Putative tuzin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Putative tuzin

Gene product:

tuzin, putative

Species:

Leishmania braziliensis

UniProt:

A4H5D0_LEIBR

TriTrypDb:

LbrM.08.0660 , LBRM2903_080013300

Length:

596

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 36
NetGPI	no	yes: 0, no: 36

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	17
GO:0110165	cellular anatomical entity	1	17

Expansion

Sequence features

A4H5D0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5D0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	298	302	PF00656	0.381
CLV_C14_Caspase3-7	556	560	PF00656	0.462
CLV_C14_Caspase3-7	65	69	PF00656	0.555
CLV_NRD_NRD_1	15	17	PF00675	0.382
CLV_NRD_NRD_1	241	243	PF00675	0.453
CLV_NRD_NRD_1	311	313	PF00675	0.626
CLV_NRD_NRD_1	435	437	PF00675	0.521
CLV_NRD_NRD_1	44	46	PF00675	0.369
CLV_NRD_NRD_1	509	511	PF00675	0.616
CLV_PCSK_FUR_1	239	243	PF00082	0.372
CLV_PCSK_KEX2_1	15	17	PF00082	0.381
CLV_PCSK_KEX2_1	241	243	PF00082	0.433
CLV_PCSK_KEX2_1	311	313	PF00082	0.626
CLV_PCSK_KEX2_1	435	437	PF00082	0.521
CLV_PCSK_KEX2_1	44	46	PF00082	0.368
CLV_PCSK_KEX2_1	509	511	PF00082	0.618
CLV_PCSK_KEX2_1	543	545	PF00082	0.589
CLV_PCSK_PC1ET2_1	543	545	PF00082	0.613
CLV_PCSK_SKI1_1	107	111	PF00082	0.300
CLV_PCSK_SKI1_1	16	20	PF00082	0.338
CLV_PCSK_SKI1_1	312	316	PF00082	0.614
CLV_PCSK_SKI1_1	320	324	PF00082	0.598
DEG_APCC_DBOX_1	495	503	PF00400	0.245
DEG_Nend_Nbox_1	1	3	PF02207	0.573
DOC_ANK_TNKS_1	547	554	PF00023	0.297
DOC_MAPK_DCC_7	52	62	PF00069	0.477
DOC_MAPK_DCC_7	67	77	PF00069	0.642
DOC_MAPK_gen_1	150	160	PF00069	0.452
DOC_MAPK_gen_1	185	194	PF00069	0.557
DOC_MAPK_gen_1	435	442	PF00069	0.283
DOC_MAPK_gen_1	44	50	PF00069	0.542
DOC_MAPK_MEF2A_6	353	361	PF00069	0.305
DOC_MAPK_MEF2A_6	407	415	PF00069	0.336
DOC_MAPK_MEF2A_6	435	444	PF00069	0.292
DOC_PP1_RVXF_1	456	462	PF00149	0.336
DOC_PP2B_LxvP_1	135	138	PF13499	0.531
DOC_PP2B_LxvP_1	378	381	PF13499	0.369
DOC_PP2B_PxIxI_1	330	336	PF00149	0.305
DOC_PP4_FxxP_1	19	22	PF00568	0.648
DOC_SPAK_OSR1_1	282	286	PF12202	0.382
DOC_USP7_MATH_1	294	298	PF00917	0.473
DOC_USP7_MATH_1	370	374	PF00917	0.229
DOC_USP7_MATH_1	73	77	PF00917	0.679
DOC_USP7_MATH_2	513	519	PF00917	0.268
DOC_USP7_UBL2_3	539	543	PF12436	0.382
DOC_WW_Pin1_4	39	44	PF00397	0.551
DOC_WW_Pin1_4	405	410	PF00397	0.293
DOC_WW_Pin1_4	509	514	PF00397	0.370
DOC_WW_Pin1_4	55	60	PF00397	0.532
DOC_WW_Pin1_4	66	71	PF00397	0.579
DOC_WW_Pin1_4	88	93	PF00397	0.589
LIG_14-3-3_CanoR_1	141	151	PF00244	0.580
LIG_14-3-3_CanoR_1	15	22	PF00244	0.661
LIG_14-3-3_CanoR_1	209	215	PF00244	0.526
LIG_14-3-3_CanoR_1	226	232	PF00244	0.541
LIG_14-3-3_CanoR_1	270	279	PF00244	0.448
LIG_14-3-3_CanoR_1	399	404	PF00244	0.398
