Amastin-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amastin-like protein

Species:

Leishmania braziliensis

UniProt:

A4H5D2_LEIBR

TriTrypDb:

LbrM.08.0680 , LBRM2903_290021100

Length:

187

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 9, no: 186
NetGPI	no	yes: 0, no: 195

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	173
GO:0110165	cellular anatomical entity	1	173

Expansion

Sequence features

A4H5D2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5D2

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016540	protein autoprocessing	6	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	57	61	PF00082	0.507
DEG_Nend_UBRbox_2	1	3	PF02207	0.548
DOC_CYCLIN_RxL_1	75	86	PF00134	0.198
DOC_MAPK_MEF2A_6	80	89	PF00069	0.240
DOC_USP7_MATH_1	149	153	PF00917	0.201
DOC_USP7_MATH_1	174	178	PF00917	0.540
DOC_USP7_MATH_1	83	87	PF00917	0.381
LIG_14-3-3_CanoR_1	52	59	PF00244	0.361
LIG_FHA_1	76	82	PF00498	0.276
LIG_GBD_Chelix_1	88	96	PF00786	0.342
LIG_HP1_1	128	132	PF01393	0.199
LIG_LIR_Gen_1	133	140	PF02991	0.313
LIG_LIR_Gen_1	152	162	PF02991	0.348
LIG_LIR_Nem_3	106	112	PF02991	0.639
LIG_LIR_Nem_3	133	138	PF02991	0.334
LIG_LIR_Nem_3	152	157	PF02991	0.363
LIG_LIR_Nem_3	45	49	PF02991	0.404
LIG_NRBOX	91	97	PF00104	0.235
LIG_Pex14_2	150	154	PF04695	0.465
LIG_Pex14_2	169	173	PF04695	0.530
LIG_PTB_Apo_2	134	141	PF02174	0.206
LIG_PTB_Apo_2	164	171	PF02174	0.392
LIG_REV1ctd_RIR_1	63	71	PF16727	0.202
LIG_SH2_CRK	10	14	PF00017	0.321
LIG_SH2_CRK	104	108	PF00017	0.409
LIG_SH2_CRK	135	139	PF00017	0.213
LIG_SH2_GRB2like	135	138	PF00017	0.229
LIG_SH2_STAT5	35	38	PF00017	0.420
LIG_SH2_STAT5	42	45	PF00017	0.314
LIG_SUMO_SIM_par_1	128	133	PF11976	0.341
LIG_SUMO_SIM_par_1	80	86	PF11976	0.381
LIG_TRFH_1	170	174	PF08558	0.274
LIG_TYR_ITIM	44	49	PF00017	0.199
LIG_TYR_ITIM	8	13	PF00017	0.394
MOD_CK1_1	122	128	PF00069	0.269
MOD_CK1_1	177	183	PF00069	0.593
MOD_CK1_1	37	43	PF00069	0.368
MOD_CK2_1	58	64	PF00069	0.238
MOD_GlcNHglycan	121	124	PF01048	0.211
MOD_GlcNHglycan	151	154	PF01048	0.357
MOD_GlcNHglycan	22	25	PF01048	0.213
MOD_GlcNHglycan	36	39	PF01048	0.548
MOD_GSK3_1	118	125	PF00069	0.379
MOD_N-GLC_1	136	141	PF02516	0.499
MOD_N-GLC_1	177	182	PF02516	0.362
MOD_NEK2_1	20	25	PF00069	0.459
MOD_PKA_2	51	57	PF00069	0.221
MOD_Plk_1	136	142	PF00069	0.299
MOD_Plk_4	22	28	PF00069	0.330
MOD_Plk_4	42	48	PF00069	0.325
MOD_Plk_4	83	89	PF00069	0.329
MOD_Plk_4	91	97	PF00069	0.350
MOD_SUMO_rev_2	51	59	PF00179	0.204
TRG_ENDOCYTIC_2	10	13	PF00928	0.403
TRG_ENDOCYTIC_2	104	107	PF00928	0.492
TRG_ENDOCYTIC_2	135	138	PF00928	0.212
TRG_ENDOCYTIC_2	46	49	PF00928	0.370
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C4	Leptomonas seymouri	24%	100%
A0A0N0P547	Leptomonas seymouri	35%	100%
A0A0N1HWY5	Leptomonas seymouri	27%	96%
A0A0N1PAD5	Leptomonas seymouri	24%	75%
A0A0N1PDH0	Leptomonas seymouri	31%	93%
A0A1X0P988	Trypanosomatidae	32%	100%
A0A381MTA7	Leishmania infantum	36%	97%
A0A381MTB8	Leishmania infantum	35%	97%
A0A381MTC7	Leishmania infantum	34%	91%
A0A381MTN2	Leishmania infantum	39%	96%
A0A381MVY0	Leishmania infantum	40%	97%
A0A3Q8ID16	Leishmania donovani	24%	100%
A0A3Q8IE85	Leishmania donovani	40%	100%
A0A3Q8IEC2	Leishmania donovani	38%	97%
A0A3Q8IEI1	Leishmania donovani	39%	97%
A0A3Q8IF65	Leishmania donovani	39%	95%
A0A3Q8IFB9	Leishmania donovani	34%	92%
A0A3Q8IFH7	Leishmania donovani	34%	91%
A0A3Q8IH65	Leishmania donovani	34%	97%
A0A3Q8IHN2	Leishmania donovani	39%	97%
A0A3Q8IHW7	Leishmania donovani	42%	100%
A0A3Q8IHZ6	Leishmania donovani	43%	89%
A0A3Q8IIH1	Leishmania donovani	36%	96%
A0A3Q8IL03	Leishmania donovani	36%	97%
A0A3Q8IUK8	Leishmania donovani	33%	98%
A0A3Q8IUR5	Leishmania donovani	39%	96%
A0A3S5H662	Leishmania donovani	41%	93%
