RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ring finger domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H5E8_LEIBR

TriTrypDb:

LbrM.08.0860

Length:

367

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H5E8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5E8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004842	ubiquitin-protein transferase activity	4	10
GO:0005488	binding	1	9
GO:0016740	transferase activity	2	10
GO:0019787	ubiquitin-like protein transferase activity	3	10
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0061630	ubiquitin protein ligase activity	5	10
GO:0061659	ubiquitin-like protein ligase activity	4	10
GO:0140096	catalytic activity, acting on a protein	2	10
GO:0008270	zinc ion binding	6	4
GO:0046914	transition metal ion binding	5	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	340	344	PF00656	0.627
CLV_NRD_NRD_1	102	104	PF00675	0.489
CLV_NRD_NRD_1	139	141	PF00675	0.350
CLV_NRD_NRD_1	189	191	PF00675	0.504
CLV_NRD_NRD_1	247	249	PF00675	0.505
CLV_NRD_NRD_1	268	270	PF00675	0.600
CLV_PCSK_FUR_1	266	270	PF00082	0.385
CLV_PCSK_KEX2_1	101	103	PF00082	0.491
CLV_PCSK_KEX2_1	16	18	PF00082	0.506
CLV_PCSK_KEX2_1	189	191	PF00082	0.522
CLV_PCSK_KEX2_1	246	248	PF00082	0.566
CLV_PCSK_KEX2_1	268	270	PF00082	0.552
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.513
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.499
CLV_PCSK_PC1ET2_1	246	248	PF00082	0.607
CLV_PCSK_SKI1_1	107	111	PF00082	0.479
DEG_Nend_UBRbox_1	1	4	PF02207	0.411
DOC_CYCLIN_yCln2_LP_2	347	353	PF00134	0.650
DOC_MAPK_MEF2A_6	342	351	PF00069	0.471
DOC_MAPK_NFAT4_5	342	350	PF00069	0.472
DOC_PP2B_LxvP_1	347	350	PF13499	0.616
DOC_PP2B_LxvP_1	356	359	PF13499	0.490
DOC_SPAK_OSR1_1	36	40	PF12202	0.398
DOC_USP7_MATH_1	136	140	PF00917	0.454
DOC_USP7_MATH_1	163	167	PF00917	0.433
DOC_USP7_MATH_1	352	356	PF00917	0.491
DOC_USP7_UBL2_3	298	302	PF12436	0.316
DOC_WW_Pin1_4	112	117	PF00397	0.327
LIG_14-3-3_CanoR_1	144	148	PF00244	0.510
LIG_14-3-3_CanoR_1	189	197	PF00244	0.521
LIG_14-3-3_CanoR_1	2	6	PF00244	0.445
LIG_14-3-3_CanoR_1	256	261	PF00244	0.469
LIG_BRCT_BRCA1_1	199	203	PF00533	0.504
LIG_BRCT_BRCA1_1	216	220	PF00533	0.463
LIG_Clathr_ClatBox_1	239	243	PF01394	0.449
LIG_FHA_1	121	127	PF00498	0.550
LIG_FHA_1	176	182	PF00498	0.403
LIG_FHA_1	2	8	PF00498	0.427
LIG_FHA_1	64	70	PF00498	0.356
LIG_LIR_Gen_1	174	185	PF02991	0.456
LIG_LIR_Gen_1	217	228	PF02991	0.581
LIG_LIR_Gen_1	234	242	PF02991	0.414
LIG_LIR_Nem_3	174	180	PF02991	0.440
LIG_LIR_Nem_3	217	223	PF02991	0.585
LIG_LIR_Nem_3	225	231	PF02991	0.479
LIG_LIR_Nem_3	234	239	PF02991	0.391
LIG_LIR_Nem_3	259	265	PF02991	0.467
LIG_NRBOX	68	74	PF00104	0.484
LIG_PALB2_WD40_1	299	307	PF16756	0.195
LIG_Pex14_1	172	176	PF04695	0.321
LIG_REV1ctd_RIR_1	73	82	PF16727	0.466
LIG_SH2_CRK	177	181	PF00017	0.404