LIG_14-3-3_CanoR_1	423	431	PF00244	0.220
LIG_14-3-3_CanoR_1	586	596	PF00244	0.363
LIG_Actin_WH2_2	357	374	PF00022	0.355
LIG_BIR_III_4	103	107	PF00653	0.559
LIG_BRCT_BRCA1_1	254	258	PF00533	0.274
LIG_deltaCOP1_diTrp_1	316	323	PF00928	0.372
LIG_deltaCOP1_diTrp_1	579	583	PF00928	0.333
LIG_eIF4E_1	516	522	PF01652	0.320
LIG_FHA_1	121	127	PF00498	0.562
LIG_FHA_1	143	149	PF00498	0.573
LIG_FHA_1	198	204	PF00498	0.466
LIG_FHA_1	406	412	PF00498	0.287
LIG_FHA_1	450	456	PF00498	0.425
LIG_FHA_2	296	302	PF00498	0.543
LIG_FHA_2	308	314	PF00498	0.372
LIG_LIR_Apic_2	17	22	PF02991	0.654
LIG_LIR_Apic_2	316	321	PF02991	0.252
LIG_LIR_Apic_2	460	465	PF02991	0.358
LIG_LIR_Gen_1	156	164	PF02991	0.461
LIG_LIR_Nem_3	123	127	PF02991	0.527
LIG_LIR_Nem_3	156	160	PF02991	0.454
LIG_LIR_Nem_3	460	464	PF02991	0.334
LIG_LIR_Nem_3	79	85	PF02991	0.555
LIG_NRBOX	498	504	PF00104	0.334
LIG_Pex14_2	258	262	PF04695	0.312
LIG_Pex14_2	62	66	PF04695	0.610
LIG_SH2_CRK	248	252	PF00017	0.451
LIG_SH2_CRK	462	466	PF00017	0.371
LIG_SH2_CRK	574	578	PF00017	0.370
LIG_SH2_NCK_1	32	36	PF00017	0.532
LIG_SH2_NCK_1	462	466	PF00017	0.323
LIG_SH2_NCK_1	574	578	PF00017	0.365
LIG_SH2_SRC	32	35	PF00017	0.565
LIG_SH2_STAP1	232	236	PF00017	0.613
LIG_SH2_STAP1	425	429	PF00017	0.400
LIG_SH2_STAT5	157	160	PF00017	0.537
LIG_SH2_STAT5	462	465	PF00017	0.368
LIG_SH2_STAT5	475	478	PF00017	0.362
LIG_SH2_STAT5	516	519	PF00017	0.369
LIG_SH2_STAT5	82	85	PF00017	0.534
LIG_SH3_1	67	73	PF00018	0.533
LIG_SH3_2	40	45	PF14604	0.546
LIG_SH3_3	149	155	PF00018	0.645
LIG_SH3_3	31	37	PF00018	0.669
LIG_SH3_3	439	445	PF00018	0.312
LIG_SH3_3	67	73	PF00018	0.540
LIG_SUMO_SIM_anti_2	408	414	PF11976	0.287
LIG_SUMO_SIM_par_1	332	337	PF11976	0.300
LIG_SUMO_SIM_par_1	358	363	PF11976	0.230
LIG_TYR_ITIM	572	577	PF00017	0.410
MOD_CDC14_SPxK_1	42	45	PF00782	0.408
MOD_CDK_SPK_2	39	44	PF00069	0.421
MOD_CDK_SPxK_1	39	45	PF00069	0.413
MOD_CK1_1	207	213	PF00069	0.304
MOD_CK1_1	230	236	PF00069	0.331
MOD_CK1_1	307	313	PF00069	0.549
MOD_CK1_1	561	567	PF00069	0.475
MOD_CK1_1	76	82	PF00069	0.575
MOD_CK2_1	210	216	PF00069	0.420
MOD_CK2_1	307	313	PF00069	0.375
MOD_CK2_1	509	515	PF00069	0.478
MOD_GlcNHglycan	16	19	PF01048	0.569
MOD_GlcNHglycan	165	168	PF01048	0.435
MOD_GlcNHglycan	169	172	PF01048	0.431
MOD_GlcNHglycan	252	255	PF01048	0.283
MOD_GSK3_1	163	170	PF00069	0.354
MOD_GSK3_1	271	278	PF00069	0.523
MOD_GSK3_1	447	454	PF00069	0.339
MOD_GSK3_1	488	495	PF00069	0.267
MOD_N-GLC_1	120	125	PF02516	0.439
MOD_N-GLC_1	465	470	PF02516	0.424
MOD_NEK2_1	120	125	PF00069	0.569
MOD_NEK2_1	252	257	PF00069	0.340
MOD_NEK2_1	449	454	PF00069	0.443
MOD_NEK2_1	467	472	PF00069	0.425
MOD_NEK2_1	488	493	PF00069	0.396
MOD_NEK2_1	558	563	PF00069	0.406
