LeishMANIAdb
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Putative ATG8/AUT7/APG8/PAZ2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative ATG8/AUT7/APG8/PAZ2
Gene product:
ATG8/AUT7/APG8/PAZ2, putative
Species:
Leishmania braziliensis
UniProt:
A4H5J3_LEIBR
TriTrypDb:
LbrM.09.0180 , LBRM2903_090006600
Length:
124

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 46
NetGPI no yes: 0, no: 46
Cellular components
Term Name Level Count
GO:0016020 membrane 2 46
GO:0110165 cellular anatomical entity 1 46

Expansion

Sequence features

A4H5J3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5J3

Function

Biological processes
Term Name Level Count
GO:0006914 autophagy 3 14
GO:0008152 metabolic process 1 14
GO:0009056 catabolic process 2 14
GO:0009987 cellular process 1 26
GO:0044237 cellular metabolic process 2 14
GO:0044248 cellular catabolic process 3 14
GO:0061919 process utilizing autophagic mechanism 2 14
GO:0006950 response to stress 2 14
GO:0006995 cellular response to nitrogen starvation 5 14
GO:0007154 cell communication 2 14
GO:0009267 cellular response to starvation 4 14
GO:0009605 response to external stimulus 2 14
GO:0009991 response to extracellular stimulus 3 14
GO:0031667 response to nutrient levels 4 14
GO:0031668 cellular response to extracellular stimulus 3 14
GO:0031669 cellular response to nutrient levels 4 14
GO:0033554 cellular response to stress 3 14
GO:0042594 response to starvation 3 14
GO:0043562 cellular response to nitrogen levels 5 14
GO:0050896 response to stimulus 1 14
GO:0051716 cellular response to stimulus 2 14
GO:0071496 cellular response to external stimulus 3 14
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 68 72 PF00082 0.554
DOC_MAPK_JIP1_4 68 74 PF00069 0.428
DOC_MAPK_MEF2A_6 21 30 PF00069 0.532
DOC_USP7_MATH_1 106 110 PF00917 0.687
DOC_USP7_MATH_1 117 121 PF00917 0.666
DOC_USP7_MATH_1 3 7 PF00917 0.649
DOC_USP7_MATH_1 75 79 PF00917 0.548
DOC_WW_Pin1_4 5 10 PF00397 0.454
DOC_WW_Pin1_4 77 82 PF00397 0.533
LIG_14-3-3_CanoR_1 16 21 PF00244 0.333
LIG_Actin_WH2_2 7 23 PF00022 0.451
LIG_BIR_II_1 1 5 PF00653 0.648
LIG_FHA_1 21 27 PF00498 0.333
LIG_FHA_1 69 75 PF00498 0.470
LIG_FHA_2 6 12 PF00498 0.459
LIG_FHA_2 82 88 PF00498 0.580
LIG_SH2_STAT5 101 104 PF00017 0.425
LIG_SH2_STAT5 4 7 PF00017 0.453
LIG_SUMO_SIM_par_1 26 32 PF11976 0.502
LIG_SUMO_SIM_par_1 68 73 PF11976 0.485
MOD_CK2_1 5 11 PF00069 0.458
MOD_CK2_1 81 87 PF00069 0.434
MOD_GlcNHglycan 1 4 PF01048 0.612
MOD_GlcNHglycan 42 45 PF01048 0.450
MOD_GlcNHglycan 81 84 PF01048 0.618
MOD_GSK3_1 102 109 PF00069 0.596
MOD_GSK3_1 16 23 PF00069 0.350
MOD_GSK3_1 75 82 PF00069 0.575
MOD_NEK2_1 20 25 PF00069 0.347
MOD_NEK2_1 54 59 PF00069 0.432
MOD_PKA_2 20 26 PF00069 0.334
MOD_PKA_2 46 52 PF00069 0.565
MOD_Plk_1 106 112 PF00069 0.451
MOD_ProDKin_1 5 11 PF00069 0.458
MOD_ProDKin_1 77 83 PF00069 0.525

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HR42 Leptomonas seymouri 40% 100%
A0A0N1P9V5 Leptomonas seymouri 46% 100%
A0A1X0P492 Trypanosomatidae 41% 88%
A0A1X0P5E7 Trypanosomatidae 42% 89%
A0A381MAT2 Leishmania infantum 87% 93%
A0A381MBG2 Leishmania infantum 85% 100%
A0A381MCF0 Leishmania infantum 86% 100%
A0A381MFR9 Leishmania infantum 49% 99%
A0A3Q8IB99 Leishmania donovani 48% 100%
A0A3Q8IK22 Leishmania donovani 41% 91%
A0A3S5H6B2 Leishmania donovani 87% 93%
A0A3S5H6B3 Leishmania donovani 85% 100%
A0A3S5H761 Leishmania donovani 48% 99%
A0A3S5H762 Leishmania donovani 48% 100%
A0A3S7WQH8 Leishmania donovani 86% 100%
A0A3S7WQJ1 Leishmania donovani 87% 100%
A0A3S7WVM4 Leishmania donovani 49% 100%
A4H5J2 Leishmania braziliensis 99% 100%
A4HA39 Leishmania braziliensis 39% 91%
A4HA42 Leishmania braziliensis 49% 100%
A4HA43 Leishmania braziliensis 49% 100%
A4HTT6 Leishmania infantum 87% 100%
A4HYA4 Leishmania infantum 47% 99%
A4HYA5 Leishmania infantum 48% 78%
E9AGS4 Leishmania infantum 40% 91%
E9AML6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
E9AS34 Leishmania mexicana (strain MHOM/GT/2001/U1103) 50% 100%
E9AS37 Leishmania mexicana (strain MHOM/GT/2001/U1103) 48% 99%
E9AS38 Leishmania mexicana (strain MHOM/GT/2001/U1103) 49% 100%
E9AS40 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 91%
E9AS41 Leishmania mexicana (strain MHOM/GT/2001/U1103) 49% 100%
Q4QDC5 Leishmania major 50% 99%
Q4QDC8 Leishmania major 50% 100%
Q4QDD0 Leishmania major 49% 99%
Q4QDD1 Leishmania major 41% 100%
Q4QDD3 Leishmania major 49% 99%
Q4QDD4 Leishmania major 42% 100%
Q4QDD6 Leishmania major 49% 99%
Q4QI08 Leishmania major 86% 100%
Q4QI09 Leishmania major 86% 100%
Q4QI11 Leishmania major 88% 100%
Q4QI13 Leishmania major 85% 100%
Q4QI15 Leishmania major 85% 100%
Q4QI18 Leishmania major 87% 100%
Q4QI19 Leishmania major 86% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS