Putative suppressive immunomodulating factor

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

suppressive immunomodulating factor, putative

Species:

Leishmania braziliensis

UniProt:

A4H5F2_LEIBR

TriTrypDb:

LbrM.08.0910 , LBRM2903_080016900

Length:

944

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H5F2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5F2

Function

Biological processes
Term	Name	Level	Count
GO:0001775	cell activation	2	1
GO:0002274	myeloid leukocyte activation	3	1
GO:0002376	immune system process	1	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0042116	macrophage activation	4	1
GO:0045321	leukocyte activation	2	1
GO:0045428	regulation of nitric oxide biosynthetic process	6	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080164	regulation of nitric oxide metabolic process	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	476	480	PF00656	0.673
CLV_NRD_NRD_1	565	567	PF00675	0.628
CLV_NRD_NRD_1	733	735	PF00675	0.708
CLV_NRD_NRD_1	737	739	PF00675	0.668
CLV_NRD_NRD_1	741	743	PF00675	0.658
CLV_NRD_NRD_1	887	889	PF00675	0.682
CLV_NRD_NRD_1	99	101	PF00675	0.583
CLV_PCSK_FUR_1	97	101	PF00082	0.482
CLV_PCSK_KEX2_1	565	567	PF00082	0.818
CLV_PCSK_KEX2_1	668	670	PF00082	0.555
CLV_PCSK_KEX2_1	721	723	PF00082	0.715
CLV_PCSK_KEX2_1	737	739	PF00082	0.552
CLV_PCSK_KEX2_1	787	789	PF00082	0.611
CLV_PCSK_KEX2_1	837	839	PF00082	0.741
CLV_PCSK_KEX2_1	886	888	PF00082	0.716
CLV_PCSK_KEX2_1	99	101	PF00082	0.719
CLV_PCSK_PC1ET2_1	668	670	PF00082	0.555
CLV_PCSK_PC1ET2_1	721	723	PF00082	0.750
CLV_PCSK_PC1ET2_1	787	789	PF00082	0.611
CLV_PCSK_PC1ET2_1	837	839	PF00082	0.557
CLV_PCSK_SKI1_1	463	467	PF00082	0.801
CLV_PCSK_SKI1_1	573	577	PF00082	0.822
CLV_PCSK_SKI1_1	65	69	PF00082	0.480
CLV_PCSK_SKI1_1	721	725	PF00082	0.748
CLV_PCSK_SKI1_1	787	791	PF00082	0.615
CLV_PCSK_SKI1_1	867	871	PF00082	0.741
CLV_Separin_Metazoa	335	339	PF03568	0.479
DEG_APCC_DBOX_1	366	374	PF00400	0.513
DEG_APCC_DBOX_1	64	72	PF00400	0.528
DEG_SPOP_SBC_1	508	512	PF00917	0.580
DEG_SPOP_SBC_1	553	557	PF00917	0.588
DEG_SPOP_SBC_1	626	630	PF00917	0.628
DOC_CDC14_PxL_1	83	91	PF14671	0.532
DOC_CKS1_1	903	908	PF01111	0.740
DOC_CYCLIN_yCln2_LP_2	931	937	PF00134	0.676
DOC_MAPK_gen_1	813	820	PF00069	0.522
DOC_MAPK_MEF2A_6	222	229	PF00069	0.605
DOC_MAPK_MEF2A_6	721	730	PF00069	0.760
DOC_MAPK_NFAT4_5	222	230	PF00069	0.600
DOC_PP1_RVXF_1	871	877	PF00149	0.781
DOC_PP2B_LxvP_1	405	408	PF13499	0.831
DOC_PP2B_LxvP_1	547	550	PF13499	0.729
