Cyclopropane-fatty-acyl-phospholipid synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclopropane-fatty-acyl-phospholipid synthase

Species:

Leishmania braziliensis

UniProt:

A4H5C3_LEIBR

TriTrypDb:

LbrM.08.0590 , LBRM2903_080011200

Length:

490

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5C3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5C3

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	1
GO:0032259	methylation	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	58	62	PF00656	0.649
CLV_NRD_NRD_1	130	132	PF00675	0.337
CLV_NRD_NRD_1	133	135	PF00675	0.352
CLV_NRD_NRD_1	197	199	PF00675	0.268
CLV_NRD_NRD_1	326	328	PF00675	0.224
CLV_NRD_NRD_1	354	356	PF00675	0.228
CLV_PCSK_KEX2_1	130	132	PF00082	0.337
CLV_PCSK_KEX2_1	162	164	PF00082	0.305
CLV_PCSK_KEX2_1	317	319	PF00082	0.207
CLV_PCSK_KEX2_1	354	356	PF00082	0.228
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.305
CLV_PCSK_PC1ET2_1	317	319	PF00082	0.188
CLV_PCSK_SKI1_1	104	108	PF00082	0.355
CLV_PCSK_SKI1_1	162	166	PF00082	0.319
CLV_PCSK_SKI1_1	213	217	PF00082	0.271
CLV_PCSK_SKI1_1	321	325	PF00082	0.203
CLV_PCSK_SKI1_1	354	358	PF00082	0.209
CLV_PCSK_SKI1_1	386	390	PF00082	0.228
CLV_PCSK_SKI1_1	94	98	PF00082	0.344
DEG_APCC_DBOX_1	262	270	PF00400	0.388
DEG_Nend_UBRbox_1	1	4	PF02207	0.548
DEG_SCF_FBW7_2	1	7	PF00400	0.500
DOC_CKS1_1	1	6	PF01111	0.502
DOC_CYCLIN_RxL_1	351	361	PF00134	0.428
DOC_MAPK_gen_1	104	113	PF00069	0.329
DOC_MAPK_gen_1	130	140	PF00069	0.377
DOC_MAPK_gen_1	259	268	PF00069	0.428
DOC_MAPK_gen_1	287	295	PF00069	0.546
DOC_MAPK_gen_1	306	315	PF00069	0.407
DOC_MAPK_gen_1	317	325	PF00069	0.424
DOC_MAPK_gen_1	327	335	PF00069	0.408
DOC_MAPK_gen_1	442	450	PF00069	0.396
DOC_MAPK_HePTP_8	256	268	PF00069	0.388
DOC_MAPK_MEF2A_6	213	220	PF00069	0.388
DOC_MAPK_MEF2A_6	259	268	PF00069	0.388
DOC_MAPK_MEF2A_6	306	315	PF00069	0.424
DOC_MAPK_MEF2A_6	328	337	PF00069	0.383
DOC_MAPK_NFAT4_5	213	221	PF00069	0.388
DOC_PP1_RVXF_1	319	326	PF00149	0.388
DOC_USP7_MATH_1	395	399	PF00917	0.388
DOC_USP7_UBL2_3	285	289	PF12436	0.462
DOC_USP7_UBL2_3	374	378	PF12436	0.388
DOC_USP7_UBL2_3	402	406	PF12436	0.383
DOC_USP7_UBL2_3	90	94	PF12436	0.386
DOC_WW_Pin1_4	474	479	PF00397	0.288
LIG_14-3-3_CanoR_1	219	227	PF00244	0.452
LIG_14-3-3_CanoR_1	331	336	PF00244	0.428
LIG_14-3-3_CanoR_1	82	88	PF00244	0.351
LIG_Actin_WH2_2	150	168	PF00022	0.253
