Calmodulin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Calmodulin

Gene product:

flagellar pocket cytoskeletal protein bilbo1

Species:

Leishmania braziliensis

UniProt:

A4H5I7_LEIBR

TriTrypDb:

LbrM.09.0120 , LBRM2903_090006100

Length:

582

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5I7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5I7

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0030030	cell projection organization	4	1
GO:0044782	cilium organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	14
GO:0005509	calcium ion binding	5	14
GO:0043167	ion binding	2	14
GO:0043169	cation binding	3	14
GO:0046872	metal ion binding	4	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	292	296	PF00656	0.650
CLV_C14_Caspase3-7	473	477	PF00656	0.685
CLV_C14_Caspase3-7	543	547	PF00656	0.470
CLV_NRD_NRD_1	152	154	PF00675	0.664
CLV_NRD_NRD_1	261	263	PF00675	0.484
CLV_NRD_NRD_1	324	326	PF00675	0.594
CLV_NRD_NRD_1	352	354	PF00675	0.484
CLV_NRD_NRD_1	368	370	PF00675	0.522
CLV_NRD_NRD_1	474	476	PF00675	0.459
CLV_NRD_NRD_1	521	523	PF00675	0.502
CLV_PCSK_KEX2_1	152	154	PF00082	0.664
CLV_PCSK_KEX2_1	368	370	PF00082	0.537
CLV_PCSK_KEX2_1	395	397	PF00082	0.541
CLV_PCSK_KEX2_1	474	476	PF00082	0.460
CLV_PCSK_KEX2_1	521	523	PF00082	0.583
CLV_PCSK_PC1ET2_1	395	397	PF00082	0.708
CLV_PCSK_SKI1_1	179	183	PF00082	0.322
CLV_PCSK_SKI1_1	325	329	PF00082	0.430
CLV_PCSK_SKI1_1	508	512	PF00082	0.519
DEG_APCC_DBOX_1	352	360	PF00400	0.477
DEG_Nend_Nbox_1	1	3	PF02207	0.423
DEG_SCF_FBW7_1	121	128	PF00400	0.764
DEG_SPOP_SBC_1	131	135	PF00917	0.711
DOC_PP1_RVXF_1	12	18	PF00149	0.407
DOC_PP1_RVXF_1	177	183	PF00149	0.314
DOC_USP7_MATH_1	109	113	PF00917	0.608
DOC_USP7_MATH_1	125	129	PF00917	0.625
DOC_USP7_MATH_1	130	134	PF00917	0.685
DOC_USP7_MATH_1	157	161	PF00917	0.688
DOC_USP7_MATH_1	272	276	PF00917	0.574
DOC_USP7_MATH_1	282	286	PF00917	0.509
DOC_USP7_MATH_1	33	37	PF00917	0.572
DOC_USP7_MATH_1	571	575	PF00917	0.614
DOC_USP7_UBL2_3	350	354	PF12436	0.616
DOC_USP7_UBL2_3	96	100	PF12436	0.565
DOC_WW_Pin1_4	121	126	PF00397	0.727
DOC_WW_Pin1_4	170	175	PF00397	0.661
LIG_14-3-3_CanoR_1	129	138	PF00244	0.793
LIG_14-3-3_CanoR_1	228	237	PF00244	0.385
LIG_14-3-3_CanoR_1	32	38	PF00244	0.565
LIG_14-3-3_CanoR_1	445	454	PF00244	0.543
LIG_APCC_ABBA_1	60	65	PF00400	0.382
LIG_APCC_ABBAyCdc20_2	59	65	PF00400	0.388
LIG_BIR_III_2	171	175	PF00653	0.597
LIG_BRCT_BRCA1_1	251	255	PF00533	0.394
LIG_FHA_1	160	166	PF00498	0.755
LIG_FHA_1	188	194	PF00498	0.383
LIG_FHA_1	243	249	PF00498	0.343
LIG_FHA_2	211	217	PF00498	0.343
LIG_FHA_2	300	306	PF00498	0.417
LIG_FHA_2	43	49	PF00498	0.645
LIG_FHA_2	526	532	PF00498	0.531
LIG_LIR_Gen_1	230	238	PF02991	0.306
LIG_LIR_Gen_1	68	74	PF02991	0.513
LIG_LIR_Gen_1	80	90	PF02991	0.469
LIG_LIR_Nem_3	230	234	PF02991	0.306
LIG_LIR_Nem_3	235	240	PF02991	0.357
LIG_LIR_Nem_3	68	73	PF02991	0.525
LIG_LIR_Nem_3	80	85	PF02991	0.469
LIG_LYPXL_S_1	240	244	PF13949	0.387
LIG_LYPXL_yS_3	241	244	PF13949	0.371
LIG_Pex14_2	17	21	PF04695	0.393
LIG_Pex14_2	198	202	PF04695	0.385
LIG_RPA_C_Fungi	481	493	PF08784	0.544
LIG_SH2_CRK	82	86	PF00017	0.463
LIG_SH2_STAT3	86	89	PF00017	0.376
LIG_SH2_STAT5	141	144	PF00017	0.687
LIG_SH2_STAT5	249	252	PF00017	0.397
LIG_SH2_STAT5	562	565	PF00017	0.622
LIG_SH2_STAT5	82	85	PF00017	0.417
LIG_SH3_3	148	154	PF00018	0.761
LIG_SH3_3	19	25	PF00018	0.456
