Sperm-tail PG-rich repeat-containing protein 2

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4586), putative

Species:

Leishmania braziliensis

UniProt:

A4H5J6_LEIBR

TriTrypDb:

LbrM.09.0210 , LBRM2903_090007100

Length:

306

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	21
GO:0005815	microtubule organizing center	2	21
GO:0110165	cellular anatomical entity	1	21

Expansion

Sequence features

A4H5J6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5J6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	174	176	PF00675	0.291
CLV_NRD_NRD_1	186	188	PF00675	0.260
CLV_NRD_NRD_1	237	239	PF00675	0.321
CLV_PCSK_KEX2_1	136	138	PF00082	0.255
CLV_PCSK_KEX2_1	16	18	PF00082	0.257
CLV_PCSK_KEX2_1	174	176	PF00082	0.293
CLV_PCSK_KEX2_1	186	188	PF00082	0.250
CLV_PCSK_KEX2_1	222	224	PF00082	0.302
CLV_PCSK_KEX2_1	35	37	PF00082	0.242
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.243
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.257
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.302
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.242
CLV_PCSK_SKI1_1	175	179	PF00082	0.279
DEG_Nend_Nbox_1	1	3	PF02207	0.431
DOC_CYCLIN_yCln2_LP_2	215	221	PF00134	0.497
DOC_PP1_RVXF_1	56	63	PF00149	0.350
DOC_PP4_FxxP_1	2	5	PF00568	0.449
DOC_PP4_FxxP_1	62	65	PF00568	0.494
DOC_USP7_MATH_1	177	181	PF00917	0.450
DOC_USP7_MATH_1	191	195	PF00917	0.465
DOC_USP7_MATH_1	47	51	PF00917	0.497
DOC_USP7_MATH_1	56	60	PF00917	0.492
DOC_USP7_UBL2_3	96	100	PF12436	0.525
DOC_WW_Pin1_4	187	192	PF00397	0.474
DOC_WW_Pin1_4	221	226	PF00397	0.487
LIG_14-3-3_CanoR_1	211	216	PF00244	0.477
LIG_AP2alpha_2	46	48	PF02296	0.436
LIG_BRCT_BRCA1_1	198	202	PF00533	0.514
LIG_BRCT_BRCA1_1	58	62	PF00533	0.528
LIG_CSL_BTD_1	240	243	PF09270	0.528
LIG_CSL_BTD_1	281	284	PF09270	0.456
LIG_FHA_1	214	220	PF00498	0.491
LIG_FHA_1	229	235	PF00498	0.435
LIG_FHA_1	293	299	PF00498	0.526
LIG_FHA_2	104	110	PF00498	0.431
LIG_FHA_2	122	128	PF00498	0.473
LIG_LIR_Apic_2	299	303	PF02991	0.500
LIG_LIR_Apic_2	59	65	PF02991	0.461
LIG_LIR_Gen_1	46	56	PF02991	0.466
LIG_LIR_Nem_3	102	107	PF02991	0.442
LIG_LIR_Nem_3	116	122	PF02991	0.442
LIG_LIR_Nem_3	148	154	PF02991	0.440
LIG_LIR_Nem_3	288	293	PF02991	0.505
LIG_LIR_Nem_3	42	48	PF02991	0.454
LIG_LIR_Nem_3	55	60	PF02991	0.377
LIG_Pex14_2	62	66	PF04695	0.497
LIG_SH2_CRK	151	155	PF00017	0.456
LIG_SH2_CRK	294	298	PF00017	0.521
LIG_SH2_CRK	300	304	PF00017	0.478
LIG_SH2_CRK	57	61	PF00017	0.528
LIG_SH2_NCK_1	300	304	PF00017	0.511
LIG_SH2_SRC	300	303	PF00017	0.537
LIG_SH2_STAT5	151	154	PF00017	0.473
LIG_SH2_STAT5	164	167	PF00017	0.447
LIG_SH2_STAT5	294	297	PF00017	0.539
