Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5E0_LEIBR

TriTrypDb:

LbrM.08.0770 , LBRM2903_080015200

Length:

146

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5E0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5E0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	124	126	PF00675	0.471
CLV_NRD_NRD_1	41	43	PF00675	0.542
CLV_NRD_NRD_1	71	73	PF00675	0.412
CLV_NRD_NRD_1	91	93	PF00675	0.491
CLV_PCSK_KEX2_1	124	126	PF00082	0.478
CLV_PCSK_KEX2_1	40	42	PF00082	0.415
CLV_PCSK_KEX2_1	71	73	PF00082	0.412
CLV_PCSK_KEX2_1	91	93	PF00082	0.491
CLV_PCSK_SKI1_1	101	105	PF00082	0.540
CLV_PCSK_SKI1_1	114	118	PF00082	0.473
CLV_PCSK_SKI1_1	125	129	PF00082	0.504
CLV_PCSK_SKI1_1	33	37	PF00082	0.538
DEG_Nend_Nbox_1	1	3	PF02207	0.498
DOC_CYCLIN_RxL_1	111	121	PF00134	0.430
DOC_CYCLIN_yCln2_LP_2	4	10	PF00134	0.432
DOC_PP1_RVXF_1	1	7	PF00149	0.587
LIG_14-3-3_CanoR_1	3	7	PF00244	0.490
LIG_14-3-3_CanoR_1	41	47	PF00244	0.581
LIG_14-3-3_CanoR_1	63	68	PF00244	0.527
LIG_14-3-3_CanoR_1	71	75	PF00244	0.477
LIG_14-3-3_CterR_2	142	146	PF00244	0.451
LIG_APCC_ABBAyCdc20_2	114	120	PF00400	0.355
LIG_Clathr_ClatBox_1	116	120	PF01394	0.347
LIG_FHA_1	121	127	PF00498	0.505
LIG_FHA_1	3	9	PF00498	0.602
LIG_FHA_2	100	106	PF00498	0.538
LIG_FHA_2	110	116	PF00498	0.437
LIG_Pex14_2	2	6	PF04695	0.435
LIG_RPA_C_Fungi	35	47	PF08784	0.389
LIG_SH2_NCK_1	83	87	PF00017	0.536
LIG_SH2_STAP1	83	87	PF00017	0.569
MOD_CK2_1	109	115	PF00069	0.440
MOD_GSK3_1	21	28	PF00069	0.529
MOD_GSK3_1	36	43	PF00069	0.549
MOD_GSK3_1	9	16	PF00069	0.567
MOD_N-GLC_1	48	53	PF02516	0.360
MOD_NEK2_1	2	7	PF00069	0.556
MOD_NEK2_1	36	41	PF00069	0.463
MOD_NEK2_1	8	13	PF00069	0.556
MOD_PIKK_1	129	135	PF00454	0.529
MOD_PIKK_1	40	46	PF00454	0.527
MOD_PKA_1	40	46	PF00069	0.572
MOD_PKA_2	2	8	PF00069	0.530
MOD_PKA_2	29	35	PF00069	0.517
MOD_PKA_2	40	46	PF00069	0.468
MOD_PKA_2	70	76	PF00069	0.474
MOD_PKB_1	40	48	PF00069	0.543
MOD_Plk_1	48	54	PF00069	0.358
TRG_ER_diArg_1	124	126	PF00400	0.529
TRG_ER_diArg_1	40	42	PF00400	0.417
TRG_NLS_MonoExtN_4	125	132	PF00514	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3W2	Leptomonas seymouri	65%	100%
A0A1X0NPN9	Trypanosomatidae	33%	95%
A0A3S5H677	Leishmania donovani	78%	100%
A4HTN5	Leishmania infantum	78%	100%
E9AMG9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QI74	Leishmania major	78%	100%