N-acetylglucosaminylphosphatidylinositol deacetylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase

Species:

Leishmania braziliensis

UniProt:

A4H5I1_LEIBR

TriTrypDb:

LbrM.09.0060 , LBRM2903_090005500

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	12
GO:0016020	membrane	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4H5I1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5I1

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	12
GO:0006505	GPI anchor metabolic process	6	12
GO:0006506	GPI anchor biosynthetic process	6	12
GO:0006629	lipid metabolic process	3	12
GO:0006643	membrane lipid metabolic process	4	12
GO:0006644	phospholipid metabolic process	4	12
GO:0006650	glycerophospholipid metabolic process	5	12
GO:0006661	phosphatidylinositol biosynthetic process	6	12
GO:0006664	glycolipid metabolic process	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008610	lipid biosynthetic process	4	12
GO:0008654	phospholipid biosynthetic process	5	12
GO:0009058	biosynthetic process	2	12
GO:0009247	glycolipid biosynthetic process	5	12
GO:0009987	cellular process	1	12
GO:0019538	protein metabolic process	3	12
GO:0019637	organophosphate metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044255	cellular lipid metabolic process	3	12
GO:0045017	glycerolipid biosynthetic process	4	12
GO:0046467	membrane lipid biosynthetic process	4	12
GO:0046474	glycerophospholipid biosynthetic process	5	12
GO:0046486	glycerolipid metabolic process	4	12
GO:0046488	phosphatidylinositol metabolic process	6	12
GO:0071704	organic substance metabolic process	2	12
GO:0090407	organophosphate biosynthetic process	4	12
GO:1901135	carbohydrate derivative metabolic process	3	12
GO:1901137	carbohydrate derivative biosynthetic process	4	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901576	organic substance biosynthetic process	3	12
GO:1903509	liposaccharide metabolic process	4	12

