Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4H5D8_LEIBR

TriTrypDb:

LbrM.08.0750 , LBRM2903_080015000

Length:

1140

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5D8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5D8

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	5
GO:0006793	phosphorus metabolic process	3	5
GO:0006796	phosphate-containing compound metabolic process	4	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0009987	cellular process	1	5
GO:0016310	phosphorylation	5	5
GO:0019538	protein metabolic process	3	5
GO:0036211	protein modification process	4	5
GO:0043170	macromolecule metabolic process	3	5
GO:0043412	macromolecule modification	4	5
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	5
GO:0071704	organic substance metabolic process	2	5
GO:1901564	organonitrogen compound metabolic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	5
GO:0003824	catalytic activity	1	5
GO:0004672	protein kinase activity	3	5
GO:0005488	binding	1	5
GO:0005524	ATP binding	5	5
GO:0016301	kinase activity	4	5
GO:0016740	transferase activity	2	5
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	5
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	5
GO:0017076	purine nucleotide binding	4	5
GO:0030554	adenyl nucleotide binding	5	5
GO:0032553	ribonucleotide binding	3	5
GO:0032555	purine ribonucleotide binding	4	5
GO:0032559	adenyl ribonucleotide binding	5	5
GO:0035639	purine ribonucleoside triphosphate binding	4	5
GO:0036094	small molecule binding	2	5
GO:0043167	ion binding	2	5
GO:0043168	anion binding	3	5
GO:0097159	organic cyclic compound binding	2	5
GO:0097367	carbohydrate derivative binding	2	5
GO:0140096	catalytic activity, acting on a protein	2	5
GO:1901265	nucleoside phosphate binding	3	5
GO:1901363	heterocyclic compound binding	2	5
GO:0004674	protein serine/threonine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.422
CLV_C14_Caspase3-7	760	764	PF00656	0.645
CLV_C14_Caspase3-7	824	828	PF00656	0.697
CLV_C14_Caspase3-7	855	859	PF00656	0.547
CLV_NRD_NRD_1	123	125	PF00675	0.502
CLV_NRD_NRD_1	165	167	PF00675	0.498
CLV_NRD_NRD_1	24	26	PF00675	0.620
CLV_NRD_NRD_1	288	290	PF00675	0.503
CLV_NRD_NRD_1	348	350	PF00675	0.612
CLV_NRD_NRD_1	426	428	PF00675	0.685
CLV_NRD_NRD_1	581	583	PF00675	0.749
CLV_NRD_NRD_1	624	626	PF00675	0.576
CLV_NRD_NRD_1	635	637	PF00675	0.540
CLV_PCSK_FUR_1	633	637	PF00082	0.491
CLV_PCSK_KEX2_1	165	167	PF00082	0.503
CLV_PCSK_KEX2_1	287	289	PF00082	0.505
CLV_PCSK_KEX2_1	428	430	PF00082	0.700
CLV_PCSK_KEX2_1	581	583	PF00082	0.796
CLV_PCSK_KEX2_1	624	626	PF00082	0.518
CLV_PCSK_KEX2_1	635	637	PF00082	0.475
CLV_PCSK_PC1ET2_1	428	430	PF00082	0.700
CLV_PCSK_SKI1_1	1072	1076	PF00082	0.461
CLV_PCSK_SKI1_1	165	169	PF00082	0.494
