Cathepsin L-like protease

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cathepsin L-like protease

Species:

Leishmania braziliensis

UniProt:

A4H5E4_LEIBR

TriTrypDb:

LbrM.08.0810 , LBRM2903_080015900

Length:

441

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 125

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 21

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 37, no: 5
NetGPI	no	yes: 0, no: 42

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	9
GO:0000323	lytic vacuole	6	8
GO:0005615	extracellular space	2	8
GO:0005764	lysosome	7	8
GO:0005773	vacuole	5	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043231	intracellular membrane-bounded organelle	4	8

Expansion

Sequence features

A4H5E4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5E4

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	43
GO:0006807	nitrogen compound metabolic process	2	43
GO:0008152	metabolic process	1	43
GO:0019538	protein metabolic process	3	43
GO:0043170	macromolecule metabolic process	3	43
GO:0044238	primary metabolic process	2	43
GO:0071704	organic substance metabolic process	2	43
GO:1901564	organonitrogen compound metabolic process	3	43
GO:0051603	proteolysis involved in protein catabolic process	5	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	43
GO:0004175	endopeptidase activity	4	29
GO:0004197	cysteine-type endopeptidase activity	5	29
GO:0008233	peptidase activity	3	43
GO:0008234	cysteine-type peptidase activity	4	43
GO:0016787	hydrolase activity	2	43
GO:0140096	catalytic activity, acting on a protein	2	43

