Movement protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Movement protein

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H5C7_LEIBR

TriTrypDb:

LbrM.08.0630 , LBRM2903_080010800

Length:

222

Annotations

LeishMANIAdb annotations

This protein family is endemic to Kinetoplastids, might have emerged de novo and also expanded. . The family also contains Leishmaniid members lacking the signal peptide and only having an MTTPA- start sequence

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 9
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4H5C7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5C7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	193	197	PF00656	0.688
CLV_MEL_PAP_1	29	35	PF00089	0.234
CLV_NRD_NRD_1	127	129	PF00675	0.391
CLV_PCSK_SKI1_1	128	132	PF00082	0.396
CLV_PCSK_SKI1_1	152	156	PF00082	0.406
CLV_PCSK_SKI1_1	22	26	PF00082	0.254
CLV_PCSK_SKI1_1	43	47	PF00082	0.574
CLV_PCSK_SKI1_1	89	93	PF00082	0.609
DEG_MDM2_SWIB_1	92	100	PF02201	0.378
DOC_MAPK_MEF2A_6	94	102	PF00069	0.251
DOC_USP7_MATH_1	172	176	PF00917	0.718
DOC_USP7_MATH_1	9	13	PF00917	0.626
DOC_WW_Pin1_4	195	200	PF00397	0.658
LIG_14-3-3_CanoR_1	164	173	PF00244	0.695
LIG_14-3-3_CanoR_1	174	182	PF00244	0.679
LIG_14-3-3_CanoR_1	32	41	PF00244	0.420
LIG_14-3-3_CanoR_1	43	48	PF00244	0.410
LIG_EVH1_2	87	91	PF00568	0.388
LIG_FHA_1	44	50	PF00498	0.418
LIG_LIR_Apic_2	82	87	PF02991	0.344
LIG_LIR_Nem_3	140	146	PF02991	0.638
LIG_LIR_Nem_3	186	192	PF02991	0.648
LIG_LIR_Nem_3	3	7	PF02991	0.580
LIG_NRBOX	177	183	PF00104	0.595
LIG_Pex14_2	92	96	PF04695	0.402
LIG_REV1ctd_RIR_1	89	98	PF16727	0.343
LIG_SH2_CRK	84	88	PF00017	0.393
LIG_SH2_NCK_1	84	88	PF00017	0.340
LIG_SH2_PTP2	111	114	PF00017	0.398
LIG_SH2_PTP2	97	100	PF00017	0.293
LIG_SH2_STAT3	124	127	PF00017	0.637
LIG_SH2_STAT5	111	114	PF00017	0.359
LIG_SH2_STAT5	149	152	PF00017	0.630
LIG_SH2_STAT5	97	100	PF00017	0.416
LIG_SH3_3	210	216	PF00018	0.655
LIG_SH3_3	67	73	PF00018	0.447
LIG_SUMO_SIM_par_1	44	52	PF11976	0.373
LIG_TRFH_1	84	88	PF08558	0.340
MOD_CK1_1	12	18	PF00069	0.589
MOD_CK1_1	165	171	PF00069	0.687
MOD_CK1_1	191	197	PF00069	0.745
MOD_CK1_1	198	204	PF00069	0.711
MOD_CK1_1	48	54	PF00069	0.433
MOD_CK1_1	62	68	PF00069	0.537
MOD_CK1_1	90	96	PF00069	0.328
MOD_GlcNHglycan	12	15	PF01048	0.387
MOD_GlcNHglycan	168	171	PF01048	0.445
MOD_GlcNHglycan	34	37	PF01048	0.325
MOD_GlcNHglycan	51	54	PF01048	0.637
MOD_GlcNHglycan	65	68	PF01048	0.663
MOD_GSK3_1	162	169	PF00069	0.704
MOD_GSK3_1	172	179	PF00069	0.673
MOD_GSK3_1	188	195	PF00069	0.692
MOD_GSK3_1	41	48	PF00069	0.430
MOD_GSK3_1	59	66	PF00069	0.410
MOD_LATS_1	8	14	PF00433	0.578
MOD_N-GLC_1	166	171	PF02516	0.426
MOD_NEK2_1	173	178	PF00069	0.673
MOD_NEK2_1	45	50	PF00069	0.417
MOD_NEK2_1	59	64	PF00069	0.373
MOD_PIKK_1	173	179	PF00454	0.600
MOD_PKA_2	163	169	PF00069	0.678
MOD_PKA_2	173	179	PF00069	0.733
MOD_PKA_2	31	37	PF00069	0.271
MOD_Plk_1	185	191	PF00069	0.667
MOD_Plk_4	73	79	PF00069	0.433
MOD_Plk_4	87	93	PF00069	0.365
MOD_ProDKin_1	195	201	PF00069	0.657
TRG_DiLeu_BaLyEn_6	177	182	PF01217	0.594
TRG_ENDOCYTIC_2	111	114	PF00928	0.356
TRG_ENDOCYTIC_2	97	100	PF00928	0.293
TRG_NLS_MonoExtC_3	127	132	PF00514	0.626
TRG_Pf-PMV_PEXEL_1	180	184	PF00026	0.396

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P923	Leptomonas seymouri	44%	100%
A0A3S5H659	Leishmania donovani	58%	100%
A0A3S7WQ87	Leishmania donovani	30%	100%
A4H5C6	Leishmania braziliensis	32%	100%
A4HTK6	Leishmania infantum	30%	100%
A4HTK7	Leishmania infantum	58%	100%
E9AMD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9AMD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	100%
Q4QIB1	Leishmania major	59%	100%
Q4QIB2	Leishmania major	37%	100%