EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2453), putative

Species:

Leishmania braziliensis

UniProt:

A4H5E2_LEIBR

TriTrypDb:

LbrM.08.0790 , LBRM2903_080015400

Length:

839

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

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Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0016020	membrane	2	6
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	6

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Expansion

Sequence features

A4H5E2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5E2

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0005509	calcium ion binding	5	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	187	191	PF00656	0.514
CLV_C14_Caspase3-7	257	261	PF00656	0.469
CLV_C14_Caspase3-7	447	451	PF00656	0.472
CLV_C14_Caspase3-7	517	521	PF00656	0.491
CLV_NRD_NRD_1	2	4	PF00675	0.495
CLV_NRD_NRD_1	32	34	PF00675	0.703
CLV_NRD_NRD_1	418	420	PF00675	0.707
CLV_NRD_NRD_1	463	465	PF00675	0.692
CLV_NRD_NRD_1	473	475	PF00675	0.714
CLV_PCSK_FUR_1	386	390	PF00082	0.693

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H678	Leishmania donovani	68%	100%
A4HTN7	Leishmania infantum	68%	100%
E9AMH1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
Q4QI72	Leishmania major	70%	100%

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