LIG_SH2_CRK	236	240	PF00017	0.516
LIG_SH2_GRB2like	89	92	PF00017	0.433
LIG_SH2_STAP1	177	181	PF00017	0.496
LIG_SH2_STAP1	236	240	PF00017	0.446
LIG_SH2_STAT5	177	180	PF00017	0.446
LIG_SH2_STAT5	185	188	PF00017	0.378
LIG_SH2_STAT5	192	195	PF00017	0.417
LIG_SH2_STAT5	262	265	PF00017	0.520
LIG_SH2_STAT5	89	92	PF00017	0.433
LIG_SH3_3	48	54	PF00018	0.310
LIG_SUMO_SIM_anti_2	68	73	PF11976	0.368
LIG_SUMO_SIM_par_1	237	243	PF11976	0.545
LIG_SUMO_SIM_par_1	349	355	PF11976	0.456
LIG_TYR_ITIM	226	231	PF00017	0.472
LIG_TYR_ITIM	260	265	PF00017	0.408
LIG_UBA3_1	239	246	PF00899	0.582
MOD_CDK_SPxxK_3	112	119	PF00069	0.317
MOD_CK1_1	120	126	PF00069	0.372
MOD_CK1_1	143	149	PF00069	0.466
MOD_CK1_1	214	220	PF00069	0.587
MOD_CK1_1	305	311	PF00069	0.394
MOD_CK1_1	337	343	PF00069	0.498
MOD_CK2_1	152	158	PF00069	0.498
MOD_CK2_1	328	334	PF00069	0.705
MOD_GlcNHglycan	154	157	PF01048	0.506
MOD_GlcNHglycan	160	163	PF01048	0.398
MOD_GlcNHglycan	59	62	PF01048	0.295
MOD_GSK3_1	136	143	PF00069	0.525
MOD_GSK3_1	154	161	PF00069	0.533
MOD_GSK3_1	171	178	PF00069	0.555
MOD_GSK3_1	192	199	PF00069	0.443
MOD_GSK3_1	333	340	PF00069	0.671
MOD_GSK3_1	55	62	PF00069	0.406
MOD_GSK3_1	63	70	PF00069	0.332
MOD_N-GLC_1	168	173	PF02516	0.544
MOD_N-GLC_1	269	274	PF02516	0.413
MOD_N-GLC_2	145	147	PF02516	0.574
MOD_NEK2_1	1	6	PF00069	0.392
MOD_NEK2_1	203	208	PF00069	0.607
MOD_NEK2_1	280	285	PF00069	0.302
MOD_NEK2_1	351	356	PF00069	0.455
MOD_NEK2_2	291	296	PF00069	0.265
MOD_NEK2_2	352	357	PF00069	0.456
MOD_PIKK_1	334	340	PF00454	0.538
MOD_PIKK_1	59	65	PF00454	0.482
MOD_PK_1	256	262	PF00069	0.362
MOD_PKA_1	140	146	PF00069	0.335
MOD_PKA_2	1	7	PF00069	0.485
MOD_PKA_2	143	149	PF00069	0.359
MOD_Plk_1	168	174	PF00069	0.643
MOD_Plk_4	1	7	PF00069	0.549
MOD_Plk_4	214	220	PF00069	0.434
MOD_Plk_4	67	73	PF00069	0.434
MOD_ProDKin_1	112	118	PF00069	0.321
MOD_SUMO_rev_2	100	109	PF00179	0.512
MOD_SUMO_rev_2	152	161	PF00179	0.506
MOD_SUMO_rev_2	355	363	PF00179	0.455
TRG_DiLeu_BaEn_1	94	99	PF01217	0.412
TRG_DiLeu_BaEn_4	253	259	PF01217	0.560
TRG_ENDOCYTIC_2	177	180	PF00928	0.392
TRG_ENDOCYTIC_2	228	231	PF00928	0.459
TRG_ENDOCYTIC_2	236	239	PF00928	0.433
TRG_ENDOCYTIC_2	262	265	PF00928	0.413
TRG_ER_diArg_1	247	249	PF00400	0.551
TRG_ER_diArg_1	265	268	PF00400	0.616
TRG_Pf-PMV_PEXEL_1	248	252	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	256	261	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	88	92	PF00026	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5H3	Leptomonas seymouri	42%	97%
A0A0S4KHN3	Bodo saltans	27%	68%
A0A1X0NP60	Trypanosomatidae	32%	80%
A0A3S7WQF3	Leishmania donovani	70%	100%
C9ZPE4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	80%
E9ACQ5	Leishmania major	70%	100%
E9AG87	Leishmania infantum	71%	100%
E9AMH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%