Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5I9_LEIBR

TriTrypDb:

LbrM.09.0140 , LBRM2903_090006300

Length:

700

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5I9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5I9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	115	117	PF00675	0.638
CLV_NRD_NRD_1	132	134	PF00675	0.376
CLV_NRD_NRD_1	185	187	PF00675	0.566
CLV_NRD_NRD_1	189	191	PF00675	0.562
CLV_NRD_NRD_1	209	211	PF00675	0.636
CLV_NRD_NRD_1	21	23	PF00675	0.494
CLV_NRD_NRD_1	294	296	PF00675	0.625
CLV_NRD_NRD_1	299	301	PF00675	0.642
CLV_NRD_NRD_1	319	321	PF00675	0.548
CLV_NRD_NRD_1	326	328	PF00675	0.505
CLV_NRD_NRD_1	415	417	PF00675	0.494
CLV_NRD_NRD_1	421	423	PF00675	0.479
CLV_NRD_NRD_1	434	436	PF00675	0.382
CLV_NRD_NRD_1	453	455	PF00675	0.488
CLV_NRD_NRD_1	475	477	PF00675	0.416
CLV_NRD_NRD_1	526	528	PF00675	0.495
CLV_NRD_NRD_1	575	577	PF00675	0.805
CLV_NRD_NRD_1	644	646	PF00675	0.762
CLV_NRD_NRD_1	677	679	PF00675	0.702
CLV_NRD_NRD_1	92	94	PF00675	0.580
CLV_PCSK_FUR_1	113	117	PF00082	0.612
CLV_PCSK_FUR_1	186	190	PF00082	0.649
CLV_PCSK_FUR_1	473	477	PF00082	0.444
CLV_PCSK_KEX2_1	115	117	PF00082	0.654
CLV_PCSK_KEX2_1	132	134	PF00082	0.356
CLV_PCSK_KEX2_1	185	187	PF00082	0.540
CLV_PCSK_KEX2_1	188	190	PF00082	0.545
CLV_PCSK_KEX2_1	209	211	PF00082	0.636
CLV_PCSK_KEX2_1	21	23	PF00082	0.494
CLV_PCSK_KEX2_1	294	296	PF00082	0.559
CLV_PCSK_KEX2_1	319	321	PF00082	0.542
CLV_PCSK_KEX2_1	325	327	PF00082	0.484
CLV_PCSK_KEX2_1	359	361	PF00082	0.635
CLV_PCSK_KEX2_1	363	365	PF00082	0.619
CLV_PCSK_KEX2_1	420	422	PF00082	0.500
CLV_PCSK_KEX2_1	433	435	PF00082	0.477
CLV_PCSK_KEX2_1	453	455	PF00082	0.488
CLV_PCSK_KEX2_1	475	477	PF00082	0.416
CLV_PCSK_KEX2_1	526	528	PF00082	0.496
CLV_PCSK_KEX2_1	575	577	PF00082	0.805
CLV_PCSK_KEX2_1	644	646	PF00082	0.762
CLV_PCSK_KEX2_1	91	93	PF00082	0.550
CLV_PCSK_PC1ET2_1	359	361	PF00082	0.496
CLV_PCSK_PC1ET2_1	363	365	PF00082	0.473
CLV_PCSK_PC1ET2_1	420	422	PF00082	0.542
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.567
CLV_PCSK_PC7_1	185	191	PF00082	0.408
CLV_PCSK_PC7_1	416	422	PF00082	0.586
CLV_PCSK_PC7_1	449	455	PF00082	0.490
CLV_PCSK_SKI1_1	190	194	PF00082	0.423
CLV_PCSK_SKI1_1	359	363	PF00082	0.705
CLV_PCSK_SKI1_1	364	368	PF00082	0.686
CLV_PCSK_SKI1_1	411	415	PF00082	0.463
CLV_PCSK_SKI1_1	465	469	PF00082	0.576
CLV_PCSK_SKI1_1	78	82	PF00082	0.558
CLV_Separin_Metazoa	28	32	PF03568	0.473
DEG_APCC_DBOX_1	144	152	PF00400	0.588
DEG_COP1_1	610	620	PF00400	0.753
DEG_SCF_FBW7_1	151	158	PF00400	0.599
DEG_SCF_FBW7_1	377	384	PF00400	0.606
DEG_SPOP_SBC_1	348	352	PF00917	0.655
DEG_SPOP_SBC_1	599	603	PF00917	0.721
