Dpy-30 motif containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Dpy-30 motif containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H5E1_LEIBR

TriTrypDb:

LbrM.08.0780 , LBRM2903_080015300

Length:

569

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	11
GO:0034708	methyltransferase complex	4	11
GO:0035097	histone methyltransferase complex	3	11
GO:0044666	MLL3/4 complex	4	11
GO:0048188	Set1C/COMPASS complex	4	11
GO:0140513	nuclear protein-containing complex	2	11
GO:1902494	catalytic complex	2	11
GO:1990234	transferase complex	3	11
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H5E1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5E1

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0034968	histone lysine methylation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0051568	histone H3-K4 methylation	7	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	162	164	PF00675	0.450
CLV_NRD_NRD_1	337	339	PF00675	0.520
CLV_NRD_NRD_1	362	364	PF00675	0.342
CLV_NRD_NRD_1	45	47	PF00675	0.494
CLV_NRD_NRD_1	537	539	PF00675	0.477
CLV_NRD_NRD_1	54	56	PF00675	0.463
CLV_PCSK_FUR_1	535	539	PF00082	0.481
CLV_PCSK_KEX2_1	162	164	PF00082	0.474
CLV_PCSK_KEX2_1	337	339	PF00082	0.520
CLV_PCSK_KEX2_1	362	364	PF00082	0.342
CLV_PCSK_KEX2_1	537	539	PF00082	0.534
CLV_PCSK_KEX2_1	54	56	PF00082	0.509
CLV_PCSK_KEX2_1	67	69	PF00082	0.348
CLV_PCSK_KEX2_1	88	90	PF00082	0.473
CLV_PCSK_KEX2_1	93	95	PF00082	0.562
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.583
CLV_PCSK_PC1ET2_1	67	69	PF00082	0.302
CLV_PCSK_PC1ET2_1	88	90	PF00082	0.471
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.537
CLV_PCSK_PC7_1	89	95	PF00082	0.544
CLV_PCSK_SKI1_1	122	126	PF00082	0.397
CLV_PCSK_SKI1_1	163	167	PF00082	0.413
CLV_PCSK_SKI1_1	170	174	PF00082	0.356
CLV_PCSK_SKI1_1	67	71	PF00082	0.469
DEG_Kelch_Keap1_1	502	507	PF01344	0.601
DEG_Nend_UBRbox_2	1	3	PF02207	0.502
DEG_SCF_FBW7_1	269	276	PF00400	0.479
DOC_CKS1_1	219	224	PF01111	0.426
DOC_MAPK_gen_1	167	175	PF00069	0.360
DOC_MAPK_gen_1	193	202	PF00069	0.322
DOC_MAPK_gen_1	67	78	PF00069	0.402
DOC_MAPK_MEF2A_6	473	480	PF00069	0.541
DOC_MAPK_NFAT4_5	473	481	PF00069	0.548
DOC_PP4_FxxP_1	353	356	PF00568	0.543
DOC_USP7_MATH_1	24	28	PF00917	0.449
DOC_WW_Pin1_4	218	223	PF00397	0.651
DOC_WW_Pin1_4	229	234	PF00397	0.643
DOC_WW_Pin1_4	269	274	PF00397	0.360
LIG_14-3-3_CanoR_1	170	176	PF00244	0.434
LIG_14-3-3_CanoR_1	454	462	PF00244	0.333
LIG_BRCT_BRCA1_1	167	171	PF00533	0.395
LIG_BRCT_BRCA1_1	349	353	PF00533	0.632
LIG_eIF4E_1	32	38	PF01652	0.446
LIG_FHA_1	356	362	PF00498	0.494
LIG_FHA_1	368	374	PF00498	0.460
LIG_FHA_1	503	509	PF00498	0.555
LIG_FHA_1	90	96	PF00498	0.329
LIG_FHA_2	128	134	PF00498	0.603
LIG_FHA_2	321	327	PF00498	0.603
LIG_FHA_2	413	419	PF00498	0.592
LIG_GBD_Chelix_1	33	41	PF00786	0.246
LIG_LIR_Apic_2	350	356	PF02991	0.583
LIG_LIR_Gen_1	247	258	PF02991	0.410
LIG_LIR_Gen_1	31	38	PF02991	0.446
LIG_LIR_Nem_3	247	253	PF02991	0.437
LIG_LIR_Nem_3	31	35	PF02991	0.462
LIG_MYND_1	229	233	PF01753	0.627
LIG_PDZ_Class_3	564	569	PF00595	0.621
