Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5D7_LEIBR

TriTrypDb:

LbrM.08.0740 , LBRM2903_080014800

Length:

205

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5D7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5D7

PDB structure(s): 7aih_D , 7ane_D

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.492
CLV_C14_Caspase3-7	195	199	PF00656	0.512
CLV_NRD_NRD_1	32	34	PF00675	0.491
CLV_NRD_NRD_1	83	85	PF00675	0.403
CLV_PCSK_KEX2_1	32	34	PF00082	0.490
CLV_PCSK_KEX2_1	83	85	PF00082	0.388
CLV_PCSK_SKI1_1	123	127	PF00082	0.434
CLV_PCSK_SKI1_1	130	134	PF00082	0.376
CLV_PCSK_SKI1_1	164	168	PF00082	0.648
CLV_Separin_Metazoa	112	116	PF03568	0.552
DEG_SPOP_SBC_1	184	188	PF00917	0.754
DOC_CDC14_PxL_1	131	139	PF14671	0.406
DOC_MAPK_DCC_7	130	139	PF00069	0.320
DOC_MAPK_HePTP_8	127	139	PF00069	0.316
DOC_MAPK_MEF2A_6	123	131	PF00069	0.403
DOC_MAPK_MEF2A_6	16	24	PF00069	0.544
DOC_PP2B_LxvP_1	143	146	PF13499	0.448
DOC_USP7_MATH_1	12	16	PF00917	0.615
DOC_USP7_MATH_1	184	188	PF00917	0.771
DOC_USP7_MATH_1	91	95	PF00917	0.557
DOC_WW_Pin1_4	16	21	PF00397	0.507
DOC_WW_Pin1_4	46	51	PF00397	0.511
LIG_14-3-3_CanoR_1	123	128	PF00244	0.479
LIG_Actin_WH2_2	7	25	PF00022	0.629
LIG_BIR_II_1	1	5	PF00653	0.533
LIG_FHA_1	108	114	PF00498	0.417
LIG_FHA_1	124	130	PF00498	0.536
LIG_FHA_1	186	192	PF00498	0.500
LIG_FHA_1	35	41	PF00498	0.521
LIG_FHA_2	166	172	PF00498	0.553
LIG_LIR_Gen_1	147	156	PF02991	0.582
LIG_LIR_Nem_3	119	125	PF02991	0.500
LIG_LIR_Nem_3	51	56	PF02991	0.491
LIG_SH2_STAT5	29	32	PF00017	0.547
LIG_SH2_STAT5	48	51	PF00017	0.507
LIG_SH2_STAT5	52	55	PF00017	0.502
LIG_SH3_1	111	117	PF00018	0.424
LIG_SH3_3	111	117	PF00018	0.460
LIG_Sin3_3	153	160	PF02671	0.370
LIG_SUMO_SIM_par_1	105	110	PF11976	0.388
LIG_TRAF2_1	200	203	PF00917	0.519
MOD_CDK_SPK_2	16	21	PF00069	0.566
MOD_CDK_SPxxK_3	16	23	PF00069	0.549
MOD_CK1_1	147	153	PF00069	0.598
MOD_CK1_1	186	192	PF00069	0.753
MOD_CK1_1	196	202	PF00069	0.586
MOD_CK1_1	89	95	PF00069	0.503
MOD_CK2_1	196	202	PF00069	0.804
MOD_GlcNHglycan	195	198	PF01048	0.647
MOD_GlcNHglycan	41	44	PF01048	0.463
MOD_GlcNHglycan	80	83	PF01048	0.505
MOD_GlcNHglycan	88	91	PF01048	0.505
MOD_GSK3_1	12	19	PF00069	0.522
MOD_GSK3_1	183	190	PF00069	0.679
MOD_GSK3_1	91	98	PF00069	0.445
MOD_NEK2_1	165	170	PF00069	0.698
MOD_NEK2_1	185	190	PF00069	0.450
MOD_NEK2_1	86	91	PF00069	0.489
MOD_Plk_1	118	124	PF00069	0.409
MOD_Plk_2-3	198	204	PF00069	0.519
MOD_Plk_4	144	150	PF00069	0.498
MOD_Plk_4	48	54	PF00069	0.442
MOD_ProDKin_1	16	22	PF00069	0.498
MOD_ProDKin_1	46	52	PF00069	0.507
MOD_SUMO_rev_2	159	166	PF00179	0.570
TRG_DiLeu_BaLyEn_6	62	67	PF01217	0.487
TRG_ER_diArg_1	20	23	PF00400	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZU7	Leptomonas seymouri	71%	100%
A0A0S4J9I7	Bodo saltans	42%	100%
A0A1X0NP61	Trypanosomatidae	57%	100%
A0A3R7NPP0	Trypanosoma rangeli	53%	100%
A0A3S5H674	Leishmania donovani	86%	100%
A4HTN2	Leishmania infantum	86%	100%
C9ZPD1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AMG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QI77	Leishmania major	76%	100%
V5BGW6	Trypanosoma cruzi	51%	97%