CLV_PCSK_SKI1_1	170	174	PF00082	0.462
CLV_PCSK_SKI1_1	755	759	PF00082	0.572
DEG_APCC_DBOX_1	1071	1079	PF00400	0.449
DEG_APCC_DBOX_1	675	683	PF00400	0.563
DEG_Nend_UBRbox_3	1	3	PF02207	0.627
DEG_SCF_FBW7_1	996	1002	PF00400	0.556
DOC_CDC14_PxL_1	302	310	PF14671	0.545
DOC_CKS1_1	530	535	PF01111	0.587
DOC_CKS1_1	996	1001	PF01111	0.556
DOC_CYCLIN_yCln2_LP_2	1050	1056	PF00134	0.730
DOC_CYCLIN_yCln2_LP_2	296	302	PF00134	0.422
DOC_MAPK_gen_1	1070	1077	PF00069	0.468
DOC_MAPK_gen_1	170	179	PF00069	0.422
DOC_MAPK_gen_1	25	32	PF00069	0.593
DOC_MAPK_MEF2A_6	17	24	PF00069	0.540
DOC_MAPK_RevD_3	11	26	PF00069	0.576
DOC_PP2B_LxvP_1	1055	1058	PF13499	0.556
DOC_PP2B_LxvP_1	355	358	PF13499	0.659
DOC_PP2B_LxvP_1	558	561	PF13499	0.658
DOC_PP2B_LxvP_1	682	685	PF13499	0.571
DOC_PP2B_LxvP_1	787	790	PF13499	0.712
DOC_PP2B_LxvP_1	922	925	PF13499	0.735
DOC_PP4_FxxP_1	47	50	PF00568	0.422
DOC_PP4_FxxP_1	506	509	PF00568	0.730
DOC_PP4_FxxP_1	672	675	PF00568	0.585
DOC_PP4_FxxP_1	688	691	PF00568	0.576
DOC_PP4_MxPP_1	507	510	PF00568	0.717
DOC_USP7_MATH_1	1003	1007	PF00917	0.613
DOC_USP7_MATH_1	1068	1072	PF00917	0.558
DOC_USP7_MATH_1	201	205	PF00917	0.451
DOC_USP7_MATH_1	222	226	PF00917	0.429
DOC_USP7_MATH_1	245	249	PF00917	0.513
DOC_USP7_MATH_1	31	35	PF00917	0.422
DOC_USP7_MATH_1	397	401	PF00917	0.612
DOC_USP7_MATH_1	404	408	PF00917	0.536
DOC_USP7_MATH_1	447	451	PF00917	0.808
DOC_USP7_MATH_1	499	503	PF00917	0.800
DOC_USP7_MATH_1	576	580	PF00917	0.672
DOC_USP7_MATH_1	595	599	PF00917	0.532
DOC_USP7_MATH_1	653	657	PF00917	0.625
DOC_USP7_MATH_1	730	734	PF00917	0.651
DOC_USP7_MATH_1	792	796	PF00917	0.610
DOC_USP7_MATH_1	888	892	PF00917	0.646
DOC_USP7_MATH_1	951	955	PF00917	0.636
DOC_WW_Pin1_4	1001	1006	PF00397	0.678
DOC_WW_Pin1_4	136	141	PF00397	0.432
DOC_WW_Pin1_4	206	211	PF00397	0.487
DOC_WW_Pin1_4	295	300	PF00397	0.422
DOC_WW_Pin1_4	318	323	PF00397	0.607
DOC_WW_Pin1_4	365	370	PF00397	0.624
DOC_WW_Pin1_4	376	381	PF00397	0.590
DOC_WW_Pin1_4	383	388	PF00397	0.622
DOC_WW_Pin1_4	456	461	PF00397	0.743
DOC_WW_Pin1_4	497	502	PF00397	0.646
DOC_WW_Pin1_4	529	534	PF00397	0.792
DOC_WW_Pin1_4	545	550	PF00397	0.573
DOC_WW_Pin1_4	659	664	PF00397	0.847
DOC_WW_Pin1_4	665	670	PF00397	0.748
DOC_WW_Pin1_4	936	941	PF00397	0.702
DOC_WW_Pin1_4	949	954	PF00397	0.560
DOC_WW_Pin1_4	969	974	PF00397	0.516
DOC_WW_Pin1_4	995	1000	PF00397	0.685
LIG_14-3-3_CanoR_1	1032	1040	PF00244	0.568
LIG_14-3-3_CanoR_1	1070	1075	PF00244	0.480
LIG_14-3-3_CanoR_1	635	645	PF00244	0.565
LIG_14-3-3_CanoR_1	755	760	PF00244	0.570
LIG_14-3-3_CanoR_1	807	815	PF00244	0.639
LIG_APCC_ABBA_1	44	49	PF00400	0.422
LIG_APCC_ABBAyCdc20_2	165	171	PF00400	0.422
LIG_BIR_III_4	763	767	PF00653	0.705
LIG_BRCT_BRCA1_1	174	178	PF00533	0.422
