Putative tuzin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Putative tuzin

Gene product:

tuzin, putative

Species:

Leishmania braziliensis

UniProt:

A4H5C9_LEIBR

TriTrypDb:

LbrM.08.0650 , LBRM2903_080013100

Length:

509

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 33
NetGPI	no	yes: 0, no: 33

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	15
GO:0110165	cellular anatomical entity	1	15

Expansion

Sequence features

A4H5C9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5C9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	193	195	PF00675	0.629
CLV_NRD_NRD_1	268	270	PF00675	0.551
CLV_NRD_NRD_1	350	352	PF00675	0.527
CLV_NRD_NRD_1	424	426	PF00675	0.595
CLV_NRD_NRD_1	441	443	PF00675	0.610
CLV_NRD_NRD_1	91	93	PF00675	0.341
CLV_PCSK_FUR_1	422	426	PF00082	0.475
CLV_PCSK_KEX2_1	127	129	PF00082	0.274
CLV_PCSK_KEX2_1	193	195	PF00082	0.657
CLV_PCSK_KEX2_1	202	204	PF00082	0.631
CLV_PCSK_KEX2_1	350	352	PF00082	0.527
CLV_PCSK_KEX2_1	424	426	PF00082	0.599
CLV_PCSK_KEX2_1	441	443	PF00082	0.631
CLV_PCSK_KEX2_1	458	460	PF00082	0.591
CLV_PCSK_KEX2_1	91	93	PF00082	0.332
CLV_PCSK_PC1ET2_1	127	129	PF00082	0.265
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.601
CLV_PCSK_PC1ET2_1	458	460	PF00082	0.591
CLV_PCSK_PC7_1	454	460	PF00082	0.437
CLV_PCSK_SKI1_1	22	26	PF00082	0.383
CLV_PCSK_SKI1_1	236	240	PF00082	0.614
CLV_PCSK_SKI1_1	273	277	PF00082	0.517
CLV_PCSK_SKI1_1	292	296	PF00082	0.589
CLV_PCSK_SKI1_1	315	319	PF00082	0.635
CLV_PCSK_SKI1_1	385	389	PF00082	0.641
CLV_PCSK_SKI1_1	493	497	PF00082	0.536
DEG_APCC_DBOX_1	74	82	PF00400	0.469
DEG_APCC_DBOX_1	94	102	PF00400	0.557
DEG_Nend_UBRbox_2	1	3	PF02207	0.605
DOC_MAPK_DCC_7	318	328	PF00069	0.345
DOC_MAPK_gen_1	105	114	PF00069	0.558
DOC_MAPK_gen_1	127	135	PF00069	0.562
DOC_MAPK_gen_1	269	280	PF00069	0.338
DOC_MAPK_MEF2A_6	127	134	PF00069	0.442
DOC_MAPK_MEF2A_6	269	278	PF00069	0.306
DOC_MAPK_MEF2A_6	318	327	PF00069	0.354
DOC_PP1_RVXF_1	371	377	PF00149	0.323
DOC_PP2B_PxIxI_1	246	252	PF00149	0.322
DOC_USP7_MATH_1	10	14	PF00917	0.610
DOC_USP7_MATH_1	230	234	PF00917	0.312
DOC_USP7_MATH_1	360	364	PF00917	0.286
DOC_USP7_MATH_1	446	450	PF00917	0.433
DOC_USP7_MATH_1	55	59	PF00917	0.506
DOC_WW_Pin1_4	215	220	PF00397	0.520
LIG_14-3-3_CanoR_1	194	200	PF00244	0.427
LIG_14-3-3_CanoR_1	203	209	PF00244	0.418
LIG_14-3-3_CanoR_1	424	429	PF00244	0.360
LIG_14-3-3_CanoR_1	493	501	PF00244	0.368
LIG_14-3-3_CanoR_1	68	74	PF00244	0.573
LIG_14-3-3_CanoR_1	97	102	PF00244	0.475
LIG_APCC_ABBAyCdc20_2	273	279	PF00400	0.364
LIG_Clathr_ClatBox_1	132	136	PF01394	0.436
LIG_Clathr_ClatBox_1	62	66	PF01394	0.492
LIG_deltaCOP1_diTrp_1	492	496	PF00928	0.325
LIG_eIF4E_1	340	346	PF01652	0.225
LIG_eIF4E_1	431	437	PF01652	0.292
LIG_FHA_1	364	370	PF00498	0.409
LIG_FHA_1	396	402	PF00498	0.283
LIG_FHA_1	41	47	PF00498	0.531
LIG_FHA_1	495	501	PF00498	0.341
LIG_FHA_2	205	211	PF00498	0.423
LIG_FHA_2	327	333	PF00498	0.373
LIG_GBD_Chelix_1	428	436	PF00786	0.426
LIG_HCF-1_HBM_1	212	215	PF13415	0.407
LIG_LIR_Apic_2	375	380	PF02991	0.340
LIG_LIR_Gen_1	173	184	PF02991	0.231
LIG_LIR_Gen_1	74	84	PF02991	0.480
LIG_LIR_Nem_3	158	164	PF02991	0.558
LIG_LIR_Nem_3	173	179	PF02991	0.286
LIG_LIR_Nem_3	375	379	PF02991	0.318