MOD_NEK2_2	260	265	PF00069	0.290
MOD_PIKK_1	204	210	PF00454	0.354
MOD_PIKK_1	467	473	PF00454	0.440
MOD_PKA_2	14	20	PF00069	0.436
MOD_PKA_2	210	216	PF00069	0.376
MOD_PKA_2	307	313	PF00069	0.444
MOD_Plk_4	210	216	PF00069	0.375
MOD_Plk_4	399	405	PF00069	0.416
MOD_Plk_4	451	457	PF00069	0.321
MOD_ProDKin_1	39	45	PF00069	0.413
MOD_ProDKin_1	405	411	PF00069	0.332
MOD_ProDKin_1	509	515	PF00069	0.448
MOD_ProDKin_1	55	61	PF00069	0.393
MOD_ProDKin_1	66	72	PF00069	0.462
MOD_ProDKin_1	88	94	PF00069	0.475
TRG_DiLeu_BaEn_1	190	195	PF01217	0.414
TRG_DiLeu_BaLyEn_6	517	522	PF01217	0.294
TRG_ENDOCYTIC_2	157	160	PF00928	0.387
TRG_ENDOCYTIC_2	248	251	PF00928	0.301
TRG_ENDOCYTIC_2	574	577	PF00928	0.440
TRG_ER_diArg_1	14	16	PF00400	0.524
TRG_ER_diArg_1	209	212	PF00400	0.580
TRG_ER_diArg_1	241	243	PF00400	0.568
TRG_ER_diArg_1	413	416	PF00400	0.420
TRG_ER_diArg_1	43	45	PF00400	0.592
TRG_ER_diArg_1	435	437	PF00400	0.356
TRG_ER_diArg_1	509	511	PF00400	0.576
TRG_ER_diArg_1	583	586	PF00400	0.257
TRG_NES_CRM1_1	355	369	PF08389	0.442
TRG_Pf-PMV_PEXEL_1	229	234	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	286	291	PF00026	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAN2	Leptomonas seymouri	40%	91%
A0A0N1PB02	Leptomonas seymouri	49%	91%
A0A0S4J6C6	Bodo saltans	42%	92%
A0A1X0P9A6	Trypanosomatidae	44%	87%
A0A3Q8IHH1	Leishmania donovani	40%	82%
A0A3R7K2Y9	Trypanosoma rangeli	49%	87%
A0A3S5H668	Leishmania donovani	44%	100%
A0A3S5H669	Leishmania donovani	75%	94%
A0A3S7X835	Leishmania donovani	44%	100%
A4H5C9	Leishmania braziliensis	44%	100%
A4HAZ7	Leishmania braziliensis	45%	100%
A4HAZ9	Leishmania braziliensis	47%	96%
A4HB01	Leishmania braziliensis	47%	100%
A4HTM0	Leishmania infantum	46%	100%
A4HTM1	Leishmania infantum	75%	94%
A4IA57	Leishmania infantum	45%	100%
C6K3V8	Leptomonas seymouri	42%	98%
C6K3V9	Leptomonas seymouri	66%	91%
C9ZMY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	88%
E8NHE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	94%
E8NHF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E8NHF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	98%
E8NHR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E8NHS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AME6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AME7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	94%
E9B571	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
Q4Q1U8	Leishmania major	40%	100%
Q4Q2R4	Leishmania major	46%	100%
Q4Q310	Leishmania major	40%	100%
Q4Q312	Leishmania major	40%	100%
Q4Q340	Leishmania major	40%	100%
Q4Q342	Leishmania major	40%	100%
Q4QI90	Leishmania major	73%	100%
Q4QI91	Leishmania major	44%	97%