J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H5G3_LEIBR

TriTrypDb:

LbrM.08.1020 , LBRM2903_080010000

Length:

305

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5G3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5G3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	220	222	PF00675	0.523
CLV_NRD_NRD_1	24	26	PF00675	0.465
CLV_NRD_NRD_1	289	291	PF00675	0.590
CLV_NRD_NRD_1	47	49	PF00675	0.290
CLV_NRD_NRD_1	97	99	PF00675	0.646
CLV_PCSK_KEX2_1	220	222	PF00082	0.523
CLV_PCSK_KEX2_1	24	26	PF00082	0.465
CLV_PCSK_KEX2_1	289	291	PF00082	0.590
CLV_PCSK_KEX2_1	70	72	PF00082	0.502
CLV_PCSK_KEX2_1	97	99	PF00082	0.646
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.288
CLV_PCSK_SKI1_1	149	153	PF00082	0.526
CLV_PCSK_SKI1_1	24	28	PF00082	0.465
DEG_COP1_1	223	232	PF00400	0.499
DEG_Nend_UBRbox_3	1	3	PF02207	0.609
DEG_SPOP_SBC_1	253	257	PF00917	0.544
DOC_CKS1_1	176	181	PF01111	0.520
DOC_CYCLIN_RxL_1	21	28	PF00134	0.252
DOC_CYCLIN_yCln2_LP_2	176	182	PF00134	0.520
DOC_CYCLIN_yCln2_LP_2	8	14	PF00134	0.504
DOC_MAPK_gen_1	48	57	PF00069	0.252
DOC_MAPK_RevD_3	207	221	PF00069	0.486
DOC_PP2B_LxvP_1	227	230	PF13499	0.498
DOC_PP2B_LxvP_1	241	244	PF13499	0.433
DOC_PP2B_LxvP_1	8	11	PF13499	0.504
DOC_USP7_MATH_1	114	118	PF00917	0.743
DOC_USP7_MATH_1	183	187	PF00917	0.545
DOC_USP7_MATH_1	215	219	PF00917	0.530
DOC_USP7_MATH_1	233	237	PF00917	0.424
DOC_USP7_MATH_1	253	257	PF00917	0.467
DOC_USP7_MATH_1	83	87	PF00917	0.387
DOC_WW_Pin1_4	175	180	PF00397	0.512
DOC_WW_Pin1_4	197	202	PF00397	0.772
DOC_WW_Pin1_4	260	265	PF00397	0.716
DOC_WW_Pin1_4	271	276	PF00397	0.471
LIG_FHA_1	113	119	PF00498	0.493
LIG_FHA_1	139	145	PF00498	0.584
LIG_FHA_1	171	177	PF00498	0.755
LIG_FHA_1	212	218	PF00498	0.737
LIG_FHA_1	224	230	PF00498	0.577
LIG_FHA_1	243	249	PF00498	0.571
LIG_FHA_1	274	280	PF00498	0.505
LIG_FHA_1	86	92	PF00498	0.586
LIG_FHA_2	1	7	PF00498	0.504
LIG_FHA_2	187	193	PF00498	0.798
LIG_FHA_2	229	235	PF00498	0.502
LIG_LIR_Gen_1	3	12	PF02991	0.504
LIG_LIR_Nem_3	205	211	PF02991	0.473
LIG_LIR_Nem_3	256	262	PF02991	0.563
LIG_LIR_Nem_3	3	8	PF02991	0.504
LIG_LIR_Nem_3	72	77	PF02991	0.422
LIG_SH2_CRK	168	172	PF00017	0.749
LIG_SH2_CRK	23	27	PF00017	0.207
LIG_SH2_CRK	5	9	PF00017	0.504
LIG_SH2_CRK	62	66	PF00017	0.504
LIG_SH2_GRB2like	168	171	PF00017	0.746
LIG_SH2_PTP2	208	211	PF00017	0.464
LIG_SH2_SRC	168	171	PF00017	0.746
LIG_SH2_SRC	208	211	PF00017	0.464
LIG_SH2_STAP1	213	217	PF00017	0.641
LIG_SH2_STAP1	74	78	PF00017	0.577
LIG_SH2_STAT3	77	80	PF00017	0.362
LIG_SH2_STAT5	208	211	PF00017	0.581
LIG_SH2_STAT5	213	216	PF00017	0.621