DOC_PP2B_LxvP_1	818	821	PF13499	0.524
DOC_PP2B_LxvP_1	931	934	PF13499	0.682
DOC_PP2B_LxvP_1	935	938	PF13499	0.666
DOC_PP4_FxxP_1	276	279	PF00568	0.538
DOC_PP4_FxxP_1	903	906	PF00568	0.667
DOC_SPAK_OSR1_1	338	342	PF12202	0.486
DOC_USP7_MATH_1	242	246	PF00917	0.559
DOC_USP7_MATH_1	303	307	PF00917	0.560
DOC_USP7_MATH_1	328	332	PF00917	0.516
DOC_USP7_MATH_1	411	415	PF00917	0.649
DOC_USP7_MATH_1	428	432	PF00917	0.517
DOC_USP7_MATH_1	504	508	PF00917	0.838
DOC_USP7_MATH_1	542	546	PF00917	0.822
DOC_USP7_MATH_1	553	557	PF00917	0.659
DOC_USP7_MATH_1	575	579	PF00917	0.577
DOC_USP7_MATH_1	586	590	PF00917	0.799
DOC_USP7_MATH_1	605	609	PF00917	0.767
DOC_USP7_MATH_1	936	940	PF00917	0.667
DOC_USP7_MATH_2	524	530	PF00917	0.586
DOC_WW_Pin1_4	174	179	PF00397	0.453
DOC_WW_Pin1_4	412	417	PF00397	0.796
DOC_WW_Pin1_4	493	498	PF00397	0.840
DOC_WW_Pin1_4	511	516	PF00397	0.536
DOC_WW_Pin1_4	618	623	PF00397	0.748
DOC_WW_Pin1_4	691	696	PF00397	0.739
DOC_WW_Pin1_4	737	742	PF00397	0.520
DOC_WW_Pin1_4	765	770	PF00397	0.567
DOC_WW_Pin1_4	90	95	PF00397	0.532
DOC_WW_Pin1_4	902	907	PF00397	0.668
LIG_14-3-3_CanoR_1	126	135	PF00244	0.458
LIG_14-3-3_CanoR_1	158	162	PF00244	0.644
LIG_14-3-3_CanoR_1	184	188	PF00244	0.325
LIG_14-3-3_CanoR_1	222	226	PF00244	0.484
LIG_14-3-3_CanoR_1	258	262	PF00244	0.353
LIG_14-3-3_CanoR_1	426	436	PF00244	0.823
LIG_14-3-3_CanoR_1	445	454	PF00244	0.508
LIG_14-3-3_CanoR_1	509	515	PF00244	0.747
LIG_14-3-3_CanoR_1	573	581	PF00244	0.733
LIG_14-3-3_CanoR_1	65	71	PF00244	0.503
LIG_14-3-3_CanoR_1	669	674	PF00244	0.551
LIG_14-3-3_CanoR_1	788	792	PF00244	0.610
LIG_14-3-3_CanoR_1	81	86	PF00244	0.391
LIG_BIR_III_4	479	483	PF00653	0.578
LIG_BRCT_BRCA1_1	272	276	PF00533	0.518
LIG_deltaCOP1_diTrp_1	364	368	PF00928	0.493
LIG_eIF4E_1	111	117	PF01652	0.494
LIG_EVH1_1	547	551	PF00568	0.829
LIG_FHA_1	10	16	PF00498	0.605
LIG_FHA_1	120	126	PF00498	0.500
LIG_FHA_1	222	228	PF00498	0.564
LIG_FHA_1	242	248	PF00498	0.607
LIG_FHA_1	254	260	PF00498	0.440
LIG_FHA_1	353	359	PF00498	0.472
LIG_FHA_1	380	386	PF00498	0.622
LIG_FHA_1	450	456	PF00498	0.839
LIG_FHA_1	464	470	PF00498	0.615
LIG_FHA_1	494	500	PF00498	0.816
LIG_FHA_1	681	687	PF00498	0.806
LIG_FHA_1	715	721	PF00498	0.568
LIG_FHA_1	779	785	PF00498	0.652
LIG_FHA_1	820	826	PF00498	0.673
LIG_FHA_2	282	288	PF00498	0.462
LIG_FHA_2	3	9	PF00498	0.688
LIG_FHA_2	388	394	PF00498	0.841
LIG_FHA_2	428	434	PF00498	0.699
LIG_FHA_2	530	536	PF00498	0.844
LIG_FHA_2	555	561	PF00498	0.803
LIG_FHA_2	580	586	PF00498	0.761