LIG_REV1ctd_RIR_1	163	171	PF16727	0.472
LIG_RPA_C_Fungi	422	434	PF08784	0.336
LIG_SH2_CRK	450	454	PF00017	0.313
LIG_SH2_GRB2like	255	258	PF00017	0.308
LIG_SH2_NCK_1	104	108	PF00017	0.425
LIG_SH2_STAP1	387	391	PF00017	0.558
LIG_SH2_STAP1	543	547	PF00017	0.535
LIG_SH2_STAT5	255	258	PF00017	0.345
LIG_SH2_STAT5	266	269	PF00017	0.276
LIG_SH2_STAT5	32	35	PF00017	0.306
LIG_SH2_STAT5	36	39	PF00017	0.209
LIG_SH2_STAT5	387	390	PF00017	0.482
LIG_SH2_STAT5	5	8	PF00017	0.285
LIG_SH3_3	227	233	PF00018	0.598
LIG_SH3_3	23	29	PF00018	0.317
LIG_SUMO_SIM_anti_2	74	80	PF11976	0.302
LIG_SUMO_SIM_par_1	171	176	PF11976	0.357
LIG_TRAF2_1	150	153	PF00917	0.496
LIG_TRAF2_1	209	212	PF00917	0.468
LIG_TRAF2_1	556	559	PF00917	0.570
LIG_TRAF2_1	96	99	PF00917	0.442
LIG_TYR_ITIM	264	269	PF00017	0.387
LIG_TYR_ITIM	448	453	PF00017	0.353
LIG_UBA3_1	172	177	PF00899	0.364
MOD_CDK_SPK_2	269	274	PF00069	0.350
MOD_CK1_1	320	326	PF00069	0.459
MOD_CK2_1	432	438	PF00069	0.326
MOD_Cter_Amidation	335	338	PF01082	0.525
MOD_GlcNHglycan	142	145	PF01048	0.695
MOD_GlcNHglycan	177	180	PF01048	0.452
MOD_GlcNHglycan	2	5	PF01048	0.285
MOD_GlcNHglycan	320	323	PF01048	0.673
MOD_GlcNHglycan	393	398	PF01048	0.513
MOD_GlcNHglycan	456	459	PF01048	0.333
MOD_GlcNHglycan	72	76	PF01048	0.305
MOD_GSK3_1	136	143	PF00069	0.724
MOD_GSK3_1	171	178	PF00069	0.447
MOD_GSK3_1	20	27	PF00069	0.427
MOD_GSK3_1	269	276	PF00069	0.368
MOD_GSK3_1	347	354	PF00069	0.522
MOD_N-GLC_1	269	274	PF02516	0.480
MOD_NEK2_1	165	170	PF00069	0.439
MOD_NEK2_1	171	176	PF00069	0.443
MOD_NEK2_1	268	273	PF00069	0.259
MOD_PIKK_1	165	171	PF00454	0.344
MOD_PIKK_1	351	357	PF00454	0.440
MOD_PKA_1	338	344	PF00069	0.505
MOD_PKA_1	46	52	PF00069	0.365
MOD_PKA_2	140	146	PF00069	0.630
MOD_PKA_2	45	51	PF00069	0.462
MOD_Plk_1	198	204	PF00069	0.502
MOD_Plk_1	71	77	PF00069	0.308
MOD_Plk_2-3	127	133	PF00069	0.498
MOD_Plk_2-3	385	391	PF00069	0.558
MOD_Plk_2-3	432	438	PF00069	0.387
MOD_Plk_4	153	159	PF00069	0.330
MOD_Plk_4	286	292	PF00069	0.483
MOD_ProDKin_1	218	224	PF00069	0.660
MOD_ProDKin_1	229	235	PF00069	0.633
MOD_ProDKin_1	269	275	PF00069	0.362
MOD_SUMO_for_1	310	313	PF00179	0.567
MOD_SUMO_for_1	397	400	PF00179	0.405
MOD_SUMO_rev_2	43	49	PF00179	0.523
TRG_DiLeu_BaEn_1	110	115	PF01217	0.400
TRG_DiLeu_BaEn_4	503	509	PF01217	0.649
TRG_ENDOCYTIC_2	258	261	PF00928	0.300
TRG_ENDOCYTIC_2	266	269	PF00928	0.320
TRG_ENDOCYTIC_2	32	35	PF00928	0.306
TRG_ENDOCYTIC_2	450	453	PF00928	0.306
TRG_ER_diArg_1	193	196	PF00400	0.512
TRG_ER_diArg_1	361	363	PF00400	0.350
TRG_ER_diArg_1	537	540	PF00400	0.557
TRG_NLS_MonoExtC_3	53	59	PF00514	0.445
TRG_Pf-PMV_PEXEL_1	434	438	PF00026	0.316
TRG_Pf-PMV_PEXEL_1	68	72	PF00026	0.425

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3H1	Leptomonas seymouri	63%	97%
A0A1X0NQN0	Trypanosomatidae	41%	94%
A0A3S7WQC3	Leishmania donovani	82%	100%
A0A422NJV4	Trypanosoma rangeli	40%	100%
A4HTN6	Leishmania infantum	82%	100%
C9ZPD6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AMH0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QI73	Leishmania major	82%	100%
V5BR17	Trypanosoma cruzi	41%	100%