Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5H9_LEIBR

TriTrypDb:

LbrM.09.0040 , LBRM2903_090005300

Length:

663

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5H9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5H9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	3
GO:0006396	RNA processing	6	3
GO:0006397	mRNA processing	7	3
GO:0006725	cellular aromatic compound metabolic process	3	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0009987	cellular process	1	3
GO:0016070	RNA metabolic process	5	3
GO:0016071	mRNA metabolic process	6	3
GO:0031123	RNA 3'-end processing	7	3
GO:0031124	mRNA 3'-end processing	8	3
GO:0034641	cellular nitrogen compound metabolic process	3	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0046483	heterocycle metabolic process	3	3
GO:0071704	organic substance metabolic process	2	3
GO:0090304	nucleic acid metabolic process	4	3
GO:1901360	organic cyclic compound metabolic process	3	3

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.404
CLV_C14_Caspase3-7	43	47	PF00656	0.319
CLV_C14_Caspase3-7	71	75	PF00656	0.289
CLV_NRD_NRD_1	137	139	PF00675	0.336
CLV_NRD_NRD_1	161	163	PF00675	0.434
CLV_NRD_NRD_1	179	181	PF00675	0.395
CLV_NRD_NRD_1	207	209	PF00675	0.288
CLV_NRD_NRD_1	233	235	PF00675	0.315
CLV_NRD_NRD_1	322	324	PF00675	0.498
CLV_NRD_NRD_1	458	460	PF00675	0.381
CLV_NRD_NRD_1	611	613	PF00675	0.711
CLV_PCSK_KEX2_1	161	163	PF00082	0.542
CLV_PCSK_KEX2_1	179	181	PF00082	0.379
CLV_PCSK_KEX2_1	207	209	PF00082	0.326
CLV_PCSK_KEX2_1	233	235	PF00082	0.315
CLV_PCSK_KEX2_1	322	324	PF00082	0.482
CLV_PCSK_KEX2_1	457	459	PF00082	0.384
CLV_PCSK_KEX2_1	523	525	PF00082	0.711
CLV_PCSK_KEX2_1	611	613	PF00082	0.659
CLV_PCSK_KEX2_1	624	626	PF00082	0.482
CLV_PCSK_PC1ET2_1	457	459	PF00082	0.469
CLV_PCSK_PC1ET2_1	523	525	PF00082	0.606
CLV_PCSK_PC1ET2_1	624	626	PF00082	0.660
CLV_PCSK_SKI1_1	412	416	PF00082	0.435
CLV_PCSK_SKI1_1	454	458	PF00082	0.447
CLV_PCSK_SKI1_1	467	471	PF00082	0.457
CLV_PCSK_SKI1_1	485	489	PF00082	0.262
CLV_PCSK_SKI1_1	56	60	PF00082	0.398
CLV_PCSK_SKI1_1	647	651	PF00082	0.651
DEG_APCC_DBOX_1	207	215	PF00400	0.353
DOC_CYCLIN_yCln2_LP_2	120	126	PF00134	0.365
DOC_CYCLIN_yCln2_LP_2	31	37	PF00134	0.407
DOC_CYCLIN_yCln2_LP_2	541	544	PF00134	0.588
DOC_MAPK_gen_1	19	27	PF00069	0.422
DOC_MAPK_gen_1	207	213	PF00069	0.317
DOC_MAPK_gen_1	566	575	PF00069	0.498
DOC_MAPK_gen_1	611	620	PF00069	0.567
DOC_MAPK_JIP1_4	614	620	PF00069	0.478
DOC_MAPK_MEF2A_6	21	29	PF00069	0.421
DOC_MAPK_MEF2A_6	443	452	PF00069	0.526
DOC_MAPK_MEF2A_6	611	620	PF00069	0.545
DOC_PP2B_LxvP_1	120	123	PF13499	0.372
DOC_PP2B_LxvP_1	146	149	PF13499	0.310
DOC_PP2B_LxvP_1	31	34	PF13499	0.411
DOC_PP2B_LxvP_1	541	544	PF13499	0.462
DOC_USP7_MATH_1	340	344	PF00917	0.489
DOC_USP7_MATH_1	533	537	PF00917	0.567
DOC_WW_Pin1_4	504	509	PF00397	0.558
DOC_WW_Pin1_4	529	534	PF00397	0.563