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	116	118	PF00675	0.569
CLV_NRD_NRD_1	322	324	PF00675	0.221
CLV_NRD_NRD_1	370	372	PF00675	0.279
CLV_PCSK_SKI1_1	391	395	PF00082	0.254
CLV_PCSK_SKI1_1	5	9	PF00082	0.695
CLV_Separin_Metazoa	67	71	PF03568	0.424
DEG_APCC_DBOX_1	4	12	PF00400	0.687
DEG_SPOP_SBC_1	348	352	PF00917	0.522
DOC_ANK_TNKS_1	416	423	PF00023	0.395
DOC_CYCLIN_RxL_1	58	71	PF00134	0.424
DOC_MAPK_gen_1	353	361	PF00069	0.221
DOC_SPAK_OSR1_1	80	84	PF12202	0.378
DOC_USP7_MATH_1	166	170	PF00917	0.273
DOC_USP7_MATH_1	215	219	PF00917	0.362
DOC_USP7_MATH_1	224	228	PF00917	0.361
DOC_USP7_MATH_1	269	273	PF00917	0.506
DOC_USP7_MATH_1	338	342	PF00917	0.437
DOC_WW_Pin1_4	136	141	PF00397	0.424
DOC_WW_Pin1_4	342	347	PF00397	0.352
LIG_14-3-3_CanoR_1	32	37	PF00244	0.388
LIG_14-3-3_CanoR_1	47	53	PF00244	0.255
LIG_BRCT_BRCA1_1	34	38	PF00533	0.283
LIG_FHA_1	165	171	PF00498	0.362
LIG_FHA_1	272	278	PF00498	0.372
LIG_FHA_1	296	302	PF00498	0.431
LIG_FHA_1	94	100	PF00498	0.287
LIG_FHA_2	277	283	PF00498	0.379
LIG_FHA_2	362	368	PF00498	0.249
LIG_FHA_2	49	55	PF00498	0.455
LIG_HP1_1	4	8	PF01393	0.510
LIG_LIR_Gen_1	35	45	PF02991	0.251
LIG_LIR_Nem_3	113	119	PF02991	0.490
LIG_LIR_Nem_3	213	217	PF02991	0.468
LIG_LIR_Nem_3	268	273	PF02991	0.354
LIG_LIR_Nem_3	300	306	PF02991	0.373
LIG_LIR_Nem_3	316	322	PF02991	0.349
LIG_LIR_Nem_3	35	41	PF02991	0.293
LIG_LIR_Nem_3	415	421	PF02991	0.668
LIG_LIR_Nem_3	44	48	PF02991	0.275
LIG_LIR_Nem_3	84	89	PF02991	0.460
LIG_LYPXL_yS_3	214	217	PF13949	0.322
LIG_PCNA_yPIPBox_3	391	403	PF02747	0.221
LIG_SH2_CRK	116	120	PF00017	0.341
LIG_SH2_CRK	418	422	PF00017	0.664
LIG_SH2_CRK	45	49	PF00017	0.377
LIG_SH2_PTP2	319	322	PF00017	0.360
LIG_SH2_SRC	237	240	PF00017	0.510
LIG_SH2_STAT5	164	167	PF00017	0.274
LIG_SH2_STAT5	209	212	PF00017	0.354
LIG_SH2_STAT5	216	219	PF00017	0.357
LIG_SH2_STAT5	237	240	PF00017	0.519
LIG_SH2_STAT5	273	276	PF00017	0.304
LIG_SH2_STAT5	29	32	PF00017	0.505
LIG_SH2_STAT5	319	322	PF00017	0.361
LIG_SH2_STAT5	368	371	PF00017	0.455
LIG_SH2_STAT5	98	101	PF00017	0.538
LIG_SH3_3	27	33	PF00018	0.550
LIG_SUMO_SIM_par_1	169	175	PF11976	0.385
LIG_SUMO_SIM_par_1	357	364	PF11976	0.245
LIG_TRAF2_1	174	177	PF00917	0.260
LIG_TRAF2_1	90	93	PF00917	0.307
LIG_TYR_ITIM	301	306	PF00017	0.431
MOD_CDK_SPxK_1	136	142	PF00069	0.424
MOD_CK1_1	100	106	PF00069	0.305
MOD_CK1_1	169	175	PF00069	0.369
MOD_CK1_1	227	233	PF00069	0.412
MOD_CK1_1	337	343	PF00069	0.450
MOD_CK1_1	410	416	PF00069	0.278
MOD_CK2_1	169	175	PF00069	0.340
MOD_CK2_1	219	225	PF00069	0.387
MOD_CK2_1	306	312	PF00069	0.371
MOD_CK2_1	48	54	PF00069	0.436
MOD_CK2_1	87	93	PF00069	0.360
MOD_GlcNHglycan	153	156	PF01048	0.478
MOD_GlcNHglycan	217	220	PF01048	0.368
MOD_GlcNHglycan	266	270	PF01048	0.441
MOD_GlcNHglycan	336	339	PF01048	0.442
MOD_GlcNHglycan	340	343	PF01048	0.354
MOD_GlcNHglycan	411	415	PF01048	0.296
MOD_GlcNHglycan	434	438	PF01048	0.528
MOD_GlcNHglycan	99	102	PF01048	0.286
MOD_GSK3_1	215	222	PF00069	0.365
MOD_GSK3_1	243	250	PF00069	0.499
MOD_GSK3_1	265	272	PF00069	0.423
MOD_GSK3_1	334	341	PF00069	0.401
MOD_GSK3_1	342	349	PF00069	0.408
MOD_GSK3_1	385	392	PF00069	0.339
MOD_GSK3_1	403	410	PF00069	0.294
