Putative ribose-phosphate pyrophosphokinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribose-phosphate pyrophosphokinase, putative

Species:

Leishmania braziliensis

UniProt:

A4H5B8_LEIBR

TriTrypDb:

LbrM.08.0540 , LBRM2903_080011700

Length:

800

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0002189	ribose phosphate diphosphokinase complex	5	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A4H5B8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5B8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	9
GO:0006725	cellular aromatic compound metabolic process	3	9
GO:0006753	nucleoside phosphate metabolic process	4	9
GO:0006793	phosphorus metabolic process	3	9
GO:0006796	phosphate-containing compound metabolic process	4	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009058	biosynthetic process	2	9
GO:0009117	nucleotide metabolic process	5	9
GO:0009165	nucleotide biosynthetic process	6	9
GO:0009987	cellular process	1	9
GO:0016310	phosphorylation	5	9
GO:0018130	heterocycle biosynthetic process	4	9
GO:0019438	aromatic compound biosynthetic process	4	9
GO:0019637	organophosphate metabolic process	3	9
GO:0034641	cellular nitrogen compound metabolic process	3	9
GO:0034654	nucleobase-containing compound biosynthetic process	4	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0044249	cellular biosynthetic process	3	9
GO:0044271	cellular nitrogen compound biosynthetic process	4	9
GO:0044281	small molecule metabolic process	2	9
GO:0046483	heterocycle metabolic process	3	9
GO:0055086	nucleobase-containing small molecule metabolic process	3	9
GO:0071704	organic substance metabolic process	2	9
GO:0090407	organophosphate biosynthetic process	4	9
GO:1901293	nucleoside phosphate biosynthetic process	5	9
GO:1901360	organic cyclic compound metabolic process	3	9
GO:1901362	organic cyclic compound biosynthetic process	4	9
GO:1901576	organic substance biosynthetic process	3	9
GO:0006015	5-phosphoribose 1-diphosphate biosynthetic process	6	1
GO:0006163	purine nucleotide metabolic process	5	1
GO:0006164	purine nucleotide biosynthetic process	6	1
GO:0019693	ribose phosphate metabolic process	4	1
GO:0046390	ribose phosphate biosynthetic process	5	1
GO:0046391	5-phosphoribose 1-diphosphate metabolic process	5	1
GO:0072521	purine-containing compound metabolic process	4	1
GO:0072522	purine-containing compound biosynthetic process	5	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901137	carbohydrate derivative biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0000287	magnesium ion binding	5	9
GO:0003824	catalytic activity	1	9
GO:0004749	ribose phosphate diphosphokinase activity	5	9
GO:0005488	binding	1	9
GO:0016301	kinase activity	4	9
GO:0016740	transferase activity	2	9
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	9
GO:0016778	diphosphotransferase activity	4	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	477	481	PF00656	0.476
CLV_C14_Caspase3-7	597	601	PF00656	0.521
CLV_C14_Caspase3-7	631	635	PF00656	0.506
CLV_NRD_NRD_1	193	195	PF00675	0.423
CLV_NRD_NRD_1	502	504	PF00675	0.646
CLV_NRD_NRD_1	674	676	PF00675	0.697
CLV_NRD_NRD_1	768	770	PF00675	0.302
CLV_PCSK_KEX2_1	502	504	PF00082	0.573
CLV_PCSK_SKI1_1	16	20	PF00082	0.528
CLV_PCSK_SKI1_1	194	198	PF00082	0.423
CLV_PCSK_SKI1_1	258	262	PF00082	0.567
CLV_PCSK_SKI1_1	311	315	PF00082	0.341
CLV_PCSK_SKI1_1	669	673	PF00082	0.469
CLV_PCSK_SKI1_1	724	728	PF00082	0.302