LIG_SH2_STAT5	7	10	PF00017	0.451
LIG_SH3_2	218	223	PF14604	0.431
LIG_SH3_3	138	144	PF00018	0.459
LIG_SH3_3	162	168	PF00018	0.470
LIG_SH3_3	215	221	PF00018	0.419
LIG_SH3_3	237	243	PF00018	0.471
LIG_SH3_3	278	284	PF00018	0.452
LIG_SH3_3	84	90	PF00018	0.437
LIG_WRC_WIRS_1	104	109	PF05994	0.431
LIG_WRPW_2	279	282	PF00400	0.456
MOD_CDC14_SPxK_1	190	193	PF00782	0.436
MOD_CDK_SPxK_1	187	193	PF00069	0.436
MOD_CK1_1	224	230	PF00069	0.510
MOD_CK1_1	232	238	PF00069	0.510
MOD_CK1_1	50	56	PF00069	0.434
MOD_CK1_1	94	100	PF00069	0.486
MOD_CK2_1	103	109	PF00069	0.431
MOD_CK2_1	177	183	PF00069	0.376
MOD_Cter_Amidation	236	239	PF01082	0.236
MOD_GlcNHglycan	193	196	PF01048	0.282
MOD_GlcNHglycan	198	201	PF01048	0.249
MOD_GlcNHglycan	2	5	PF01048	0.319
MOD_GlcNHglycan	231	234	PF01048	0.353
MOD_GlcNHglycan	276	279	PF01048	0.305
MOD_GlcNHglycan	32	35	PF01048	0.314
MOD_GlcNHglycan	79	82	PF01048	0.359
MOD_GlcNHglycan	97	100	PF01048	0.146
MOD_GSK3_1	145	152	PF00069	0.477
MOD_GSK3_1	177	184	PF00069	0.444
MOD_GSK3_1	18	25	PF00069	0.443
MOD_GSK3_1	187	194	PF00069	0.494
MOD_GSK3_1	207	214	PF00069	0.437
MOD_GSK3_1	224	231	PF00069	0.338
MOD_GSK3_1	91	98	PF00069	0.406
MOD_NEK2_1	202	207	PF00069	0.484
MOD_NEK2_1	30	35	PF00069	0.524
MOD_PIKK_1	224	230	PF00454	0.505
MOD_PKA_1	145	151	PF00069	0.444
MOD_PKA_1	95	101	PF00069	0.523
MOD_Plk_1	41	47	PF00069	0.528
MOD_ProDKin_1	187	193	PF00069	0.474
MOD_ProDKin_1	221	227	PF00069	0.487
MOD_SUMO_rev_2	260	269	PF00179	0.487
TRG_ENDOCYTIC_2	104	107	PF00928	0.437
TRG_ENDOCYTIC_2	151	154	PF00928	0.472
TRG_ENDOCYTIC_2	290	293	PF00928	0.513
TRG_ENDOCYTIC_2	57	60	PF00928	0.448
TRG_ENDOCYTIC_2	7	10	PF00928	0.456
TRG_ER_diArg_1	173	175	PF00400	0.528
TRG_ER_diArg_1	186	188	PF00400	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4L7	Leptomonas seymouri	74%	100%
A0A0N1I8Z0	Leptomonas seymouri	30%	100%
A0A0S4IYY4	Bodo saltans	40%	100%
A0A0S4KM52	Bodo saltans	29%	100%
A0A1X0NMW4	Trypanosomatidae	52%	100%
A0A1X0NRI3	Trypanosomatidae	30%	100%
A0A3Q8IGT8	Leishmania donovani	30%	100%
A0A3S5H6B7	Leishmania donovani	86%	100%
A0A422NDP9	Trypanosoma rangeli	47%	100%
A0A422NZ19	Trypanosoma rangeli	30%	100%
A4HGN9	Leishmania braziliensis	31%	100%
A4HTT9	Leishmania infantum	86%	100%
A4I3R2	Leishmania infantum	30%	100%
A7E2U8	Homo sapiens	25%	99%
D0A995	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AMM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E9B005	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
Q2T9M0	Bos taurus	26%	99%
Q3U1D9	Mus musculus	28%	97%
Q4Q880	Leishmania major	30%	100%
Q4QI05	Leishmania major	88%	100%
Q5XHC1	Xenopus laevis	25%	100%
V5BSF6	Trypanosoma cruzi	46%	100%