Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5D9_LEIBR

TriTrypDb:

LbrM.08.0760 , LBRM2903_080015100

Length:

284

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H5D9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5D9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	203	207	PF00656	0.592
CLV_NRD_NRD_1	143	145	PF00675	0.731
CLV_NRD_NRD_1	165	167	PF00675	0.537
CLV_NRD_NRD_1	234	236	PF00675	0.691
CLV_NRD_NRD_1	77	79	PF00675	0.566
CLV_NRD_NRD_1	80	82	PF00675	0.602
CLV_NRD_NRD_1	83	85	PF00675	0.633
CLV_PCSK_FUR_1	78	82	PF00082	0.433
CLV_PCSK_KEX2_1	143	145	PF00082	0.731
CLV_PCSK_KEX2_1	165	167	PF00082	0.660
CLV_PCSK_KEX2_1	234	236	PF00082	0.691
CLV_PCSK_KEX2_1	49	51	PF00082	0.665
CLV_PCSK_KEX2_1	77	79	PF00082	0.566
CLV_PCSK_KEX2_1	80	82	PF00082	0.602
CLV_PCSK_KEX2_1	83	85	PF00082	0.633
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.736
CLV_PCSK_SKI1_1	106	110	PF00082	0.538
CLV_PCSK_SKI1_1	14	18	PF00082	0.579
DEG_SPOP_SBC_1	168	172	PF00917	0.676
DEG_SPOP_SBC_1	191	195	PF00917	0.520
DOC_ANK_TNKS_1	147	154	PF00023	0.745
DOC_CYCLIN_yCln2_LP_2	110	116	PF00134	0.562
DOC_MAPK_RevD_3	36	49	PF00069	0.509
DOC_USP7_MATH_1	176	180	PF00917	0.737
DOC_USP7_MATH_1	224	228	PF00917	0.705
DOC_USP7_MATH_1	23	27	PF00917	0.721
DOC_USP7_MATH_1	61	65	PF00917	0.582
DOC_WW_Pin1_4	109	114	PF00397	0.563
DOC_WW_Pin1_4	219	224	PF00397	0.765
LIG_14-3-3_CanoR_1	14	19	PF00244	0.661
LIG_14-3-3_CanoR_1	188	197	PF00244	0.713
LIG_14-3-3_CanoR_1	22	28	PF00244	0.503
LIG_14-3-3_CanoR_1	234	244	PF00244	0.560
LIG_14-3-3_CanoR_1	34	39	PF00244	0.446
LIG_14-3-3_CanoR_1	89	95	PF00244	0.603
LIG_APCC_ABBA_1	94	99	PF00400	0.705
LIG_BIR_II_1	1	5	PF00653	0.594
LIG_BRCT_BRCA1_1	69	73	PF00533	0.601
LIG_CSL_BTD_1	110	113	PF09270	0.672
LIG_FHA_1	155	161	PF00498	0.681
LIG_FHA_1	170	176	PF00498	0.764
LIG_FHA_1	272	278	PF00498	0.591
LIG_FHA_1	7	13	PF00498	0.509
LIG_FHA_2	52	58	PF00498	0.779
LIG_LIR_Apic_2	170	176	PF02991	0.560
LIG_LIR_Gen_1	227	236	PF02991	0.790
LIG_LIR_Gen_1	88	98	PF02991	0.567
LIG_LIR_Nem_3	133	139	PF02991	0.593
LIG_LIR_Nem_3	227	231	PF02991	0.785
LIG_LIR_Nem_3	70	76	PF02991	0.582
LIG_LIR_Nem_3	88	94	PF02991	0.583
LIG_MLH1_MIPbox_1	69	73	PF16413	0.481
LIG_REV1ctd_RIR_1	70	78	PF16727	0.426
LIG_SH2_CRK	173	177	PF00017	0.574
LIG_SH2_CRK	91	95	PF00017	0.606
LIG_SH2_NCK_1	173	177	PF00017	0.574
LIG_SH2_NCK_1	280	284	PF00017	0.681
LIG_SH2_PTP2	138	141	PF00017	0.621
LIG_SH2_STAP1	197	201	PF00017	0.641
LIG_SH2_STAT5	129	132	PF00017	0.659
LIG_SH2_STAT5	138	141	PF00017	0.702
LIG_SH2_STAT5	280	283	PF00017	0.704
LIG_SH2_STAT5	91	94	PF00017	0.608
LIG_SH2_STAT5	97	100	PF00017	0.537
LIG_SH3_3	136	142	PF00018	0.650
LIG_SH3_3	246	252	PF00018	0.663
LIG_SUMO_SIM_par_1	265	271	PF11976	0.423
LIG_TRAF2_1	252	255	PF00917	0.822
LIG_WRC_WIRS_1	225	230	PF05994	0.779
MOD_CK1_1	154	160	PF00069	0.670
MOD_CK1_1	179	185	PF00069	0.713
MOD_CK1_1	187	193	PF00069	0.667
MOD_CK1_1	53	59	PF00069	0.678
MOD_CK1_1	64	70	PF00069	0.480
MOD_CK2_1	224	230	PF00069	0.777
MOD_GlcNHglycan	152	156	PF01048	0.762
MOD_GlcNHglycan	34	37	PF01048	0.526
MOD_GlcNHglycan	69	72	PF01048	0.602
MOD_GSK3_1	154	161	PF00069	0.684
MOD_GSK3_1	167	174	PF00069	0.761
MOD_GSK3_1	186	193	PF00069	0.692
MOD_GSK3_1	23	30	PF00069	0.608
MOD_GSK3_1	61	68	PF00069	0.513
MOD_LATS_1	87	93	PF00433	0.485
MOD_N-GLC_1	176	181	PF02516	0.767
MOD_N-GLC_1	5	10	PF02516	0.514
MOD_N-GLC_1	65	70	PF02516	0.484
MOD_NEK2_1	118	123	PF00069	0.436
MOD_NEK2_1	5	10	PF00069	0.572
MOD_NEK2_1	51	56	PF00069	0.772
MOD_NEK2_2	224	229	PF00069	0.774
MOD_PIKK_1	176	182	PF00454	0.690
MOD_PIKK_1	271	277	PF00454	0.685
MOD_PIKK_1	29	35	PF00454	0.531
MOD_PKA_2	187	193	PF00069	0.720
MOD_PKA_2	199	205	PF00069	0.457
MOD_Plk_1	5	11	PF00069	0.513
MOD_Plk_4	159	165	PF00069	0.692
MOD_Plk_4	92	98	PF00069	0.609
MOD_ProDKin_1	109	115	PF00069	0.560
MOD_ProDKin_1	219	225	PF00069	0.767
TRG_DiLeu_BaLyEn_6	110	115	PF01217	0.532
TRG_ENDOCYTIC_2	138	141	PF00928	0.706
TRG_ENDOCYTIC_2	76	79	PF00928	0.596
TRG_ENDOCYTIC_2	91	94	PF00928	0.629
TRG_ER_diArg_1	142	144	PF00400	0.718
TRG_ER_diArg_1	164	166	PF00400	0.546
TRG_ER_diArg_1	233	235	PF00400	0.680
TRG_ER_diArg_1	76	78	PF00400	0.605
TRG_ER_diArg_1	79	81	PF00400	0.600

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUT6	Leptomonas seymouri	39%	71%
A0A3S5H676	Leishmania donovani	68%	100%
A4HTN4	Leishmania infantum	68%	100%
E9AMG8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4QI75	Leishmania major	70%	100%