DUF3498 domain containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5H6_LEIBR

TriTrypDb:

LbrM.09.0010 , LBRM2903_090005000

Length:

156

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 4
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5H6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5H6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	73	77	PF00656	0.494
CLV_NRD_NRD_1	118	120	PF00675	0.455
CLV_NRD_NRD_1	128	130	PF00675	0.507
CLV_NRD_NRD_1	43	45	PF00675	0.436
CLV_PCSK_KEX2_1	118	120	PF00082	0.543
CLV_PCSK_KEX2_1	128	130	PF00082	0.420
CLV_PCSK_KEX2_1	42	44	PF00082	0.582
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.582
CLV_PCSK_PC7_1	114	120	PF00082	0.543
CLV_PCSK_SKI1_1	131	135	PF00082	0.531
CLV_PCSK_SKI1_1	62	66	PF00082	0.421
CLV_Separin_Metazoa	63	67	PF03568	0.370
DOC_CYCLIN_RxL_1	128	137	PF00134	0.531
DOC_CYCLIN_yClb5_NLxxxL_5	1	10	PF00134	0.386
DOC_MAPK_gen_1	118	126	PF00069	0.528
DOC_MAPK_gen_1	128	134	PF00069	0.418
DOC_USP7_MATH_1	136	140	PF00917	0.362
LIG_14-3-3_CanoR_1	118	127	PF00244	0.353
LIG_Actin_WH2_2	53	70	PF00022	0.551
LIG_FHA_1	86	92	PF00498	0.508
LIG_FHA_2	47	53	PF00498	0.395
LIG_FHA_2	79	85	PF00498	0.600
LIG_FHA_2	9	15	PF00498	0.480
LIG_FHA_2	95	101	PF00498	0.567
LIG_GBD_Chelix_1	2	10	PF00786	0.381
LIG_NRBOX	5	11	PF00104	0.373
LIG_PCNA_yPIPBox_3	110	119	PF02747	0.524
LIG_PCNA_yPIPBox_3	120	131	PF02747	0.394
LIG_SUMO_SIM_par_1	5	11	PF11976	0.373
LIG_TRAF2_1	49	52	PF00917	0.458
LIG_UBA3_1	123	131	PF00899	0.526
MOD_CK1_1	17	23	PF00069	0.690
MOD_CK1_1	79	85	PF00069	0.521
MOD_CK2_1	23	29	PF00069	0.470
MOD_CK2_1	46	52	PF00069	0.397
MOD_CK2_1	8	14	PF00069	0.388
MOD_CK2_1	94	100	PF00069	0.592
MOD_GlcNHglycan	120	123	PF01048	0.377
MOD_GlcNHglycan	135	139	PF01048	0.491
MOD_GlcNHglycan	142	145	PF01048	0.477
MOD_GlcNHglycan	16	19	PF01048	0.546
MOD_GlcNHglycan	22	25	PF01048	0.591
MOD_GlcNHglycan	76	79	PF01048	0.506
MOD_GSK3_1	134	141	PF00069	0.362
MOD_GSK3_1	14	21	PF00069	0.746
MOD_GSK3_1	70	77	PF00069	0.555
MOD_N-GLC_1	94	99	PF02516	0.486
MOD_NEK2_1	134	139	PF00069	0.532
MOD_NEK2_1	8	13	PF00069	0.425
MOD_PIKK_1	99	105	PF00454	0.440
MOD_PKA_1	118	124	PF00069	0.357
MOD_PKA_1	74	80	PF00069	0.562
MOD_PKA_2	118	124	PF00069	0.367
MOD_PKA_2	14	20	PF00069	0.573
MOD_Plk_1	46	52	PF00069	0.397
MOD_Plk_1	86	92	PF00069	0.508
MOD_Plk_4	8	14	PF00069	0.409
MOD_Plk_4	86	92	PF00069	0.568
TRG_ER_diArg_1	117	119	PF00400	0.458
TRG_ER_diArg_1	127	129	PF00400	0.507
TRG_ER_diArg_1	65	68	PF00400	0.420
TRG_Pf-PMV_PEXEL_1	131	135	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.589
TRG_Pf-PMV_PEXEL_1	48	52	PF00026	0.363

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WQF4	Leishmania donovani	58%	100%
A4HTR7	Leishmania infantum	58%	100%
E9AMK0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
Q4QI36	Leishmania major	56%	100%