Amastin surface glycofamily protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Amastin surface glycoprotein, putative

Species:

Leishmania braziliensis

UniProt:

A4H5G2_LEIBR

TriTrypDb:

LbrM.08.1010 , LBRM2903_080010200

Length:

298

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4H5G2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5G2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	177	179	PF00675	0.688
CLV_NRD_NRD_1	217	219	PF00675	0.532
CLV_NRD_NRD_1	275	277	PF00675	0.488
CLV_PCSK_KEX2_1	177	179	PF00082	0.661
CLV_PCSK_KEX2_1	217	219	PF00082	0.521
CLV_PCSK_KEX2_1	275	277	PF00082	0.488
CLV_PCSK_SKI1_1	217	221	PF00082	0.520
CLV_PCSK_SKI1_1	67	71	PF00082	0.532
DEG_APCC_DBOX_1	176	184	PF00400	0.354
DEG_SCF_FBW7_2	55	61	PF00400	0.345
DOC_CDC14_PxL_1	189	197	PF14671	0.374
DOC_CKS1_1	55	60	PF01111	0.343
DOC_MAPK_FxFP_2	164	167	PF00069	0.391
DOC_PP4_FxxP_1	164	167	PF00568	0.399
DOC_PP4_FxxP_1	190	193	PF00568	0.391
DOC_USP7_MATH_1	83	87	PF00917	0.393
DOC_USP7_UBL2_3	67	71	PF12436	0.397
DOC_WW_Pin1_4	103	108	PF00397	0.538
DOC_WW_Pin1_4	199	204	PF00397	0.471
DOC_WW_Pin1_4	226	231	PF00397	0.271
DOC_WW_Pin1_4	54	59	PF00397	0.336
LIG_14-3-3_CanoR_1	115	120	PF00244	0.678
LIG_14-3-3_CanoR_1	210	216	PF00244	0.370
LIG_14-3-3_CanoR_1	217	225	PF00244	0.304
LIG_BRCT_BRCA1_1	105	109	PF00533	0.608
LIG_deltaCOP1_diTrp_1	182	190	PF00928	0.335
LIG_FHA_1	127	133	PF00498	0.395
LIG_FHA_1	167	173	PF00498	0.408
LIG_FHA_1	219	225	PF00498	0.425
LIG_FHA_1	27	33	PF00498	0.447
LIG_FHA_1	45	51	PF00498	0.321
LIG_LIR_Apic_2	162	167	PF02991	0.398
LIG_LIR_Gen_1	252	260	PF02991	0.285
LIG_LIR_Gen_1	261	272	PF02991	0.326
LIG_LIR_Nem_3	240	246	PF02991	0.341
LIG_LIR_Nem_3	252	256	PF02991	0.307
LIG_LIR_Nem_3	261	267	PF02991	0.326
LIG_LIR_Nem_3	53	59	PF02991	0.272
LIG_MYND_1	199	203	PF01753	0.415
LIG_PCNA_yPIPBox_3	41	50	PF02747	0.262
LIG_SH2_GRB2like	146	149	PF00017	0.342
LIG_SH2_STAP1	146	150	PF00017	0.400
LIG_SH2_STAT5	140	143	PF00017	0.327
LIG_SH2_STAT5	179	182	PF00017	0.363
LIG_SH2_STAT5	25	28	PF00017	0.340
LIG_SH2_STAT5	56	59	PF00017	0.351
LIG_SUMO_SIM_anti_2	129	135	PF11976	0.233
LIG_SUMO_SIM_anti_2	266	271	PF11976	0.394
LIG_SUMO_SIM_anti_2	284	291	PF11976	0.671
LIG_UBA3_1	141	149	PF00899	0.266
LIG_UBA3_1	34	41	PF00899	0.269
LIG_WRC_WIRS_1	235	240	PF05994	0.386
LIG_WRC_WIRS_1	66	71	PF05994	0.338
MOD_CDK_SPxxK_3	199	206	PF00069	0.450
MOD_CK1_1	170	176	PF00069	0.434
MOD_CK1_1	3	9	PF00069	0.654
MOD_CK1_1	44	50	PF00069	0.316
MOD_CK1_1	65	71	PF00069	0.281
MOD_CK2_1	151	157	PF00069	0.357
MOD_CK2_1	234	240	PF00069	0.309
MOD_CMANNOS	184	187	PF00535	0.538
MOD_Cter_Amidation	273	276	PF01082	0.414
MOD_GlcNHglycan	152	156	PF01048	0.590
MOD_GlcNHglycan	169	172	PF01048	0.599
MOD_GlcNHglycan	17	20	PF01048	0.387
MOD_GlcNHglycan	284	287	PF01048	0.550
MOD_GSK3_1	103	110	PF00069	0.632
MOD_GSK3_1	11	18	PF00069	0.445
MOD_GSK3_1	162	169	PF00069	0.480
MOD_GSK3_1	205	212	PF00069	0.461
MOD_GSK3_1	50	57	PF00069	0.318
MOD_N-GLC_1	42	47	PF02516	0.579
MOD_NEK2_1	109	114	PF00069	0.619
MOD_NEK2_1	11	16	PF00069	0.559
MOD_NEK2_1	132	137	PF00069	0.308
MOD_NEK2_1	159	164	PF00069	0.444
MOD_NEK2_1	26	31	PF00069	0.290
MOD_NEK2_1	42	47	PF00069	0.245
MOD_NEK2_2	205	210	PF00069	0.404
MOD_NEK2_2	234	239	PF00069	0.383
MOD_PIKK_1	107	113	PF00454	0.566
MOD_PIKK_1	170	176	PF00454	0.407
MOD_PIKK_1	44	50	PF00454	0.306
MOD_PK_1	188	194	PF00069	0.360
MOD_PK_1	62	68	PF00069	0.282
MOD_PKA_2	11	17	PF00069	0.490
MOD_PKA_2	209	215	PF00069	0.367
MOD_PKB_1	113	121	PF00069	0.547
MOD_Plk_1	151	157	PF00069	0.404
MOD_Plk_1	42	48	PF00069	0.443
MOD_Plk_4	11	17	PF00069	0.477
MOD_Plk_4	123	129	PF00069	0.233
MOD_Plk_4	65	71	PF00069	0.340
MOD_Plk_4	84	90	PF00069	0.395
MOD_ProDKin_1	103	109	PF00069	0.544
MOD_ProDKin_1	199	205	PF00069	0.470
MOD_ProDKin_1	226	232	PF00069	0.277
MOD_ProDKin_1	54	60	PF00069	0.339
TRG_DiLeu_BaEn_1	293	298	PF01217	0.659
TRG_DiLeu_LyEn_5	293	298	PF01217	0.685
TRG_ENDOCYTIC_2	156	159	PF00928	0.401
TRG_ENDOCYTIC_2	186	189	PF00928	0.399
TRG_ENDOCYTIC_2	56	59	PF00928	0.291
TRG_ER_diArg_1	114	117	PF00400	0.678
TRG_ER_diArg_1	177	179	PF00400	0.397
TRG_ER_diArg_1	193	196	PF00400	0.430
TRG_ER_diArg_1	216	218	PF00400	0.325
TRG_ER_diArg_1	275	277	PF00400	0.589
TRG_Pf-PMV_PEXEL_1	178	182	PF00026	0.550
TRG_Pf-PMV_PEXEL_1	275	279	PF00026	0.373

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I287	Leptomonas seymouri	40%	100%
A0A3S7WQ88	Leishmania donovani	58%	99%
A4HTL2	Leishmania infantum	58%	99%
E9AME3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	98%
Q4QIA5	Leishmania major	58%	96%