A0A3S5H663	Leishmania donovani	41%	93%
A0A3S5H665	Leishmania donovani	42%	93%
A0A3S5H666	Leishmania donovani	43%	97%
A0A3S5H667	Leishmania donovani	42%	92%
A0A3S5H7D2	Leishmania donovani	28%	100%
A0A3S5H7L2	Leishmania donovani	41%	91%
A0A3S5H7V9	Leishmania donovani	35%	94%
A0A3S5H7W2	Leishmania donovani	27%	97%
A0A3S5H7W6	Leishmania donovani	35%	94%
A0A3S7WQA0	Leishmania donovani	42%	92%
A0A3S7WQA8	Leishmania donovani	43%	100%
A0A3S7WQC1	Leishmania donovani	43%	97%
A0A3S7X2E6	Leishmania donovani	39%	97%
A0A3S7X357	Leishmania donovani	26%	84%
A0A3S7X453	Leishmania donovani	38%	95%
A0A3S7X472	Leishmania donovani	38%	94%
A0A3S7X7E5	Leishmania donovani	42%	75%
A0A3S7X7M4	Leishmania donovani	42%	89%
A0A3S7X7U1	Leishmania donovani	35%	89%
A0A3S7X7U4	Leishmania donovani	38%	72%
A0A3S7X7W2	Leishmania donovani	35%	89%
A0A3S7X7Y0	Leishmania donovani	35%	96%
A4H595	Leishmania braziliensis	38%	100%
A4H596	Leishmania braziliensis	37%	100%
A4H597	Leishmania braziliensis	38%	100%
A4H5D1	Leishmania braziliensis	37%	100%
A4H5G0	Leishmania braziliensis	41%	100%
A4H5G4	Leishmania braziliensis	37%	89%
A4H5G6	Leishmania braziliensis	33%	85%
A4H5G7	Leishmania braziliensis	36%	86%
A4H5G9	Leishmania braziliensis	44%	100%
A4H5H0	Leishmania braziliensis	44%	99%
A4H5H1	Leishmania braziliensis	45%	100%
A4H5H2	Leishmania braziliensis	46%	100%
A4H5H3	Leishmania braziliensis	36%	90%
A4H6C8	Leishmania braziliensis	40%	94%
A4H7D7	Leishmania braziliensis	40%	96%
A4H9E8	Leishmania braziliensis	38%	89%
A4H9E9	Leishmania braziliensis	36%	96%
A4HAJ4	Leishmania braziliensis	41%	89%
A4HAJ5	Leishmania braziliensis	32%	84%
A4HAJ6	Leishmania braziliensis	38%	81%
A4HAL1	Leishmania braziliensis	36%	100%
A4HAL2	Leishmania braziliensis	25%	97%
A4HAM2	Leishmania braziliensis	38%	97%
A4HAM4	Leishmania braziliensis	37%	97%
A4HAR1	Leishmania braziliensis	38%	97%
A4HAZ8	Leishmania braziliensis	39%	99%
A4HB00	Leishmania braziliensis	36%	97%
A4HB02	Leishmania braziliensis	39%	97%
A4HB47	Leishmania braziliensis	34%	92%
A4HBJ0	Leishmania braziliensis	41%	97%
A4HBJ1	Leishmania braziliensis	38%	97%
A4HBJ2	Leishmania braziliensis	41%	90%
A4HDI4	Leishmania braziliensis	25%	100%
A4HDL3	Leishmania braziliensis	25%	100%
A4HDL4	Leishmania braziliensis	25%	100%
A4HI43	Leishmania braziliensis	25%	88%
A4HTM3	Leishmania infantum	43%	97%
A4HTM4	Leishmania infantum	41%	100%
A4HTM5	Leishmania infantum	42%	97%
A4I0W4	Leishmania infantum	28%	100%
A4I0W5	Leishmania infantum	24%	100%
A4I4J2	Leishmania infantum	38%	91%
A4I4J3	Leishmania infantum	36%	72%
A4I5B9	Leishmania infantum	26%	84%
A4I6E5	Leishmania infantum	37%	94%
A4I9Q4	Leishmania infantum	43%	100%
A4I9R4	Leishmania infantum	27%	97%
A4I9R5	Leishmania infantum	34%	92%
A4I9R7	Leishmania infantum	42%	95%
A4I9W8	Leishmania infantum	39%	72%
A4I9X0	Leishmania infantum	34%	89%
A4IA59	Leishmania infantum	39%	72%
A4IAL7	Leishmania infantum	40%	100%
A4IAM1	Leishmania infantum	38%	97%
A4IAM2	Leishmania infantum	40%	97%
E8NHC3	Leishmania infantum	42%	93%
E8NHD3	Leishmania infantum	40%	91%
E8NHD6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E8NHD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E8NHE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	89%
E8NHF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	90%
E8NHF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	98%
E8NHF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	97%
E8NHG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	89%
E8NHH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	89%
E8NHH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E8NHI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	96%
E8NHI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	97%