LIG_14-3-3_CanoR_1	138	142	PF00244	0.530
LIG_14-3-3_CanoR_1	339	345	PF00244	0.563
LIG_14-3-3_CanoR_1	36	42	PF00244	0.543
LIG_14-3-3_CanoR_1	467	472	PF00244	0.498
LIG_14-3-3_CanoR_1	625	630	PF00244	0.517
LIG_BIR_III_4	266	270	PF00653	0.271
LIG_Clathr_ClatBox_1	441	445	PF01394	0.423
LIG_CtBP_PxDLS_1	615	619	PF00389	0.539
LIG_deltaCOP1_diTrp_1	188	197	PF00928	0.293
LIG_deltaCOP1_diTrp_1	249	259	PF00928	0.320
LIG_deltaCOP1_diTrp_1	355	362	PF00928	0.341
LIG_deltaCOP1_diTrp_1	87	95	PF00928	0.317
LIG_eIF4E_1	151	157	PF01652	0.245
LIG_FHA_1	102	108	PF00498	0.402
LIG_FHA_1	306	312	PF00498	0.499
LIG_FHA_1	313	319	PF00498	0.429
LIG_FHA_1	621	627	PF00498	0.623
LIG_FHA_2	197	203	PF00498	0.473
LIG_FHA_2	311	317	PF00498	0.460
LIG_FHA_2	362	368	PF00498	0.378
LIG_FHA_2	468	474	PF00498	0.510
LIG_FHA_2	530	536	PF00498	0.579
LIG_FHA_2	593	599	PF00498	0.452
LIG_FHA_2	637	643	PF00498	0.496
LIG_LIR_Gen_1	192	201	PF02991	0.451
LIG_LIR_Gen_1	437	444	PF02991	0.346
LIG_LIR_Gen_1	486	494	PF02991	0.447
LIG_LIR_Gen_1	8	18	PF02991	0.425
LIG_LIR_Nem_3	192	197	PF02991	0.414
LIG_LIR_Nem_3	355	359	PF02991	0.346
LIG_LIR_Nem_3	437	441	PF02991	0.342
LIG_LIR_Nem_3	445	450	PF02991	0.389
LIG_LIR_Nem_3	486	491	PF02991	0.382
LIG_LIR_Nem_3	506	512	PF02991	0.503
LIG_LIR_Nem_3	535	541	PF02991	0.541
LIG_LIR_Nem_3	8	14	PF02991	0.425
LIG_LIR_Nem_3	87	92	PF02991	0.363
LIG_NRBOX	26	32	PF00104	0.419
LIG_PCNA_yPIPBox_3	458	472	PF02747	0.530
LIG_Pex14_1	153	157	PF04695	0.460
LIG_Pex14_1	190	194	PF04695	0.367
LIG_Pex14_1	89	93	PF04695	0.316
LIG_Pex14_2	50	54	PF04695	0.517
LIG_SH2_CRK	11	15	PF00017	0.426
LIG_SH2_CRK	404	408	PF00017	0.497
LIG_SH2_SRC	254	257	PF00017	0.251
LIG_SH2_STAT3	151	154	PF00017	0.357
LIG_SH2_STAT3	417	420	PF00017	0.512
LIG_SH2_STAT5	480	483	PF00017	0.409
LIG_SH2_STAT5	85	88	PF00017	0.371
LIG_SH2_STAT5	92	95	PF00017	0.354
LIG_SH3_3	537	543	PF00018	0.617
LIG_SUMO_SIM_anti_2	74	82	PF11976	0.273
LIG_SUMO_SIM_par_1	295	301	PF11976	0.436
LIG_SUMO_SIM_par_1	636	642	PF11976	0.527
LIG_SUMO_SIM_par_1	74	82	PF11976	0.456
LIG_TRAF2_1	324	327	PF00917	0.465
LIG_TRAF2_1	503	506	PF00917	0.574
LIG_TRAF2_1	550	553	PF00917	0.628
LIG_TRAF2_1	595	598	PF00917	0.450
LIG_WRC_WIRS_1	468	473	PF05994	0.479
LIG_WW_3	513	517	PF00397	0.590
MOD_CK1_1	134	140	PF00069	0.496
MOD_CK1_1	301	307	PF00069	0.604
MOD_CK1_1	437	443	PF00069	0.477
MOD_CK1_1	57	63	PF00069	0.347
MOD_CK1_1	66	72	PF00069	0.412
MOD_CK1_1	75	81	PF00069	0.328
MOD_CK2_1	137	143	PF00069	0.424
MOD_CK2_1	171	177	PF00069	0.503
MOD_CK2_1	196	202	PF00069	0.554
MOD_CK2_1	310	316	PF00069	0.424
MOD_CK2_1	37	43	PF00069	0.567
MOD_CK2_1	467	473	PF00069	0.399
MOD_CK2_1	500	506	PF00069	0.544
MOD_CK2_1	547	553	PF00069	0.598
MOD_CK2_1	592	598	PF00069	0.446
MOD_CK2_1	62	68	PF00069	0.397
MOD_CK2_1	636	642	PF00069	0.494
MOD_GlcNHglycan	120	123	PF01048	0.322
MOD_GlcNHglycan	21	24	PF01048	0.423
