Thiopurine S-methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Thiopurine S-methyltransferase (TPMT), putative

Species:

Leishmania braziliensis

UniProt:

A4H5F4_LEIBR

TriTrypDb:

LbrM.08.0930 , LBRM2903_080017100

Length:

422

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4H5F4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5F4

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	10
GO:0032259	methylation	2	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0008168	methyltransferase activity	4	11
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	11
GO:0016740	transferase activity	2	11
GO:0016741	transferase activity, transferring one-carbon groups	3	11
GO:0008119	thiopurine S-methyltransferase activity	6	1
GO:0008172	S-methyltransferase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	231	235	PF00656	0.455
CLV_C14_Caspase3-7	359	363	PF00656	0.441
CLV_NRD_NRD_1	101	103	PF00675	0.587
CLV_NRD_NRD_1	29	31	PF00675	0.397
CLV_PCSK_KEX2_1	306	308	PF00082	0.373
CLV_PCSK_KEX2_1	340	342	PF00082	0.284
CLV_PCSK_KEX2_1	375	377	PF00082	0.322
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.382
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.346
CLV_PCSK_PC1ET2_1	375	377	PF00082	0.374
CLV_PCSK_SKI1_1	123	127	PF00082	0.535
CLV_PCSK_SKI1_1	264	268	PF00082	0.242
CLV_PCSK_SKI1_1	307	311	PF00082	0.272
CLV_PCSK_SKI1_1	35	39	PF00082	0.481
CLV_PCSK_SKI1_1	372	376	PF00082	0.328
CLV_PCSK_SKI1_1	392	396	PF00082	0.222
CLV_PCSK_SKI1_1	41	45	PF00082	0.422
DEG_SCF_FBW7_2	411	418	PF00400	0.647
DEG_SPOP_SBC_1	172	176	PF00917	0.395
DEG_SPOP_SBC_1	42	46	PF00917	0.520
DOC_CKS1_1	412	417	PF01111	0.578
DOC_MAPK_gen_1	306	317	PF00069	0.566
DOC_MAPK_gen_1	375	383	PF00069	0.628
DOC_PP2B_LxvP_1	413	416	PF13499	0.646
DOC_PP4_FxxP_1	118	121	PF00568	0.368
DOC_PP4_FxxP_1	266	269	PF00568	0.536
DOC_PP4_FxxP_1	64	67	PF00568	0.297
DOC_PP4_MxPP_1	332	335	PF00568	0.496
DOC_USP7_MATH_1	110	114	PF00917	0.503
DOC_USP7_MATH_1	172	176	PF00917	0.562
DOC_USP7_MATH_1	196	200	PF00917	0.463
DOC_USP7_MATH_1	239	243	PF00917	0.500
DOC_USP7_UBL2_3	306	310	PF12436	0.498
DOC_USP7_UBL2_3	31	35	PF12436	0.653
DOC_USP7_UBL2_3	375	379	PF12436	0.496
DOC_WW_Pin1_4	140	145	PF00397	0.457
DOC_WW_Pin1_4	168	173	PF00397	0.522
DOC_WW_Pin1_4	203	208	PF00397	0.494
DOC_WW_Pin1_4	214	219	PF00397	0.457
DOC_WW_Pin1_4	265	270	PF00397	0.536
DOC_WW_Pin1_4	381	386	PF00397	0.544
DOC_WW_Pin1_4	411	416	PF00397	0.733
DOC_WW_Pin1_4	90	95	PF00397	0.422
LIG_14-3-3_CanoR_1	195	204	PF00244	0.414
LIG_14-3-3_CanoR_1	399	404	PF00244	0.653
LIG_Actin_WH2_2	17	32	PF00022	0.678
LIG_Actin_WH2_2	360	377	PF00022	0.538
LIG_BRCT_BRCA1_1	114	118	PF00533	0.396
LIG_BRCT_BRCA1_1	142	146	PF00533	0.272
LIG_CaM_IQ_9	361	377	PF13499	0.496
LIG_Clathr_ClatBox_1	314	318	PF01394	0.536
LIG_deltaCOP1_diTrp_1	95	101	PF00928	0.395
LIG_FHA_1	220	226	PF00498	0.543
LIG_FHA_1	321	327	PF00498	0.454
LIG_FHA_1	393	399	PF00498	0.604
LIG_FHA_1	400	406	PF00498	0.666
LIG_FHA_1	5	11	PF00498	0.720
LIG_FHA_2	127	133	PF00498	0.316
LIG_FHA_2	398	404	PF00498	0.696
LIG_FHA_2	90	96	PF00498	0.442
LIG_LIR_Apic_2	115	121	PF02991	0.341
LIG_LIR_Apic_2	270	275	PF02991	0.478
LIG_LIR_Gen_1	300	309	PF02991	0.444
LIG_LIR_Gen_1	384	394	PF02991	0.549
LIG_LIR_Nem_3	300	304	PF02991	0.444
LIG_LIR_Nem_3	384	389	PF02991	0.575