LIG_SH2_STAT5	77	80	PF00017	0.449
LIG_SH3_3	204	210	PF00018	0.478
LIG_SH3_3	282	288	PF00018	0.703
LIG_SUMO_SIM_anti_2	296	302	PF11976	0.419
LIG_TRAF2_1	153	156	PF00917	0.737
LIG_TRAF2_1	189	192	PF00917	0.546
LIG_TRFH_1	89	93	PF08558	0.475
LIG_TYR_ITIM	206	211	PF00017	0.470
MOD_CDK_SPxK_1	175	181	PF00069	0.516
MOD_CK1_1	136	142	PF00069	0.506
MOD_CK1_1	186	192	PF00069	0.612
MOD_CK1_1	202	208	PF00069	0.657
MOD_CK1_1	223	229	PF00069	0.592
MOD_CK1_1	271	277	PF00069	0.604
MOD_CK1_1	280	286	PF00069	0.574
MOD_CK2_1	12	18	PF00069	0.407
MOD_CK2_1	150	156	PF00069	0.777
MOD_CK2_1	186	192	PF00069	0.793
MOD_CK2_1	228	234	PF00069	0.509
MOD_GlcNHglycan	118	121	PF01048	0.620
MOD_GlcNHglycan	138	141	PF01048	0.665
MOD_GlcNHglycan	145	148	PF01048	0.733
MOD_GlcNHglycan	184	188	PF01048	0.535
MOD_GlcNHglycan	250	253	PF01048	0.653
MOD_GlcNHglycan	270	273	PF01048	0.801
MOD_GlcNHglycan	279	282	PF01048	0.621
MOD_GlcNHglycan	85	88	PF01048	0.534
MOD_GSK3_1	112	119	PF00069	0.492
MOD_GSK3_1	129	136	PF00069	0.539
MOD_GSK3_1	182	189	PF00069	0.663
MOD_GSK3_1	211	218	PF00069	0.569
MOD_GSK3_1	248	255	PF00069	0.762
MOD_GSK3_1	273	280	PF00069	0.528
MOD_GSK3_1	81	88	PF00069	0.383
MOD_N-GLC_1	134	139	PF02516	0.506
MOD_N-GLC_1	38	43	PF02516	0.504
MOD_NEK2_1	12	17	PF00069	0.252
MOD_NEK2_2	215	220	PF00069	0.498
MOD_NEK2_2	233	238	PF00069	0.423
MOD_PIKK_1	100	106	PF00454	0.563
MOD_PIKK_1	12	18	PF00454	0.504
MOD_PIKK_1	151	157	PF00454	0.538
MOD_PK_1	134	140	PF00069	0.523
MOD_PKA_1	220	226	PF00069	0.522
MOD_PKA_2	220	226	PF00069	0.522
MOD_Plk_1	134	140	PF00069	0.504
MOD_Plk_1	223	229	PF00069	0.521
MOD_Plk_1	38	44	PF00069	0.504
MOD_ProDKin_1	175	181	PF00069	0.516
MOD_ProDKin_1	197	203	PF00069	0.764
MOD_ProDKin_1	260	266	PF00069	0.715
MOD_ProDKin_1	271	277	PF00069	0.470
MOD_SUMO_rev_2	119	128	PF00179	0.509
TRG_DiLeu_BaEn_1	53	58	PF01217	0.252
TRG_DiLeu_BaLyEn_6	22	27	PF01217	0.504
TRG_ENDOCYTIC_2	208	211	PF00928	0.464
TRG_ENDOCYTIC_2	23	26	PF00928	0.207
TRG_ENDOCYTIC_2	5	8	PF00928	0.504
TRG_ENDOCYTIC_2	62	65	PF00928	0.504
TRG_ER_diArg_1	219	221	PF00400	0.519
TRG_ER_diArg_1	23	25	PF00400	0.465
TRG_ER_diArg_1	288	290	PF00400	0.710
TRG_ER_diArg_1	96	98	PF00400	0.737
TRG_Pf-PMV_PEXEL_1	292	296	PF00026	0.686
TRG_Pf-PMV_PEXEL_1	48	53	PF00026	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WQB1	Leishmania donovani	57%	100%
A4HTL3	Leishmania infantum	56%	100%
E9AME4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
Q4QIA4	Leishmania major	55%	95%
Q5F5M1	Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)	26%	82%