E8NHK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	89%
E8NHK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	96%
E8NHL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	97%
E8NHL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	97%
E8NHM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	99%
E8NHM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	96%
E8NHM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	89%
E8NHM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	89%
E8NHM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	98%
E8NHM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E8NHP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	91%
E8NHQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	89%
E8NHQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	96%
E8NHR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	96%
E8NHR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	96%
E8NHS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	89%
E9AG81	Leishmania infantum	41%	92%
E9AG82	Leishmania infantum	41%	92%
E9AG83	Leishmania infantum	42%	94%
E9AG85	Leishmania infantum	41%	92%
E9AHI9	Leishmania infantum	39%	97%
E9AHT2	Leishmania infantum	44%	89%
E9AME9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9AMF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9AMF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	90%
E9AMF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	96%
E9AMF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	96%
E9AMF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	73%
E9AMF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	90%
E9AMF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9AMF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	97%
E9AMF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	97%
E9ASP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	89%
E9AWW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B0L6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	84%
E9B1J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	96%
E9B1J4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	90%
E9B1J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	89%
E9B4L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	94%
E9B4R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	94%
E9B4R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	95%
E9B4R9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	92%
E9B4S0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	97%
E9B4Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	91%
Q4Q1U9	Leishmania major	38%	100%
Q4Q305	Leishmania major	35%	100%
Q4Q309	Leishmania major	39%	100%
Q4Q313	Leishmania major	35%	100%
Q4Q317	Leishmania major	34%	100%
Q4Q325	Leishmania major	38%	100%
Q4Q327	Leishmania major	34%	100%
Q4Q329	Leishmania major	36%	100%
Q4Q333	Leishmania major	36%	100%
Q4Q335	Leishmania major	36%	100%
Q4Q337	Leishmania major	39%	100%
Q4Q339	Leishmania major	35%	100%
Q4Q341	Leishmania major	38%	99%
Q4Q397	Leishmania major	41%	100%
Q4Q3A7	Leishmania major	29%	100%
Q4Q3A8	Leishmania major	34%	100%
Q4Q3A9	Leishmania major	40%	100%
Q4Q3F7	Leishmania major	44%	100%
Q4Q6L8	Leishmania major	38%	100%
Q4Q7L6	Leishmania major	27%	100%
Q4QAK5	Leishmania major	26%	100%
Q4QAK6	Leishmania major	28%	99%
Q4QI84	Leishmania major	39%	100%
Q4QI85	Leishmania major	42%	100%
Q4QI86	Leishmania major	40%	100%
Q4QI87	Leishmania major	44%	100%
Q4QI88	Leishmania major	39%	100%
Q4QI92	Leishmania major	41%	100%
Q4QI93	Leishmania major	41%	100%
Q4QI95	Leishmania major	39%	100%
Q4QI97	Leishmania major	41%	100%
Q4QIA0	Leishmania major	40%	100%
Q4QIA1	Leishmania major	40%	100%