Pre-mRNA-splicing factor SLU7

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5F6_LEIBR

TriTrypDb:

LbrM.08.0950 , LBRM2903_080017300

Length:

417

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0140513	nuclear protein-containing complex	2	12
GO:1990904	ribonucleoprotein complex	2	12

Expansion

Sequence features

A4H5F6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5F6

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	12
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	12
GO:0000398	mRNA splicing, via spliceosome	8	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006397	mRNA processing	7	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008380	RNA splicing	7	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016071	mRNA metabolic process	6	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0000386	second spliceosomal transesterification activity	4	12
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0030628	pre-mRNA 3'-splice site binding	6	12
GO:0036002	pre-mRNA binding	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0008270	zinc ion binding	6	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	215	219	PF00656	0.529
CLV_C14_Caspase3-7	405	409	PF00656	0.364
CLV_NRD_NRD_1	122	124	PF00675	0.327
CLV_NRD_NRD_1	27	29	PF00675	0.367
CLV_NRD_NRD_1	282	284	PF00675	0.490
CLV_NRD_NRD_1	70	72	PF00675	0.513
CLV_PCSK_KEX2_1	151	153	PF00082	0.407
CLV_PCSK_KEX2_1	282	284	PF00082	0.466
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.407
CLV_PCSK_SKI1_1	15	19	PF00082	0.562
CLV_PCSK_SKI1_1	263	267	PF00082	0.404
CLV_PCSK_SKI1_1	407	411	PF00082	0.337
CLV_PCSK_SKI1_1	91	95	PF00082	0.301
DEG_Nend_UBRbox_2	1	3	PF02207	0.725
DEG_SPOP_SBC_1	333	337	PF00917	0.731
DEG_SPOP_SBC_1	344	348	PF00917	0.671
DOC_AGCK_PIF_2	272	277	PF00069	0.534
DOC_ANK_TNKS_1	70	77	PF00023	0.379
DOC_CYCLIN_yClb3_PxF_3	47	55	PF00134	0.514
DOC_MAPK_DCC_7	28	37	PF00069	0.379
DOC_MAPK_gen_1	151	161	PF00069	0.518
DOC_MAPK_MEF2A_6	133	141	PF00069	0.287
DOC_MAPK_MEF2A_6	154	163	PF00069	0.532
DOC_PP1_RVXF_1	89	95	PF00149	0.298
DOC_PP4_FxxP_1	221	224	PF00568	0.437
DOC_USP7_MATH_1	345	349	PF00917	0.540
DOC_USP7_MATH_1	364	368	PF00917	0.618
DOC_USP7_UBL2_3	205	209	PF12436	0.432
DOC_USP7_UBL2_3	403	407	PF12436	0.454
DOC_WW_Pin1_4	308	313	PF00397	0.576
DOC_WW_Pin1_4	43	48	PF00397	0.379
LIG_14-3-3_CanoR_1	379	389	PF00244	0.447
LIG_APCC_ABBA_1	139	144	PF00400	0.467
LIG_BIR_III_4	408	412	PF00653	0.383
LIG_BRCT_BRCA1_1	116	120	PF00533	0.430
LIG_BRCT_BRCA1_1	268	272	PF00533	0.439
LIG_BRCT_BRCA1_1	391	395	PF00533	0.426
LIG_FHA_1	129	135	PF00498	0.465
LIG_FHA_1	303	309	PF00498	0.707
LIG_FHA_1	335	341	PF00498	0.469
LIG_FHA_1	9	15	PF00498	0.519
LIG_FHA_2	133	139	PF00498	0.389
LIG_FHA_2	309	315	PF00498	0.477
LIG_FHA_2	39	45	PF00498	0.486
LIG_FHA_2	403	409	PF00498	0.311
LIG_LIR_Apic_2	218	224	PF02991	0.488
LIG_LIR_Gen_1	253	259	PF02991	0.386
LIG_LIR_Gen_1	269	280	PF02991	0.434
LIG_LIR_Gen_1	388	395	PF02991	0.267
LIG_LIR_Nem_3	251	257	PF02991	0.399
LIG_LIR_Nem_3	269	275	PF02991	0.453
LIG_LIR_Nem_3	383	389	PF02991	0.402
LIG_PDZ_Class_1	412	417	PF00595	0.552
LIG_SH2_GRB2like	130	133	PF00017	0.533
LIG_SH2_GRB2like	254	257	PF00017	0.441
LIG_SH2_SRC	257	260	PF00017	0.502
LIG_SH2_STAP1	130	134	PF00017	0.520
LIG_SH2_STAT5	130	133	PF00017	0.533
LIG_SH2_STAT5	210	213	PF00017	0.460
LIG_SH2_STAT5	257	260	PF00017	0.422
LIG_SH2_STAT5	389	392	PF00017	0.336
LIG_SH3_3	175	181	PF00018	0.605
LIG_SH3_3	44	50	PF00018	0.373
LIG_SUMO_SIM_par_1	33	41	PF11976	0.383
LIG_TRAF2_1	290	293	PF00917	0.383
LIG_TRAF2_1	41	44	PF00917	0.431
LIG_TRFH_1	30	34	PF08558	0.387
MOD_CK1_1	128	134	PF00069	0.505
MOD_CK1_1	238	244	PF00069	0.525
MOD_CK1_1	335	341	PF00069	0.635
MOD_CK2_1	287	293	PF00069	0.455
MOD_CK2_1	333	339	PF00069	0.553
MOD_CK2_1	38	44	PF00069	0.441
MOD_GSK3_1	110	117	PF00069	0.434
MOD_GSK3_1	128	135	PF00069	0.277
MOD_GSK3_1	232	239	PF00069	0.565
MOD_GSK3_1	302	309	PF00069	0.660
MOD_GSK3_1	316	323	PF00069	0.494
MOD_GSK3_1	335	342	PF00069	0.569
MOD_GSK3_1	352	359	PF00069	0.518
MOD_GSK3_1	360	367	PF00069	0.492
MOD_GSK3_1	371	378	PF00069	0.569
MOD_GSK3_1	385	392	PF00069	0.404
MOD_GSK3_1	407	414	PF00069	0.460
MOD_NEK2_1	316	321	PF00069	0.464
MOD_NEK2_2	389	394	PF00069	0.263
MOD_PIKK_1	146	152	PF00454	0.595
MOD_PIKK_1	257	263	PF00454	0.493
MOD_PIKK_1	287	293	PF00454	0.376
MOD_PK_1	10	16	PF00069	0.591
MOD_PK_1	125	131	PF00069	0.493
MOD_PKA_1	9	15	PF00069	0.687
MOD_PKA_2	132	138	PF00069	0.517
MOD_PKA_2	99	105	PF00069	0.539
MOD_Plk_4	125	131	PF00069	0.503
MOD_Plk_4	268	274	PF00069	0.463
MOD_Plk_4	303	309	PF00069	0.529
MOD_Plk_4	339	345	PF00069	0.625
MOD_Plk_4	371	377	PF00069	0.603
MOD_Plk_4	385	391	PF00069	0.280
MOD_Plk_4	63	69	PF00069	0.448
MOD_ProDKin_1	308	314	PF00069	0.571
MOD_ProDKin_1	43	49	PF00069	0.376
MOD_SUMO_rev_2	138	147	PF00179	0.528
MOD_SUMO_rev_2	218	226	PF00179	0.455
MOD_SUMO_rev_2	335	343	PF00179	0.613
TRG_DiLeu_BaEn_1	339	344	PF01217	0.475
TRG_ENDOCYTIC_2	255	258	PF00928	0.385
TRG_ER_diArg_1	185	188	PF00400	0.621
TRG_ER_diArg_1	281	283	PF00400	0.560
TRG_Pf-PMV_PEXEL_1	15	20	PF00026	0.483
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.383
TRG_Pf-PMV_PEXEL_1	263	268	PF00026	0.364