LIG_CtBP_PxDLS_1	380	384	PF00389	0.574
LIG_eIF4E_1	40	46	PF01652	0.263
LIG_EVH1_1	787	791	PF00568	0.565
LIG_FHA_1	1021	1027	PF00498	0.691
LIG_FHA_1	1105	1111	PF00498	0.480
LIG_FHA_1	1123	1129	PF00498	0.504
LIG_FHA_1	137	143	PF00498	0.465
LIG_FHA_1	154	160	PF00498	0.233
LIG_FHA_1	319	325	PF00498	0.623
LIG_FHA_1	441	447	PF00498	0.733
LIG_FHA_1	546	552	PF00498	0.571
LIG_FHA_1	641	647	PF00498	0.612
LIG_FHA_1	879	885	PF00498	0.657
LIG_FHA_2	1016	1022	PF00498	0.543
LIG_FHA_2	1101	1107	PF00498	0.473
LIG_FHA_2	765	771	PF00498	0.618
LIG_FHA_2	792	798	PF00498	0.577
LIG_FHA_2	853	859	PF00498	0.551
LIG_FHA_2	937	943	PF00498	0.666
LIG_GSK3_LRP6_1	665	670	PF00069	0.716
LIG_Integrin_RGD_1	133	135	PF01839	0.263
LIG_LIR_Apic_2	209	215	PF02991	0.422
LIG_LIR_Apic_2	670	675	PF02991	0.584
LIG_LIR_Gen_1	112	122	PF02991	0.422
LIG_LIR_Gen_1	272	282	PF02991	0.414
LIG_LIR_Gen_1	891	902	PF02991	0.500
LIG_LIR_Gen_1	920	928	PF02991	0.718
LIG_LIR_Nem_3	1073	1079	PF02991	0.459
LIG_LIR_Nem_3	112	117	PF02991	0.422
LIG_LIR_Nem_3	27	32	PF02991	0.491
LIG_LIR_Nem_3	272	278	PF02991	0.414
LIG_LIR_Nem_3	837	842	PF02991	0.592
LIG_LIR_Nem_3	896	902	PF02991	0.685
LIG_LIR_Nem_3	920	924	PF02991	0.714
LIG_MYND_1	1053	1057	PF01753	0.556
LIG_NBox_RRM_1	761	771	PF00076	0.703
LIG_NRBOX	231	237	PF00104	0.422
LIG_NRBOX	6	12	PF00104	0.623
LIG_OCRL_FandH_1	54	66	PF00620	0.422
LIG_SH2_CRK	1079	1083	PF00017	0.621
LIG_SH2_CRK	114	118	PF00017	0.422
LIG_SH2_SRC	107	110	PF00017	0.233
LIG_SH2_SRC	29	32	PF00017	0.489
LIG_SH2_SRC	95	98	PF00017	0.422
LIG_SH2_STAP1	237	241	PF00017	0.422
LIG_SH2_STAP1	91	95	PF00017	0.327
LIG_SH2_STAT5	102	105	PF00017	0.295
LIG_SH2_STAT5	1076	1079	PF00017	0.578
LIG_SH2_STAT5	212	215	PF00017	0.422
LIG_SH2_STAT5	29	32	PF00017	0.489
LIG_SH2_STAT5	54	57	PF00017	0.422
LIG_SH2_STAT5	894	897	PF00017	0.501
LIG_SH3_1	261	267	PF00018	0.422
LIG_SH3_1	785	791	PF00018	0.571
LIG_SH3_2	344	349	PF14604	0.741
LIG_SH3_2	533	538	PF14604	0.583
LIG_SH3_3	1037	1043	PF00018	0.656
LIG_SH3_3	1051	1057	PF00018	0.670
LIG_SH3_3	12	18	PF00018	0.618
LIG_SH3_3	261	267	PF00018	0.422
LIG_SH3_3	333	339	PF00018	0.756
LIG_SH3_3	340	346	PF00018	0.828
LIG_SH3_3	351	357	PF00018	0.656
LIG_SH3_3	363	369	PF00018	0.551
LIG_SH3_3	481	487	PF00018	0.715
LIG_SH3_3	506	512	PF00018	0.801
LIG_SH3_3	527	533	PF00018	0.733
LIG_SH3_3	643	649	PF00018	0.668
LIG_SH3_3	660	666	PF00018	0.694
LIG_SH3_3	783	789	PF00018	0.642
LIG_SH3_3	993	999	PF00018	0.808
LIG_SH3_CIN85_PxpxPR_1	344	349	PF14604	0.757
LIG_SUMO_SIM_anti_2	1109	1115	PF11976	0.613
LIG_SUMO_SIM_par_1	379	384	PF11976	0.565
LIG_TRAF2_1	794	797	PF00917	0.611
LIG_TYR_ITIM	1077	1082	PF00017	0.582
LIG_UBA3_1	254	261	PF00899	0.422
LIG_UBA3_1	277	284	PF00899	0.422
LIG_WRC_WIRS_1	899	904	PF05994	0.649
LIG_WW_2	509	512	PF00397	0.718