DOC_CKS1_1	374	379	PF01111	0.582
DOC_CYCLIN_RxL_1	324	332	PF00134	0.640
DOC_CYCLIN_RxL_1	72	85	PF00134	0.601
DOC_MAPK_gen_1	113	123	PF00069	0.501
DOC_MAPK_gen_1	166	176	PF00069	0.668
DOC_MAPK_gen_1	21	29	PF00069	0.544
DOC_MAPK_gen_1	325	331	PF00069	0.637
DOC_MAPK_gen_1	420	429	PF00069	0.583
DOC_MAPK_MEF2A_6	116	125	PF00069	0.546
DOC_MAPK_MEF2A_6	169	178	PF00069	0.685
DOC_MAPK_MEF2A_6	629	636	PF00069	0.524
DOC_PP1_RVXF_1	219	225	PF00149	0.669
DOC_PP1_RVXF_1	409	416	PF00149	0.468
DOC_PP4_FxxP_1	502	505	PF00568	0.626
DOC_USP7_MATH_1	111	115	PF00917	0.616
DOC_USP7_MATH_1	198	202	PF00917	0.680
DOC_USP7_MATH_1	217	221	PF00917	0.642
DOC_USP7_MATH_1	303	307	PF00917	0.644
DOC_USP7_MATH_1	46	50	PF00917	0.589
DOC_USP7_MATH_1	571	575	PF00917	0.795
DOC_USP7_MATH_1	600	604	PF00917	0.653
DOC_USP7_UBL2_3	359	363	PF12436	0.709
DOC_WW_Pin1_4	101	106	PF00397	0.684
DOC_WW_Pin1_4	151	156	PF00397	0.603
DOC_WW_Pin1_4	209	214	PF00397	0.625
DOC_WW_Pin1_4	293	298	PF00397	0.476
DOC_WW_Pin1_4	338	343	PF00397	0.593
DOC_WW_Pin1_4	373	378	PF00397	0.706
DOC_WW_Pin1_4	381	386	PF00397	0.559
DOC_WW_Pin1_4	549	554	PF00397	0.672
DOC_WW_Pin1_4	620	625	PF00397	0.713
DOC_WW_Pin1_4	668	673	PF00397	0.579
LIG_14-3-3_CanoR_1	202	211	PF00244	0.614
LIG_14-3-3_CanoR_1	300	308	PF00244	0.669
LIG_14-3-3_CanoR_1	364	371	PF00244	0.655
LIG_14-3-3_CanoR_1	569	577	PF00244	0.657
LIG_14-3-3_CanoR_1	611	618	PF00244	0.778
LIG_14-3-3_CanoR_1	62	71	PF00244	0.654
LIG_14-3-3_CanoR_1	651	656	PF00244	0.694
LIG_14-3-3_CanoR_1	694	699	PF00244	0.526
LIG_Actin_WH2_2	383	401	PF00022	0.360
LIG_APCC_ABBA_1	494	499	PF00400	0.671
LIG_BIR_II_1	1	5	PF00653	0.609
LIG_BIR_III_2	508	512	PF00653	0.696
LIG_EVH1_2	631	635	PF00568	0.518
LIG_FHA_1	120	126	PF00498	0.423
LIG_FHA_1	152	158	PF00498	0.601
LIG_FHA_1	349	355	PF00498	0.583
LIG_FHA_1	378	384	PF00498	0.694
LIG_FHA_1	546	552	PF00498	0.671
LIG_FHA_1	637	643	PF00498	0.746
LIG_FHA_2	142	148	PF00498	0.584
LIG_FHA_2	365	371	PF00498	0.607
LIG_FHA_2	426	432	PF00498	0.636
LIG_FHA_2	486	492	PF00498	0.617
LIG_FHA_2	56	62	PF00498	0.636
LIG_LIR_Apic_2	499	505	PF02991	0.600
LIG_LIR_Apic_2	533	538	PF02991	0.561
LIG_LIR_Apic_2	592	598	PF02991	0.752
LIG_LIR_Apic_2	676	680	PF02991	0.736
LIG_LIR_Gen_1	14	23	PF02991	0.569
LIG_LIR_Gen_1	607	617	PF02991	0.775
LIG_LIR_Nem_3	14	18	PF02991	0.550
LIG_LIR_Nem_3	607	612	PF02991	0.772
LIG_PDZ_Class_2	695	700	PF00595	0.504
LIG_Pex14_1	536	540	PF04695	0.693
LIG_Pex14_2	591	595	PF04695	0.760
LIG_SH2_CRK	559	563	PF00017	0.493
LIG_SH2_CRK	683	687	PF00017	0.770
LIG_SH2_NCK_1	540	544	PF00017	0.715
LIG_SH2_SRC	683	686	PF00017	0.521
LIG_SH2_STAP1	218	222	PF00017	0.530
