Amastin-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amastin-like protein

Species:

Leishmania braziliensis

UniProt:

A4H5H1_LEIBR

TriTrypDb:

LbrM.08.1100 , LBRM2903_100024300

Length:

187

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 10, no: 190
NetGPI	no	yes: 0, no: 200

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	178
GO:0110165	cellular anatomical entity	1	178

Expansion

Sequence features

A4H5H1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5H1

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016540	protein autoprocessing	6	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	34	40	PF00089	0.397
CLV_NRD_NRD_1	72	74	PF00675	0.493
CLV_NRD_NRD_1	77	79	PF00675	0.498
CLV_PCSK_FUR_1	75	79	PF00082	0.410
CLV_PCSK_KEX2_1	72	74	PF00082	0.518
CLV_PCSK_KEX2_1	77	79	PF00082	0.519
CLV_PCSK_PC7_1	73	79	PF00082	0.410
DEG_Nend_UBRbox_2	1	3	PF02207	0.536
DOC_CKS1_1	23	28	PF01111	0.376
DOC_CYCLIN_yCln2_LP_2	170	176	PF00134	0.591
DOC_MAPK_HePTP_8	34	46	PF00069	0.197
DOC_MAPK_MEF2A_6	108	116	PF00069	0.592
DOC_MAPK_MEF2A_6	37	46	PF00069	0.224
DOC_PP2B_LxvP_1	170	173	PF13499	0.585
DOC_USP7_MATH_1	179	183	PF00917	0.777
DOC_WW_Pin1_4	22	27	PF00397	0.372
DOC_WW_Pin1_4	38	43	PF00397	0.255
LIG_Actin_WH2_2	92	110	PF00022	0.390
LIG_eIF4E_1	90	96	PF01652	0.279
LIG_FHA_1	119	125	PF00498	0.393
LIG_FHA_1	2	8	PF00498	0.523
LIG_FHA_1	39	45	PF00498	0.290
LIG_FHA_2	23	29	PF00498	0.413
LIG_LIR_Gen_1	151	159	PF02991	0.370
LIG_LIR_Nem_3	151	156	PF02991	0.358
LIG_NRBOX	4	10	PF00104	0.210
LIG_NRBOX	91	97	PF00104	0.394
LIG_Pex14_2	149	153	PF04695	0.440
LIG_PTB_Apo_2	163	170	PF02174	0.420
LIG_SH2_PTP2	10	13	PF00017	0.364
LIG_SH2_SRC	10	13	PF00017	0.227
LIG_SH2_SRC	135	138	PF00017	0.196
LIG_SH2_STAT5	10	13	PF00017	0.458
LIG_SH2_STAT5	135	138	PF00017	0.266
LIG_SH2_STAT5	54	57	PF00017	0.377
LIG_SUMO_SIM_anti_2	4	9	PF11976	0.410
LIG_TRAF2_2	173	178	PF00917	0.533
LIG_TYR_ITIM	131	136	PF00017	0.203
LIG_TYR_ITIM	8	13	PF00017	0.455
MOD_GlcNHglycan	150	153	PF01048	0.390
MOD_GSK3_1	144	151	PF00069	0.197
MOD_GSK3_1	179	186	PF00069	0.763
MOD_GSK3_1	38	45	PF00069	0.279
MOD_NEK2_1	1	6	PF00069	0.695
MOD_Plk_1	1	7	PF00069	0.412
MOD_Plk_1	58	64	PF00069	0.386
MOD_Plk_4	125	131	PF00069	0.301
MOD_Plk_4	144	150	PF00069	0.207
MOD_ProDKin_1	22	28	PF00069	0.372
MOD_ProDKin_1	38	44	PF00069	0.255
TRG_ENDOCYTIC_2	10	13	PF00928	0.462
TRG_ENDOCYTIC_2	133	136	PF00928	0.289
TRG_ER_diArg_1	71	73	PF00400	0.343
TRG_ER_diArg_1	76	78	PF00400	0.339
TRG_NES_CRM1_1	163	175	PF08389	0.455
TRG_Pf-PMV_PEXEL_1	139	143	PF00026	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C4	Leptomonas seymouri	31%	100%
A0A0N0P547	Leptomonas seymouri	46%	100%
A0A0N0P6P9	Leptomonas seymouri	25%	81%
A0A0N0P993	Leptomonas seymouri	25%	83%
A0A0N1HWY5	Leptomonas seymouri	24%	96%
A0A0N1PDH0	Leptomonas seymouri	39%	93%
A0A1X0NQ58	Trypanosomatidae	31%	100%
A0A1X0P2R3	Trypanosomatidae	28%	89%
A0A1X0P988	Trypanosomatidae	42%	100%
A0A381MTA7	Leishmania infantum	48%	97%
A0A381MTB8	Leishmania infantum	52%	97%
A0A381MTC7	Leishmania infantum	46%	91%
A0A381MTN2	Leishmania infantum	44%	96%
A0A381MVY0	Leishmania infantum	47%	97%
A0A3Q8ID16	Leishmania donovani	28%	100%
A0A3Q8IE85	Leishmania donovani	50%	100%
A0A3Q8IEC2	Leishmania donovani	43%	97%
A0A3Q8IEI1	Leishmania donovani	46%	97%
A0A3Q8IF65	Leishmania donovani	44%	95%
A0A3Q8IFB9	Leishmania donovani	32%	92%
A0A3Q8IFH7	Leishmania donovani	46%	91%
A0A3Q8IH65	Leishmania donovani	52%	97%
A0A3Q8IHN2	Leishmania donovani	47%	97%
A0A3Q8IHW7	Leishmania donovani	54%	100%
A0A3Q8IHZ6	Leishmania donovani	49%	89%
A0A3Q8IIH1	Leishmania donovani	48%	96%
A0A3Q8IL03	Leishmania donovani	44%	97%
A0A3Q8IUK8	Leishmania donovani	46%	98%
A0A3Q8IUR5	Leishmania donovani	44%	96%
A0A3S5H662	Leishmania donovani	47%	93%
