Ribosome biogenesis protein NSA1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5H7_LEIBR

TriTrypDb:

LbrM.09.0020 , LBRM2903_090005100

Length:

373

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0030684	preribosome	3	1
GO:0030687	preribosome, large subunit precursor	4	1
GO:0032991	protein-containing complex	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4H5H7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5H7

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	11
GO:0022613	ribonucleoprotein complex biogenesis	4	11
GO:0042273	ribosomal large subunit biogenesis	5	11
GO:0044085	cellular component biogenesis	3	11
GO:0071840	cellular component organization or biogenesis	2	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	336	340	PF00656	0.623
CLV_C14_Caspase3-7	357	361	PF00656	0.475
CLV_C14_Caspase3-7	54	58	PF00656	0.311
CLV_NRD_NRD_1	127	129	PF00675	0.389
CLV_NRD_NRD_1	200	202	PF00675	0.405
CLV_NRD_NRD_1	218	220	PF00675	0.387
CLV_NRD_NRD_1	246	248	PF00675	0.436
CLV_NRD_NRD_1	281	283	PF00675	0.382
CLV_NRD_NRD_1	35	37	PF00675	0.366
CLV_NRD_NRD_1	366	368	PF00675	0.680
CLV_NRD_NRD_1	370	372	PF00675	0.640
CLV_PCSK_KEX2_1	200	202	PF00082	0.405
CLV_PCSK_KEX2_1	218	220	PF00082	0.387
CLV_PCSK_KEX2_1	246	248	PF00082	0.436
CLV_PCSK_KEX2_1	34	36	PF00082	0.392
CLV_PCSK_KEX2_1	355	357	PF00082	0.552
CLV_PCSK_KEX2_1	366	368	PF00082	0.648
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.466
CLV_PCSK_PC7_1	196	202	PF00082	0.381
CLV_PCSK_PC7_1	214	220	PF00082	0.338
CLV_PCSK_SKI1_1	26	30	PF00082	0.302
CLV_PCSK_SKI1_1	293	297	PF00082	0.382
CLV_PCSK_SKI1_1	92	96	PF00082	0.459
DEG_SPOP_SBC_1	69	73	PF00917	0.309
DOC_CYCLIN_RxL_1	288	297	PF00134	0.378
DOC_CYCLIN_yCln2_LP_2	167	173	PF00134	0.386
DOC_MAPK_gen_1	301	309	PF00069	0.348
DOC_MAPK_MEF2A_6	293	300	PF00069	0.477
DOC_PP2B_LxvP_1	167	170	PF13499	0.407
DOC_USP7_MATH_1	111	115	PF00917	0.440
DOC_USP7_MATH_1	52	56	PF00917	0.456
DOC_USP7_UBL2_3	329	333	PF12436	0.531
DOC_USP7_UBL2_3	368	372	PF12436	0.656
LIG_14-3-3_CanoR_1	218	224	PF00244	0.472
LIG_14-3-3_CanoR_1	246	255	PF00244	0.404
LIG_Actin_WH2_2	10	28	PF00022	0.492
LIG_BIR_II_1	1	5	PF00653	0.335
LIG_BRCT_BRCA1_1	111	115	PF00533	0.510
LIG_BRCT_BRCA1_1	49	53	PF00533	0.454
LIG_FHA_1	121	127	PF00498	0.504
LIG_FHA_1	149	155	PF00498	0.318
LIG_FHA_1	289	295	PF00498	0.366
LIG_FHA_1	46	52	PF00498	0.357
LIG_FHA_1	7	13	PF00498	0.322
LIG_FHA_2	276	282	PF00498	0.477
LIG_FHA_2	3	9	PF00498	0.312
LIG_FHA_2	334	340	PF00498	0.549
LIG_FHA_2	355	361	PF00498	0.637
LIG_IBAR_NPY_1	182	184	PF08397	0.475
LIG_LIR_Gen_1	190	198	PF02991	0.329
LIG_LIR_Gen_1	321	326	PF02991	0.496
LIG_LIR_Gen_1	339	349	PF02991	0.478
LIG_LIR_Nem_3	168	174	PF02991	0.372
LIG_LIR_Nem_3	190	195	PF02991	0.329
LIG_LIR_Nem_3	321	325	PF02991	0.464
LIG_SH2_CRK	192	196	PF00017	0.332
LIG_SH2_CRK	287	291	PF00017	0.352
LIG_SH2_STAP1	145	149	PF00017	0.290
LIG_SH2_STAT3	299	302	PF00017	0.356
LIG_SH2_STAT5	184	187	PF00017	0.359
LIG_SH2_STAT5	299	302	PF00017	0.400
LIG_SUMO_SIM_par_1	57	64	PF11976	0.340
LIG_TRAF2_1	206	209	PF00917	0.399
LIG_TYR_ITSM	188	195	PF00017	0.316
LIG_UBA3_1	11	19	PF00899	0.244
LIG_UBA3_1	294	303	PF00899	0.282
LIG_WRC_WIRS_1	319	324	PF05994	0.396
MOD_CK1_1	107	113	PF00069	0.528
MOD_CK1_1	18	24	PF00069	0.446
MOD_CK1_1	46	52	PF00069	0.374
MOD_GlcNHglycan	20	23	PF01048	0.536
MOD_GlcNHglycan	235	239	PF01048	0.335
MOD_GlcNHglycan	322	325	PF01048	0.541
MOD_GlcNHglycan	72	75	PF01048	0.349
MOD_GSK3_1	103	110	PF00069	0.439
MOD_GSK3_1	17	24	PF00069	0.430
MOD_GSK3_1	2	9	PF00069	0.336
MOD_GSK3_1	43	50	PF00069	0.491
MOD_NEK2_1	109	114	PF00069	0.461
MOD_NEK2_1	242	247	PF00069	0.370
MOD_NEK2_1	275	280	PF00069	0.469
MOD_NEK2_1	294	299	PF00069	0.369
MOD_NEK2_2	120	125	PF00069	0.251
MOD_NEK2_2	258	263	PF00069	0.377
MOD_PKA_1	218	224	PF00069	0.482
MOD_PKA_2	199	205	PF00069	0.412
MOD_PKA_2	218	224	PF00069	0.266
MOD_Plk_2-3	354	360	PF00069	0.468
MOD_Plk_4	111	117	PF00069	0.386
MOD_Plk_4	219	225	PF00069	0.370
MOD_Plk_4	294	300	PF00069	0.343
MOD_Plk_4	58	64	PF00069	0.323
MOD_Plk_4	84	90	PF00069	0.381
MOD_SUMO_rev_2	350	357	PF00179	0.632
TRG_ENDOCYTIC_2	171	174	PF00928	0.259
TRG_ENDOCYTIC_2	192	195	PF00928	0.336
TRG_ER_diArg_1	218	220	PF00400	0.387
TRG_ER_diArg_1	34	36	PF00400	0.309

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9A9	Leptomonas seymouri	78%	100%
A0A1X0NMW6	Trypanosomatidae	67%	100%
A0A3S7WQG6	Leishmania donovani	86%	100%
A0A422NE17	Trypanosoma rangeli	64%	100%
A4HTR8	Leishmania infantum	86%	100%
D0A977	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	96%
E9AMK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
O94698	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	96%
Q4QI35	Leishmania major	86%	100%
Q58D06	Bos taurus	28%	97%
Q6CEC9	Yarrowia lipolytica (strain CLIB 122 / E 150)	22%	91%
Q6RFH5	Homo sapiens	28%	97%
Q8VCG3	Mus musculus	28%	97%
V5BIB3	Trypanosoma cruzi	63%	100%