LIG_Actin_WH2_2	238	256	PF00022	0.444
LIG_deltaCOP1_diTrp_1	146	154	PF00928	0.308
LIG_deltaCOP1_diTrp_1	381	389	PF00928	0.428
LIG_eIF4E_1	155	161	PF01652	0.234
LIG_FHA_1	106	112	PF00498	0.282
LIG_FHA_1	63	69	PF00498	0.592
LIG_FHA_2	1	7	PF00498	0.500
LIG_FHA_2	242	248	PF00498	0.428
LIG_FHA_2	292	298	PF00498	0.428
LIG_LIR_Apic_2	170	174	PF02991	0.421
LIG_LIR_Apic_2	44	50	PF02991	0.520
LIG_LIR_Gen_1	116	127	PF02991	0.328
LIG_LIR_Gen_1	326	337	PF02991	0.462
LIG_LIR_Gen_1	85	96	PF02991	0.378
LIG_LIR_Nem_3	116	122	PF02991	0.332
LIG_LIR_Nem_3	151	157	PF02991	0.307
LIG_LIR_Nem_3	159	164	PF02991	0.295
LIG_LIR_Nem_3	319	323	PF02991	0.436
LIG_LIR_Nem_3	326	332	PF02991	0.449
LIG_LIR_Nem_3	381	387	PF02991	0.428
LIG_LIR_Nem_3	417	422	PF02991	0.388
LIG_LIR_Nem_3	447	453	PF02991	0.428
LIG_LIR_Nem_3	85	91	PF02991	0.389
LIG_LIR_Nem_3	95	101	PF02991	0.339
LIG_OCRL_FandH_1	153	165	PF00620	0.245
LIG_PCNA_TLS_4	166	173	PF02747	0.323
LIG_Pex14_1	383	387	PF04695	0.428
LIG_Pex14_1	427	431	PF04695	0.428
LIG_Pex14_2	325	329	PF04695	0.428
LIG_Pex14_2	431	435	PF04695	0.428
LIG_Pex14_2	449	453	PF04695	0.428
LIG_PTB_Apo_2	206	213	PF02174	0.428
LIG_PTB_Apo_2	412	419	PF02174	0.428
LIG_REV1ctd_RIR_1	209	217	PF16727	0.428
LIG_REV1ctd_RIR_1	347	355	PF16727	0.428
LIG_REV1ctd_RIR_1	447	455	PF16727	0.462
LIG_SH2_CRK	119	123	PF00017	0.369
LIG_SH2_CRK	47	51	PF00017	0.513
LIG_SH2_CRK	484	488	PF00017	0.339
LIG_SH2_CRK	71	75	PF00017	0.448
LIG_SH2_CRK	88	92	PF00017	0.343
LIG_SH2_NCK_1	222	226	PF00017	0.428
LIG_SH2_NCK_1	484	488	PF00017	0.339
LIG_SH2_PTP2	387	390	PF00017	0.428
LIG_SH2_SRC	205	208	PF00017	0.462
LIG_SH2_STAP1	119	123	PF00017	0.528
LIG_SH2_STAP1	222	226	PF00017	0.428
LIG_SH2_STAP1	484	488	PF00017	0.339
LIG_SH2_STAT3	226	229	PF00017	0.388
LIG_SH2_STAT5	172	175	PF00017	0.415
LIG_SH2_STAT5	281	284	PF00017	0.383
LIG_SH2_STAT5	384	387	PF00017	0.428
LIG_SH2_STAT5	407	410	PF00017	0.428
LIG_SH2_STAT5	456	459	PF00017	0.428
LIG_SH2_STAT5	98	101	PF00017	0.391
LIG_SH3_3	120	126	PF00018	0.317
LIG_SH3_3	27	33	PF00018	0.640
LIG_SH3_3	472	478	PF00018	0.476
LIG_SH3_3	484	490	PF00018	0.468
LIG_SUMO_SIM_anti_2	363	370	PF11976	0.462
LIG_SUMO_SIM_par_1	363	370	PF11976	0.462
LIG_TRAF2_1	84	87	PF00917	0.358
LIG_TYR_ITAM	85	101	PF00017	0.312
LIG_UBA3_1	180	187	PF00899	0.459
LIG_WRC_WIRS_1	346	351	PF05994	0.428
MOD_CDK_SPK_2	474	479	PF00069	0.336
MOD_CK1_1	18	24	PF00069	0.454