A0A3S5H663	Leishmania donovani	47%	93%
A0A3S5H665	Leishmania donovani	48%	93%
A0A3S5H666	Leishmania donovani	51%	97%
A0A3S5H667	Leishmania donovani	48%	92%
A0A3S5H7D2	Leishmania donovani	31%	100%
A0A3S5H7L2	Leishmania donovani	51%	91%
A0A3S5H7V9	Leishmania donovani	48%	94%
A0A3S5H7W2	Leishmania donovani	30%	97%
A0A3S5H7W6	Leishmania donovani	49%	94%
A0A3S7WQA0	Leishmania donovani	48%	92%
A0A3S7WQA8	Leishmania donovani	55%	100%
A0A3S7WQC1	Leishmania donovani	57%	97%
A0A3S7X2E6	Leishmania donovani	50%	97%
A0A3S7X357	Leishmania donovani	30%	84%
A0A3S7X453	Leishmania donovani	44%	95%
A0A3S7X472	Leishmania donovani	45%	94%
A0A3S7X7E5	Leishmania donovani	57%	75%
A0A3S7X7M4	Leishmania donovani	49%	89%
A0A3S7X7U1	Leishmania donovani	46%	89%
A0A3S7X7U4	Leishmania donovani	54%	72%
A0A3S7X7W2	Leishmania donovani	38%	89%
A0A3S7X7Y0	Leishmania donovani	44%	96%
A4H595	Leishmania braziliensis	47%	100%
A4H596	Leishmania braziliensis	48%	100%
A4H597	Leishmania braziliensis	47%	100%
A4H5D1	Leishmania braziliensis	49%	100%
A4H5D2	Leishmania braziliensis	45%	100%
A4H5G0	Leishmania braziliensis	63%	100%
A4H5G4	Leishmania braziliensis	43%	100%
A4H5G6	Leishmania braziliensis	44%	100%
A4H5G7	Leishmania braziliensis	52%	100%
A4H5G9	Leishmania braziliensis	76%	99%
A4H5H0	Leishmania braziliensis	76%	100%
A4H5H2	Leishmania braziliensis	59%	100%
A4H5H3	Leishmania braziliensis	44%	90%
A4H6C8	Leishmania braziliensis	52%	94%
A4H7D7	Leishmania braziliensis	46%	96%
A4H9E8	Leishmania braziliensis	51%	89%
A4H9E9	Leishmania braziliensis	47%	96%
A4HAJ4	Leishmania braziliensis	50%	89%
A4HAJ5	Leishmania braziliensis	44%	84%
A4HAJ6	Leishmania braziliensis	47%	81%
A4HAL1	Leishmania braziliensis	48%	100%
A4HAL2	Leishmania braziliensis	31%	97%
A4HAM2	Leishmania braziliensis	49%	97%
A4HAM4	Leishmania braziliensis	47%	97%
A4HAR1	Leishmania braziliensis	47%	97%
A4HAZ8	Leishmania braziliensis	45%	99%
A4HB00	Leishmania braziliensis	45%	97%
A4HB02	Leishmania braziliensis	45%	97%
A4HB47	Leishmania braziliensis	34%	92%
A4HBJ0	Leishmania braziliensis	54%	97%
A4HBJ1	Leishmania braziliensis	47%	97%
A4HBJ2	Leishmania braziliensis	48%	90%
A4HDI3	Leishmania braziliensis	30%	77%
A4HDI4	Leishmania braziliensis	27%	100%
A4HDL3	Leishmania braziliensis	30%	100%
A4HDL4	Leishmania braziliensis	27%	100%
A4HI43	Leishmania braziliensis	27%	88%
A4HTM3	Leishmania infantum	57%	97%
A4HTM4	Leishmania infantum	54%	100%
A4HTM5	Leishmania infantum	53%	97%
A4I0W4	Leishmania infantum	31%	100%
A4I0W5	Leishmania infantum	28%	100%
A4I4J2	Leishmania infantum	48%	91%
A4I4J3	Leishmania infantum	48%	72%
A4I5B9	Leishmania infantum	30%	84%
A4I6E5	Leishmania infantum	45%	94%
A4I9Q4	Leishmania infantum	50%	100%
A4I9R4	Leishmania infantum	30%	97%
A4I9R5	Leishmania infantum	33%	92%
A4I9R7	Leishmania infantum	51%	95%
A4I9W8	Leishmania infantum	54%	72%
A4I9X0	Leishmania infantum	39%	89%
A4IA59	Leishmania infantum	44%	72%
A4IAL7	Leishmania infantum	54%	100%
A4IAM1	Leishmania infantum	46%	97%
A4IAM2	Leishmania infantum	45%	97%
E8NHC3	Leishmania infantum	48%	93%
E8NHD3	Leishmania infantum	50%	91%
E8NHD6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E8NHD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E8NHE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	89%
E8NHF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	90%
E8NHF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	98%
E8NHF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	97%
E8NHG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	89%
E8NHH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	89%
E8NHH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
E8NHI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	96%
E8NHI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	97%
