RAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MRB1 complex subunit MRB3010

Species:

Leishmania braziliensis

UniProt:

A4H5F5_LEIBR

TriTrypDb:

LbrM.08.0940 , LBRM2903_080017200

Length:

442

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H5F5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5F5

Function

Biological processes
Term	Name	Level	Count
GO:0000959	mitochondrial RNA metabolic process	6	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1900864	mitochondrial RNA modification	6	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	175	177	PF00675	0.375
CLV_NRD_NRD_1	19	21	PF00675	0.378
CLV_NRD_NRD_1	375	377	PF00675	0.289
CLV_PCSK_KEX2_1	175	177	PF00082	0.331
CLV_PCSK_KEX2_1	19	21	PF00082	0.378
CLV_PCSK_KEX2_1	208	210	PF00082	0.354
CLV_PCSK_KEX2_1	319	321	PF00082	0.319
CLV_PCSK_KEX2_1	375	377	PF00082	0.289
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.354
CLV_PCSK_PC1ET2_1	319	321	PF00082	0.334
CLV_PCSK_SKI1_1	111	115	PF00082	0.330
CLV_PCSK_SKI1_1	19	23	PF00082	0.379
CLV_PCSK_SKI1_1	346	350	PF00082	0.474
CLV_PCSK_SKI1_1	375	379	PF00082	0.269
DEG_APCC_DBOX_1	374	382	PF00400	0.270
DEG_Nend_UBRbox_1	1	4	PF02207	0.411
DOC_CYCLIN_RxL_1	17	26	PF00134	0.360
DOC_CYCLIN_RxL_1	372	380	PF00134	0.435
DOC_CYCLIN_RxL_1	395	405	PF00134	0.321
DOC_MAPK_gen_1	129	138	PF00069	0.211
DOC_MAPK_gen_1	54	62	PF00069	0.402
DOC_MAPK_gen_1	65	74	PF00069	0.356
DOC_MAPK_gen_1	88	96	PF00069	0.322
DOC_MAPK_MEF2A_6	65	74	PF00069	0.346
DOC_PP1_RVXF_1	17	24	PF00149	0.366
DOC_PP1_RVXF_1	296	303	PF00149	0.196
DOC_PP1_RVXF_1	373	380	PF00149	0.285
DOC_PP4_FxxP_1	407	410	PF00568	0.370
DOC_PP4_FxxP_1	427	430	PF00568	0.353
DOC_USP7_UBL2_3	198	202	PF12436	0.358
DOC_USP7_UBL2_3	383	387	PF12436	0.299
LIG_14-3-3_CanoR_1	132	137	PF00244	0.316
LIG_14-3-3_CanoR_1	175	181	PF00244	0.365
LIG_14-3-3_CanoR_1	183	187	PF00244	0.349
LIG_14-3-3_CanoR_1	320	328	PF00244	0.293
LIG_14-3-3_CanoR_1	376	382	PF00244	0.297
LIG_14-3-3_CterR_2	438	442	PF00244	0.408
LIG_APCC_ABBA_1	400	405	PF00400	0.349
LIG_BIR_III_4	109	113	PF00653	0.374
LIG_BRCT_BRCA1_1	206	210	PF00533	0.338
LIG_FHA_1	112	118	PF00498	0.368
LIG_FHA_1	345	351	PF00498	0.335
LIG_FHA_2	183	189	PF00498	0.350
LIG_LIR_Apic_2	405	410	PF02991	0.356
LIG_LIR_Gen_1	269	278	PF02991	0.373
LIG_LIR_Gen_1	279	289	PF02991	0.287
LIG_LIR_Gen_1	417	427	PF02991	0.476
LIG_LIR_Gen_1	67	77	PF02991	0.490
LIG_LIR_Nem_3	128	134	PF02991	0.290
LIG_LIR_Nem_3	241	247	PF02991	0.376
LIG_LIR_Nem_3	269	273	PF02991	0.317
LIG_LIR_Nem_3	279	284	PF02991	0.242
LIG_LIR_Nem_3	315	321	PF02991	0.320
LIG_LIR_Nem_3	330	335	PF02991	0.340
LIG_LIR_Nem_3	417	423	PF02991	0.325
LIG_LIR_Nem_3	67	72	PF02991	0.386
LIG_NRBOX	129	135	PF00104	0.294
LIG_Pex14_2	344	348	PF04695	0.455
LIG_Pex14_2	423	427	PF04695	0.478
LIG_PTB_Apo_2	63	70	PF02174	0.471
