Stress-induced protein sti1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

stress-induced protein sti1

Species:

Leishmania braziliensis

UniProt:

A4H5F0_LEIBR

TriTrypDb:

LbrM.08.0880 , LBRM2903_080016600

Length:

547

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H5F0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5F0

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	12
GO:0009987	cellular process	1	12

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0030544	Hsp70 protein binding	4	12
GO:0031072	heat shock protein binding	3	12
GO:0051879	Hsp90 protein binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	462	466	PF00656	0.533
CLV_NRD_NRD_1	135	137	PF00675	0.371
CLV_NRD_NRD_1	431	433	PF00675	0.353
CLV_NRD_NRD_1	490	492	PF00675	0.344
CLV_NRD_NRD_1	76	78	PF00675	0.398
CLV_NRD_NRD_1	85	87	PF00675	0.338
CLV_PCSK_KEX2_1	238	240	PF00082	0.460
CLV_PCSK_KEX2_1	323	325	PF00082	0.497
CLV_PCSK_KEX2_1	387	389	PF00082	0.456
CLV_PCSK_KEX2_1	490	492	PF00082	0.303
CLV_PCSK_KEX2_1	76	78	PF00082	0.395
CLV_PCSK_KEX2_1	85	87	PF00082	0.310
CLV_PCSK_PC1ET2_1	238	240	PF00082	0.558
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.506
CLV_PCSK_PC1ET2_1	387	389	PF00082	0.456
CLV_PCSK_SKI1_1	128	132	PF00082	0.553
CLV_PCSK_SKI1_1	175	179	PF00082	0.371
CLV_PCSK_SKI1_1	214	218	PF00082	0.656
CLV_PCSK_SKI1_1	276	280	PF00082	0.556
CLV_PCSK_SKI1_1	300	304	PF00082	0.400
CLV_PCSK_SKI1_1	323	327	PF00082	0.454
CLV_PCSK_SKI1_1	336	340	PF00082	0.463
CLV_PCSK_SKI1_1	54	58	PF00082	0.549
DEG_APCC_DBOX_1	174	182	PF00400	0.608
DEG_Nend_UBRbox_2	1	3	PF02207	0.520
DOC_CKS1_1	129	134	PF01111	0.580
DOC_MAPK_gen_1	253	261	PF00069	0.543
DOC_MAPK_gen_1	311	321	PF00069	0.422
DOC_MAPK_gen_1	464	474	PF00069	0.477
DOC_MAPK_MEF2A_6	137	146	PF00069	0.528
DOC_MAPK_MEF2A_6	526	534	PF00069	0.428
DOC_PP2B_PxIxI_1	527	533	PF00149	0.428
DOC_USP7_MATH_1	102	106	PF00917	0.445
DOC_USP7_MATH_2	390	396	PF00917	0.568
DOC_USP7_UBL2_3	211	215	PF12436	0.607
DOC_USP7_UBL2_3	343	347	PF12436	0.467
DOC_USP7_UBL2_3	414	418	PF12436	0.476
DOC_WW_Pin1_4	128	133	PF00397	0.559
LIG_14-3-3_CanoR_1	175	181	PF00244	0.503
LIG_BRCT_BRCA1_1	236	240	PF00533	0.589
LIG_BRCT_BRCA1_1	43	47	PF00533	0.513
LIG_FHA_1	106	112	PF00498	0.397
LIG_FHA_1	256	262	PF00498	0.433
LIG_FHA_1	381	387	PF00498	0.446
LIG_FHA_2	216	222	PF00498	0.663
LIG_FHA_2	277	283	PF00498	0.463
LIG_FHA_2	337	343	PF00498	0.507
LIG_LIR_Apic_2	328	332	PF02991	0.593
LIG_LIR_Apic_2	350	356	PF02991	0.492
LIG_LIR_Gen_1	152	161	PF02991	0.514
LIG_LIR_Gen_1	294	302	PF02991	0.426
LIG_LIR_Gen_1	44	53	PF02991	0.484
