Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5C6_LEIBR

TriTrypDb:

LbrM.08.0620 , LBRM2903_080010900

Length:

217

Annotations

LeishMANIAdb annotations

This protein family is endemic to Kinetoplastids, might have emerged de novo and also expanded. . The family also contains Leishmaniid members lacking the signal peptide and only having an MTTPA- start sequence

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 2, no: 9
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4H5C6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5C6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	177	179	PF00675	0.492
CLV_NRD_NRD_1	36	38	PF00675	0.616
CLV_PCSK_KEX2_1	177	179	PF00082	0.490
CLV_PCSK_KEX2_1	36	38	PF00082	0.616
CLV_PCSK_SKI1_1	16	20	PF00082	0.577
DEG_APCC_DBOX_1	20	28	PF00400	0.344
DEG_MDM2_SWIB_1	93	101	PF02201	0.426
DOC_MAPK_gen_1	36	42	PF00069	0.569
DOC_MAPK_MEF2A_6	94	103	PF00069	0.251
DOC_USP7_MATH_1	12	16	PF00917	0.486
DOC_USP7_MATH_1	179	183	PF00917	0.740
DOC_USP7_MATH_1	199	203	PF00917	0.649
DOC_USP7_MATH_1	43	47	PF00917	0.594
DOC_USP7_MATH_1	65	69	PF00917	0.464
DOC_USP7_MATH_1	88	92	PF00917	0.398
DOC_WW_Pin1_4	164	169	PF00397	0.616
DOC_WW_Pin1_4	185	190	PF00397	0.721
DOC_WW_Pin1_4	195	200	PF00397	0.691
DOC_WW_Pin1_4	59	64	PF00397	0.368
LIG_14-3-3_CanoR_1	14	22	PF00244	0.422
LIG_14-3-3_CanoR_1	166	175	PF00244	0.747
LIG_BIR_II_1	1	5	PF00653	0.508
LIG_BIR_III_3	1	5	PF00653	0.464
LIG_BRCT_BRCA1_1	199	203	PF00533	0.604
LIG_BRCT_BRCA1_1	88	92	PF00533	0.349
LIG_eIF4E_1	98	104	PF01652	0.365
LIG_FHA_1	100	106	PF00498	0.327
LIG_FHA_1	37	43	PF00498	0.578
LIG_LIR_Gen_1	17	27	PF02991	0.383
LIG_LIR_Gen_1	95	105	PF02991	0.279
LIG_LIR_Nem_3	141	147	PF02991	0.696
LIG_LIR_Nem_3	17	22	PF02991	0.399
LIG_LIR_Nem_3	191	197	PF02991	0.672
LIG_LIR_Nem_3	25	31	PF02991	0.362
LIG_LIR_Nem_3	90	96	PF02991	0.444
LIG_Pex14_2	93	97	PF04695	0.449
LIG_REV1ctd_RIR_1	90	98	PF16727	0.351
LIG_SH2_CRK	194	198	PF00017	0.619
LIG_SH2_PTP2	112	115	PF00017	0.451
LIG_SH2_PTP2	98	101	PF00017	0.394
LIG_SH2_SRC	183	186	PF00017	0.633
LIG_SH2_STAT3	126	129	PF00017	0.619
LIG_SH2_STAT3	80	83	PF00017	0.456
LIG_SH2_STAT5	112	115	PF00017	0.419
LIG_SH2_STAT5	144	147	PF00017	0.717
LIG_SH2_STAT5	56	59	PF00017	0.420
LIG_SH2_STAT5	98	101	PF00017	0.523
LIG_SH3_3	68	74	PF00018	0.456
MOD_CK1_1	169	175	PF00069	0.771
MOD_CK1_1	198	204	PF00069	0.717
MOD_CK1_1	48	54	PF00069	0.483
MOD_CK1_1	6	12	PF00069	0.498
MOD_CK2_1	198	204	PF00069	0.800
MOD_GlcNHglycan	45	48	PF01048	0.632
MOD_GlcNHglycan	5	8	PF01048	0.603
MOD_GlcNHglycan	67	70	PF01048	0.657
MOD_GSK3_1	166	173	PF00069	0.742
MOD_GSK3_1	193	200	PF00069	0.772
MOD_GSK3_1	48	55	PF00069	0.502
MOD_GSK3_1	6	13	PF00069	0.440
MOD_GSK3_1	88	95	PF00069	0.456
MOD_N-GLC_1	83	88	PF02516	0.630
MOD_NEK2_1	22	27	PF00069	0.356
MOD_NEK2_1	3	8	PF00069	0.649
MOD_NEK2_1	92	97	PF00069	0.352
MOD_NEK2_2	121	126	PF00069	0.502
MOD_NEK2_2	88	93	PF00069	0.365
MOD_PIKK_1	154	160	PF00454	0.734
MOD_PK_1	193	199	PF00069	0.620
MOD_PKA_1	177	183	PF00069	0.694
MOD_PKA_1	36	42	PF00069	0.438
MOD_PKA_2	177	183	PF00069	0.769
MOD_PKA_2	36	42	PF00069	0.658
MOD_Plk_1	205	211	PF00069	0.792
MOD_Plk_1	83	89	PF00069	0.426
MOD_Plk_4	205	211	PF00069	0.637
MOD_Plk_4	54	60	PF00069	0.391
MOD_Plk_4	88	94	PF00069	0.367
MOD_ProDKin_1	164	170	PF00069	0.617
MOD_ProDKin_1	185	191	PF00069	0.721
MOD_ProDKin_1	195	201	PF00069	0.689
MOD_ProDKin_1	59	65	PF00069	0.367
MOD_SUMO_rev_2	142	152	PF00179	0.582
TRG_ENDOCYTIC_2	112	115	PF00928	0.313
TRG_ENDOCYTIC_2	144	147	PF00928	0.749
TRG_ENDOCYTIC_2	194	197	PF00928	0.648
TRG_ENDOCYTIC_2	96	99	PF00928	0.388
TRG_ER_diArg_1	177	179	PF00400	0.657
TRG_ER_diArg_1	35	37	PF00400	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P923	Leptomonas seymouri	38%	100%
A0A3S5H659	Leishmania donovani	39%	100%
A0A3S7WQ87	Leishmania donovani	56%	100%
A4H5C7	Leishmania braziliensis	32%	98%
A4HTK6	Leishmania infantum	56%	100%
A4HTK7	Leishmania infantum	39%	100%
E9AMD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
E9AMD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
Q4QIB1	Leishmania major	36%	100%
Q4QIB2	Leishmania major	58%	100%