LIG_MLH1_MIPbox_1	114	118	PF16413	0.396
LIG_MYND_1	411	415	PF01753	0.717
LIG_Pex14_1	263	267	PF04695	0.455
LIG_Pex14_2	64	68	PF04695	0.297
LIG_SH2_CRK	122	126	PF00017	0.339
LIG_SH2_CRK	256	260	PF00017	0.477
LIG_SH2_CRK	281	285	PF00017	0.498
LIG_SH2_CRK	301	305	PF00017	0.442
LIG_SH2_NCK_1	281	285	PF00017	0.536
LIG_SH2_PTP2	81	84	PF00017	0.473
LIG_SH2_SRC	316	319	PF00017	0.442
LIG_SH2_STAP1	281	285	PF00017	0.477
LIG_SH2_STAP1	301	305	PF00017	0.453
LIG_SH2_STAT3	285	288	PF00017	0.442
LIG_SH2_STAT5	303	306	PF00017	0.450
LIG_SH2_STAT5	316	319	PF00017	0.424
LIG_SH2_STAT5	354	357	PF00017	0.475
LIG_SH2_STAT5	81	84	PF00017	0.473
LIG_SH3_1	80	86	PF00018	0.428
LIG_SH3_3	145	151	PF00018	0.371
LIG_SH3_3	198	204	PF00018	0.402
LIG_SH3_3	405	411	PF00018	0.748
LIG_SH3_3	79	85	PF00018	0.430
LIG_SH3_3	9	15	PF00018	0.714
LIG_TRAF2_1	415	418	PF00917	0.680
LIG_TYR_ITIM	254	259	PF00017	0.478
LIG_UBA3_1	25	31	PF00899	0.667
LIG_UBA3_1	37	41	PF00899	0.514
MOD_CDK_SPxxK_3	214	221	PF00069	0.442
MOD_CK1_1	134	140	PF00069	0.445
MOD_CK1_1	171	177	PF00069	0.525
MOD_CK1_1	235	241	PF00069	0.547
MOD_CK1_1	242	248	PF00069	0.559
MOD_CK1_1	36	42	PF00069	0.678
MOD_CK2_1	185	191	PF00069	0.282
MOD_CK2_1	242	248	PF00069	0.407
MOD_CK2_1	336	342	PF00069	0.455
MOD_CK2_1	397	403	PF00069	0.643
MOD_CK2_1	89	95	PF00069	0.488
MOD_Cter_Amidation	277	280	PF01082	0.298
MOD_DYRK1A_RPxSP_1	168	172	PF00069	0.420
MOD_GlcNHglycan	134	137	PF01048	0.614
MOD_GlcNHglycan	168	171	PF01048	0.660
MOD_GlcNHglycan	196	199	PF01048	0.436
MOD_GlcNHglycan	241	244	PF01048	0.282
MOD_GSK3_1	140	147	PF00069	0.455
MOD_GSK3_1	166	173	PF00069	0.533
MOD_GSK3_1	235	242	PF00069	0.494
MOD_GSK3_1	29	36	PF00069	0.695
MOD_NEK2_1	1	6	PF00069	0.683
MOD_NEK2_1	139	144	PF00069	0.379
MOD_NEK2_1	166	171	PF00069	0.486
MOD_NEK2_1	29	34	PF00069	0.688
MOD_NEK2_1	43	48	PF00069	0.585
MOD_PIKK_1	2	8	PF00454	0.582
MOD_PIKK_1	233	239	PF00454	0.536
MOD_PIKK_1	84	90	PF00454	0.523
MOD_PK_1	33	39	PF00069	0.658
MOD_PKA_2	160	166	PF00069	0.522
MOD_PKA_2	194	200	PF00069	0.355
MOD_PKA_2	29	35	PF00069	0.645
MOD_Plk_1	392	398	PF00069	0.569
MOD_Plk_4	33	39	PF00069	0.658
MOD_ProDKin_1	140	146	PF00069	0.460
MOD_ProDKin_1	168	174	PF00069	0.523
MOD_ProDKin_1	203	209	PF00069	0.494
MOD_ProDKin_1	214	220	PF00069	0.457
MOD_ProDKin_1	265	271	PF00069	0.536
MOD_ProDKin_1	381	387	PF00069	0.538
MOD_ProDKin_1	411	417	PF00069	0.731
MOD_ProDKin_1	90	96	PF00069	0.420
TRG_DiLeu_BaEn_1	21	26	PF01217	0.553
TRG_DiLeu_BaEn_1	72	77	PF01217	0.420
TRG_ENDOCYTIC_2	122	125	PF00928	0.351
TRG_ENDOCYTIC_2	156	159	PF00928	0.348
TRG_ENDOCYTIC_2	256	259	PF00928	0.481
TRG_ENDOCYTIC_2	281	284	PF00928	0.498
TRG_ENDOCYTIC_2	301	304	PF00928	0.442
TRG_ENDOCYTIC_2	81	84	PF00928	0.464
TRG_ER_diArg_1	398	401	PF00400	0.692
TRG_NLS_MonoExtC_3	29	34	PF00514	0.688
TRG_NLS_MonoExtN_4	28	34	PF00514	0.650
TRG_Pf-PMV_PEXEL_1	341	345	PF00026	0.303

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4U9	Leptomonas seymouri	69%	100%
A0A0S4INW4	Bodo saltans	39%	100%
A0A1X0NF48	Trypanosomatidae	51%	100%
A0A3S5H690	Leishmania donovani	86%	99%
A4HTP9	Leishmania infantum	86%	99%
C9ZPF3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AMI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%
Q4QI53	Leishmania major	84%	100%
V5BIU8	Trypanosoma cruzi	50%	100%