MOD_GSK3_1	93	100	PF00069	0.443
MOD_N-GLC_1	219	224	PF02516	0.527
MOD_N-GLC_1	295	300	PF02516	0.470
MOD_N-GLC_2	327	329	PF02516	0.392
MOD_NEK2_1	146	151	PF00069	0.353
MOD_NEK2_1	271	276	PF00069	0.389
MOD_NEK2_1	379	384	PF00069	0.465
MOD_NEK2_1	403	408	PF00069	0.312
MOD_NEK2_1	41	46	PF00069	0.484
MOD_NEK2_1	433	438	PF00069	0.710
MOD_NEK2_1	81	86	PF00069	0.509
MOD_PIKK_1	110	116	PF00454	0.591
MOD_PIKK_1	412	418	PF00454	0.218
MOD_PK_1	32	38	PF00069	0.285
MOD_PKA_1	323	329	PF00069	0.221
MOD_PKB_1	321	329	PF00069	0.221
MOD_Plk_1	247	253	PF00069	0.472
MOD_Plk_1	265	271	PF00069	0.326
MOD_Plk_4	166	172	PF00069	0.424
MOD_Plk_4	32	38	PF00069	0.477
MOD_ProDKin_1	136	142	PF00069	0.424
MOD_ProDKin_1	342	348	PF00069	0.352
MOD_SUMO_rev_2	280	286	PF00179	0.221
MOD_SUMO_rev_2	35	44	PF00179	0.519
TRG_DiLeu_BaEn_1	228	233	PF01217	0.221
TRG_DiLeu_BaEn_4	54	60	PF01217	0.427
TRG_ENDOCYTIC_2	116	119	PF00928	0.630
TRG_ENDOCYTIC_2	214	217	PF00928	0.343
TRG_ENDOCYTIC_2	303	306	PF00928	0.353
TRG_ENDOCYTIC_2	319	322	PF00928	0.353
TRG_ENDOCYTIC_2	418	421	PF00928	0.641
TRG_ENDOCYTIC_2	45	48	PF00928	0.405
TRG_ENDOCYTIC_2	49	52	PF00928	0.431
TRG_ER_diArg_1	320	323	PF00400	0.221
TRG_NES_CRM1_1	57	71	PF08389	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A072UTP9	Medicago truncatula	36%	100%
A0A0N0P293	Leptomonas seymouri	31%	100%
A0A0N0P8D1	Leptomonas seymouri	28%	100%
A0A0N1PA65	Leptomonas seymouri	48%	94%
A0A0S4IMD3	Bodo saltans	45%	100%
A0A0S4ISD8	Bodo saltans	44%	82%
A0A0S4IWQ5	Bodo saltans	36%	100%
A0A0S4IY45	Bodo saltans	34%	100%
A0A0S4J328	Bodo saltans	50%	100%
A0A0S4J3Q7	Bodo saltans	31%	100%
A0A0S4J628	Bodo saltans	44%	80%
A0A0S4J918	Bodo saltans	38%	100%
A0A0S4J9K9	Bodo saltans	49%	100%
A0A0S4JPQ2	Bodo saltans	31%	100%
A0A0S4JSZ3	Bodo saltans	33%	100%
A0A0S4JV57	Bodo saltans	32%	100%
A0A0S4JXJ3	Bodo saltans	31%	100%
A0A0S4KJA5	Bodo saltans	43%	95%
A0A1X0NIG8	Trypanosomatidae	31%	100%
A0A1X0NM52	Trypanosomatidae	54%	100%
A0A1X0NXC8	Trypanosomatidae	30%	100%
A0A3R7L7E7	Trypanosoma rangeli	53%	83%
A0A3S5H682	Leishmania donovani	73%	100%
A0A3S5H683	Leishmania donovani	68%	100%
A0A3S5H684	Leishmania donovani	68%	100%
A0A3S5H685	Leishmania donovani	68%	100%
A0A3S7WQD0	Leishmania donovani	68%	100%
A0A6L0WJ22	Leishmania infantum	68%	100%
A0E358	Paramecium tetraurelia	34%	100%
A1KXI0	Blomia tropicalis	32%	100%
A2XQE8	Oryza sativa subsp. indica	36%	100%
A4H5E5	Leishmania braziliensis	98%	100%
A4H5E6	Leishmania braziliensis	99%	100%
A4HA92	Leishmania braziliensis	45%	92%
A4HH90	Leishmania braziliensis	28%	100%
A4HTP0	Leishmania infantum	71%	100%
A4HYH2	Leishmania infantum	46%	100%
A4I4D6	Leishmania infantum	31%	100%
A5HII1	Actinidia deliciosa	34%	100%
A8DS38	Tabernaemontana divaricata	37%	100%
B2LSD2	Mucuna pruriens	39%	100%
C9ZQB3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	98%
C9ZQB5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	98%
C9ZQB6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
D3ZZ07	Rattus norvegicus	32%	100%
E8NHD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
E8NHH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