LIG_SH2_STAP1	51	55	PF00017	0.565
LIG_SH2_STAT5	15	18	PF00017	0.574
LIG_SH2_STAT5	457	460	PF00017	0.626
LIG_SH3_3	40	46	PF00018	0.556
LIG_SH3_3	455	461	PF00018	0.659
LIG_SH3_3	497	503	PF00018	0.624
LIG_SH3_3	631	637	PF00018	0.633
LIG_SH3_3	653	659	PF00018	0.688
LIG_SUMO_SIM_anti_2	122	127	PF11976	0.531
LIG_SUMO_SIM_anti_2	25	31	PF11976	0.549
LIG_SUMO_SIM_par_1	172	177	PF11976	0.425
LIG_SUMO_SIM_par_1	423	431	PF11976	0.373
LIG_SxIP_EBH_1	635	645	PF03271	0.519
LIG_TRAF2_1	428	431	PF00917	0.520
LIG_TRAF2_1	488	491	PF00917	0.567
LIG_TRAF2_1	86	89	PF00917	0.608
LIG_TYR_ITIM	13	18	PF00017	0.577
LIG_TYR_ITIM	681	686	PF00017	0.774
MOD_CDK_SPK_2	293	298	PF00069	0.476
MOD_CDK_SPK_2	549	554	PF00069	0.663
MOD_CDK_SPxxK_3	293	300	PF00069	0.482
MOD_CDK_SPxxK_3	338	345	PF00069	0.587
MOD_CK1_1	114	120	PF00069	0.638
MOD_CK1_1	149	155	PF00069	0.651
MOD_CK1_1	201	207	PF00069	0.622
MOD_CK1_1	264	270	PF00069	0.567
MOD_CK1_1	306	312	PF00069	0.677
MOD_CK1_1	315	321	PF00069	0.491
MOD_CK1_1	341	347	PF00069	0.635
MOD_CK1_1	384	390	PF00069	0.551
MOD_CK1_1	563	569	PF00069	0.713
MOD_CK1_1	607	613	PF00069	0.675
MOD_CK1_1	619	625	PF00069	0.635
MOD_CK2_1	141	147	PF00069	0.612
MOD_CK2_1	217	223	PF00069	0.668
MOD_CK2_1	364	370	PF00069	0.477
MOD_CK2_1	403	409	PF00069	0.489
MOD_CK2_1	425	431	PF00069	0.636
MOD_CK2_1	484	490	PF00069	0.539
MOD_CK2_1	55	61	PF00069	0.632
MOD_CK2_1	576	582	PF00069	0.776
MOD_Cter_Amidation	19	22	PF01082	0.553
MOD_GlcNHglycan	116	119	PF01048	0.603
MOD_GlcNHglycan	151	154	PF01048	0.694
MOD_GlcNHglycan	206	209	PF01048	0.701
MOD_GlcNHglycan	215	218	PF01048	0.539
MOD_GlcNHglycan	263	266	PF01048	0.654
MOD_GlcNHglycan	301	304	PF01048	0.665
MOD_GlcNHglycan	335	338	PF01048	0.675
MOD_GlcNHglycan	395	398	PF01048	0.557
MOD_GlcNHglycan	400	403	PF01048	0.621
MOD_GlcNHglycan	571	574	PF01048	0.777
MOD_GlcNHglycan	618	621	PF01048	0.728
MOD_GlcNHglycan	686	689	PF01048	0.712
MOD_GSK3_1	101	108	PF00069	0.697
MOD_GSK3_1	151	158	PF00069	0.611
MOD_GSK3_1	193	200	PF00069	0.586
MOD_GSK3_1	209	216	PF00069	0.618
MOD_GSK3_1	264	271	PF00069	0.526
MOD_GSK3_1	299	306	PF00069	0.683
MOD_GSK3_1	349	356	PF00069	0.607
MOD_GSK3_1	373	380	PF00069	0.621
MOD_GSK3_1	545	552	PF00069	0.711
MOD_GSK3_1	598	605	PF00069	0.670
MOD_GSK3_1	616	623	PF00069	0.525
MOD_N-GLC_1	484	489	PF02516	0.558
MOD_N-GLC_1	668	673	PF02516	0.567
MOD_NEK2_1	193	198	PF00069	0.566
MOD_NEK2_1	255	260	PF00069	0.654
MOD_NEK2_1	290	295	PF00069	0.724
MOD_NEK2_1	398	403	PF00069	0.592
MOD_NEK2_1	484	489	PF00069	0.416
MOD_NEK2_1	55	60	PF00069	0.595
MOD_NEK2_1	604	609	PF00069	0.701
MOD_NEK2_2	439	444	PF00069	0.627
MOD_PIKK_1	560	566	PF00454	0.746
