Complex 1 protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Complex 1 protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5C2_LEIBR

TriTrypDb:

LbrM.08.0580 , LBRM2903_080011300

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H5C2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5C2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	69	73	PF00656	0.705
CLV_NRD_NRD_1	133	135	PF00675	0.610
CLV_NRD_NRD_1	214	216	PF00675	0.477
CLV_NRD_NRD_1	227	229	PF00675	0.537
CLV_NRD_NRD_1	245	247	PF00675	0.411
CLV_PCSK_KEX2_1	133	135	PF00082	0.610
CLV_PCSK_KEX2_1	213	215	PF00082	0.484
CLV_PCSK_KEX2_1	226	228	PF00082	0.536
CLV_PCSK_KEX2_1	245	247	PF00082	0.417
CLV_PCSK_PC7_1	222	228	PF00082	0.438
CLV_PCSK_SKI1_1	16	20	PF00082	0.516
CLV_PCSK_SKI1_1	200	204	PF00082	0.391
DEG_APCC_DBOX_1	199	207	PF00400	0.395
DOC_CYCLIN_RxL_1	13	22	PF00134	0.541
DOC_PP1_RVXF_1	14	21	PF00149	0.521
DOC_PP1_RVXF_1	290	296	PF00149	0.455
DOC_PP2B_LxvP_1	342	345	PF13499	0.598
DOC_USP7_MATH_1	288	292	PF00917	0.620
DOC_WW_Pin1_4	183	188	PF00397	0.475
LIG_14-3-3_CanoR_1	133	139	PF00244	0.510
LIG_14-3-3_CanoR_1	180	184	PF00244	0.535
LIG_14-3-3_CanoR_1	213	218	PF00244	0.482
LIG_14-3-3_CanoR_1	228	237	PF00244	0.467
LIG_14-3-3_CanoR_1	76	82	PF00244	0.565
LIG_BRCT_BRCA1_1	181	185	PF00533	0.506
LIG_BRCT_BRCA1_1	327	331	PF00533	0.572
LIG_CtBP_PxDLS_1	347	351	PF00389	0.530
LIG_DCNL_PONY_1	1	4	PF03556	0.637
LIG_FHA_1	230	236	PF00498	0.444
LIG_FHA_2	272	278	PF00498	0.543
LIG_FHA_2	314	320	PF00498	0.511
LIG_FHA_2	324	330	PF00498	0.611
LIG_LIR_Gen_1	262	271	PF02991	0.542
LIG_NRBOX	193	199	PF00104	0.406
LIG_SH2_CRK	199	203	PF00017	0.386
LIG_SH2_CRK	209	213	PF00017	0.467
LIG_SH2_STAP1	138	142	PF00017	0.489
LIG_SH2_STAT5	249	252	PF00017	0.443
LIG_SH3_2	173	178	PF14604	0.626
LIG_SH3_3	167	173	PF00018	0.571
LIG_SH3_3	282	288	PF00018	0.514
LIG_SH3_3	341	347	PF00018	0.597
LIG_SH3_3	56	62	PF00018	0.698
LIG_SUMO_SIM_anti_2	193	199	PF11976	0.482
LIG_TRAF2_2	113	118	PF00917	0.553
LIG_TYR_ITIM	197	202	PF00017	0.388
MOD_CDK_SPxxK_3	185	192	PF00069	0.452
MOD_CK1_1	22	28	PF00069	0.496
MOD_CK1_1	77	83	PF00069	0.697
MOD_CK2_1	277	283	PF00069	0.516
MOD_CK2_1	313	319	PF00069	0.514
MOD_CK2_1	323	329	PF00069	0.555
MOD_GlcNHglycan	316	319	PF01048	0.579
MOD_GlcNHglycan	32	35	PF01048	0.625
MOD_GSK3_1	179	186	PF00069	0.553
MOD_GSK3_1	255	262	PF00069	0.527
MOD_GSK3_1	30	37	PF00069	0.609
MOD_GSK3_1	71	78	PF00069	0.695
MOD_LATS_1	321	327	PF00433	0.497
MOD_N-GLC_1	255	260	PF02516	0.521
MOD_N-GLC_1	296	301	PF02516	0.637
MOD_NEK2_1	19	24	PF00069	0.590
MOD_NEK2_1	257	262	PF00069	0.550
MOD_NEK2_1	71	76	PF00069	0.651
MOD_NEK2_2	244	249	PF00069	0.481
MOD_PIKK_1	154	160	PF00454	0.705
MOD_PKA_1	213	219	PF00069	0.447
MOD_PKA_2	179	185	PF00069	0.517
MOD_PKA_2	213	219	PF00069	0.481
MOD_PKA_2	244	250	PF00069	0.490
MOD_PKA_2	25	31	PF00069	0.646
MOD_PKA_2	75	81	PF00069	0.551
MOD_Plk_1	288	294	PF00069	0.607
MOD_Plk_1	34	40	PF00069	0.532
MOD_Plk_2-3	179	185	PF00069	0.436
MOD_Plk_2-3	277	283	PF00069	0.514
MOD_Plk_4	190	196	PF00069	0.556
MOD_Plk_4	277	283	PF00069	0.514
MOD_Plk_4	42	48	PF00069	0.669
MOD_ProDKin_1	183	189	PF00069	0.474
MOD_SUMO_for_1	331	334	PF00179	0.658
MOD_SUMO_rev_2	184	194	PF00179	0.446
MOD_SUMO_rev_2	273	280	PF00179	0.536
MOD_SUMO_rev_2	334	342	PF00179	0.516
TRG_DiLeu_BaEn_1	190	195	PF01217	0.423
TRG_DiLeu_BaLyEn_6	14	19	PF01217	0.510
TRG_ENDOCYTIC_2	199	202	PF00928	0.390
TRG_ENDOCYTIC_2	209	212	PF00928	0.464
TRG_ENDOCYTIC_2	220	223	PF00928	0.436
TRG_ER_diArg_1	133	135	PF00400	0.610
TRG_ER_diArg_1	212	215	PF00400	0.500
TRG_ER_diArg_1	225	228	PF00400	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I921	Leptomonas seymouri	73%	97%
A0A3S7WQ84	Leishmania donovani	86%	100%
A4HTK2	Leishmania infantum	87%	100%
E9AMD3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QIB5	Leishmania major	86%	100%