycan	229	232	PF01048	0.412
MOD_GlcNHglycan	454	457	PF01048	0.392
MOD_GlcNHglycan	491	494	PF01048	0.248
MOD_GlcNHglycan	633	636	PF01048	0.553
MOD_GlcNHglycan	643	647	PF01048	0.681
MOD_GlcNHglycan	684	687	PF01048	0.722
MOD_GlcNHglycan	75	78	PF01048	0.419
MOD_GlcNHglycan	770	773	PF01048	0.264
MOD_GlcNHglycan	814	817	PF01048	0.411
MOD_GlcNHglycan	875	878	PF01048	0.577
MOD_GlcNHglycan	894	897	PF01048	0.290
MOD_GSK3_1	321	328	PF00069	0.368
MOD_GSK3_1	359	366	PF00069	0.614
MOD_GSK3_1	407	414	PF00069	0.248
MOD_GSK3_1	433	440	PF00069	0.392
MOD_GSK3_1	472	479	PF00069	0.248
MOD_GSK3_1	489	496	PF00069	0.248
MOD_GSK3_1	5	12	PF00069	0.631
MOD_GSK3_1	619	626	PF00069	0.170
MOD_GSK3_1	667	674	PF00069	0.693
MOD_GSK3_1	678	685	PF00069	0.735
MOD_GSK3_1	72	79	PF00069	0.350
MOD_GSK3_1	764	771	PF00069	0.251
MOD_GSK3_1	790	797	PF00069	0.184
MOD_GSK3_1	814	821	PF00069	0.428
MOD_GSK3_1	899	906	PF00069	0.380
MOD_N-GLC_1	255	260	PF02516	0.271
MOD_N-GLC_1	83	88	PF02516	0.159
MOD_NEK2_1	292	297	PF00069	0.243
MOD_NEK2_1	369	374	PF00069	0.696
MOD_NEK2_1	385	390	PF00069	0.554
MOD_NEK2_1	393	398	PF00069	0.303
MOD_NEK2_1	407	412	PF00069	0.174
MOD_NEK2_1	430	435	PF00069	0.263
MOD_NEK2_1	629	634	PF00069	0.592
MOD_NEK2_1	812	817	PF00069	0.419
MOD_NEK2_1	903	908	PF00069	0.381
MOD_NEK2_1	910	915	PF00069	0.427
MOD_NEK2_2	131	136	PF00069	0.392
MOD_NEK2_2	61	66	PF00069	0.159
MOD_NEK2_2	737	742	PF00069	0.263
MOD_PIKK_1	472	478	PF00454	0.248
MOD_PIKK_1	5	11	PF00454	0.406
MOD_PIKK_1	577	583	PF00454	0.248
MOD_PIKK_1	667	673	PF00454	0.623
MOD_PK_1	806	812	PF00069	0.159
MOD_PKA_1	349	355	PF00069	0.484
MOD_PKA_2	112	118	PF00069	0.351
MOD_PKA_2	203	209	PF00069	0.248
MOD_PKA_2	338	344	PF00069	0.549
MOD_PKA_2	5	11	PF00069	0.406
MOD_PKA_2	567	573	PF00069	0.248
MOD_PKA_2	672	678	PF00069	0.681
MOD_PKA_2	737	743	PF00069	0.269
MOD_PKA_2	763	769	PF00069	0.308
MOD_PKA_2	781	787	PF00069	0.283
MOD_PKA_2	790	796	PF00069	0.392
MOD_PKA_2	858	864	PF00069	0.404
MOD_Plk_1	118	124	PF00069	0.331
MOD_Plk_1	13	19	PF00069	0.415
MOD_Plk_1	225	231	PF00069	0.342
MOD_Plk_1	255	261	PF00069	0.271
MOD_Plk_1	667	673	PF00069	0.623
MOD_Plk_1	794	800	PF00069	0.308
MOD_Plk_4	13	19	PF00069	0.415
MOD_Plk_4	177	183	PF00069	0.533
MOD_Plk_4	255	261	PF00069	0.263
MOD_Plk_4	292	298	PF00069	0.383
MOD_Plk_4	321	327	PF00069	0.525
MOD_Plk_4	433	439	PF00069	0.392
MOD_Plk_4	567	573	PF00069	0.248
MOD_Plk_4	594	600	PF00069	0.248
MOD_Plk_4	623	629	PF00069	0.248
MOD_Plk_4	737	743	PF00069	0.322
MOD_Plk_4	776	782	PF00069	0.248
MOD_Plk_4	90	96	PF00069	0.289
MOD_Plk_4	906	912	PF00069	0.336
MOD_ProDKin_1	185	191	PF00069	0.348
MOD_ProDKin_1	268	274	PF00069	0.342
MOD_ProDKin_1	277	283	PF00069	0.162
MOD_ProDKin_1	308	314	PF00069	0.392
MOD_ProDKin_1	359	365	PF00069	0.651
MOD_ProDKin_1	49	55	PF00069	0.391
MOD_SUMO_rev_2	258	265	PF00179	0.263
MOD_SUMO_rev_2	797	807	PF00179	0.251
TRG_DiLeu_BaEn_1	261	266	PF01217	0.283
TRG_DiLeu_BaEn_1	461	466	PF01217	0.342
TRG_DiLeu_BaEn_1	517	522	PF01217	0.271
TRG_DiLeu_BaEn_1	889	894	PF01217	0.352
TRG_DiLeu_BaEn_3	802	808	PF01217	0.159