LIG_LYPXL_SIV_4	356	364	PF13949	0.214
LIG_MYND_3	296	300	PF01753	0.287
LIG_Pex14_2	185	189	PF04695	0.373
LIG_PTB_Apo_2	47	54	PF02174	0.563
LIG_Rb_LxCxE_1	383	405	PF01857	0.246
LIG_SH2_CRK	487	491	PF00017	0.349
LIG_SH2_SRC	487	490	PF00017	0.363
LIG_SH2_STAP1	357	361	PF00017	0.332
LIG_SH2_STAT3	163	166	PF00017	0.596
LIG_SH2_STAT3	431	434	PF00017	0.277
LIG_SH2_STAT3	466	469	PF00017	0.371
LIG_SH2_STAT5	113	116	PF00017	0.539
LIG_SH2_STAT5	125	128	PF00017	0.548
LIG_SH2_STAT5	163	166	PF00017	0.522
LIG_SH2_STAT5	215	218	PF00017	0.422
LIG_SH2_STAT5	377	380	PF00017	0.349
LIG_SH2_STAT5	431	434	PF00017	0.338
LIG_SH2_STAT5	466	469	PF00017	0.393
LIG_SH2_STAT5	77	80	PF00017	0.534
LIG_SH3_3	216	222	PF00018	0.505
LIG_SH3_3	366	372	PF00018	0.325
LIG_SUMO_SIM_anti_2	60	66	PF11976	0.618
LIG_SUMO_SIM_par_1	131	136	PF11976	0.434
LIG_SUMO_SIM_par_1	322	329	PF11976	0.345
LIG_SUMO_SIM_par_1	60	66	PF11976	0.578
LIG_TRAF2_1	229	232	PF00917	0.389
LIG_TRFH_1	113	117	PF08558	0.459
LIG_TRFH_1	376	380	PF08558	0.236
LIG_TYR_ITIM	485	490	PF00017	0.321
MOD_CK1_1	206	212	PF00069	0.380
MOD_CK1_1	363	369	PF00069	0.408
MOD_CK1_1	40	46	PF00069	0.571
MOD_CK1_1	449	455	PF00069	0.258
MOD_CK2_1	215	221	PF00069	0.564
MOD_CK2_1	326	332	PF00069	0.338
MOD_GlcNHglycan	168	171	PF01048	0.295
MOD_GlcNHglycan	172	175	PF01048	0.287
MOD_GlcNHglycan	265	268	PF01048	0.581
MOD_GlcNHglycan	342	345	PF01048	0.425
MOD_GlcNHglycan	6	9	PF01048	0.377
MOD_GSK3_1	166	173	PF00069	0.447
MOD_GSK3_1	204	211	PF00069	0.422
MOD_GSK3_1	259	266	PF00069	0.352
MOD_N-GLC_1	340	345	PF02516	0.538
MOD_N-GLC_1	380	385	PF02516	0.535
MOD_N-GLC_1	40	45	PF02516	0.336
MOD_N-GLC_1	409	414	PF02516	0.540
MOD_N-GLC_2	50	52	PF02516	0.295
MOD_NEK2_1	263	268	PF00069	0.325
MOD_NEK2_1	326	331	PF00069	0.329
MOD_NEK2_2	180	185	PF00069	0.284
MOD_PIKK_1	363	369	PF00454	0.241
MOD_PIKK_1	55	61	PF00454	0.611
MOD_PK_1	424	430	PF00069	0.370
MOD_PK_1	97	103	PF00069	0.427
MOD_PKA_1	424	430	PF00069	0.411
MOD_PKA_2	166	172	PF00069	0.484
MOD_PKA_2	424	430	PF00069	0.374
MOD_PKA_2	69	75	PF00069	0.580
MOD_PKA_2	96	102	PF00069	0.433
MOD_PKB_1	422	430	PF00069	0.259
MOD_PKB_1	95	103	PF00069	0.478
MOD_Plk_1	230	236	PF00069	0.370
MOD_Plk_1	283	289	PF00069	0.396
MOD_Plk_1	334	340	PF00069	0.315
MOD_Plk_1	395	401	PF00069	0.384
MOD_Plk_4	121	127	PF00069	0.502
MOD_Plk_4	180	186	PF00069	0.237
MOD_Plk_4	259	265	PF00069	0.289
MOD_Plk_4	396	402	PF00069	0.314
MOD_Plk_4	424	430	PF00069	0.340
MOD_Plk_4	471	477	PF00069	0.456
MOD_Plk_4	97	103	PF00069	0.474
MOD_ProDKin_1	215	221	PF00069	0.522
MOD_SUMO_rev_2	427	437	PF00179	0.256
MOD_SUMO_rev_2	474	484	PF00179	0.256
TRG_DiLeu_BaEn_1	322	327	PF01217	0.315
TRG_DiLeu_BaEn_2	220	226	PF01217	0.394
TRG_DiLeu_BaLyEn_6	128	133	PF01217	0.457
TRG_ENDOCYTIC_2	168	171	PF00928	0.296
TRG_ENDOCYTIC_2	487	490	PF00928	0.343
TRG_ENDOCYTIC_2	77	80	PF00928	0.525
TRG_ER_diArg_1	192	194	PF00400	0.458
TRG_ER_diArg_1	350	352	PF00400	0.303
TRG_ER_diArg_1	421	424	PF00400	0.433
TRG_ER_diArg_1	440	442	PF00400	0.448
TRG_ER_diArg_1	68	71	PF00400	0.612
TRG_NES_CRM1_1	285	300	PF08389	0.351
TRG_Pf-PMV_PEXEL_1	131	136	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	149	154	PF00026	0.376
TRG_Pf-PMV_PEXEL_1	458	462	PF00026	0.568

