LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4H5J4_LEIBR
TriTrypDb:
LbrM.09.0190 , LBRM2903_090006900 *
Length:
121

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0016020 membrane 2 4
GO:0110165 cellular anatomical entity 1 4

Expansion

Sequence features

A4H5J4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5J4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 35 37 PF00675 0.327
CLV_PCSK_FUR_1 33 37 PF00082 0.323
CLV_PCSK_KEX2_1 35 37 PF00082 0.313
DOC_PP4_FxxP_1 26 29 PF00568 0.474
DOC_USP7_MATH_1 103 107 PF00917 0.403
DOC_USP7_MATH_1 109 113 PF00917 0.391
DOC_USP7_MATH_1 57 61 PF00917 0.266
DOC_USP7_MATH_1 6 10 PF00917 0.517
DOC_WW_Pin1_4 19 24 PF00397 0.517
DOC_WW_Pin1_4 25 30 PF00397 0.496
LIG_BIR_II_1 1 5 PF00653 0.655
LIG_BRCT_BRCA1_1 1 5 PF00533 0.573
LIG_EH1_1 43 51 PF00400 0.203
LIG_FHA_1 12 18 PF00498 0.554
LIG_LIR_Apic_2 24 29 PF02991 0.473
LIG_LIR_Nem_3 60 66 PF02991 0.412
LIG_LIR_Nem_3 76 82 PF02991 0.354
LIG_NRBOX 16 22 PF00104 0.514
LIG_SH2_CRK 63 67 PF00017 0.299
LIG_SH2_STAT5 19 22 PF00017 0.536
LIG_SH2_STAT5 39 42 PF00017 0.283
LIG_SH2_STAT5 51 54 PF00017 0.262
LIG_SH2_STAT5 82 85 PF00017 0.379
LIG_SH3_3 74 80 PF00018 0.323
LIG_TRFH_1 19 23 PF08558 0.542
MOD_CDC14_SPxK_1 22 25 PF00782 0.505
MOD_CDK_SPxK_1 19 25 PF00069 0.510
MOD_CK1_1 94 100 PF00069 0.431
MOD_CK2_1 25 31 PF00069 0.576
MOD_CK2_1 6 12 PF00069 0.512
MOD_GlcNHglycan 107 110 PF01048 0.744
MOD_GlcNHglycan 112 115 PF01048 0.611
MOD_GSK3_1 105 112 PF00069 0.407
MOD_GSK3_1 21 28 PF00069 0.522
MOD_NEK2_1 44 49 PF00069 0.198
MOD_PIKK_1 103 109 PF00454 0.379
MOD_PIKK_1 85 91 PF00454 0.342
MOD_PIKK_1 94 100 PF00454 0.385
MOD_PKA_2 110 116 PF00069 0.384
MOD_PKA_2 12 18 PF00069 0.528
MOD_PKA_2 91 97 PF00069 0.398
MOD_Plk_4 44 50 PF00069 0.273
MOD_ProDKin_1 19 25 PF00069 0.510
TRG_ENDOCYTIC_2 63 66 PF00928 0.382
TRG_ENDOCYTIC_2 82 85 PF00928 0.385
TRG_ER_diArg_1 34 36 PF00400 0.524
TRG_ER_diArg_1 66 69 PF00400 0.328

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5B9 Leptomonas seymouri 60% 100%
A0A3S7WQJ7 Leishmania donovani 73% 100%
A4HTT7 Leishmania infantum 75% 100%
D0A994 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 100%
E9AML8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 77% 96%
Q4QI07 Leishmania major 71% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS