Amastin-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amastin-like protein

Species:

Leishmania braziliensis

UniProt:

A4H5G6_LEIBR

TriTrypDb:

LbrM.08.1050 , LBRM2903_200014900

Length:

221

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Amastin, Kinetoplastid host adhesion protein. A host adhesion protein family greatly expanded in Leishmaniids.. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 10, no: 179
NetGPI	no	yes: 0, no: 189

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	168
GO:0110165	cellular anatomical entity	1	168

Expansion

Sequence features

A4H5G6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5G6

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016540	protein autoprocessing	6	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	185	187	PF00675	0.458
CLV_NRD_NRD_1	33	35	PF00675	0.433
CLV_PCSK_FUR_1	31	35	PF00082	0.397
CLV_PCSK_KEX2_1	33	35	PF00082	0.462
CLV_PCSK_SKI1_1	199	203	PF00082	0.354
CLV_PCSK_SKI1_1	75	79	PF00082	0.501
DEG_Nend_UBRbox_1	1	4	PF02207	0.546
DEG_SCF_FBW7_1	37	42	PF00400	0.254
DOC_CKS1_1	23	28	PF01111	0.355
DOC_CKS1_1	36	41	PF01111	0.194
DOC_CYCLIN_yCln2_LP_2	171	177	PF00134	0.563
DOC_CYCLIN_yCln2_LP_2	23	29	PF00134	0.195
DOC_MAPK_gen_1	106	114	PF00069	0.457
DOC_MAPK_MEF2A_6	106	114	PF00069	0.547
DOC_PP2B_LxvP_1	171	174	PF13499	0.566
DOC_USP7_UBL2_3	180	184	PF12436	0.664
DOC_WW_Pin1_4	22	27	PF00397	0.359
DOC_WW_Pin1_4	35	40	PF00397	0.295
LIG_Actin_WH2_2	92	110	PF00022	0.380
LIG_deltaCOP1_diTrp_1	140	147	PF00928	0.245
LIG_deltaCOP1_diTrp_1	204	210	PF00928	0.522
LIG_EH1_1	165	173	PF00400	0.198
LIG_EH1_1	81	89	PF00400	0.318
LIG_EH1_1	9	17	PF00400	0.394
LIG_eIF4E_1	10	16	PF01652	0.388
LIG_FHA_1	119	125	PF00498	0.377
LIG_FHA_1	54	60	PF00498	0.399
LIG_FHA_2	23	29	PF00498	0.399
LIG_LIR_Apic_2	35	39	PF02991	0.231
LIG_LIR_Gen_1	164	174	PF02991	0.428
LIG_LIR_Nem_3	132	136	PF02991	0.280
LIG_LIR_Nem_3	144	150	PF02991	0.313
LIG_LIR_Nem_3	164	169	PF02991	0.420
LIG_NRBOX	158	164	PF00104	0.210
LIG_PCNA_yPIPBox_3	33	47	PF02747	0.204
LIG_Pex14_2	202	206	PF04695	0.531
LIG_SH2_CRK	10	14	PF00017	0.373
LIG_SH2_NCK_1	10	14	PF00017	0.216
LIG_SH2_PTP2	36	39	PF00017	0.211
LIG_SH2_SRC	10	13	PF00017	0.227
LIG_SH2_STAT5	102	105	PF00017	0.371
LIG_SH2_STAT5	36	39	PF00017	0.343
LIG_SH2_STAT5	63	66	PF00017	0.253
LIG_TRAF2_1	209	212	PF00917	0.537
LIG_TYR_ITIM	8	13	PF00017	0.443
LIG_UBA3_1	171	180	PF00899	0.315
MOD_CK1_1	145	151	PF00069	0.207
MOD_CK2_1	202	208	PF00069	0.552
MOD_GSK3_1	142	149	PF00069	0.270
MOD_GSK3_1	35	42	PF00069	0.287
MOD_N-GLC_1	202	207	PF02516	0.336
MOD_N-GLC_1	39	44	PF02516	0.433
MOD_N-GLC_1	54	59	PF02516	0.438
MOD_NEK2_1	202	207	PF00069	0.539
MOD_NEK2_1	54	59	PF00069	0.328
MOD_NEK2_2	142	147	PF00069	0.201
MOD_Plk_1	202	208	PF00069	0.539
MOD_Plk_1	39	45	PF00069	0.339
MOD_Plk_4	142	148	PF00069	0.211
MOD_Plk_4	42	48	PF00069	0.319
MOD_Plk_4	59	65	PF00069	0.333
MOD_Plk_4	91	97	PF00069	0.362
MOD_ProDKin_1	22	28	PF00069	0.359
MOD_ProDKin_1	35	41	PF00069	0.295
TRG_DiLeu_BaLyEn_6	171	176	PF01217	0.279
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.411
TRG_ENDOCYTIC_2	10	13	PF00928	0.450
TRG_ER_diArg_1	106	109	PF00400	0.434
TRG_ER_diArg_1	32	34	PF00400	0.242
TRG_NES_CRM1_1	164	179	PF08389	0.464
TRG_Pf-PMV_PEXEL_1	75	80	PF00026	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C4	Leptomonas seymouri	31%	100%
A0A0N0P547	Leptomonas seymouri	40%	100%
A0A0N1HWY5	Leptomonas seymouri	23%	100%
A0A0N1PAD5	Leptomonas seymouri	27%	88%
A0A0N1PDH0	Leptomonas seymouri	32%	100%
A0A1X0NQ58	Trypanosomatidae	29%	100%
A0A1X0NUH1	Trypanosomatidae	27%	97%
A0A1X0NX02	Trypanosomatidae	27%	100%
A0A1X0P2R3	Trypanosomatidae	28%	100%
A0A1X0P988	Trypanosomatidae	38%	100%
A0A381MTA7	Leishmania infantum	47%	100%
A0A381MTB8	Leishmania infantum	42%	100%
A0A381MTC7	Leishmania infantum	46%	100%
A0A381MTN2	Leishmania infantum	40%	100%
A0A381MVY0	Leishmania infantum	46%	100%
A0A3Q8ID16	Leishmania donovani	28%	100%
A0A3Q8IEC2	Leishmania donovani	43%	100%
A0A3Q8IEI1	Leishmania donovani	46%	100%
A0A3Q8IF65	Leishmania donovani	39%	100%
A0A3Q8IFB9	Leishmania donovani	32%	100%
A0A3Q8IFH7	Leishmania donovani	46%	100%
A0A3Q8IH65	Leishmania donovani	42%	100%
A0A3Q8IHN2	Leishmania donovani	47%	100%
A0A3Q8IHW7	Leishmania donovani	47%	100%
A0A3Q8IHZ6	Leishmania donovani	43%	100%
A0A3Q8IIH1	Leishmania donovani	42%	100%
A0A3Q8IL03	Leishmania donovani	42%	100%
A0A3Q8IUK8	Leishmania donovani	40%	100%
A0A3Q8IUR5	Leishmania donovani	40%	100%
A0A3S5H662	Leishmania donovani	43%	100%
A0A3S5H663	Leishmania donovani	44%	100%
A0A3S5H665	Leishmania donovani	44%	100%
A0A3S5H666	Leishmania donovani	42%	100%
A0A3S5H667	Leishmania donovani	44%	100%
A0A3S5H7D2	Leishmania donovani	32%	100%
A0A3S5H7L2	Leishmania donovani	42%	100%
A0A3S5H7V9	Leishmania donovani	42%	100%
A0A3S5H7W2	Leishmania donovani	27%	100%
A0A3S5H7W6	Leishmania donovani	40%	100%
A0A3S7WQA0	Leishmania donovani	44%	100%
A0A3S7WQA8	Leishmania donovani	42%	100%
A0A3S7WQC1	Leishmania donovani	38%	100%
A0A3S7X2E6	Leishmania donovani	41%	100%
A0A3S7X453	Leishmania donovani	39%	100%
A0A3S7X472	Leishmania donovani	37%	100%
A0A3S7X7E5	Leishmania donovani	50%	88%
A0A3S7X7M4	Leishmania donovani	43%	100%
A0A3S7X7U1	Leishmania donovani	38%	100%
A0A3S7X7U4	Leishmania donovani	50%	85%
A0A3S7X7W2	Leishmania donovani	36%	100%
A0A3S7X7Y0	Leishmania donovani	46%	100%
A4H595	Leishmania braziliensis	69%	100%
A4H596	Leishmania braziliensis	69%	100%
A4H597	Leishmania braziliensis	68%	100%
A4H5D1	Leishmania braziliensis	50%	98%
A4H5D2	Leishmania braziliensis	33%	100%
A4H5G0	Leishmania braziliensis	45%	100%
A4H5G4	Leishmania braziliensis	40%	97%
A4H5G7	Leishmania braziliensis	62%	100%
A4H5G9	Leishmania braziliensis	42%	100%
A4H5H0	Leishmania braziliensis	42%	100%
A4H5H1	Leishmania braziliensis	44%	100%
A4H5H2	Leishmania braziliensis	46%	100%
A4H5H3	Leishmania braziliensis	45%	100%
A4H6C8	Leishmania braziliensis	41%	100%
A4H7D7	Leishmania braziliensis	47%	100%
A4H9E8	Leishmania braziliensis	51%	100%
A4H9E9	Leishmania braziliensis	44%	100%
A4HAJ4	Leishmania braziliensis	52%	100%
A4HAJ5	Leishmania braziliensis	68%	100%
A4HAJ6	Leishmania braziliensis	62%	96%
A4HAL2	Leishmania braziliensis	30%	100%
A4HAM2	Leishmania braziliensis	46%	100%
A4HAM4	Leishmania braziliensis	46%	100%
A4HAR1	Leishmania braziliensis	44%	100%
A4HAZ8	Leishmania braziliensis	43%	100%
A4HB00	Leishmania braziliensis	42%	100%
A4HB02	Leishmania braziliensis	41%	100%
A4HB47	Leishmania braziliensis	31%	100%
A4HBJ0	Leishmania braziliensis	58%	100%
A4HBJ1	Leishmania braziliensis	45%	100%
A4HBJ2	Leishmania braziliensis	50%	100%
A4HDL3	Leishmania braziliensis	30%	100%
A4HTM3	Leishmania infantum	39%	100%
A4HTM4	Leishmania infantum	42%	100%
A4HTM5	Leishmania infantum	42%	100%
A4I0W4	Leishmania infantum	31%	100%
A4I0W5	Leishmania infantum	28%	100%
A4I4J2	Leishmania infantum	45%	100%
A4I4J3	Leishmania infantum	42%	86%
A4I6E5	Leishmania infantum	36%	100%
A4I9Q4	Leishmania infantum	43%	100%
A4I9R4	Leishmania infantum	27%	100%
A4I9R5	Leishmania infantum	32%	100%
A4I9R7	Leishmania infantum	45%	100%
A4I9W8	Leishmania infantum	51%	85%
A4I9X0	Leishmania infantum	36%	100%
A4IA59	Leishmania infantum	40%	85%
A4IAL7	Leishmania infantum	47%	100%
A4IAM1	Leishmania infantum	44%	100%
A4IAM2	Leishmania infantum	47%	100%
E8NHC3	Leishmania infantum	44%	100%
E8NHD3	Leishmania infantum	43%	100%
E8NHD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E8NHE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E8NHF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E8NHF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E8NHF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E8NHG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E8NHH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E8NHI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E8NHI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E8NHK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E8NHK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E8NHL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E8NHL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E8NHM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E8NHM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E8NHM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E8NHM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E8NHM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E8NHP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E8NHQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E8NHQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E8NHR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E8NHR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E8NHS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E8NHS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	71%
E9AG81	Leishmania infantum	44%	100%
E9AG82	Leishmania infantum	44%	100%
E9AG83	Leishmania infantum	38%	100%
E9AG85	Leishmania infantum	44%	100%
E9AHI9	Leishmania infantum	42%	100%
E9AHT2	Leishmania infantum	45%	100%
E9AME9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9AMF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9AMF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9AMF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9AMF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9AMF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	86%
E9AMF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AMF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9AMF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9AMF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9ASP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9AWW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B1J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9B1J4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9B1J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9B4L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9B4R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9B4R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9B4R9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B4S0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B4Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
Q4Q1U9	Leishmania major	45%	98%
Q4Q305	Leishmania major	41%	96%
Q4Q309	Leishmania major	42%	100%
Q4Q313	Leishmania major	41%	98%
Q4Q317	Leishmania major	43%	100%
Q4Q325	Leishmania major	41%	98%
Q4Q327	Leishmania major	43%	97%
Q4Q329	Leishmania major	42%	96%
Q4Q333	Leishmania major	41%	96%
Q4Q335	Leishmania major	42%	98%
Q4Q337	Leishmania major	47%	100%
Q4Q339	Leishmania major	41%	98%
Q4Q341	Leishmania major	45%	99%
Q4Q397	Leishmania major	46%	84%
Q4Q3A7	Leishmania major	28%	100%
Q4Q3A8	Leishmania major	31%	100%
Q4Q3A9	Leishmania major	42%	99%
Q4Q3F7	Leishmania major	42%	100%
Q4Q6L8	Leishmania major	37%	100%
Q4QAK5	Leishmania major	27%	100%
Q4QAK6	Leishmania major	32%	100%
Q4QI84	Leishmania major	42%	100%
Q4QI85	Leishmania major	44%	100%
Q4QI86	Leishmania major	43%	100%
Q4QI87	Leishmania major	43%	100%
Q4QI88	Leishmania major	40%	100%
Q4QI92	Leishmania major	41%	100%
Q4QI93	Leishmania major	41%	100%
Q4QI95	Leishmania major	40%	100%
Q4QI97	Leishmania major	40%	100%
Q4QIA0	Leishmania major	44%	100%
Q4QIA1	Leishmania major	44%	100%
V5BEW6	Trypanosoma cruzi	33%	68%