LIG_SH2_CRK	240	244	PF00017	0.311
LIG_SH2_STAP1	240	244	PF00017	0.311
LIG_SH2_STAT3	164	167	PF00017	0.243
LIG_SH2_STAT3	217	220	PF00017	0.334
LIG_SH2_STAT5	217	220	PF00017	0.334
LIG_SH2_STAT5	235	238	PF00017	0.330
LIG_SH2_STAT5	262	265	PF00017	0.296
LIG_SH2_STAT5	364	367	PF00017	0.361
LIG_SH2_STAT5	46	49	PF00017	0.344
LIG_SH3_3	383	389	PF00018	0.353
LIG_SH3_3	419	425	PF00018	0.489
LIG_SUMO_SIM_anti_2	36	41	PF11976	0.321
LIG_SUMO_SIM_anti_2	71	76	PF11976	0.323
LIG_SUMO_SIM_par_1	352	360	PF11976	0.401
LIG_SUMO_SIM_par_1	75	80	PF11976	0.326
LIG_TYR_ITIM	238	243	PF00017	0.328
LIG_UBA3_1	377	383	PF00899	0.285
LIG_WRC_WIRS_1	267	272	PF05994	0.493
LIG_WW_1	429	432	PF00397	0.326
MOD_CK1_1	118	124	PF00069	0.330
MOD_CK2_1	176	182	PF00069	0.403
MOD_GlcNHglycan	117	120	PF01048	0.353
MOD_GlcNHglycan	170	173	PF01048	0.212
MOD_GSK3_1	111	118	PF00069	0.318
MOD_GSK3_1	262	269	PF00069	0.312
MOD_GSK3_1	298	305	PF00069	0.199
MOD_GSK3_1	320	327	PF00069	0.265
MOD_GSK3_1	434	441	PF00069	0.464
MOD_GSK3_1	77	84	PF00069	0.303
MOD_N-GLC_2	397	399	PF02516	0.315
MOD_N-GLC_2	426	428	PF02516	0.301
MOD_NEK2_1	120	125	PF00069	0.334
MOD_NEK2_1	22	27	PF00069	0.346
MOD_NEK2_1	302	307	PF00069	0.411
MOD_NEK2_1	337	342	PF00069	0.285
MOD_NEK2_1	344	349	PF00069	0.318
MOD_NEK2_1	377	382	PF00069	0.265
MOD_NEK2_1	40	45	PF00069	0.434
MOD_NEK2_1	434	439	PF00069	0.357
MOD_NEK2_2	81	86	PF00069	0.312
MOD_PKA_2	182	188	PF00069	0.346
MOD_Plk_1	298	304	PF00069	0.241
MOD_Plk_2-3	182	188	PF00069	0.353
MOD_SUMO_for_1	312	315	PF00179	0.355
MOD_SUMO_rev_2	197	207	PF00179	0.347
MOD_SUMO_rev_2	294	300	PF00179	0.455
TRG_DiLeu_BaEn_1	148	153	PF01217	0.306
TRG_DiLeu_BaLyEn_6	129	134	PF01217	0.219
TRG_DiLeu_BaLyEn_6	373	378	PF01217	0.424
TRG_DiLeu_LyEn_5	188	193	PF01217	0.296
TRG_ENDOCYTIC_2	235	238	PF00928	0.334
TRG_ENDOCYTIC_2	240	243	PF00928	0.315
TRG_ENDOCYTIC_2	46	49	PF00928	0.359
TRG_ER_diArg_1	161	164	PF00400	0.347
TRG_ER_diArg_1	19	21	PF00400	0.378
TRG_ER_diArg_1	374	376	PF00400	0.292
TRG_NES_CRM1_1	128	139	PF08389	0.297

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Z9	Leptomonas seymouri	24%	92%
A0A0N1HY66	Leptomonas seymouri	89%	82%
A0A0S4IS85	Bodo saltans	83%	84%
A0A1X0NEZ9	Trypanosomatidae	87%	86%
A0A1X0P8G7	Trypanosomatidae	25%	91%
A0A3S5H691	Leishmania donovani	97%	100%
A0A422NFX5	Trypanosoma rangeli	87%	85%
A0A422P283	Trypanosoma rangeli	26%	92%
A4HNQ2	Leishmania braziliensis	23%	92%
A4HTQ0	Leishmania infantum	97%	100%
C9ZPF4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	87%	86%
D0A2L1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	94%
E9AMI7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9ASG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	92%
Q4QI52	Leishmania major	96%	100%
V5BEF0	Trypanosoma cruzi	87%	85%
V5BQI6	Trypanosoma cruzi	25%	92%