Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H5E7_LEIBR

TriTrypDb:

LbrM.08.0850 , LBRM2903_080010600

Length:

142

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 3, no: 3
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4H5E7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5E7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	51	53	PF00675	0.619
CLV_NRD_NRD_1	99	101	PF00675	0.397
CLV_PCSK_FUR_1	97	101	PF00082	0.335
CLV_PCSK_KEX2_1	14	16	PF00082	0.680
CLV_PCSK_KEX2_1	51	53	PF00082	0.622
CLV_PCSK_KEX2_1	99	101	PF00082	0.403
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.611
CLV_PCSK_SKI1_1	14	18	PF00082	0.602
DEG_Nend_UBRbox_2	1	3	PF02207	0.643
DEG_SCF_FBW7_1	40	47	PF00400	0.400
DOC_CKS1_1	41	46	PF01111	0.487
DOC_PP1_RVXF_1	55	61	PF00149	0.333
DOC_SPAK_OSR1_1	107	111	PF12202	0.539
DOC_USP7_MATH_1	138	142	PF00917	0.600
DOC_USP7_MATH_1	56	60	PF00917	0.328
DOC_WW_Pin1_4	40	45	PF00397	0.441
LIG_14-3-3_CanoR_1	129	135	PF00244	0.726
LIG_14-3-3_CanoR_1	51	55	PF00244	0.417
LIG_EH1_1	20	28	PF00400	0.377
LIG_FHA_1	22	28	PF00498	0.373
LIG_FHA_1	31	37	PF00498	0.442
LIG_FHA_1	45	51	PF00498	0.431
LIG_LIR_Nem_3	59	64	PF02991	0.398
LIG_NRP_CendR_1	140	142	PF00754	0.408
LIG_Pex14_1	65	69	PF04695	0.303
LIG_Pex14_2	61	65	PF04695	0.367
LIG_Pex14_2	69	73	PF04695	0.312
LIG_REV1ctd_RIR_1	58	67	PF16727	0.302
LIG_SH2_PTP2	84	87	PF00017	0.231
LIG_SH2_STAP1	54	58	PF00017	0.440
LIG_SH2_STAT5	49	52	PF00017	0.452
LIG_SH2_STAT5	84	87	PF00017	0.237
LIG_SH3_3	38	44	PF00018	0.616
LIG_Sin3_3	75	82	PF02671	0.231
LIG_SUMO_SIM_par_1	23	28	PF11976	0.378
LIG_TYR_ITSM	60	67	PF00017	0.362
MOD_CDK_SPxxK_3	44	51	PF00069	0.462
MOD_CK1_1	130	136	PF00069	0.785
MOD_CK1_1	59	65	PF00069	0.310
MOD_GlcNHglycan	129	132	PF01048	0.492
MOD_GSK3_1	40	47	PF00069	0.499
MOD_NEK2_1	21	26	PF00069	0.412
MOD_NEK2_1	30	35	PF00069	0.477
MOD_NEK2_2	56	61	PF00069	0.330
MOD_PKA_2	106	112	PF00069	0.553
MOD_PKA_2	50	56	PF00069	0.415
MOD_Plk_1	30	36	PF00069	0.418
MOD_Plk_4	21	27	PF00069	0.520
MOD_Plk_4	56	62	PF00069	0.356
MOD_ProDKin_1	40	46	PF00069	0.442
TRG_DiLeu_BaLyEn_6	12	17	PF01217	0.504
TRG_ENDOCYTIC_2	64	67	PF00928	0.346
TRG_ENDOCYTIC_2	84	87	PF00928	0.442
TRG_ER_diArg_1	139	142	PF00400	0.602
TRG_ER_diArg_1	50	52	PF00400	0.419

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IC93	Leptomonas seymouri	49%	100%
A0A3S5H661	Leishmania donovani	59%	99%
A4HTK9	Leishmania infantum	60%	99%
E9AME0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	99%
Q4QIA9	Leishmania major	56%	100%