MIX domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MIX protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H5F8_LEIBR

TriTrypDb:

LbrM.08.0970 , LBRM2903_080017500

Length:

195

Annotations

LeishMANIAdb annotations

Appears to be a small signal-anchored protein, specific to Kinetoplastids. Generally not duplicated, only in Strigomonas

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

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Expansion

Sequence features

A4H5F8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5F8

PDB structure(s): 3ha4_A , 3ha4_B , 3ha4_C , 3ha4_D , 3ha4_E , 3ha4_F , 3ha4_G , 3ha4_H

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0042802	identical protein binding	3	1
GO:0042803	protein homodimerization activity	4	1
GO:0046983	protein dimerization activity	3	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	138	140	PF00675	0.296
CLV_NRD_NRD_1	3	5	PF00675	0.654
CLV_NRD_NRD_1	71	73	PF00675	0.277
CLV_PCSK_KEX2_1	3	5	PF00082	0.654
CLV_PCSK_KEX2_1	71	73	PF00082	0.282
CLV_PCSK_SKI1_1	140	144	PF00082	0.282
CLV_PCSK_SKI1_1	26	30	PF00082	0.492
CLV_PCSK_SKI1_1	81	85	PF00082	0.282
DEG_Nend_Nbox_1	1	3	PF02207	0.491
DOC_MAPK_gen_1	139	146	PF00069	0.496

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3I0	Leptomonas seymouri	88%	100%
A0A0S4IQY8	Bodo saltans	55%	100%
A0A1X0NFN6	Trypanosomatidae	73%	98%
A0A3R7KDG8	Trypanosoma rangeli	73%	98%
A0A3S5H693	Leishmania donovani	93%	100%
A4HTQ3	Leishmania infantum	94%	100%
C9ZPF9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	98%
E9AMJ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QI49	Leishmania major	94%	100%

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