Endonuclease III homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endonuclease III, putative

Species:

Leishmania braziliensis

UniProt:

A4H5I2_LEIBR

TriTrypDb:

LbrM.09.0070 , LBRM2903_090005600

Length:

259

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0005739	mitochondrion	5	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4H5I2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5I2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006259	DNA metabolic process	4	11
GO:0006285	base-excision repair, AP site formation	5	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:0006296	obsolete nucleotide-excision repair, DNA incision, 5'-to lesion	7	1
GO:0033683	obsolete nucleotide-excision repair, DNA incision	6	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1

Molecular functions
Term	Name	Level	Count
GO:0000702	oxidized base lesion DNA N-glycosylase activity	5	11
GO:0000703	oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity	6	11
GO:0003676	nucleic acid binding	3	11
GO:0003677	DNA binding	4	11
GO:0003824	catalytic activity	1	11
GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	4	11
GO:0004518	nuclease activity	4	11
GO:0004519	endonuclease activity	5	11
GO:0005488	binding	1	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	11
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	4	11
GO:0016829	lyase activity	2	11
GO:0016835	carbon-oxygen lyase activity	3	11
GO:0019104	DNA N-glycosylase activity	4	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0051536	iron-sulfur cluster binding	3	11
GO:0051539	4 iron, 4 sulfur cluster binding	4	11
GO:0051540	metal cluster binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:0140078	class I DNA-(apurinic or apyrimidinic site) endonuclease activity	4	11
GO:0140097	catalytic activity, acting on DNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	69	73	PF00656	0.381
CLV_NRD_NRD_1	182	184	PF00675	0.246
CLV_NRD_NRD_1	22	24	PF00675	0.442
CLV_NRD_NRD_1	246	248	PF00675	0.667
CLV_NRD_NRD_1	256	258	PF00675	0.664
CLV_PCSK_KEX2_1	246	248	PF00082	0.617
CLV_PCSK_KEX2_1	255	257	PF00082	0.644
CLV_PCSK_KEX2_1	76	78	PF00082	0.278
CLV_PCSK_PC1ET2_1	255	257	PF00082	0.644
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.278
CLV_PCSK_SKI1_1	107	111	PF00082	0.251
CLV_PCSK_SKI1_1	183	187	PF00082	0.258
CLV_PCSK_SKI1_1	24	28	PF00082	0.547
CLV_PCSK_SKI1_1	77	81	PF00082	0.301
DEG_SCF_FBW7_1	176	182	PF00400	0.472
DEG_SPOP_SBC_1	86	90	PF00917	0.367
DOC_ANK_TNKS_1	151	158	PF00023	0.538
DOC_CKS1_1	176	181	PF01111	0.472
DOC_CKS1_1	209	214	PF01111	0.393
DOC_CYCLIN_RxL_1	18	31	PF00134	0.272
DOC_MAPK_gen_1	107	117	PF00069	0.468
DOC_MAPK_MEF2A_6	49	58	PF00069	0.345
DOC_PP1_RVXF_1	96	102	PF00149	0.458
DOC_PP2B_LxvP_1	26	29	PF13499	0.406
DOC_PP4_FxxP_1	6	9	PF00568	0.422
DOC_USP7_MATH_1	185	189	PF00917	0.476
DOC_USP7_UBL2_3	255	259	PF12436	0.727
DOC_WW_Pin1_4	175	180	PF00397	0.458
DOC_WW_Pin1_4	208	213	PF00397	0.362
DOC_WW_Pin1_4	4	9	PF00397	0.564
LIG_14-3-3_CanoR_1	164	172	PF00244	0.510
LIG_14-3-3_CanoR_1	49	54	PF00244	0.458
LIG_14-3-3_CanoR_1	77	84	PF00244	0.408
LIG_BIR_II_1	1	5	PF00653	0.447
LIG_deltaCOP1_diTrp_1	187	195	PF00928	0.458
LIG_FHA_1	151	157	PF00498	0.381
LIG_FHA_1	60	66	PF00498	0.566
LIG_FHA_1	87	93	PF00498	0.437
LIG_FHA_2	176	182	PF00498	0.472
LIG_FHA_2	67	73	PF00498	0.529
LIG_FHA_2	86	92	PF00498	0.504
LIG_LIR_Apic_2	5	9	PF02991	0.582
LIG_LIR_Gen_1	10	19	PF02991	0.377
LIG_LIR_Gen_1	127	135	PF02991	0.472
LIG_LIR_Nem_3	10	15	PF02991	0.402
LIG_LIR_Nem_3	127	131	PF02991	0.458
LIG_LIR_Nem_3	166	172	PF02991	0.488
LIG_LYPXL_L_2	213	222	PF13949	0.279
LIG_Pex14_1	12	16	PF04695	0.377
LIG_PTB_Apo_2	140	147	PF02174	0.561
LIG_SH2_STAP1	128	132	PF00017	0.472
LIG_SH3_3	173	179	PF00018	0.458
LIG_SH3_3	206	212	PF00018	0.374
LIG_SUMO_SIM_anti_2	52	59	PF11976	0.423
LIG_UBA3_1	15	24	PF00899	0.512
MOD_CK1_1	2	8	PF00069	0.462
MOD_CK1_1	59	65	PF00069	0.485
MOD_CK2_1	85	91	PF00069	0.546
MOD_GlcNHglycan	58	61	PF01048	0.258
MOD_GSK3_1	171	178	PF00069	0.473
MOD_GSK3_1	237	244	PF00069	0.721
MOD_NEK2_1	101	106	PF00069	0.435
MOD_NEK2_1	205	210	PF00069	0.335
MOD_NEK2_1	56	61	PF00069	0.482
MOD_PIKK_1	163	169	PF00454	0.510
MOD_PKA_2	163	169	PF00069	0.488
MOD_Plk_4	185	191	PF00069	0.472
MOD_Plk_4	197	203	PF00069	0.509
MOD_Plk_4	49	55	PF00069	0.424
MOD_ProDKin_1	175	181	PF00069	0.458
MOD_ProDKin_1	208	214	PF00069	0.372
MOD_ProDKin_1	4	10	PF00069	0.564
TRG_DiLeu_BaEn_1	127	132	PF01217	0.533
TRG_DiLeu_BaEn_4	129	135	PF01217	0.381
TRG_ENDOCYTIC_2	128	131	PF00928	0.458
TRG_ENDOCYTIC_2	169	172	PF00928	0.561
TRG_ER_diArg_1	256	258	PF00400	0.608
TRG_NLS_MonoCore_2	253	258	PF00514	0.711
TRG_NLS_MonoExtC_3	254	259	PF00514	0.644
TRG_NLS_MonoExtN_4	252	259	PF00514	0.528
TRG_Pf-PMV_PEXEL_1	77	82	PF00026	0.294