MOD_CK1_1	373	379	PF00069	0.428
MOD_CK1_1	438	444	PF00069	0.428
MOD_CK2_1	164	170	PF00069	0.343
MOD_CK2_1	241	247	PF00069	0.475
MOD_CK2_1	291	297	PF00069	0.444
MOD_CK2_1	81	87	PF00069	0.438
MOD_GlcNHglycan	166	169	PF01048	0.394
MOD_GlcNHglycan	378	381	PF01048	0.228
MOD_GlcNHglycan	437	440	PF01048	0.225
MOD_GlcNHglycan	459	462	PF01048	0.228
MOD_GSK3_1	105	112	PF00069	0.280
MOD_GSK3_1	190	197	PF00069	0.434
MOD_GSK3_1	35	42	PF00069	0.621
MOD_GSK3_1	372	379	PF00069	0.428
MOD_N-GLC_1	311	316	PF02516	0.340
MOD_N-GLC_1	414	419	PF02516	0.188
MOD_N-GLC_1	435	440	PF02516	0.228
MOD_N-GLC_1	76	81	PF02516	0.463
MOD_NEK2_1	211	216	PF00069	0.441
MOD_NEK2_1	220	225	PF00069	0.420
MOD_NEK2_1	238	243	PF00069	0.428
MOD_NEK2_1	311	316	PF00069	0.388
MOD_NEK2_1	457	462	PF00069	0.428
MOD_NEK2_2	76	81	PF00069	0.495
MOD_PK_1	331	337	PF00069	0.428
MOD_PKA_1	134	140	PF00069	0.378
MOD_PKA_2	18	24	PF00069	0.518
MOD_PKA_2	81	87	PF00069	0.360
MOD_Plk_1	311	317	PF00069	0.462
MOD_Plk_1	321	327	PF00069	0.407
MOD_Plk_1	414	420	PF00069	0.388
MOD_Plk_4	311	317	PF00069	0.428
MOD_Plk_4	345	351	PF00069	0.428
MOD_Plk_4	420	426	PF00069	0.420
MOD_Plk_4	76	82	PF00069	0.497
MOD_ProDKin_1	474	480	PF00069	0.293
MOD_SUMO_for_1	9	12	PF00179	0.428
MOD_SUMO_rev_2	246	253	PF00179	0.428
MOD_SUMO_rev_2	322	329	PF00179	0.462
TRG_DiLeu_BaEn_1	12	17	PF01217	0.386
TRG_DiLeu_BaEn_4	12	18	PF01217	0.389
TRG_DiLeu_BaEn_4	86	92	PF01217	0.354
TRG_DiLeu_BaLyEn_6	352	357	PF01217	0.428
TRG_ENDOCYTIC_2	119	122	PF00928	0.365
TRG_ENDOCYTIC_2	320	323	PF00928	0.388
TRG_ENDOCYTIC_2	346	349	PF00928	0.428
TRG_ENDOCYTIC_2	407	410	PF00928	0.428
TRG_ENDOCYTIC_2	454	457	PF00928	0.428
TRG_ENDOCYTIC_2	484	487	PF00928	0.387
TRG_ENDOCYTIC_2	88	91	PF00928	0.368
TRG_ENDOCYTIC_2	98	101	PF00928	0.334
TRG_ER_diArg_1	129	131	PF00400	0.330
TRG_ER_diArg_1	260	263	PF00400	0.462
TRG_ER_diArg_1	353	355	PF00400	0.428
TRG_Pf-PMV_PEXEL_1	354	359	PF00026	0.228

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P927	Leptomonas seymouri	69%	100%
A0A3S5H657	Leishmania donovani	82%	100%
A4HTK3	Leishmania infantum	82%	100%
E9AMD4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
O53732	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	28%	100%
O69687	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	31%	100%
P0A9H7	Escherichia coli (strain K12)	49%	100%
P0A9H8	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	49%	100%