Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5E9_LEIBR

TriTrypDb:

LbrM.08.0870 , LBRM2903_080016500

Length:

342

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5E9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5E9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	307	311	PF00656	0.603
CLV_NRD_NRD_1	194	196	PF00675	0.557
CLV_NRD_NRD_1	269	271	PF00675	0.540
CLV_NRD_NRD_1	29	31	PF00675	0.601
CLV_NRD_NRD_1	40	42	PF00675	0.477
CLV_NRD_NRD_1	64	66	PF00675	0.524
CLV_PCSK_FUR_1	134	138	PF00082	0.487
CLV_PCSK_KEX2_1	121	123	PF00082	0.459
CLV_PCSK_KEX2_1	136	138	PF00082	0.503
CLV_PCSK_KEX2_1	168	170	PF00082	0.429
CLV_PCSK_KEX2_1	201	203	PF00082	0.489
CLV_PCSK_KEX2_1	269	271	PF00082	0.518
CLV_PCSK_KEX2_1	29	31	PF00082	0.580
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.459
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.473
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.429
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.520
CLV_PCSK_SKI1_1	136	140	PF00082	0.595
CLV_PCSK_SKI1_1	157	161	PF00082	0.361
CLV_PCSK_SKI1_1	214	218	PF00082	0.428
CLV_PCSK_SKI1_1	269	273	PF00082	0.517
CLV_PCSK_SKI1_1	315	319	PF00082	0.449
CLV_PCSK_SKI1_1	66	70	PF00082	0.675
CLV_PCSK_SKI1_1	85	89	PF00082	0.357
CLV_Separin_Metazoa	26	30	PF03568	0.418
DEG_Nend_Nbox_1	1	3	PF02207	0.442
DEG_SCF_FBW7_2	107	114	PF00400	0.470
DOC_CKS1_1	108	113	PF01111	0.474
DOC_MAPK_gen_1	18	25	PF00069	0.502
DOC_MAPK_gen_1	201	209	PF00069	0.441
DOC_MAPK_gen_1	248	257	PF00069	0.486
DOC_MAPK_gen_1	269	276	PF00069	0.511
DOC_MAPK_gen_1	315	323	PF00069	0.441
DOC_MAPK_MEF2A_6	18	27	PF00069	0.491
DOC_MAPK_MEF2A_6	248	257	PF00069	0.486
DOC_MAPK_MEF2A_6	269	276	PF00069	0.511
DOC_USP7_MATH_1	143	147	PF00917	0.452
DOC_USP7_MATH_1	295	299	PF00917	0.543
DOC_USP7_MATH_1	302	306	PF00917	0.546
DOC_USP7_MATH_1	7	11	PF00917	0.625
DOC_USP7_UBL2_3	18	22	PF12436	0.580
DOC_USP7_UBL2_3	93	97	PF12436	0.514
DOC_WW_Pin1_4	107	112	PF00397	0.475
DOC_WW_Pin1_4	261	266	PF00397	0.510
DOC_WW_Pin1_4	32	37	PF00397	0.447
LIG_14-3-3_CanoR_1	275	280	PF00244	0.486
LIG_14-3-3_CanoR_1	41	50	PF00244	0.500
LIG_14-3-3_CanoR_1	65	74	PF00244	0.544
LIG_Actin_WH2_2	70	87	PF00022	0.493
LIG_CSL_BTD_1	262	265	PF09270	0.500
LIG_EVH1_1	3	7	PF00568	0.613
LIG_EVH1_2	4	8	PF00568	0.617
LIG_FHA_1	42	48	PF00498	0.560
LIG_FHA_2	108	114	PF00498	0.473
LIG_FHA_2	158	164	PF00498	0.587
LIG_FHA_2	9	15	PF00498	0.434
LIG_LIR_Gen_1	99	108	PF02991	0.454
LIG_LIR_Nem_3	153	159	PF02991	0.479
LIG_LIR_Nem_3	211	216	PF02991	0.442
LIG_LIR_Nem_3	99	103	PF02991	0.446
LIG_NRBOX	205	211	PF00104	0.429
LIG_PCNA_yPIPBox_3	229	241	PF02747	0.427
LIG_Pex14_1	152	156	PF04695	0.418