Molecular functions
Term	Name	Level	Count
GO:0000225	N-acetylglucosaminylphosphatidylinositol deacetylase activity	4	12
GO:0003824	catalytic activity	1	12
GO:0016787	hydrolase activity	2	12
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	12
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	12
GO:0019213	deacetylase activity	3	12
GO:0005488	binding	1	1
GO:0008270	zinc ion binding	6	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.472
CLV_NRD_NRD_1	120	122	PF00675	0.323
CLV_NRD_NRD_1	220	222	PF00675	0.346
CLV_NRD_NRD_1	95	97	PF00675	0.308
CLV_PCSK_KEX2_1	120	122	PF00082	0.323
CLV_PCSK_KEX2_1	95	97	PF00082	0.308
CLV_PCSK_SKI1_1	158	162	PF00082	0.320
CLV_PCSK_SKI1_1	176	180	PF00082	0.193
CLV_PCSK_SKI1_1	231	235	PF00082	0.239
DEG_APCC_KENBOX_2	160	164	PF00400	0.526
DOC_AGCK_PIF_1	237	242	PF00069	0.254
DOC_CKS1_1	48	53	PF01111	0.508
DOC_MAPK_gen_1	57	65	PF00069	0.472
DOC_MAPK_MEF2A_6	32	39	PF00069	0.464
DOC_MAPK_MEF2A_6	57	65	PF00069	0.472
DOC_PP1_RVXF_1	174	181	PF00149	0.587
DOC_PP4_FxxP_1	48	51	PF00568	0.463
DOC_USP7_MATH_1	213	217	PF00917	0.462
DOC_USP7_MATH_1	27	31	PF00917	0.522
DOC_USP7_UBL2_3	78	82	PF12436	0.508
DOC_WW_Pin1_4	112	117	PF00397	0.451
DOC_WW_Pin1_4	47	52	PF00397	0.415
LIG_14-3-3_CanoR_1	174	179	PF00244	0.511
LIG_14-3-3_CanoR_1	201	205	PF00244	0.503
LIG_14-3-3_CanoR_1	221	230	PF00244	0.398
LIG_14-3-3_CanoR_1	60	64	PF00244	0.451
LIG_Actin_WH2_2	6	24	PF00022	0.268
LIG_BRCT_BRCA1_1	176	180	PF00533	0.485
LIG_BRCT_BRCA1_1	86	90	PF00533	0.451
LIG_CaM_IQ_9	168	183	PF13499	0.543
LIG_CSL_BTD_1	113	116	PF09270	0.451
LIG_FHA_1	200	206	PF00498	0.524
LIG_FHA_1	48	54	PF00498	0.508
LIG_FHA_1	60	66	PF00498	0.508
LIG_GBD_Chelix_1	11	19	PF00786	0.337
LIG_IRF3_LxIS_1	17	24	PF10401	0.162
LIG_LIR_Apic_2	45	51	PF02991	0.439
LIG_LIR_Gen_1	202	211	PF02991	0.527
LIG_LIR_Gen_1	212	220	PF02991	0.432
LIG_LIR_Gen_1	225	235	PF02991	0.359
LIG_LIR_Gen_1	238	246	PF02991	0.266
LIG_LIR_Nem_3	138	142	PF02991	0.508
LIG_LIR_Nem_3	177	183	PF02991	0.515
LIG_LIR_Nem_3	202	207	PF02991	0.496
LIG_LIR_Nem_3	225	230	PF02991	0.446
LIG_LIR_Nem_3	238	243	PF02991	0.270
LIG_LIR_Nem_3	87	93	PF02991	0.464
LIG_NRBOX	12	18	PF00104	0.388
LIG_PALB2_WD40_1	225	233	PF16756	0.405
LIG_PCNA_yPIPBox_3	107	121	PF02747	0.399
LIG_PDZ_Class_3	244	249	PF00595	0.338
LIG_Pex14_2	230	234	PF04695	0.239
LIG_PTB_Apo_2	67	74	PF02174	0.429
LIG_PTB_Phospho_1	67	73	PF10480	0.447
LIG_SH2_CRK	240	244	PF00017	0.264
LIG_SH2_GRB2like	242	245	PF00017	0.229
LIG_SH2_PTP2	182	185	PF00017	0.506
LIG_SH2_STAT5	182	185	PF00017	0.496
LIG_SH2_STAT5	191	194	PF00017	0.487
LIG_SH2_STAT5	232	235	PF00017	0.264
LIG_SH2_STAT5	240	243	PF00017	0.423
LIG_SH3_3	110	116	PF00018	0.530
LIG_SH3_3	204	210	PF00018	0.553
LIG_Sin3_3	204	211	PF02671	0.481
LIG_SUMO_SIM_anti_2	202	209	PF11976	0.481
LIG_SUMO_SIM_anti_2	3	8	PF11976	0.401
LIG_SUMO_SIM_anti_2	33	40	PF11976	0.352
LIG_UBA3_1	15	22	PF00899	0.304
LIG_WRC_WIRS_1	136	141	PF05994	0.405
MOD_CK1_1	195	201	PF00069	0.608
MOD_CK1_1	238	244	PF00069	0.254
MOD_CK1_1	30	36	PF00069	0.507
MOD_CK2_1	209	215	PF00069	0.598
MOD_GlcNHglycan	144	147	PF01048	0.272
MOD_GlcNHglycan	197	200	PF01048	0.353
MOD_GlcNHglycan	211	214	PF01048	0.323
MOD_GlcNHglycan	86	89	PF01048	0.222
MOD_GSK3_1	131	138	PF00069	0.514
MOD_GSK3_1	193	200	PF00069	0.590
MOD_GSK3_1	209	216	PF00069	0.422
MOD_GSK3_1	26	33	PF00069	0.515
MOD_N-GLC_1	131	136	PF02516	0.299
MOD_NEK2_1	193	198	PF00069	0.610
MOD_NEK2_1	21	26	PF00069	0.494
MOD_NEK2_1	52	57	PF00069	0.447
MOD_NEK2_1	66	71	PF00069	0.360
MOD_NEK2_1	84	89	PF00069	0.405
MOD_NEK2_2	27	32	PF00069	0.532
MOD_PIKK_1	222	228	PF00454	0.376
MOD_PKA_2	200	206	PF00069	0.500
MOD_PKA_2	59	65	PF00069	0.451
MOD_Plk_1	131	137	PF00069	0.463
MOD_Plk_4	122	128	PF00069	0.481
MOD_Plk_4	132	138	PF00069	0.448
MOD_Plk_4	2	8	PF00069	0.205
MOD_Plk_4	200	206	PF00069	0.513
MOD_Plk_4	238	244	PF00069	0.282
MOD_ProDKin_1	112	118	PF00069	0.451
MOD_ProDKin_1	47	53	PF00069	0.415
TRG_DiLeu_BaLyEn_6	48	53	PF01217	0.429
TRG_ENDOCYTIC_2	182	185	PF00928	0.466
TRG_ENDOCYTIC_2	232	235	PF00928	0.239
TRG_ENDOCYTIC_2	240	243	PF00928	0.249
TRG_ENDOCYTIC_2	73	76	PF00928	0.451
TRG_ER_diArg_1	119	121	PF00400	0.523
TRG_ER_diArg_1	173	176	PF00400	0.471
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.383

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1P5	Leptomonas seymouri	68%	100%
A0A0S4JQJ0	Bodo saltans	52%	100%
A0A1X0NPJ2	Trypanosomatidae	60%	100%
A0A3R7NBF4	Trypanosoma rangeli	54%	99%
A0A3S5H6A6	Leishmania donovani	91%	100%
A4HTS2	Leishmania infantum	92%	100%
A6QQ24	Bos taurus	38%	98%
D0A982	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	91%
D4B4K9	Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)	27%	74%
E9AMK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O35790	Rattus norvegicus	37%	99%
P23797	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	82%
Q54C64	Dictyostelium discoideum	32%	97%
Q5SX19	Mus musculus	37%	99%
Q8I8A4	Leishmania major	91%	100%
Q9HDW9	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	100%
Q9Y2B2	Homo sapiens	34%	99%
V5DJB0	Trypanosoma cruzi	56%	99%