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0C0	Leptomonas seymouri	66%	95%
A0A0S4JYX2	Bodo saltans	50%	98%
A0A1X0NPD2	Trypanosomatidae	59%	100%
A0A3S5IR15	Trypanosoma rangeli	58%	99%
A0A3S7WQG8	Leishmania donovani	86%	100%
A0R567	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	31%	88%
A4HTS3	Leishmania infantum	86%	100%
A7M7B9	Gallus gallus	51%	92%
B9DFZ0	Arabidopsis thaliana	44%	67%
D0A983	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9AMK6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
O05956	Rickettsia prowazekii (strain Madrid E)	31%	100%
O35980	Mus musculus	48%	86%
O83754	Treponema pallidum (strain Nichols)	31%	100%
P0AB83	Escherichia coli (strain K12)	29%	100%
P0AB84	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	29%	100%
P39788	Bacillus subtilis (strain 168)	33%	100%
P44319	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	32%	100%
P46303	Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230)	33%	93%
P54137	Caenorhabditis elegans	46%	87%
P57219	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	29%	100%
P57617	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	24%	74%
P63541	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	34%	100%
P73715	Synechocystis sp. (strain PCC 6803 / Kazusa)	34%	100%
P78549	Homo sapiens	48%	83%
P83847	Geobacillus stearothermophilus	25%	71%
P9WQ08	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	29%	85%
P9WQ09	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	29%	85%
P9WQ10	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	34%	100%
P9WQ11	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	34%	100%
Q08214	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	68%
Q09907	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	47%	73%
Q2KID2	Bos taurus	48%	85%
Q4QI30	Leishmania major	85%	100%
Q4UK93	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	34%	100%
Q58030	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	40%	75%
Q68W04	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	33%	100%
Q89A45	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	25%	74%
Q89AW4	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	33%	100%
Q8KA16	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	30%	100%
Q8SRB8	Encephalitozoon cuniculi (strain GB-M1)	41%	100%
Q92GH4	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	32%	100%
Q9CB92	Mycobacterium leprae (strain TN)	30%	100%
Q9SIC4	Arabidopsis thaliana	42%	68%
Q9WYK0	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	39%	100%
Q9YDP0	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	25%	100%
V5BMU8	Trypanosoma cruzi	61%	100%