Peroxisomal membrane protein PEX16

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Peroxisomal biogenesis factor 11 (PEX11), putative

Species:

Leishmania braziliensis

UniProt:

A4H5I0_LEIBR

TriTrypDb:

LbrM.09.0050 , LBRM2903_090005400

Length:

379

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005778	peroxisomal membrane	6	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0031903	microbody membrane	5	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H5I0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5I0

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	10
GO:0009987	cellular process	1	10
GO:0016043	cellular component organization	3	10
GO:0016559	peroxisome fission	6	10
GO:0032535	regulation of cellular component size	4	1
GO:0044375	regulation of peroxisome size	5	1
GO:0048285	organelle fission	5	10
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071840	cellular component organization or biogenesis	2	10
GO:0090066	regulation of anatomical structure size	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	144	146	PF00675	0.482
CLV_NRD_NRD_1	283	285	PF00675	0.466
CLV_NRD_NRD_1	86	88	PF00675	0.518
CLV_PCSK_KEX2_1	144	146	PF00082	0.482
CLV_PCSK_KEX2_1	283	285	PF00082	0.464
CLV_PCSK_KEX2_1	85	87	PF00082	0.512
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.398
CLV_PCSK_SKI1_1	100	104	PF00082	0.457
CLV_PCSK_SKI1_1	144	148	PF00082	0.437
CLV_PCSK_SKI1_1	195	199	PF00082	0.514
CLV_PCSK_SKI1_1	201	205	PF00082	0.321
CLV_PCSK_SKI1_1	213	217	PF00082	0.422
CLV_PCSK_SKI1_1	338	342	PF00082	0.429
CLV_PCSK_SKI1_1	89	93	PF00082	0.483
DEG_APCC_DBOX_1	229	237	PF00400	0.484
DEG_APCC_DBOX_1	97	105	PF00400	0.471
DEG_MDM2_SWIB_1	327	334	PF02201	0.396
DEG_Nend_Nbox_1	1	3	PF02207	0.414
DEG_SPOP_SBC_1	53	57	PF00917	0.396
DOC_CYCLIN_RxL_1	192	202	PF00134	0.463
DOC_CYCLIN_RxL_1	85	94	PF00134	0.476
DOC_MAPK_DCC_7	230	238	PF00069	0.442
DOC_MAPK_gen_1	132	140	PF00069	0.603
DOC_MAPK_MEF2A_6	165	174	PF00069	0.451
DOC_MAPK_MEF2A_6	230	238	PF00069	0.392
DOC_MAPK_MEF2A_6	338	347	PF00069	0.393
DOC_PP1_RVXF_1	110	116	PF00149	0.605
DOC_PP1_RVXF_1	193	200	PF00149	0.515
DOC_USP7_MATH_1	52	56	PF00917	0.395
DOC_USP7_MATH_2	126	132	PF00917	0.600
DOC_USP7_UBL2_3	281	285	PF12436	0.568
DOC_USP7_UBL2_3	295	299	PF12436	0.562
LIG_14-3-3_CanoR_1	158	164	PF00244	0.438
LIG_14-3-3_CanoR_1	284	294	PF00244	0.405
LIG_14-3-3_CanoR_1	373	378	PF00244	0.462
LIG_14-3-3_CanoR_1	54	60	PF00244	0.680
LIG_Actin_WH2_2	279	297	PF00022	0.396
LIG_AP2alpha_1	2	6	PF02296	0.415
LIG_BRCT_BRCA1_1	116	120	PF00533	0.574
LIG_BRCT_BRCA1_1	29	33	PF00533	0.379
LIG_deltaCOP1_diTrp_1	321	331	PF00928	0.358
LIG_EH_1	76	80	PF12763	0.532
LIG_FHA_1	235	241	PF00498	0.407
LIG_FHA_1	242	248	PF00498	0.385
LIG_FHA_1	54	60	PF00498	0.511
LIG_FHA_2	287	293	PF00498	0.701
LIG_FHA_2	323	329	PF00498	0.593
LIG_FHA_2	59	65	PF00498	0.618
LIG_GBD_Chelix_1	180	188	PF00786	0.410
LIG_LIR_Gen_1	128	138	PF02991	0.511
LIG_LIR_Gen_1	155	164	PF02991	0.424
LIG_LIR_Gen_1	267	276	PF02991	0.416
LIG_LIR_Gen_1	317	327	PF02991	0.461
LIG_LIR_Gen_1	328	339	PF02991	0.383
LIG_LIR_Nem_3	267	273	PF02991	0.423
LIG_LIR_Nem_3	274	279	PF02991	0.443
LIG_LIR_Nem_3	317	322	PF02991	0.474