LIG_SH2_CRK	156	160	PF00017	0.467
LIG_SH2_CRK	172	176	PF00017	0.425
LIG_SH2_CRK	194	198	PF00017	0.508
LIG_SH2_NCK_1	172	176	PF00017	0.516
LIG_SH2_STAP1	172	176	PF00017	0.565
LIG_SH2_STAT5	109	112	PF00017	0.486
LIG_SH2_STAT5	2	5	PF00017	0.562
LIG_SH2_STAT5	39	42	PF00017	0.538
LIG_SH3_3	1	7	PF00018	0.628
LIG_SH3_3	105	111	PF00018	0.479
LIG_SH3_3	296	302	PF00018	0.455
LIG_SUMO_SIM_anti_2	204	211	PF11976	0.461
LIG_SUMO_SIM_par_1	204	211	PF11976	0.427
LIG_TRAF2_1	12	15	PF00917	0.595
LIG_TRAF2_1	265	268	PF00917	0.508
LIG_TRAF2_1	334	337	PF00917	0.685
LIG_TYR_ITIM	170	175	PF00017	0.523
LIG_UBA3_1	222	229	PF00899	0.434
MOD_CK2_1	157	163	PF00069	0.654
MOD_CK2_1	261	267	PF00069	0.507
MOD_CK2_1	275	281	PF00069	0.477
MOD_CK2_1	8	14	PF00069	0.526
MOD_GlcNHglycan	144	148	PF01048	0.476
MOD_GlcNHglycan	256	260	PF01048	0.605
MOD_GlcNHglycan	306	309	PF01048	0.559
MOD_GSK3_1	37	44	PF00069	0.560
MOD_NEK2_1	286	291	PF00069	0.498
MOD_NEK2_1	58	63	PF00069	0.551
MOD_NEK2_1	8	13	PF00069	0.565
MOD_NEK2_2	295	300	PF00069	0.441
MOD_PIKK_1	286	292	PF00454	0.522
MOD_PIKK_1	302	308	PF00454	0.606
MOD_PIKK_1	58	64	PF00454	0.411
MOD_PK_1	275	281	PF00069	0.498
MOD_PKA_1	18	24	PF00069	0.502
MOD_PKA_1	41	47	PF00069	0.530
MOD_PKA_2	224	230	PF00069	0.430
MOD_PKB_1	169	177	PF00069	0.504
MOD_Plk_1	295	301	PF00069	0.445
MOD_Plk_2-3	155	161	PF00069	0.416
MOD_ProDKin_1	107	113	PF00069	0.471
MOD_ProDKin_1	261	267	PF00069	0.512
MOD_ProDKin_1	32	38	PF00069	0.449
MOD_SUMO_rev_2	112	118	PF00179	0.482
MOD_SUMO_rev_2	153	159	PF00179	0.458
MOD_SUMO_rev_2	331	341	PF00179	0.693
TRG_DiLeu_BaEn_1	205	210	PF01217	0.458
TRG_DiLeu_BaEn_1	267	272	PF01217	0.514
TRG_DiLeu_BaEn_1	53	58	PF01217	0.463
TRG_DiLeu_BaEn_4	267	273	PF01217	0.515
TRG_DiLeu_BaLyEn_6	145	150	PF01217	0.382
TRG_DiLeu_BaLyEn_6	312	317	PF01217	0.485
TRG_DiLeu_LyEn_5	267	272	PF01217	0.514
TRG_ENDOCYTIC_2	156	159	PF00928	0.460
TRG_ENDOCYTIC_2	172	175	PF00928	0.474
TRG_ER_diArg_1	169	172	PF00400	0.443
TRG_ER_diArg_1	269	271	PF00400	0.518
TRG_ER_diArg_1	274	277	PF00400	0.493
TRG_ER_diArg_1	28	30	PF00400	0.694
TRG_ER_diLys_1	338	342	PF00400	0.521
TRG_Pf-PMV_PEXEL_1	162	167	PF00026	0.566
TRG_Pf-PMV_PEXEL_1	201	205	PF00026	0.551
TRG_Pf-PMV_PEXEL_1	315	319	PF00026	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5W5	Leptomonas seymouri	84%	94%
A0A0S4IPK0	Bodo saltans	66%	93%
A0A1X0NPG5	Trypanosomatidae	75%	92%
A0A3S5H687	Leishmania donovani	93%	94%
A0A422NFX7	Trypanosoma rangeli	69%	92%
A4HTP3	Leishmania infantum	93%	94%
C9ZPE5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	92%
E9AMI0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	94%
Q4QI59	Leishmania major	93%	100%
V5DAE9	Trypanosoma cruzi	72%	92%