LIG_WW_3	346	350	PF00397	0.748
MOD_CDK_SPK_2	545	550	PF00069	0.576
MOD_CDK_SPxxK_3	1001	1008	PF00069	0.560
MOD_CDK_SPxxK_3	531	538	PF00069	0.668
MOD_CDK_SPxxK_3	545	552	PF00069	0.554
MOD_CK1_1	1004	1010	PF00069	0.653
MOD_CK1_1	1035	1041	PF00069	0.606
MOD_CK1_1	115	121	PF00069	0.503
MOD_CK1_1	136	142	PF00069	0.422
MOD_CK1_1	318	324	PF00069	0.622
MOD_CK1_1	379	385	PF00069	0.633
MOD_CK1_1	386	392	PF00069	0.618
MOD_CK1_1	456	462	PF00069	0.606
MOD_CK1_1	488	494	PF00069	0.598
MOD_CK1_1	534	540	PF00069	0.746
MOD_CK1_1	613	619	PF00069	0.579
MOD_CK1_1	640	646	PF00069	0.671
MOD_CK1_1	670	676	PF00069	0.709
MOD_CK1_1	735	741	PF00069	0.599
MOD_CK1_1	811	817	PF00069	0.638
MOD_CK1_1	828	834	PF00069	0.480
MOD_CK1_1	936	942	PF00069	0.663
MOD_CK1_1	969	975	PF00069	0.578
MOD_CK2_1	1015	1021	PF00069	0.552
MOD_CK2_1	404	410	PF00069	0.692
MOD_CK2_1	447	453	PF00069	0.602
MOD_CK2_1	614	620	PF00069	0.579
MOD_CK2_1	791	797	PF00069	0.733
MOD_GlcNHglycan	1013	1016	PF01048	0.713
MOD_GlcNHglycan	118	121	PF01048	0.427
MOD_GlcNHglycan	135	138	PF01048	0.492
MOD_GlcNHglycan	26	29	PF01048	0.520
MOD_GlcNHglycan	317	320	PF01048	0.604
MOD_GlcNHglycan	399	402	PF01048	0.612
MOD_GlcNHglycan	430	433	PF01048	0.779
MOD_GlcNHglycan	449	452	PF01048	0.827
MOD_GlcNHglycan	461	464	PF01048	0.620
MOD_GlcNHglycan	490	493	PF01048	0.744
MOD_GlcNHglycan	589	593	PF01048	0.746
MOD_GlcNHglycan	597	600	PF01048	0.653
MOD_GlcNHglycan	669	672	PF01048	0.792
MOD_GlcNHglycan	734	737	PF01048	0.587
MOD_GlcNHglycan	754	758	PF01048	0.572
MOD_GlcNHglycan	799	802	PF01048	0.779
MOD_GlcNHglycan	804	807	PF01048	0.622
MOD_GlcNHglycan	953	956	PF01048	0.798
MOD_GlcNHglycan	990	993	PF01048	0.606
MOD_GSK3_1	1011	1018	PF00069	0.589
MOD_GSK3_1	1066	1073	PF00069	0.554
MOD_GSK3_1	1100	1107	PF00069	0.472
MOD_GSK3_1	112	119	PF00069	0.513
MOD_GSK3_1	191	198	PF00069	0.432
MOD_GSK3_1	20	27	PF00069	0.522
MOD_GSK3_1	202	209	PF00069	0.323
MOD_GSK3_1	379	386	PF00069	0.717
MOD_GSK3_1	610	617	PF00069	0.544
MOD_GSK3_1	636	643	PF00069	0.613
MOD_GSK3_1	655	662	PF00069	0.590
MOD_GSK3_1	720	727	PF00069	0.635
MOD_GSK3_1	753	760	PF00069	0.730
MOD_GSK3_1	811	818	PF00069	0.720
MOD_GSK3_1	825	832	PF00069	0.619
MOD_GSK3_1	848	855	PF00069	0.606
MOD_GSK3_1	898	905	PF00069	0.657
MOD_GSK3_1	934	941	PF00069	0.621
MOD_GSK3_1	945	952	PF00069	0.572
MOD_GSK3_1	995	1002	PF00069	0.612
MOD_N-GLC_1	636	641	PF02516	0.517
MOD_NEK2_1	116	121	PF00069	0.422
MOD_NEK2_1	152	157	PF00069	0.406
MOD_NEK2_1	190	195	PF00069	0.518
MOD_NEK2_1	196	201	PF00069	0.422
MOD_NEK2_1	202	207	PF00069	0.327
MOD_NEK2_1	24	29	PF00069	0.521
MOD_NEK2_1	246	251	PF00069	0.422
MOD_NEK2_1	437	442	PF00069	0.570
MOD_NEK2_1	588	593	PF00069	0.588
MOD_NEK2_1	815	820	PF00069	0.722
MOD_NEK2_1	829	834	PF00069	0.596