LIG_FHA_2	628	634	PF00498	0.595
LIG_FHA_2	67	73	PF00498	0.553
LIG_FHA_2	822	828	PF00498	0.672
LIG_FHA_2	923	929	PF00498	0.776
LIG_LIR_Apic_2	273	279	PF02991	0.529
LIG_LIR_Apic_2	364	369	PF02991	0.499
LIG_LIR_Apic_2	900	906	PF02991	0.559
LIG_LIR_Gen_1	260	267	PF02991	0.335
LIG_LIR_Gen_1	827	834	PF02991	0.763
LIG_LIR_Gen_1	924	935	PF02991	0.666
LIG_LIR_LC3C_4	355	359	PF02991	0.453
LIG_LIR_Nem_3	206	212	PF02991	0.457
LIG_LIR_Nem_3	260	265	PF02991	0.309
LIG_LIR_Nem_3	61	67	PF02991	0.509
LIG_LIR_Nem_3	827	833	PF02991	0.657
LIG_LIR_Nem_3	868	874	PF02991	0.676
LIG_LIR_Nem_3	924	930	PF02991	0.665
LIG_NRBOX	719	725	PF00104	0.478
LIG_PDZ_Class_1	939	944	PF00595	0.674
LIG_Pex14_1	183	187	PF04695	0.364
LIG_PTAP_UEV_1	937	942	PF05743	0.514
LIG_Rb_LxCxE_1	141	163	PF01857	0.486
LIG_SH2_CRK	209	213	PF00017	0.392
LIG_SH2_CRK	343	347	PF00017	0.313
LIG_SH2_CRK	871	875	PF00017	0.682
LIG_SH2_GRB2like	111	114	PF00017	0.520
LIG_SH2_STAP1	107	111	PF00017	0.515
LIG_SH2_STAP1	324	328	PF00017	0.450
LIG_SH2_STAP1	432	436	PF00017	0.620
LIG_SH2_STAT3	823	826	PF00017	0.676
LIG_SH2_STAT5	144	147	PF00017	0.454
LIG_SH2_STAT5	311	314	PF00017	0.545
LIG_SH2_STAT5	436	439	PF00017	0.731
LIG_SH2_STAT5	679	682	PF00017	0.553
LIG_SH2_STAT5	70	73	PF00017	0.588
LIG_SH2_STAT5	823	826	PF00017	0.676
LIG_SH3_3	175	181	PF00018	0.446
LIG_SH3_3	398	404	PF00018	0.735
LIG_SH3_3	405	411	PF00018	0.725
LIG_SH3_3	419	425	PF00018	0.600
LIG_SH3_3	545	551	PF00018	0.782
LIG_SH3_3	617	623	PF00018	0.750
LIG_SH3_3	766	772	PF00018	0.821
LIG_SH3_3	917	923	PF00018	0.677
LIG_SH3_3	935	941	PF00018	0.710
LIG_Sin3_3	854	861	PF02671	0.554
LIG_SUMO_SIM_anti_2	318	325	PF11976	0.446
LIG_SUMO_SIM_anti_2	355	361	PF11976	0.464
LIG_SUMO_SIM_anti_2	928	934	PF11976	0.683
LIG_SUMO_SIM_par_1	224	230	PF11976	0.453
LIG_SUMO_SIM_par_1	318	325	PF11976	0.451
LIG_SUMO_SIM_par_1	353	361	PF11976	0.470
LIG_TRAF2_1	160	163	PF00917	0.525
LIG_TRAF2_1	926	929	PF00917	0.669
LIG_TRFH_1	83	87	PF08558	0.537
LIG_TYR_ITIM	341	346	PF00017	0.321
LIG_TYR_ITIM	869	874	PF00017	0.777
LIG_WRC_WIRS_1	670	675	PF05994	0.588
LIG_WW_2	401	404	PF00397	0.832
LIG_WW_2	550	553	PF00397	0.573
MOD_CDC14_SPxK_1	740	743	PF00782	0.511
MOD_CDK_SPK_2	511	516	PF00069	0.580
MOD_CDK_SPK_2	737	742	PF00069	0.520
MOD_CDK_SPxK_1	737	743	PF00069	0.516
MOD_CDK_SPxxK_3	90	97	PF00069	0.451
MOD_CK1_1	133	139	PF00069	0.467
MOD_CK1_1	169	175	PF00069	0.703
MOD_CK1_1	257	263	PF00069	0.377
MOD_CK1_1	283	289	PF00069	0.564
MOD_CK1_1	502	508	PF00069	0.841
