Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5C5_LEIBR

TriTrypDb:

LbrM.08.0610 , LBRM2903_080011000

Length:

276

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5C5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5C5

PDB structure(s): 7aih_Ad , 7am2_Ad , 7ane_Ad

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.529
CLV_NRD_NRD_1	43	45	PF00675	0.727
CLV_NRD_NRD_1	96	98	PF00675	0.419
CLV_PCSK_KEX2_1	43	45	PF00082	0.727
CLV_PCSK_SKI1_1	113	117	PF00082	0.472
CLV_PCSK_SKI1_1	245	249	PF00082	0.395
CLV_PCSK_SKI1_1	264	268	PF00082	0.362
DEG_Nend_Nbox_1	1	3	PF02207	0.487
DOC_ANK_TNKS_1	69	76	PF00023	0.689
DOC_CDC14_PxL_1	63	71	PF14671	0.623
DOC_CYCLIN_yCln2_LP_2	108	114	PF00134	0.415
DOC_CYCLIN_yCln2_LP_2	216	222	PF00134	0.421
DOC_PP2B_LxvP_1	108	111	PF13499	0.429
DOC_USP7_MATH_1	136	140	PF00917	0.689
DOC_USP7_MATH_1	153	157	PF00917	0.438
DOC_USP7_MATH_1	76	80	PF00917	0.723
DOC_USP7_UBL2_3	94	98	PF12436	0.539
DOC_WW_Pin1_4	15	20	PF00397	0.530
DOC_WW_Pin1_4	24	29	PF00397	0.502
DOC_WW_Pin1_4	49	54	PF00397	0.726
LIG_14-3-3_CanoR_1	250	255	PF00244	0.501
LIG_14-3-3_CanoR_1	3	11	PF00244	0.529
LIG_14-3-3_CanoR_1	43	49	PF00244	0.638
LIG_14-3-3_CanoR_1	97	107	PF00244	0.433
LIG_APCC_ABBAyCdc20_2	100	106	PF00400	0.415
LIG_BRCT_BRCA1_1	154	158	PF00533	0.452
LIG_BRCT_BRCA1_2	154	160	PF00533	0.454
LIG_FHA_1	242	248	PF00498	0.404
LIG_LIR_Gen_1	101	112	PF02991	0.420
LIG_LIR_Nem_3	101	107	PF02991	0.407
LIG_LIR_Nem_3	118	122	PF02991	0.428
LIG_LIR_Nem_3	166	170	PF02991	0.517
LIG_MYND_1	181	185	PF01753	0.457
LIG_MYND_1	86	90	PF01753	0.682
LIG_PDZ_Class_2	271	276	PF00595	0.354
LIG_REV1ctd_RIR_1	192	202	PF16727	0.405
LIG_SH2_CRK	179	183	PF00017	0.503
LIG_SH2_CRK	221	225	PF00017	0.477
LIG_SH2_NCK_1	168	172	PF00017	0.615
LIG_SH2_NCK_1	63	67	PF00017	0.624
LIG_SH2_SRC	179	182	PF00017	0.512
LIG_SH2_SRC	63	66	PF00017	0.628
LIG_SH2_STAP1	104	108	PF00017	0.402
LIG_SH2_STAP1	209	213	PF00017	0.462
LIG_SH2_STAT5	255	258	PF00017	0.369
LIG_SH3_1	179	185	PF00018	0.456
LIG_SH3_3	179	185	PF00018	0.368
LIG_SH3_3	84	90	PF00018	0.438
LIG_SUMO_SIM_anti_2	187	193	PF11976	0.577
LIG_UBA3_1	238	246	PF00899	0.397
MOD_CK1_1	15	21	PF00069	0.545
MOD_CK1_1	93	99	PF00069	0.591
MOD_GlcNHglycan	134	137	PF01048	0.630
MOD_GlcNHglycan	138	141	PF01048	0.759
MOD_GlcNHglycan	14	17	PF01048	0.486
MOD_GlcNHglycan	174	177	PF01048	0.485
MOD_GlcNHglycan	4	7	PF01048	0.622
MOD_GlcNHglycan	80	83	PF01048	0.690
MOD_GSK3_1	132	139	PF00069	0.630
MOD_GSK3_1	159	166	PF00069	0.590
MOD_GSK3_1	54	61	PF00069	0.710
MOD_N-GLC_1	136	141	PF02516	0.716
MOD_NEK2_1	12	17	PF00069	0.379
MOD_NEK2_1	2	7	PF00069	0.465
MOD_NEK2_1	248	253	PF00069	0.394
MOD_NEK2_1	58	63	PF00069	0.700
MOD_NEK2_1	78	83	PF00069	0.397
MOD_NEK2_2	153	158	PF00069	0.444
MOD_PIKK_1	37	43	PF00454	0.585
MOD_PK_1	250	256	PF00069	0.383
MOD_PKA_2	172	178	PF00069	0.483
MOD_PKA_2	197	203	PF00069	0.409
MOD_PKA_2	2	8	PF00069	0.526
MOD_PKA_2	42	48	PF00069	0.632
MOD_Plk_4	153	159	PF00069	0.446
MOD_Plk_4	163	169	PF00069	0.472
MOD_Plk_4	212	218	PF00069	0.577
MOD_Plk_4	250	256	PF00069	0.383
MOD_ProDKin_1	15	21	PF00069	0.541
MOD_ProDKin_1	24	30	PF00069	0.498
MOD_ProDKin_1	49	55	PF00069	0.719
TRG_ENDOCYTIC_2	104	107	PF00928	0.396
TRG_ENDOCYTIC_2	167	170	PF00928	0.565
TRG_ENDOCYTIC_2	221	224	PF00928	0.405
TRG_ER_diArg_1	42	44	PF00400	0.719
TRG_NLS_MonoExtC_3	96	102	PF00514	0.417
TRG_NLS_MonoExtN_4	94	101	PF00514	0.430
TRG_Pf-PMV_PEXEL_1	223	228	PF00026	0.256
TRG_Pf-PMV_PEXEL_1	97	102	PF00026	0.428

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9E3	Leptomonas seymouri	75%	97%
A0A1X0NP31	Trypanosomatidae	50%	100%
A0A3R7M469	Trypanosoma rangeli	50%	100%
A0A3S7WQ78	Leishmania donovani	91%	100%
A4HTK5	Leishmania infantum	91%	100%
C9ZPG7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AMD6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QIB3	Leishmania major	90%	100%
V5B1E9	Trypanosoma cruzi	50%	100%