Translation initiation factor-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

eukaryotic translation initiation factor 2 beta subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4H5C4_LEIBR

TriTrypDb:

LbrM.08.0600 , LBRM2903_080011100

Length:

344

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005850	eukaryotic translation initiation factor 2 complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H5C4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5C4

Function

Biological processes
Term	Name	Level	Count
GO:0001731	formation of translation preinitiation complex	7	1
GO:0001732	formation of cytoplasmic translation initiation complex	7	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003743	translation initiation factor activity	4	12
GO:0005488	binding	1	12
GO:0008135	translation factor activity, RNA binding	3	12
GO:0045182	translation regulator activity	1	12
GO:0090079	translation regulator activity, nucleic acid binding	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0005515	protein binding	2	1
GO:0031369	translation initiation factor binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.710
CLV_NRD_NRD_1	270	272	PF00675	0.487
CLV_NRD_NRD_1	305	307	PF00675	0.379
CLV_PCSK_FUR_1	7	11	PF00082	0.718
CLV_PCSK_KEX2_1	123	125	PF00082	0.510
CLV_PCSK_KEX2_1	305	307	PF00082	0.379
CLV_PCSK_KEX2_1	334	336	PF00082	0.494
CLV_PCSK_KEX2_1	9	11	PF00082	0.688
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.512
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.494
CLV_PCSK_SKI1_1	318	322	PF00082	0.515
DEG_Kelch_Keap1_1	12	17	PF01344	0.576
DEG_Nend_UBRbox_3	1	3	PF02207	0.572
DEG_SCF_TRCP1_1	14	20	PF00400	0.578
DOC_MAPK_gen_1	334	344	PF00069	0.523
DOC_MAPK_MEF2A_6	209	216	PF00069	0.450
DOC_PP2B_LxvP_1	212	215	PF13499	0.421
DOC_PP4_FxxP_1	237	240	PF00568	0.342
DOC_PP4_MxPP_1	37	40	PF00568	0.529
DOC_USP7_MATH_1	160	164	PF00917	0.657
DOC_USP7_MATH_1	51	55	PF00917	0.759
DOC_USP7_MATH_1	79	83	PF00917	0.734
DOC_WW_Pin1_4	89	94	PF00397	0.632
LIG_14-3-3_CanoR_1	271	280	PF00244	0.482
LIG_14-3-3_CanoR_1	59	64	PF00244	0.734
LIG_APCC_ABBA_1	58	63	PF00400	0.724
LIG_FHA_1	26	32	PF00498	0.821
LIG_FHA_1	315	321	PF00498	0.434
LIG_FHA_2	272	278	PF00498	0.342
LIG_FHA_2	28	34	PF00498	0.865
LIG_LIR_Apic_2	235	240	PF02991	0.421
LIG_LIR_Gen_1	112	122	PF02991	0.516
LIG_LIR_Gen_1	154	162	PF02991	0.630
LIG_LIR_Gen_1	274	284	PF02991	0.385
LIG_LIR_Nem_3	112	118	PF02991	0.551
LIG_LIR_Nem_3	154	159	PF02991	0.592
LIG_LIR_Nem_3	191	197	PF02991	0.558
LIG_LIR_Nem_3	274	279	PF02991	0.367
LIG_MYND_3	214	218	PF01753	0.469
LIG_PCNA_yPIPBox_3	185	194	PF02747	0.594
LIG_PTAP_UEV_1	63	68	PF05743	0.550
LIG_SH2_CRK	110	114	PF00017	0.594
LIG_SH2_CRK	115	119	PF00017	0.516
LIG_SH2_STAP1	115	119	PF00017	0.563
LIG_SH2_STAT5	283	286	PF00017	0.327
LIG_SH2_STAT5	287	290	PF00017	0.327
LIG_SH3_3	50	56	PF00018	0.731
LIG_SH3_3	61	67	PF00018	0.700
LIG_SH3_3	71	77	PF00018	0.699
LIG_TRAF2_1	129	132	PF00917	0.536
LIG_TYR_ITIM	108	113	PF00017	0.578
LIG_UBA3_1	118	123	PF00899	0.542
LIG_UBA3_1	216	224	PF00899	0.469
LIG_UBA3_1	280	289	PF00899	0.385
MOD_CK1_1	15	21	PF00069	0.874
MOD_CK1_1	204	210	PF00069	0.329
MOD_CK2_1	15	21	PF00069	0.761
MOD_CK2_1	171	177	PF00069	0.685
MOD_Cter_Amidation	220	223	PF01082	0.362
MOD_Cter_Amidation	303	306	PF01082	0.342
MOD_GlcNHglycan	14	17	PF01048	0.693
MOD_GlcNHglycan	163	166	PF01048	0.637
MOD_GlcNHglycan	174	177	PF01048	0.589
MOD_GlcNHglycan	202	206	PF01048	0.560
MOD_GlcNHglycan	328	331	PF01048	0.526
MOD_GlcNHglycan	53	56	PF01048	0.765
MOD_GSK3_1	12	19	PF00069	0.854
MOD_GSK3_1	23	30	PF00069	0.614
MOD_GSK3_1	312	319	PF00069	0.344
MOD_GSK3_1	322	329	PF00069	0.556
MOD_GSK3_1	79	86	PF00069	0.761
MOD_N-GLC_1	171	176	PF02516	0.668
MOD_N-GLC_2	291	293	PF02516	0.342
MOD_N-GLC_2	312	314	PF02516	0.327
MOD_PK_1	250	256	PF00069	0.342
MOD_PKA_1	123	129	PF00069	0.460
MOD_PKA_1	222	228	PF00069	0.469
MOD_PKA_1	271	277	PF00069	0.469
MOD_PKA_2	123	129	PF00069	0.547
MOD_PKA_2	2	8	PF00069	0.765
MOD_Plk_1	141	147	PF00069	0.623
MOD_Plk_1	250	256	PF00069	0.341
MOD_Plk_1	296	302	PF00069	0.327
MOD_Plk_2-3	17	23	PF00069	0.774
MOD_Plk_2-3	83	89	PF00069	0.572
MOD_Plk_4	222	228	PF00069	0.469
MOD_ProDKin_1	89	95	PF00069	0.629
MOD_SUMO_for_1	266	269	PF00179	0.342
MOD_SUMO_rev_2	242	247	PF00179	0.469
TRG_ENDOCYTIC_2	110	113	PF00928	0.557
TRG_ENDOCYTIC_2	115	118	PF00928	0.503
TRG_ENDOCYTIC_2	186	189	PF00928	0.443
TRG_ER_diArg_1	305	307	PF00400	0.378
TRG_ER_diArg_1	41	44	PF00400	0.656
TRG_ER_diArg_1	7	10	PF00400	0.713
TRG_NLS_MonoExtN_4	219	226	PF00514	0.342
TRG_Pf-PMV_PEXEL_1	282	286	PF00026	0.342

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3Y9	Leptomonas seymouri	72%	98%
A0A0S4KLD6	Bodo saltans	39%	100%
A0A1X0NPQ0	Trypanosomatidae	48%	91%
A0A3R7JYX9	Trypanosoma rangeli	58%	100%
A0A3S5H658	Leishmania donovani	86%	100%
A4HTK4	Leishmania infantum	86%	100%
C9ZPG8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AMD5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QIB4	Leishmania major	87%	100%
V5BGW0	Trypanosoma cruzi	51%	100%