LIG_SH3_3	87	93	PF00018	0.485
LIG_SH3_3	98	104	PF00018	0.546
LIG_Sin3_3	370	377	PF02671	0.639
LIG_SUMO_SIM_par_1	190	197	PF11976	0.354
LIG_TRAF2_1	173	176	PF00917	0.495
LIG_TRAF2_1	26	29	PF00917	0.435
MOD_CDK_SPxxK_3	170	177	PF00069	0.633
MOD_CK1_1	20	26	PF00069	0.507
MOD_CK1_1	210	216	PF00069	0.341
MOD_CK1_1	275	281	PF00069	0.564
MOD_CK1_1	36	42	PF00069	0.408
MOD_CK1_1	360	366	PF00069	0.458
MOD_CK1_1	557	563	PF00069	0.492
MOD_CK2_1	170	176	PF00069	0.552
MOD_CK2_1	227	233	PF00069	0.331
MOD_CK2_1	23	29	PF00069	0.488
MOD_CK2_1	42	48	PF00069	0.382
MOD_CK2_1	525	531	PF00069	0.467
MOD_GlcNHglycan	117	120	PF01048	0.757
MOD_GlcNHglycan	125	128	PF01048	0.745
MOD_GlcNHglycan	147	150	PF01048	0.790
MOD_GlcNHglycan	210	213	PF01048	0.371
MOD_GlcNHglycan	297	300	PF01048	0.544
MOD_GlcNHglycan	35	38	PF01048	0.511
MOD_GlcNHglycan	448	451	PF01048	0.466
MOD_GlcNHglycan	458	461	PF01048	0.495
MOD_GSK3_1	103	110	PF00069	0.583
MOD_GSK3_1	115	122	PF00069	0.701
MOD_GSK3_1	139	146	PF00069	0.698
MOD_GSK3_1	295	302	PF00069	0.492
MOD_GSK3_1	33	40	PF00069	0.498
MOD_GSK3_1	550	557	PF00069	0.492
MOD_GSK3_1	558	565	PF00069	0.481
MOD_GSK3_1	569	576	PF00069	0.535
MOD_NEK2_1	115	120	PF00069	0.764
MOD_NEK2_1	17	22	PF00069	0.363
MOD_NEK2_1	207	212	PF00069	0.370
MOD_NEK2_1	55	60	PF00069	0.531
MOD_NEK2_2	562	567	PF00069	0.390
MOD_PIKK_1	525	531	PF00454	0.467
MOD_PIKK_1	95	101	PF00454	0.539
MOD_PKA_2	227	233	PF00069	0.385
MOD_PKA_2	23	29	PF00069	0.469
MOD_PKA_2	31	37	PF00069	0.561
MOD_PKA_2	360	366	PF00069	0.569
MOD_PKA_2	544	550	PF00069	0.476
MOD_Plk_1	17	23	PF00069	0.382
MOD_Plk_1	275	281	PF00069	0.607
MOD_Plk_1	530	536	PF00069	0.587
MOD_Plk_1	557	563	PF00069	0.415
MOD_Plk_4	558	564	PF00069	0.406
MOD_ProDKin_1	121	127	PF00069	0.727
MOD_ProDKin_1	170	176	PF00069	0.657
MOD_SUMO_for_1	434	437	PF00179	0.611
MOD_SUMO_rev_2	171	178	PF00179	0.468
MOD_SUMO_rev_2	183	190	PF00179	0.300
MOD_SUMO_rev_2	376	384	PF00179	0.544
MOD_SUMO_rev_2	392	397	PF00179	0.554
MOD_SUMO_rev_2	546	556	PF00179	0.487
MOD_SUMO_rev_2	64	68	PF00179	0.509
TRG_ENDOCYTIC_2	231	234	PF00928	0.392
TRG_ENDOCYTIC_2	241	244	PF00928	0.387
TRG_ENDOCYTIC_2	82	85	PF00928	0.465
TRG_ER_diArg_1	151	153	PF00400	0.688
TRG_ER_diArg_1	521	524	PF00400	0.582
TRG_ER_diArg_1	539	542	PF00400	0.347
TRG_Pf-PMV_PEXEL_1	315	320	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	508	512	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	524	529	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	532	536	PF00026	0.428

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II86	Leptomonas seymouri	82%	99%
A0A0S4JFD7	Bodo saltans	33%	95%
A0A0S4JWH7	Bodo saltans	50%	98%
A0A0S4KKB4	Bodo saltans	24%	85%
A0A1X0NMV7	Trypanosomatidae	57%	98%
A0A3R7KQJ5	Trypanosoma rangeli	25%	100%
A0A3S5H6A9	Leishmania donovani	92%	100%
A0A3S7X1F4	Leishmania donovani	24%	100%
A0A422NE50	Trypanosoma rangeli	54%	100%
A4HGH2	Leishmania braziliensis	26%	100%
A4HTS8	Leishmania infantum	92%	100%
A4I3K4	Leishmania infantum	24%	100%
D0A836	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
D0A989	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	99%
E9AML1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9AZU4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
Q4Q8E1	Leishmania major	24%	100%
Q4QI25	Leishmania major	92%	100%
V5DJB6	Trypanosoma cruzi	56%	90%