MOD_CK1_1	511	517	PF00069	0.683
MOD_CK1_1	529	535	PF00069	0.576
MOD_CK1_1	556	562	PF00069	0.675
MOD_CK1_1	621	627	PF00069	0.750
MOD_CK1_1	765	771	PF00069	0.635
MOD_CK2_1	157	163	PF00069	0.531
MOD_CK2_1	2	8	PF00069	0.700
MOD_CK2_1	281	287	PF00069	0.608
MOD_CK2_1	377	383	PF00069	0.705
MOD_CK2_1	387	393	PF00069	0.671
MOD_CK2_1	427	433	PF00069	0.700
MOD_CK2_1	554	560	PF00069	0.590
MOD_CK2_1	636	642	PF00069	0.700
MOD_CK2_1	841	847	PF00069	0.676
MOD_CK2_1	922	928	PF00069	0.775
MOD_GlcNHglycan	168	171	PF01048	0.644
MOD_GlcNHglycan	174	177	PF01048	0.716
MOD_GlcNHglycan	205	208	PF01048	0.451
MOD_GlcNHglycan	272	275	PF01048	0.745
MOD_GlcNHglycan	317	320	PF01048	0.466
MOD_GlcNHglycan	352	355	PF01048	0.434
MOD_GlcNHglycan	377	380	PF01048	0.765
MOD_GlcNHglycan	447	450	PF01048	0.806
MOD_GlcNHglycan	504	507	PF01048	0.793
MOD_GlcNHglycan	511	514	PF01048	0.722
MOD_GlcNHglycan	602	605	PF01048	0.797
MOD_GlcNHglycan	607	610	PF01048	0.834
MOD_GlcNHglycan	637	641	PF01048	0.846
MOD_GlcNHglycan	843	846	PF01048	0.749
MOD_GlcNHglycan	858	861	PF01048	0.558
MOD_GlcNHglycan	907	910	PF01048	0.646
MOD_GlcNHglycan	938	941	PF01048	0.510
MOD_GSK3_1	105	112	PF00069	0.491
MOD_GSK3_1	168	175	PF00069	0.726
MOD_GSK3_1	183	190	PF00069	0.399
MOD_GSK3_1	242	249	PF00069	0.563
MOD_GSK3_1	253	260	PF00069	0.470
MOD_GSK3_1	270	277	PF00069	0.605
MOD_GSK3_1	279	286	PF00069	0.551
MOD_GSK3_1	375	382	PF00069	0.515
MOD_GSK3_1	428	435	PF00069	0.699
MOD_GSK3_1	445	452	PF00069	0.711
MOD_GSK3_1	495	502	PF00069	0.853
MOD_GSK3_1	504	511	PF00069	0.734
MOD_GSK3_1	536	543	PF00069	0.664
MOD_GSK3_1	552	559	PF00069	0.820
MOD_GSK3_1	575	582	PF00069	0.675
MOD_GSK3_1	596	603	PF00069	0.813
MOD_GSK3_1	605	612	PF00069	0.726
MOD_GSK3_1	618	625	PF00069	0.708
MOD_GSK3_1	81	88	PF00069	0.500
MOD_GSK3_1	829	836	PF00069	0.621
MOD_GSK3_1	901	908	PF00069	0.640
MOD_N-GLC_1	375	380	PF02516	0.538
MOD_N-GLC_1	417	422	PF02516	0.669
MOD_N-GLC_1	596	601	PF02516	0.577
MOD_N-GLC_1	749	754	PF02516	0.719
MOD_N-GLC_1	778	783	PF02516	0.667
MOD_NEK2_1	105	110	PF00069	0.478
MOD_NEK2_1	182	187	PF00069	0.496
MOD_NEK2_1	188	193	PF00069	0.455
MOD_NEK2_1	236	241	PF00069	0.528
MOD_NEK2_1	246	251	PF00069	0.432
MOD_NEK2_1	267	272	PF00069	0.474
MOD_NEK2_1	357	362	PF00069	0.470
MOD_NEK2_1	374	379	PF00069	0.626
MOD_NEK2_1	455	460	PF00069	0.592
MOD_NEK2_1	56	61	PF00069	0.474
MOD_NEK2_1	636	641	PF00069	0.846
MOD_NEK2_1	66	71	PF00069	0.442
MOD_NEK2_1	714	719	PF00069	0.467
MOD_NEK2_1	76	81	PF00069	0.323
MOD_NEK2_1	778	783	PF00069	0.614