E8NHK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	89%
E8NHK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	96%
E8NHL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	97%
E8NHL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	97%
E8NHM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	99%
E8NHM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	96%
E8NHM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	89%
E8NHM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	89%
E8NHM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	98%
E8NHM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E8NHP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	91%
E8NHQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	89%
E8NHQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	96%
E8NHR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	96%
E8NHR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	96%
E8NHS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	89%
E9AG81	Leishmania infantum	47%	92%
E9AG82	Leishmania infantum	46%	92%
E9AG83	Leishmania infantum	50%	94%
E9AG85	Leishmania infantum	46%	92%
E9AHI9	Leishmania infantum	49%	97%
E9AHT2	Leishmania infantum	51%	89%
E9AME9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9AMF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
E9AMF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	90%
E9AMF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	96%
E9AMF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	96%
E9AMF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	73%
E9AMF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	90%
E9AMF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9AMF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	97%
E9AMF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	97%
E9ASP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	89%
E9AWW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AWW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B0L6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	84%
E9B1J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	96%
E9B1J4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	90%
E9B1J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	89%
E9B4L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	94%
E9B4R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	94%
E9B4R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	95%
E9B4R9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	92%
E9B4S0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B4Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	91%
Q4Q1U9	Leishmania major	45%	99%
Q4Q305	Leishmania major	45%	99%
Q4Q309	Leishmania major	47%	100%
Q4Q313	Leishmania major	45%	99%
Q4Q317	Leishmania major	49%	100%
Q4Q325	Leishmania major	47%	100%
Q4Q327	Leishmania major	44%	99%
Q4Q329	Leishmania major	44%	99%
Q4Q333	Leishmania major	45%	99%
Q4Q335	Leishmania major	46%	99%
Q4Q337	Leishmania major	47%	100%
Q4Q339	Leishmania major	45%	99%
Q4Q341	Leishmania major	51%	100%
Q4Q397	Leishmania major	49%	71%
Q4Q3A7	Leishmania major	31%	100%
Q4Q3A8	Leishmania major	32%	100%
Q4Q3A9	Leishmania major	50%	100%
Q4Q3F7	Leishmania major	48%	100%
Q4Q6L8	Leishmania major	43%	100%
Q4Q7L6	Leishmania major	30%	100%
Q4QAK5	Leishmania major	28%	100%
Q4QAK6	Leishmania major	34%	100%
Q4QI84	Leishmania major	54%	100%
Q4QI85	Leishmania major	58%	100%
Q4QI86	Leishmania major	58%	100%
Q4QI87	Leishmania major	59%	100%
Q4QI88	Leishmania major	50%	100%
Q4QI92	Leishmania major	48%	100%
Q4QI93	Leishmania major	48%	100%
Q4QI95	Leishmania major	47%	100%
Q4QI97	Leishmania major	48%	100%
Q4QIA0	Leishmania major	47%	100%
Q4QIA1	Leishmania major	47%	100%