MOD_NEK2_1	852	857	PF00069	0.567
MOD_NEK2_1	879	884	PF00069	0.661
MOD_NEK2_1	902	907	PF00069	0.560
MOD_NEK2_1	934	939	PF00069	0.538
MOD_NEK2_2	326	331	PF00069	0.580
MOD_PIKK_1	1035	1041	PF00454	0.534
MOD_PIKK_1	1104	1110	PF00454	0.458
MOD_PIKK_1	386	392	PF00454	0.650
MOD_PIKK_1	499	505	PF00454	0.596
MOD_PIKK_1	576	582	PF00454	0.590
MOD_PIKK_1	808	814	PF00454	0.627
MOD_PIKK_1	997	1003	PF00454	0.590
MOD_PK_1	1070	1076	PF00069	0.475
MOD_PK_1	619	625	PF00069	0.609
MOD_PKA_1	428	434	PF00069	0.705
MOD_PKA_2	24	30	PF00069	0.509
MOD_PKA_2	428	434	PF00069	0.752
MOD_PKA_2	485	491	PF00069	0.755
MOD_PKA_2	494	500	PF00069	0.579
MOD_PKA_2	539	545	PF00069	0.757
MOD_PKA_2	852	858	PF00069	0.603
MOD_PKA_2	879	885	PF00069	0.526
MOD_PKA_2	910	916	PF00069	0.645
MOD_PKB_1	131	139	PF00069	0.263
MOD_PKB_1	393	401	PF00069	0.616
MOD_Plk_1	246	252	PF00069	0.432
MOD_Plk_1	613	619	PF00069	0.524
MOD_Plk_1	640	646	PF00069	0.558
MOD_Plk_2-3	1106	1112	PF00069	0.619
MOD_Plk_2-3	614	620	PF00069	0.579
MOD_Plk_4	1057	1063	PF00069	0.559
MOD_Plk_4	112	118	PF00069	0.422
MOD_Plk_4	147	153	PF00069	0.330
MOD_Plk_4	191	197	PF00069	0.422
MOD_Plk_4	640	646	PF00069	0.573
MOD_Plk_4	757	763	PF00069	0.723
MOD_Plk_4	829	835	PF00069	0.694
MOD_Plk_4	893	899	PF00069	0.655
MOD_ProDKin_1	136	142	PF00069	0.432
MOD_ProDKin_1	206	212	PF00069	0.487
MOD_ProDKin_1	295	301	PF00069	0.422
MOD_ProDKin_1	318	324	PF00069	0.612
MOD_ProDKin_1	365	371	PF00069	0.624
MOD_ProDKin_1	376	382	PF00069	0.592
MOD_ProDKin_1	383	389	PF00069	0.622
MOD_ProDKin_1	456	462	PF00069	0.744
MOD_ProDKin_1	497	503	PF00069	0.647
MOD_ProDKin_1	529	535	PF00069	0.786
MOD_ProDKin_1	545	551	PF00069	0.571
MOD_ProDKin_1	659	665	PF00069	0.847
MOD_ProDKin_1	936	942	PF00069	0.703
MOD_ProDKin_1	949	955	PF00069	0.560
MOD_ProDKin_1	969	975	PF00069	0.515
MOD_ProDKin_1	995	1001	PF00069	0.687
TRG_DiLeu_BaEn_1	6	11	PF01217	0.620
TRG_DiLeu_BaEn_4	96	102	PF01217	0.422
TRG_DiLeu_BaLyEn_6	163	168	PF01217	0.422
TRG_ENDOCYTIC_2	102	105	PF00928	0.422
TRG_ENDOCYTIC_2	1079	1082	PF00928	0.676
TRG_ENDOCYTIC_2	114	117	PF00928	0.422
TRG_ENDOCYTIC_2	29	32	PF00928	0.489
TRG_ENDOCYTIC_2	54	57	PF00928	0.422
TRG_ENDOCYTIC_2	894	897	PF00928	0.621
TRG_ENDOCYTIC_2	899	902	PF00928	0.641
TRG_ER_diArg_1	165	167	PF00400	0.508
TRG_ER_diArg_1	287	289	PF00400	0.508
TRG_ER_diArg_1	623	625	PF00400	0.551
TRG_ER_diArg_1	633	636	PF00400	0.481
TRG_NLS_MonoCore_2	426	431	PF00514	0.696
TRG_NLS_MonoExtN_4	427	432	PF00514	0.537
TRG_Pf-PMV_PEXEL_1	166	171	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	625	629	PF00026	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H675	Leishmania donovani	68%	99%
E9AMG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	98%
Q4QI76	Leishmania major	68%	99%