RNA-binding protein 5-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein 5-like protein

Species:

Leishmania braziliensis

UniProt:

A4H5I5_LEIBR

TriTrypDb:

LbrM.09.0100 , LBRM2903_090005900

Length:

244

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4H5I5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5I5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	93	95	PF00675	0.468
CLV_PCSK_KEX2_1	93	95	PF00082	0.453
CLV_PCSK_PC7_1	89	95	PF00082	0.367
DEG_SIAH_1	161	169	PF03145	0.577
DOC_CKS1_1	107	112	PF01111	0.608
DOC_CYCLIN_yCln2_LP_2	107	113	PF00134	0.609
DOC_USP7_MATH_1	118	122	PF00917	0.568
DOC_USP7_MATH_1	133	137	PF00917	0.428
DOC_USP7_MATH_1	53	57	PF00917	0.444
DOC_USP7_MATH_1	97	101	PF00917	0.481
DOC_WW_Pin1_4	106	111	PF00397	0.745
DOC_WW_Pin1_4	113	118	PF00397	0.649
DOC_WW_Pin1_4	174	179	PF00397	0.618
DOC_WW_Pin1_4	37	42	PF00397	0.470
DOC_WW_Pin1_4	6	11	PF00397	0.477
LIG_14-3-3_CanoR_1	44	51	PF00244	0.446
LIG_14-3-3_CanoR_1	52	62	PF00244	0.444
LIG_APCC_ABBA_1	64	69	PF00400	0.478
LIG_BRCT_BRCA1_1	99	103	PF00533	0.456
LIG_BRCT_BRCA1_2	99	105	PF00533	0.537
LIG_EVH1_2	157	161	PF00568	0.438
LIG_LIR_Gen_1	100	111	PF02991	0.510
LIG_LIR_Gen_1	160	171	PF02991	0.534
LIG_LIR_Gen_1	204	214	PF02991	0.706
LIG_LIR_Nem_3	100	106	PF02991	0.486
LIG_LIR_Nem_3	160	166	PF02991	0.527
LIG_LIR_Nem_3	184	188	PF02991	0.609
LIG_LIR_Nem_3	204	209	PF02991	0.704
LIG_LIR_Nem_3	37	42	PF02991	0.456
LIG_LIR_Nem_3	59	65	PF02991	0.463
LIG_MAD2	105	113	PF02301	0.604
LIG_SH2_CRK	130	134	PF00017	0.429
LIG_SH2_CRK	163	167	PF00017	0.538
LIG_SH2_CRK	185	189	PF00017	0.543
LIG_SH2_CRK	226	230	PF00017	0.417
LIG_SH2_CRK	42	46	PF00017	0.444
LIG_SH2_CRK	62	66	PF00017	0.444
LIG_SH2_NCK_1	130	134	PF00017	0.517
LIG_SH2_NCK_1	163	167	PF00017	0.602
LIG_SH2_SRC	163	166	PF00017	0.604
LIG_SH2_STAP1	142	146	PF00017	0.578
LIG_SH2_STAP1	163	167	PF00017	0.530
LIG_SH2_STAT3	171	174	PF00017	0.529
LIG_SH2_STAT5	130	133	PF00017	0.566
LIG_SH2_STAT5	22	25	PF00017	0.478
LIG_SH3_3	107	113	PF00018	0.609
LIG_SH3_3	225	231	PF00018	0.631
LIG_SUMO_SIM_par_1	226	232	PF11976	0.414
MOD_CDK_SPxxK_3	37	44	PF00069	0.444
MOD_CK1_1	204	210	PF00069	0.477
MOD_CK1_1	56	62	PF00069	0.444
MOD_CK2_1	68	74	PF00069	0.490
MOD_GlcNHglycan	135	138	PF01048	0.507
MOD_GlcNHglycan	197	200	PF01048	0.534
MOD_GlcNHglycan	214	217	PF01048	0.568
MOD_GlcNHglycan	46	49	PF01048	0.270
MOD_GSK3_1	11	18	PF00069	0.501
MOD_GSK3_1	112	119	PF00069	0.720
MOD_GSK3_1	177	184	PF00069	0.634
MOD_GSK3_1	2	9	PF00069	0.558
MOD_GSK3_1	22	29	PF00069	0.512
MOD_GSK3_1	97	104	PF00069	0.487
MOD_N-GLC_1	181	186	PF02516	0.524
MOD_NEK2_1	101	106	PF00069	0.556
MOD_NEK2_1	128	133	PF00069	0.651
MOD_NEK2_1	15	20	PF00069	0.541
MOD_PIKK_1	116	122	PF00454	0.614
MOD_Plk_1	11	17	PF00069	0.552
MOD_Plk_1	181	187	PF00069	0.472
MOD_Plk_1	97	103	PF00069	0.534
MOD_Plk_4	123	129	PF00069	0.611
MOD_ProDKin_1	106	112	PF00069	0.745
MOD_ProDKin_1	113	119	PF00069	0.648
MOD_ProDKin_1	174	180	PF00069	0.618
MOD_ProDKin_1	37	43	PF00069	0.470
MOD_ProDKin_1	6	12	PF00069	0.469
TRG_ENDOCYTIC_2	163	166	PF00928	0.539
TRG_ENDOCYTIC_2	185	188	PF00928	0.591
TRG_ENDOCYTIC_2	226	229	PF00928	0.602
TRG_ENDOCYTIC_2	42	45	PF00928	0.444
TRG_ENDOCYTIC_2	62	65	PF00928	0.444
TRG_ER_diArg_1	92	94	PF00400	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P379	Leptomonas seymouri	45%	100%
A0A3S5H6A8	Leishmania donovani	81%	100%
A4HTS6	Leishmania infantum	81%	100%
B5DF91	Rattus norvegicus	27%	75%
E9AMK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
P70372	Mus musculus	27%	75%
Q15717	Homo sapiens	27%	75%
Q4QI27	Leishmania major	81%	100%
Q5U259	Xenopus laevis	27%	75%
Q6GLB5	Xenopus tropicalis	25%	75%