E8NHJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	88%
E8NHL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	83%
E8NHS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
E9ADT5	Leishmania major	29%	100%
E9ALZ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AMH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
E9AMH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
E9AMH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
E9AS96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
F4JNL3	Arabidopsis thaliana	32%	100%
O10364	Orgyia pseudotsugata multicapsid polyhedrosis virus	35%	100%
O17473	Brugia pahangi	34%	100%
O23791	Ananas comosus	34%	100%
O35186	Rattus norvegicus	33%	100%
O45734	Caenorhabditis elegans	38%	100%
O46427	Sus scrofa	33%	100%
O60911	Homo sapiens	37%	100%
O65039	Ricinus communis	37%	100%
O65493	Arabidopsis thaliana	39%	100%
O70370	Mus musculus	36%	100%
O91466	Cydia pomonella granulosis virus (isolate Mexico/1963)	37%	100%
O97397	Phaedon cochleariae	33%	100%
P00784	Carica papaya	31%	100%
P00785	Actinidia chinensis var. chinensis	34%	100%
P00786	Rattus norvegicus	34%	100%
P04988	Dictyostelium discoideum	37%	100%
P04989	Dictyostelium discoideum	34%	100%
P05167	Hordeum vulgare	37%	100%
P06797	Mus musculus	38%	100%
P07154	Rattus norvegicus	39%	100%
P07711	Homo sapiens	36%	100%
P08176	Dermatophagoides pteronyssinus	33%	100%
P09668	Homo sapiens	35%	100%
P12412	Vigna mungo	36%	100%
P13277	Homarus americanus	40%	100%
P14658	Trypanosoma brucei brucei	49%	98%
P15242	Rattus norvegicus	35%	100%
P16311	Dermatophagoides farinae	32%	100%
P22497	Theileria parva	32%	100%
P22895	Glycine max	39%	100%
P25249	Hordeum vulgare	40%	100%
P25250	Hordeum vulgare	38%	100%
P25326	Bos taurus	36%	100%
P25773	Felis catus	35%	100%
P25774	Homo sapiens	34%	100%
P25775	Leishmania mexicana	44%	100%
P25776	Oryza sativa subsp. japonica	41%	96%
P25778	Oryza sativa subsp. japonica	37%	100%
P25779	Trypanosoma cruzi	50%	94%
P25780	Euroglyphus maynei	30%	100%
P25781	Theileria annulata	34%	100%
P25782	Homarus americanus	38%	100%
P25783	Autographa californica nuclear polyhedrosis virus	35%	100%
P25784	Homarus americanus	37%	100%
P25803	Phaseolus vulgaris	33%	100%
P25804	Pisum sativum	42%	100%
P25805	Plasmodium falciparum	30%	78%
P25975	Bos taurus	36%	100%
P35591	Leishmania pifanoi	44%	100%
P36184	Entamoeba histolytica	32%	100%
P36400	Leishmania mexicana	67%	100%
P41715	Choristoneura fumiferana nuclear polyhedrosis virus	37%	100%
P41721	Bombyx mori nuclear polyhedrosis virus	35%	100%
P42666	Plasmodium vivax (strain Salvador I)	28%	76%
P43156	Hemerocallis sp.	37%	100%
P43235	Homo sapiens	35%	100%
P43236	Oryctolagus cuniculus	33%	100%
P43295	Arabidopsis thaliana	42%	100%
P43296	Arabidopsis thaliana	40%	100%
P46102	Plasmodium vinckei	32%	87%
P49935	Mus musculus	34%	100%
P54639	Dictyostelium discoideum	33%	100%
P54640	Dictyostelium discoideum	32%	100%
P55097	Mus musculus	33%	100%
P56202	Homo sapiens	32%	100%
P56203	Mus musculus	32%	100%
P61276	Macaca fascicularis	35%	100%
P61277	Macaca mulatta	35%	100%
P80884	Ananas comosus	33%	100%
Q02765	Rattus norvegicus	33%	100%