MOD_GlcNHglycan	275	278	PF01048	0.455
MOD_GlcNHglycan	304	307	PF01048	0.702
MOD_GlcNHglycan	484	488	PF01048	0.302
MOD_GlcNHglycan	56	59	PF01048	0.340
MOD_GlcNHglycan	629	632	PF01048	0.539
MOD_GSK3_1	213	220	PF00069	0.404
MOD_GSK3_1	296	303	PF00069	0.432
MOD_GSK3_1	327	334	PF00069	0.447
MOD_GSK3_1	357	364	PF00069	0.322
MOD_GSK3_1	37	44	PF00069	0.510
MOD_GSK3_1	385	392	PF00069	0.588
MOD_GSK3_1	467	474	PF00069	0.407
MOD_GSK3_1	500	507	PF00069	0.595
MOD_GSK3_1	529	536	PF00069	0.580
MOD_GSK3_1	543	550	PF00069	0.572
MOD_GSK3_1	586	593	PF00069	0.687
MOD_GSK3_1	616	623	PF00069	0.612
MOD_GSK3_1	62	69	PF00069	0.467
MOD_N-GLC_1	301	306	PF02516	0.549
MOD_N-GLC_1	616	621	PF02516	0.541
MOD_NEK2_1	144	149	PF00069	0.434
MOD_NEK2_1	213	218	PF00069	0.333
MOD_NEK2_1	221	226	PF00069	0.407
MOD_NEK2_1	298	303	PF00069	0.414
MOD_NEK2_1	448	453	PF00069	0.504
MOD_NEK2_1	471	476	PF00069	0.477
MOD_NEK2_1	5	10	PF00069	0.543
MOD_PIKK_1	357	363	PF00454	0.517
MOD_PIKK_1	533	539	PF00454	0.582
MOD_PK_1	625	631	PF00069	0.604
MOD_PKA_1	161	167	PF00069	0.475
MOD_PKA_1	179	185	PF00069	0.271
MOD_PKA_2	137	143	PF00069	0.326
MOD_PKA_2	161	167	PF00069	0.475
MOD_PKA_2	179	185	PF00069	0.555
MOD_PKA_2	72	78	PF00069	0.282
MOD_Plk_1	221	227	PF00069	0.339
MOD_Plk_1	248	254	PF00069	0.473
MOD_Plk_1	483	489	PF00069	0.553
MOD_Plk_1	533	539	PF00069	0.637
MOD_Plk_1	616	622	PF00069	0.508
MOD_Plk_2-3	171	177	PF00069	0.332
MOD_Plk_2-3	196	202	PF00069	0.381
MOD_Plk_2-3	500	506	PF00069	0.598
MOD_Plk_4	137	143	PF00069	0.526
MOD_Plk_4	213	219	PF00069	0.336
MOD_Plk_4	437	443	PF00069	0.370
MOD_Plk_4	467	473	PF00069	0.382
MOD_Plk_4	6	12	PF00069	0.426
MOD_Plk_4	72	78	PF00069	0.433
MOD_ProDKin_1	504	510	PF00069	0.562
MOD_ProDKin_1	529	535	PF00069	0.560
MOD_SUMO_rev_2	40	50	PF00179	0.325
TRG_DiLeu_BaEn_1	423	428	PF01217	0.326
TRG_ENDOCYTIC_2	11	14	PF00928	0.429
TRG_ENDOCYTIC_2	194	197	PF00928	0.505
TRG_ENDOCYTIC_2	404	407	PF00928	0.445
TRG_ENDOCYTIC_2	92	95	PF00928	0.454
TRG_ER_diArg_1	160	162	PF00400	0.420
TRG_ER_diArg_1	179	181	PF00400	0.395
TRG_ER_diArg_1	206	208	PF00400	0.367
TRG_ER_diArg_1	232	234	PF00400	0.320
TRG_ER_diArg_1	610	612	PF00400	0.716
TRG_NES_CRM1_1	564	576	PF08389	0.658
TRG_Pf-PMV_PEXEL_1	139	143	PF00026	0.397
TRG_Pf-PMV_PEXEL_1	262	266	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	524	529	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	647	651	PF00026	0.611

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9R7	Leptomonas seymouri	65%	100%
A0A0S4IQN5	Bodo saltans	27%	100%
A0A1X0NMW7	Trypanosomatidae	34%	100%
A0A3S7WQJ2	Leishmania donovani	86%	100%
A0A422NEC5	Trypanosoma rangeli	36%	100%
A4HTS0	Leishmania infantum	85%	100%
D0A979	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AMK3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QI33	Leishmania major	85%	100%
V5BN50	Trypanosoma cruzi	36%	100%