Ion_trans domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5I8_LEIBR

TriTrypDb:

LbrM.09.0130 , LBRM2903_090006200

Length:

159

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4H5I8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5I8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	26	30	PF00656	0.672
CLV_C14_Caspase3-7	45	49	PF00656	0.483
CLV_NRD_NRD_1	142	144	PF00675	0.581
CLV_NRD_NRD_1	147	149	PF00675	0.625
CLV_NRD_NRD_1	6	8	PF00675	0.369
CLV_NRD_NRD_1	61	63	PF00675	0.373
CLV_NRD_NRD_1	69	71	PF00675	0.373
CLV_PCSK_KEX2_1	144	146	PF00082	0.577
CLV_PCSK_KEX2_1	6	8	PF00082	0.362
CLV_PCSK_KEX2_1	61	63	PF00082	0.390
CLV_PCSK_KEX2_1	69	71	PF00082	0.352
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.640
CLV_PCSK_PC7_1	2	8	PF00082	0.407
CLV_PCSK_SKI1_1	20	24	PF00082	0.375
CLV_PCSK_SKI1_1	42	46	PF00082	0.420
CLV_PCSK_SKI1_1	6	10	PF00082	0.425
DEG_Nend_UBRbox_1	1	4	PF02207	0.480
DOC_CKS1_1	52	57	PF01111	0.688
DOC_CYCLIN_RxL_1	2	13	PF00134	0.651
DOC_MAPK_gen_1	122	130	PF00069	0.415
DOC_MAPK_MEF2A_6	122	130	PF00069	0.374
DOC_PP2B_LxvP_1	126	129	PF13499	0.396
DOC_WW_Pin1_4	51	56	PF00397	0.684
LIG_14-3-3_CanoR_1	122	127	PF00244	0.394
LIG_14-3-3_CanoR_1	20	25	PF00244	0.512
LIG_14-3-3_CanoR_1	42	48	PF00244	0.567
LIG_FHA_1	109	115	PF00498	0.359
LIG_FHA_1	123	129	PF00498	0.399
LIG_FHA_1	30	36	PF00498	0.598
LIG_FHA_2	43	49	PF00498	0.633
LIG_GBD_Chelix_1	89	97	PF00786	0.475
LIG_LIR_Nem_3	100	106	PF02991	0.372
LIG_LIR_Nem_3	120	126	PF02991	0.396
LIG_LIR_Nem_3	3	8	PF02991	0.547
LIG_LIR_Nem_3	54	59	PF02991	0.576
LIG_NRBOX	92	98	PF00104	0.449
LIG_NRP_CendR_1	157	159	PF00754	0.615
LIG_SH2_CRK	123	127	PF00017	0.415
LIG_SH2_CRK	5	9	PF00017	0.555
LIG_SH2_STAP1	106	110	PF00017	0.337
LIG_SH2_STAP1	72	76	PF00017	0.604
LIG_SH2_STAT5	110	113	PF00017	0.361
LIG_SH2_STAT5	95	98	PF00017	0.363
LIG_TRAF2_1	11	14	PF00917	0.649
MOD_CDK_SPxxK_3	51	58	PF00069	0.623
MOD_CK1_1	75	81	PF00069	0.467
MOD_Cter_Amidation	59	62	PF01082	0.374
MOD_GSK3_1	23	30	PF00069	0.507
MOD_NEK2_1	27	32	PF00069	0.517
MOD_NEK2_1	97	102	PF00069	0.427
MOD_Plk_4	13	19	PF00069	0.472
MOD_ProDKin_1	51	57	PF00069	0.623
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.445
TRG_DiLeu_BaLyEn_6	4	9	PF01217	0.529
TRG_ENDOCYTIC_2	123	126	PF00928	0.471
TRG_ENDOCYTIC_2	5	8	PF00928	0.433
TRG_ENDOCYTIC_2	95	98	PF00928	0.344
TRG_ER_diArg_1	5	7	PF00400	0.472
TRG_ER_diArg_1	61	64	PF00400	0.463
TRG_ER_diArg_1	69	71	PF00400	0.462
TRG_ER_diArg_1	83	86	PF00400	0.425
TRG_Pf-PMV_PEXEL_1	145	150	PF00026	0.592

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCG1	Leptomonas seymouri	77%	73%
A0A0S4JU75	Bodo saltans	35%	86%
A0A1X0NNG1	Trypanosomatidae	57%	80%
A0A3S7WQI9	Leishmania donovani	90%	72%
A0A422NED0	Trypanosoma rangeli	49%	79%
A4HTS9	Leishmania infantum	90%	72%
D0A990	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	80%
E9AML2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	72%
Q4QI24	Leishmania major	88%	100%
V5B321	Trypanosoma cruzi	52%	82%