LIG_LIR_Nem_3	328	334	PF02991	0.392
LIG_LIR_Nem_3	342	347	PF02991	0.401
LIG_NRBOX	87	93	PF00104	0.509
LIG_PCNA_PIPBox_1	146	155	PF02747	0.574
LIG_Pex14_1	179	183	PF04695	0.414
LIG_Pex14_1	45	49	PF04695	0.398
LIG_Pex14_2	152	156	PF04695	0.426
LIG_Pex14_2	199	203	PF04695	0.382
LIG_Pex14_2	2	6	PF04695	0.558
LIG_Pex14_2	29	33	PF04695	0.379
LIG_Pex14_2	327	331	PF04695	0.404
LIG_SH2_CRK	248	252	PF00017	0.557
LIG_SH2_NCK_1	276	280	PF00017	0.418
LIG_SH2_SRC	124	127	PF00017	0.521
LIG_SH2_SRC	315	318	PF00017	0.539
LIG_SH2_STAP1	319	323	PF00017	0.567
LIG_SH2_STAT5	107	110	PF00017	0.465
LIG_SH2_STAT5	124	127	PF00017	0.494
LIG_SH2_STAT5	226	229	PF00017	0.537
LIG_SH2_STAT5	315	318	PF00017	0.620
LIG_SH2_STAT5	50	53	PF00017	0.393
LIG_SH3_3	167	173	PF00018	0.451
LIG_SUMO_SIM_par_1	234	239	PF11976	0.408
LIG_WRC_WIRS_1	200	205	PF05994	0.379
MOD_CK1_1	22	28	PF00069	0.410
MOD_CK1_1	266	272	PF00069	0.487
MOD_CK2_1	128	134	PF00069	0.455
MOD_CK2_1	199	205	PF00069	0.382
MOD_CK2_1	286	292	PF00069	0.683
MOD_CK2_1	315	321	PF00069	0.507
MOD_CK2_1	322	328	PF00069	0.514
MOD_GlcNHglycan	253	257	PF01048	0.636
MOD_GlcNHglycan	347	350	PF01048	0.587
MOD_GlcNHglycan	359	362	PF01048	0.362
MOD_GlcNHglycan	365	368	PF01048	0.302
MOD_GSK3_1	13	20	PF00069	0.525
MOD_GSK3_1	136	143	PF00069	0.474
MOD_GSK3_1	2	9	PF00069	0.462
MOD_GSK3_1	363	370	PF00069	0.433
MOD_GSK3_1	54	61	PF00069	0.405
MOD_NEK2_1	159	164	PF00069	0.409
MOD_NEK2_1	199	204	PF00069	0.473
MOD_NEK2_1	2	7	PF00069	0.411
MOD_NEK2_1	21	26	PF00069	0.455
MOD_NEK2_1	215	220	PF00069	0.435
MOD_NEK2_1	241	246	PF00069	0.437
MOD_NEK2_1	252	257	PF00069	0.549
MOD_NEK2_1	27	32	PF00069	0.412
MOD_NEK2_1	347	352	PF00069	0.569
MOD_NEK2_1	355	360	PF00069	0.604
MOD_NEK2_1	37	42	PF00069	0.343
MOD_NEK2_1	91	96	PF00069	0.482
MOD_NEK2_2	367	372	PF00069	0.418
MOD_OFUCOSY	11	17	PF10250	0.414
MOD_PKA_2	159	165	PF00069	0.420
MOD_PKA_2	53	59	PF00069	0.480
MOD_Plk_1	128	134	PF00069	0.516
MOD_Plk_1	252	258	PF00069	0.663
MOD_Plk_1	266	272	PF00069	0.423
MOD_Plk_2-3	58	64	PF00069	0.423
MOD_Plk_4	136	142	PF00069	0.490
MOD_Plk_4	159	165	PF00069	0.407
MOD_Plk_4	199	205	PF00069	0.527
MOD_Plk_4	367	373	PF00069	0.416
MOD_SUMO_rev_2	288	294	PF00179	0.632
TRG_AP2beta_CARGO_1	342	351	PF09066	0.554
TRG_DiLeu_BaEn_1	268	273	PF01217	0.387
TRG_DiLeu_BaEn_1	336	341	PF01217	0.380
TRG_DiLeu_BaEn_2	204	210	PF01217	0.397
TRG_DiLeu_BaLyEn_6	220	225	PF01217	0.493
TRG_ENDOCYTIC_2	248	251	PF00928	0.556
TRG_ENDOCYTIC_2	276	279	PF00928	0.412
TRG_ENDOCYTIC_2	319	322	PF00928	0.475
TRG_ER_diArg_1	109	112	PF00400	0.557
TRG_ER_diArg_1	144	146	PF00400	0.446
TRG_ER_diArg_1	157	160	PF00400	0.419
TRG_ER_diArg_1	282	284	PF00400	0.460
TRG_ER_diArg_1	86	89	PF00400	0.526
TRG_NLS_MonoExtC_3	84	89	PF00514	0.399
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHS3	Leptomonas seymouri	80%	100%
A0A0S4JT81	Bodo saltans	44%	100%
A0A1X0NNH2	Trypanosomatidae	67%	100%
A0A3S5H6A5	Leishmania donovani	91%	100%
A0A422NE20	Trypanosoma rangeli	66%	100%
A4HTS1	Leishmania infantum	91%	100%
D0A980	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9AMK4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QI32	Leishmania major	92%	100%
V5B2S3	Trypanosoma cruzi	64%	100%