LIG_LIR_Gen_1	504	514	PF02991	0.503
LIG_LIR_Nem_3	133	138	PF02991	0.563
LIG_LIR_Nem_3	294	298	PF02991	0.454
LIG_LIR_Nem_3	504	509	PF02991	0.514
LIG_Pex14_1	439	443	PF04695	0.355
LIG_Pex14_1	70	74	PF04695	0.371
LIG_SH2_CRK	295	299	PF00017	0.448
LIG_SH2_CRK	506	510	PF00017	0.514
LIG_SH2_GRB2like	396	399	PF00017	0.355
LIG_SH2_GRB2like	40	43	PF00017	0.431
LIG_SH2_NCK_1	295	299	PF00017	0.505
LIG_SH2_PTP2	353	356	PF00017	0.496
LIG_SH2_PTP2	403	406	PF00017	0.502
LIG_SH2_SRC	19	22	PF00017	0.554
LIG_SH2_SRC	247	250	PF00017	0.479
LIG_SH2_SRC	353	356	PF00017	0.481
LIG_SH2_SRC	450	453	PF00017	0.390
LIG_SH2_SRC	87	90	PF00017	0.390
LIG_SH2_STAP1	274	278	PF00017	0.439
LIG_SH2_STAP1	295	299	PF00017	0.464
LIG_SH2_STAP1	315	319	PF00017	0.493
LIG_SH2_STAP1	382	386	PF00017	0.424
LIG_SH2_STAP1	396	400	PF00017	0.355
LIG_SH2_STAP1	87	91	PF00017	0.390
LIG_SH2_STAT3	268	271	PF00017	0.537
LIG_SH2_STAT5	153	156	PF00017	0.510
LIG_SH2_STAT5	182	185	PF00017	0.613
LIG_SH2_STAT5	19	22	PF00017	0.499
LIG_SH2_STAT5	235	238	PF00017	0.569
LIG_SH2_STAT5	25	28	PF00017	0.461
LIG_SH2_STAT5	260	263	PF00017	0.421
LIG_SH2_STAT5	268	271	PF00017	0.432
LIG_SH2_STAT5	295	298	PF00017	0.450
LIG_SH2_STAT5	353	356	PF00017	0.481
LIG_SH2_STAT5	369	372	PF00017	0.612
LIG_SH2_STAT5	382	385	PF00017	0.424
LIG_SH2_STAT5	403	406	PF00017	0.355
LIG_SH2_STAT5	437	440	PF00017	0.440
LIG_SH2_STAT5	74	77	PF00017	0.371
LIG_SH3_3	126	132	PF00018	0.519
LIG_SH3_3	158	164	PF00018	0.481
LIG_TRAF2_1	210	213	PF00917	0.717
LIG_TRAF2_1	348	351	PF00917	0.585
LIG_UBA3_1	180	187	PF00899	0.694
MOD_CK1_1	105	111	PF00069	0.554
MOD_CK1_1	41	47	PF00069	0.408
MOD_CK1_1	479	485	PF00069	0.597
MOD_CK2_1	215	221	PF00069	0.651
MOD_CK2_1	276	282	PF00069	0.326
MOD_CK2_1	336	342	PF00069	0.506
MOD_DYRK1A_RPxSP_1	128	132	PF00069	0.589
MOD_GlcNHglycan	104	107	PF01048	0.508
MOD_GlcNHglycan	13	17	PF01048	0.480
MOD_GlcNHglycan	183	186	PF01048	0.476
MOD_GlcNHglycan	200	203	PF01048	0.606
MOD_GlcNHglycan	264	267	PF01048	0.535
MOD_GlcNHglycan	43	46	PF01048	0.407
MOD_GlcNHglycan	478	481	PF01048	0.531
MOD_GlcNHglycan	538	541	PF01048	0.410
MOD_GSK3_1	34	41	PF00069	0.557
MOD_GSK3_1	96	103	PF00069	0.275
MOD_N-GLC_1	262	267	PF02516	0.391
MOD_N-GLC_1	41	46	PF02516	0.407
MOD_N-GLC_2	291	293	PF02516	0.519
MOD_NEK2_1	156	161	PF00069	0.558
MOD_NEK2_1	176	181	PF00069	0.415
MOD_NEK2_1	234	239	PF00069	0.585
MOD_NEK2_1	262	267	PF00069	0.396
MOD_NEK2_1	502	507	PF00069	0.503
MOD_NEK2_2	255	260	PF00069	0.501
MOD_NEK2_2	528	533	PF00069	0.428
MOD_PIKK_1	105	111	PF00454	0.492
MOD_PIKK_1	162	168	PF00454	0.589
MOD_PK_1	62	68	PF00069	0.489
MOD_PK_1	96	102	PF00069	0.385