TRG_DiLeu_BaLyEn_6	67	72	PF01217	0.159
TRG_ENDOCYTIC_2	15	18	PF00928	0.513
TRG_ENDOCYTIC_2	153	156	PF00928	0.392
TRG_ENDOCYTIC_2	289	292	PF00928	0.308
TRG_ENDOCYTIC_2	404	407	PF00928	0.263
TRG_ENDOCYTIC_2	733	736	PF00928	0.248
TRG_ENDOCYTIC_2	757	760	PF00928	0.248
TRG_ER_diArg_1	32	34	PF00400	0.403
TRG_ER_diArg_1	618	620	PF00400	0.263
TRG_ER_diArg_1	843	845	PF00400	0.484
TRG_ER_diArg_1	852	854	PF00400	0.377
TRG_NES_CRM1_1	585	595	PF08389	0.392
TRG_Pf-PMV_PEXEL_1	844	848	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	853	857	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P860	Leptomonas seymouri	30%	93%
A0A0N1I383	Leptomonas seymouri	76%	90%
A0A0S4IK09	Bodo saltans	30%	94%
A0A0S4IW18	Bodo saltans	55%	100%
A0A0S4JM41	Bodo saltans	29%	100%
A0A1X0NNF6	Trypanosomatidae	57%	100%
A0A1X0NZT6	Trypanosomatidae	31%	98%
A0A3Q8IAX4	Leishmania donovani	31%	95%
A0A3R7K9K0	Trypanosoma rangeli	30%	100%
A0A3R7NBN0	Trypanosoma rangeli	31%	97%
A0A3S7WQI8	Leishmania donovani	88%	100%
A0A3S7WY81	Leishmania donovani	31%	100%
A0A422NDD9	Trypanosoma rangeli	56%	100%
A4FUD9	Bos taurus	32%	100%
A4HGC9	Leishmania braziliensis	32%	95%
A4HLY1	Leishmania braziliensis	30%	100%
A4HTX2	Leishmania infantum	88%	100%
A4I0T0	Leishmania infantum	31%	100%
A4I3G2	Leishmania infantum	31%	95%
B8AZ14	Oryza sativa subsp. indica	29%	100%
B8AZ99	Oryza sativa subsp. indica	30%	100%
B9FKM7	Oryza sativa subsp. japonica	29%	100%
D0A7X6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	97%
D0A999	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
D3ZVK1	Rattus norvegicus	30%	100%
E1BPX4	Bos taurus	29%	100%
E9AMM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9AWT2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AZQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	95%
I0IUP3	Gallus gallus	29%	100%
P24279	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	95%
P25205	Homo sapiens	32%	100%
P25206	Mus musculus	32%	100%
P29469	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
P30664	Xenopus laevis	42%	100%
P30666	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
P33991	Homo sapiens	41%	100%
P49739	Xenopus laevis	32%	100%
P55861	Xenopus laevis	30%	100%
Q0DHC4	Oryza sativa subsp. japonica	30%	100%
Q0V9Q6	Xenopus tropicalis	30%	100%
Q21902	Caenorhabditis elegans	28%	100%
Q26454	Drosophila melanogaster	40%	100%
Q43704	Zea mays	30%	100%
Q4Q8I2	Leishmania major	32%	95%
Q4QAP2	Leishmania major	30%	100%
Q4QI01	Leishmania major	87%	98%
Q5F310	Xenopus laevis	29%	100%
Q5R8G6	Pongo abelii	32%	100%
Q5XK83	Xenopus laevis	41%	100%
Q6DIH3	Xenopus tropicalis	30%	100%
Q6GL41	Xenopus tropicalis	42%	100%
Q7ZXZ0	Xenopus laevis	32%	100%
Q95XQ8	Caenorhabditis elegans	40%	100%
Q9CWV1	Mus musculus	30%	100%
Q9FL33	Arabidopsis thaliana	30%	100%
Q9SF37	Arabidopsis thaliana	29%	100%
Q9SX03	Zea mays	30%	100%
Q9SX04	Zea mays	30%	100%
Q9UJA3	Homo sapiens	28%	100%
Q9VF30	Drosophila melanogaster	24%	100%
Q9XYU1	Drosophila melanogaster	32%	100%
V5BAH7	Trypanosoma cruzi	30%	100%
V5BQA9	Trypanosoma cruzi	31%	100%
V5BSG2	Trypanosoma cruzi	57%	100%