Q05094	Leishmania pifanoi	67%	99%
Q10716	Zea mays	39%	100%
Q10717	Zea mays	38%	100%
Q1EIQ3	Psoroptes ovis	33%	100%
Q23894	Dictyostelium discoideum	33%	100%
Q24940	Fasciola hepatica	37%	100%
Q26534	Schistosoma mansoni	36%	100%
Q26636	Sarcophaga peregrina	38%	100%
Q28944	Sus scrofa	36%	100%
Q3T0I2	Bos taurus	35%	100%
Q3ZKN1	Canis lupus familiaris	34%	100%
Q40143	Solanum lycopersicum	36%	100%
Q4QD68	Leishmania major	48%	100%
Q4QI61	Leishmania major	70%	100%
Q4QI62	Leishmania major	75%	100%
Q4QI64	Leishmania major	75%	100%
Q4QI65	Leishmania major	75%	100%
Q4QI66	Leishmania major	70%	100%
Q4QI67	Leishmania major	75%	100%
Q4QI68	Leishmania major	74%	100%
Q54TR1	Dictyostelium discoideum	35%	83%
Q5E968	Bos taurus	35%	100%
Q5E998	Bos taurus	36%	100%
Q63088	Rattus norvegicus	35%	100%
Q6VTL7	Choristoneura fumiferana defective polyhedrosis virus	37%	100%
Q6YD92	Petrosia ficiformis	36%	100%
Q7F3A8	Oryza sativa subsp. japonica	38%	100%
Q7XR52	Oryza sativa subsp. japonica	37%	90%
Q7XWK5	Oryza sativa subsp. japonica	36%	100%
Q80LP4	Adoxophyes honmai nucleopolyhedrovirus	35%	100%
Q80UB0	Mus musculus	32%	100%
Q86GF7	Pandalus borealis	37%	100%
Q8B9D5	Rachiplusia ou multiple nucleopolyhedrovirus (strain R1)	35%	100%
Q8H166	Arabidopsis thaliana	37%	100%
Q8HY81	Canis lupus familiaris	37%	100%
Q8HY82	Saimiri boliviensis boliviensis	33%	100%
Q8QLK1	Mamestra configurata nucleopolyhedrovirus	36%	100%
Q8RWQ9	Arabidopsis thaliana	36%	100%
Q8V5U0	Heliothis zea nuclear polyhedrosis virus	38%	100%
Q8VYS0	Arabidopsis thaliana	37%	100%
Q91BH1	Spodoptera litura multicapsid nucleopolyhedrovirus	37%	100%
Q91CL9	Antheraea pernyi nuclear polyhedrosis virus	35%	100%
Q91GE3	Epiphyas postvittana nucleopolyhedrovirus	36%	100%
Q91ZF2	Mus musculus	34%	100%
Q94503	Dictyostelium discoideum	33%	100%
Q94714	Paramecium tetraurelia	34%	100%
Q94715	Paramecium tetraurelia	30%	100%
Q95029	Drosophila melanogaster	37%	100%
Q9BIE1	Leishmania donovani	46%	100%
Q9EQT5	Rattus norvegicus	26%	94%
Q9FGR9	Arabidopsis thaliana	37%	100%
Q9FJ47	Arabidopsis thaliana	35%	100%
Q9GKL8	Chlorocebus aethiops	36%	100%
Q9GL24	Canis lupus familiaris	36%	100%
Q9GLE3	Sus scrofa	34%	100%
Q9GQM5	Leishmania donovani	31%	100%
Q9J8B9	Spodoptera exigua nuclear polyhedrosis virus (strain US)	36%	100%
Q9JI81	Mus musculus	31%	100%
Q9JIA9	Mus musculus	34%	100%
Q9JL96	Mus musculus	34%	100%
Q9LM66	Arabidopsis thaliana	38%	100%
Q9LT77	Arabidopsis thaliana	38%	100%
Q9LT78	Arabidopsis thaliana	39%	98%
Q9LXW3	Arabidopsis thaliana	35%	100%
Q9PYY5	Xestia c-nigrum granulosis virus	36%	100%
Q9QZE3	Rattus norvegicus	31%	100%
Q9R013	Mus musculus	43%	95%
Q9R014	Mus musculus	34%	100%
Q9STL4	Arabidopsis thaliana	35%	100%
Q9STL5	Arabidopsis thaliana	35%	100%
Q9SUL1	Arabidopsis thaliana	40%	100%
Q9SUS9	Arabidopsis thaliana	34%	100%
Q9SUT0	Arabidopsis thaliana	36%	100%
Q9TST1	Felis catus	32%	100%
Q9UBX1	Homo sapiens	42%	91%
Q9VN93	Drosophila melanogaster	40%	72%
Q9WGE0	Hyphantria cunea nuclear polyhedrosis virus	35%	100%
Q9YMP9	Lymantria dispar multicapsid nuclear polyhedrosis virus	38%	100%
V5B261	Trypanosoma cruzi	33%	100%
V5LU01	Ambrosia artemisiifolia	32%	100%