MOD_PKA_1	336	342	PF00069	0.576
MOD_PKA_2	198	204	PF00069	0.802
MOD_Plk_1	262	268	PF00069	0.402
MOD_Plk_1	293	299	PF00069	0.458
MOD_Plk_1	391	397	PF00069	0.437
MOD_Plk_4	142	148	PF00069	0.511
MOD_Plk_4	156	162	PF00069	0.483
MOD_Plk_4	176	182	PF00069	0.423
MOD_Plk_4	255	261	PF00069	0.437
MOD_Plk_4	293	299	PF00069	0.458
MOD_Plk_4	34	40	PF00069	0.566
MOD_Plk_4	502	508	PF00069	0.506
MOD_ProDKin_1	128	134	PF00069	0.552
MOD_SUMO_for_1	210	213	PF00179	0.735
MOD_SUMO_for_1	227	230	PF00179	0.485
MOD_SUMO_for_1	6	9	PF00179	0.346
MOD_SUMO_rev_2	201	210	PF00179	0.742
MOD_SUMO_rev_2	212	217	PF00179	0.584
MOD_SUMO_rev_2	249	258	PF00179	0.556
MOD_SUMO_rev_2	415	424	PF00179	0.440
TRG_DiLeu_BaEn_1	212	217	PF01217	0.497
TRG_DiLeu_BaEn_4	212	218	PF01217	0.669
TRG_DiLeu_BaEn_4	229	235	PF01217	0.451
TRG_ENDOCYTIC_2	153	156	PF00928	0.503
TRG_ENDOCYTIC_2	295	298	PF00928	0.458
TRG_ENDOCYTIC_2	403	406	PF00928	0.355
TRG_ENDOCYTIC_2	506	509	PF00928	0.503
TRG_ER_diArg_1	75	77	PF00400	0.408
TRG_ER_diArg_1	84	86	PF00400	0.327
TRG_Pf-PMV_PEXEL_1	136	140	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	324	328	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	336	340	PF00026	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK79	Leptomonas seymouri	84%	100%
A0A0S4IP08	Bodo saltans	54%	94%
A0A0S4ITS9	Bodo saltans	20%	73%
A0A0S4JM87	Bodo saltans	21%	78%
A0A1X0NFP0	Trypanosomatidae	66%	100%
A0A1X0P1G8	Trypanosomatidae	22%	77%
A0A422NFX1	Trypanosoma rangeli	63%	98%
A4HTP4	Leishmania infantum	94%	100%
C9ZPE6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	99%
E9AMI1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
F8RP11	Triticum aestivum	42%	94%
O35814	Rattus norvegicus	40%	100%
O54981	Cricetulus griseus	40%	100%
P15705	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	93%
P31948	Homo sapiens	40%	100%
Q3ZBZ8	Bos taurus	40%	100%
Q43468	Glycine max	41%	96%
Q4JHN0	Leishmania donovani	94%	100%
Q4QI58	Leishmania major	93%	100%
Q4R8N7	Macaca fascicularis	40%	100%
Q54DA8	Dictyostelium discoideum	36%	97%
Q54IP0	Dictyostelium discoideum	23%	100%
Q5R8D8	Pongo abelii	23%	100%
Q5XEP2	Arabidopsis thaliana	41%	96%
Q60864	Mus musculus	40%	100%
Q75Q39	Rattus norvegicus	23%	90%
Q7ZWU1	Xenopus laevis	39%	100%
Q8ILC1	Plasmodium falciparum (isolate 3D7)	37%	97%
Q99615	Homo sapiens	23%	100%
Q9CZW5	Mus musculus	23%	90%
Q9LNB6	Arabidopsis thaliana	40%	96%
Q9QYI3	Mus musculus	23%	100%
Q9STH1	Arabidopsis thaliana	40%	98%
Q9USI5	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	93%
V5AUF3	Trypanosoma cruzi	63%	98%
V5BSG3	Trypanosoma cruzi	22%	78%