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAN2	Leptomonas seymouri	42%	77%
A0A0N1PB02	Leptomonas seymouri	49%	78%
A0A0S4J6C6	Bodo saltans	43%	79%
A0A1X0P9A6	Trypanosomatidae	48%	75%
A0A3Q8IHH1	Leishmania donovani	41%	70%
A0A3R7K2Y9	Trypanosoma rangeli	49%	74%
A0A3S5H668	Leishmania donovani	76%	100%
A0A3S5H669	Leishmania donovani	46%	80%
A0A3S7X835	Leishmania donovani	48%	91%
A4H5D0	Leishmania braziliensis	44%	85%
A4HAZ7	Leishmania braziliensis	46%	100%
A4HAZ9	Leishmania braziliensis	47%	82%
A4HB01	Leishmania braziliensis	48%	87%
A4HTM0	Leishmania infantum	76%	100%
A4HTM1	Leishmania infantum	46%	80%
A4IA57	Leishmania infantum	48%	91%
C6K3V8	Leptomonas seymouri	73%	84%
C6K3V9	Leptomonas seymouri	42%	78%
C9ZMY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	75%
E8NHE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	81%
E8NHF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	84%
E9AME6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
E9AME7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	80%
E9B571	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	92%
Q4Q1U8	Leishmania major	38%	100%
Q4Q2R4	Leishmania major	49%	100%
Q4Q310	Leishmania major	38%	100%
Q4Q312	Leishmania major	38%	100%
Q4Q340	Leishmania major	38%	100%
Q4Q342	Leishmania major	38%	100%
Q4QI90	Leishmania major	44%	100%
Q4QI91	Leishmania major	75%	100%