MOD_PIKK_1	610	616	PF00454	0.699
MOD_PKA_2	109	115	PF00069	0.703
MOD_PKA_2	201	207	PF00069	0.614
MOD_PKA_2	290	296	PF00069	0.668
MOD_PKA_2	299	305	PF00069	0.641
MOD_PKA_2	393	399	PF00069	0.544
MOD_PKA_2	404	410	PF00069	0.568
MOD_PKA_2	61	67	PF00069	0.610
MOD_PKA_2	610	616	PF00069	0.749
MOD_PKA_2	650	656	PF00069	0.801
MOD_Plk_1	119	125	PF00069	0.312
MOD_Plk_1	174	180	PF00069	0.626
MOD_Plk_1	193	199	PF00069	0.426
MOD_Plk_1	439	445	PF00069	0.559
MOD_Plk_1	484	490	PF00069	0.504
MOD_Plk_1	587	593	PF00069	0.700
MOD_Plk_1	99	105	PF00069	0.640
MOD_Plk_2-3	425	431	PF00069	0.375
MOD_Plk_2-3	587	593	PF00069	0.537
MOD_Plk_4	303	309	PF00069	0.722
MOD_Plk_4	349	355	PF00069	0.490
MOD_ProDKin_1	101	107	PF00069	0.682
MOD_ProDKin_1	151	157	PF00069	0.601
MOD_ProDKin_1	209	215	PF00069	0.620
MOD_ProDKin_1	293	299	PF00069	0.479
MOD_ProDKin_1	338	344	PF00069	0.592
MOD_ProDKin_1	373	379	PF00069	0.707
MOD_ProDKin_1	381	387	PF00069	0.552
MOD_ProDKin_1	549	555	PF00069	0.673
MOD_ProDKin_1	620	626	PF00069	0.714
MOD_ProDKin_1	668	674	PF00069	0.569
MOD_SUMO_rev_2	507	512	PF00179	0.447
TRG_DiLeu_BaEn_1	25	30	PF01217	0.475
TRG_DiLeu_BaEn_1	409	414	PF01217	0.530
TRG_DiLeu_BaEn_4	424	430	PF01217	0.627
TRG_ENDOCYTIC_2	15	18	PF00928	0.557
TRG_ENDOCYTIC_2	457	460	PF00928	0.595
TRG_ENDOCYTIC_2	559	562	PF00928	0.495
TRG_ENDOCYTIC_2	683	686	PF00928	0.774
TRG_ER_diArg_1	113	116	PF00400	0.672
TRG_ER_diArg_1	132	135	PF00400	0.460
TRG_ER_diArg_1	169	172	PF00400	0.686
TRG_ER_diArg_1	185	188	PF00400	0.573
TRG_ER_diArg_1	209	211	PF00400	0.650
TRG_ER_diArg_1	21	23	PF00400	0.488
TRG_ER_diArg_1	319	321	PF00400	0.638
TRG_ER_diArg_1	325	327	PF00400	0.631
TRG_ER_diArg_1	391	394	PF00400	0.556
TRG_ER_diArg_1	433	435	PF00400	0.577
TRG_ER_diArg_1	473	476	PF00400	0.455
TRG_ER_diArg_1	526	529	PF00400	0.495
TRG_ER_diArg_1	575	577	PF00400	0.780
TRG_ER_diArg_1	643	645	PF00400	0.707
TRG_ER_diArg_1	693	696	PF00400	0.537
TRG_NLS_Bipartite_1	77	95	PF00514	0.637
TRG_Pf-PMV_PEXEL_1	171	175	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	319	323	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	327	332	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	475	479	PF00026	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHI3	Leptomonas seymouri	55%	96%
A0A0S4JTQ5	Bodo saltans	29%	92%
A0A1X0NN57	Trypanosomatidae	33%	100%
A0A3R7NK16	Trypanosoma rangeli	36%	100%
A0A3S5H6B0	Leishmania donovani	74%	98%
A4HTT0	Leishmania infantum	74%	98%
D0A991	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AML3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	98%
Q4QI23	Leishmania major	74%	100%
V5BSF1	Trypanosoma cruzi	36%	100%