MOD_NEK2_1	901	906	PF00069	0.779
MOD_NEK2_2	183	188	PF00069	0.316
MOD_NEK2_2	504	509	PF00069	0.777
MOD_PIKK_1	395	401	PF00454	0.587
MOD_PIKK_1	434	440	PF00454	0.830
MOD_PIKK_1	455	461	PF00454	0.625
MOD_PIKK_1	575	581	PF00454	0.642
MOD_PKA_1	787	793	PF00069	0.716
MOD_PKA_2	133	139	PF00069	0.467
MOD_PKA_2	157	163	PF00069	0.534
MOD_PKA_2	166	172	PF00069	0.609
MOD_PKA_2	183	189	PF00069	0.259
MOD_PKA_2	221	227	PF00069	0.479
MOD_PKA_2	257	263	PF00069	0.450
MOD_PKA_2	374	380	PF00069	0.484
MOD_PKA_2	508	514	PF00069	0.584
MOD_PKA_2	526	532	PF00069	0.521
MOD_PKA_2	579	585	PF00069	0.798
MOD_PKA_2	787	793	PF00069	0.716
MOD_PKB_1	461	469	PF00069	0.843
MOD_Plk_1	188	194	PF00069	0.453
MOD_Plk_1	417	423	PF00069	0.811
MOD_Plk_1	432	438	PF00069	0.645
MOD_Plk_1	443	449	PF00069	0.721
MOD_Plk_1	469	475	PF00069	0.603
MOD_Plk_1	596	602	PF00069	0.577
MOD_Plk_1	76	82	PF00069	0.547
MOD_Plk_1	867	873	PF00069	0.678
MOD_Plk_2-3	387	393	PF00069	0.845
MOD_Plk_4	133	139	PF00069	0.467
MOD_Plk_4	183	189	PF00069	0.408
MOD_Plk_4	242	248	PF00069	0.706
MOD_Plk_4	328	334	PF00069	0.507
MOD_Plk_4	352	358	PF00069	0.485
MOD_Plk_4	450	456	PF00069	0.586
MOD_Plk_4	469	475	PF00069	0.534
MOD_Plk_4	567	573	PF00069	0.576
MOD_Plk_4	579	585	PF00069	0.540
MOD_Plk_4	66	72	PF00069	0.533
MOD_Plk_4	85	91	PF00069	0.529
MOD_Plk_4	909	915	PF00069	0.653
MOD_ProDKin_1	174	180	PF00069	0.446
MOD_ProDKin_1	412	418	PF00069	0.801
MOD_ProDKin_1	493	499	PF00069	0.842
MOD_ProDKin_1	511	517	PF00069	0.535
MOD_ProDKin_1	618	624	PF00069	0.746
MOD_ProDKin_1	691	697	PF00069	0.737
MOD_ProDKin_1	737	743	PF00069	0.516
MOD_ProDKin_1	765	771	PF00069	0.567
MOD_ProDKin_1	90	96	PF00069	0.539
MOD_ProDKin_1	902	908	PF00069	0.667
MOD_SUMO_rev_2	780	789	PF00179	0.632
TRG_DiLeu_BaEn_1	928	933	PF01217	0.679
TRG_DiLeu_BaEn_2	62	68	PF01217	0.507
TRG_DiLeu_BaEn_4	928	934	PF01217	0.683
TRG_DiLeu_BaLyEn_6	719	724	PF01217	0.727
TRG_ENDOCYTIC_2	209	212	PF00928	0.397
TRG_ENDOCYTIC_2	343	346	PF00928	0.317
TRG_ENDOCYTIC_2	871	874	PF00928	0.682
TRG_ER_diArg_1	737	739	PF00400	0.690
TRG_ER_diArg_1	886	888	PF00400	0.764
TRG_ER_diArg_1	97	100	PF00400	0.599
TRG_NLS_Bipartite_1	721	738	PF00514	0.525
TRG_NLS_MonoExtC_3	733	738	PF00514	0.545
TRG_Pf-PMV_PEXEL_1	782	786	PF00026	0.633

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKP7	Leptomonas seymouri	50%	100%
A0A3S7WQE7	Leishmania donovani	78%	100%
A4HTP7	Leishmania infantum	78%	100%
E9AMI4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4QI55	Leishmania major	78%	100%