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD09	Leptomonas seymouri	66%	98%
A0A0S4IP46	Bodo saltans	35%	97%
A0A1X0NEY6	Trypanosomatidae	47%	92%
A0A3R7NLB9	Trypanosoma rangeli	45%	98%
A0A3S5H692	Leishmania donovani	82%	100%
A4HTQ1	Leishmania infantum	82%	100%
C9ZPF5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	87%
E9AMI8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
O23174	Arabidopsis thaliana	27%	78%
O95391	Homo sapiens	27%	71%
Q3ZBE5	Bos taurus	27%	71%
Q4QI51	Leishmania major	84%	100%
Q4R4P2	Macaca fascicularis	27%	71%
Q4WWR2	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	26%	88%
Q51LA6	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	26%	88%
Q54TA0	Dictyostelium discoideum	26%	75%
Q5B3U2	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	26%	89%
Q5U3F2	Danio rerio	27%	73%
Q5ZIG2	Gallus gallus	27%	74%
Q7SDY6	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	24%	100%
Q80ZG5	Rattus norvegicus	27%	71%
Q8BHJ9	Mus musculus	27%	71%
Q9SHY8	Arabidopsis thaliana	29%	78%
Q9VAQ7	Drosophila melanogaster	29%	73%
V5DAD7	Trypanosoma cruzi	46%	90%