CLV_Separin_Metazoa	521	525	PF03568	0.750
DEG_Nend_Nbox_1	1	3	PF02207	0.710
DOC_CKS1_1	578	583	PF01111	0.489
DOC_CKS1_1	593	598	PF01111	0.530
DOC_CYCLIN_RxL_1	13	21	PF00134	0.528
DOC_MAPK_gen_1	136	144	PF00069	0.490
DOC_MAPK_gen_1	184	193	PF00069	0.378
DOC_MAPK_gen_1	292	300	PF00069	0.377
DOC_MAPK_gen_1	769	776	PF00069	0.514
DOC_MAPK_MEF2A_6	235	243	PF00069	0.538
DOC_MAPK_MEF2A_6	546	554	PF00069	0.523
DOC_PP4_FxxP_1	431	434	PF00568	0.402
DOC_PP4_FxxP_1	88	91	PF00568	0.580
DOC_PP4_FxxP_1	97	100	PF00568	0.573
DOC_SPAK_OSR1_1	295	299	PF12202	0.352
DOC_USP7_MATH_1	107	111	PF00917	0.371
DOC_USP7_MATH_1	205	209	PF00917	0.449
DOC_USP7_MATH_1	323	327	PF00917	0.504
DOC_USP7_MATH_1	356	360	PF00917	0.575
DOC_USP7_MATH_1	563	567	PF00917	0.671
DOC_USP7_MATH_1	569	573	PF00917	0.683
DOC_USP7_MATH_1	678	682	PF00917	0.409
DOC_USP7_MATH_1	73	77	PF00917	0.531
DOC_USP7_MATH_1	732	736	PF00917	0.578
DOC_USP7_MATH_1	80	84	PF00917	0.459
DOC_USP7_MATH_2	434	440	PF00917	0.380
DOC_USP7_UBL2_3	125	129	PF12436	0.321
DOC_USP7_UBL2_3	195	199	PF12436	0.402
DOC_USP7_UBL2_3	38	42	PF12436	0.418
DOC_WW_Pin1_4	531	536	PF00397	0.527
DOC_WW_Pin1_4	559	564	PF00397	0.770
DOC_WW_Pin1_4	577	582	PF00397	0.435
DOC_WW_Pin1_4	589	594	PF00397	0.728
DOC_WW_Pin1_4	742	747	PF00397	0.502
DOC_WW_Pin1_4	90	95	PF00397	0.646
DOC_WW_Pin1_4	96	101	PF00397	0.562
LIG_14-3-3_CanoR_1	16	26	PF00244	0.522
LIG_14-3-3_CanoR_1	250	254	PF00244	0.434
LIG_14-3-3_CanoR_1	385	393	PF00244	0.477
LIG_14-3-3_CanoR_1	58	64	PF00244	0.496
LIG_Actin_WH2_2	25	40	PF00022	0.465
LIG_APCC_ABBA_1	420	425	PF00400	0.434
LIG_BIR_III_2	285	289	PF00653	0.619
LIG_BIR_III_4	583	587	PF00653	0.705
LIG_BRCT_BRCA1_1	230	234	PF00533	0.548
LIG_BRCT_BRCA1_1	277	281	PF00533	0.550
LIG_BRCT_BRCA1_1	92	96	PF00533	0.552
LIG_BRCT_BRCA1_1	98	102	PF00533	0.560
LIG_Clathr_ClatBox_1	141	145	PF01394	0.470
LIG_CORNRBOX	696	704	PF00104	0.575
LIG_CtBP_PxDLS_1	538	542	PF00389	0.526
LIG_EH1_1	348	356	PF00400	0.542
LIG_eIF4E_1	185	191	PF01652	0.381
LIG_eIF4E_1	683	689	PF01652	0.413
LIG_FHA_1	278	284	PF00498	0.697
LIG_FHA_1	302	308	PF00498	0.518
LIG_FHA_1	312	318	PF00498	0.473
LIG_FHA_1	385	391	PF00498	0.502
LIG_FHA_1	394	400	PF00498	0.533
LIG_FHA_1	490	496	PF00498	0.562
LIG_FHA_1	553	559	PF00498	0.527
LIG_FHA_1	653	659	PF00498	0.496
LIG_FHA_1	69	75	PF00498	0.744
LIG_FHA_1	728	734	PF00498	0.477
LIG_FHA_1	751	757	PF00498	0.477
LIG_FHA_1	82	88	PF00498	0.715
LIG_FHA_2	155	161	PF00498	0.442
LIG_FHA_2	2	8	PF00498	0.686
LIG_FHA_2	52	58	PF00498	0.571
LIG_FHA_2	578	584	PF00498	0.682
LIG_FHA_2	629	635	PF00498	0.510
LIG_FHA_2	700	706	PF00498	0.455
LIG_FHA_2	73	79	PF00498	0.605
LIG_FHA_2	793	799	PF00498	0.477
LIG_Integrin_RGD_1	344	346	PF01839	0.277
LIG_LIR_Apic_2	428	434	PF02991	0.414
LIG_LIR_Apic_2	518	523	PF02991	0.687
LIG_LIR_Apic_2	85	91	PF02991	0.603
LIG_LIR_Gen_1	124	135	PF02991	0.399
LIG_LIR_Gen_1	174	183	PF02991	0.482
LIG_LIR_Gen_1	439	448	PF02991	0.374
LIG_LIR_Gen_1	458	467	PF02991	0.401
LIG_LIR_Gen_1	492	501	PF02991	0.448
LIG_LIR_Gen_1	545	554	PF02991	0.615
LIG_LIR_Gen_1	99	107	PF02991	0.505
LIG_LIR_Nem_3	124	130	PF02991	0.398
LIG_LIR_Nem_3	132	137	PF02991	0.395
LIG_LIR_Nem_3	174	179	PF02991	0.478
LIG_LIR_Nem_3	29	34	PF02991	0.469
LIG_LIR_Nem_3	439	445	PF02991	0.370
LIG_LIR_Nem_3	458	462	PF02991	0.434
LIG_LIR_Nem_3	492	497	PF02991	0.434
LIG_LIR_Nem_3	545	550	PF02991	0.575
LIG_LIR_Nem_3	681	686	PF02991	0.542
LIG_LIR_Nem_3	99	105	PF02991	0.543
LIG_NRBOX	635	641	PF00104	0.510
LIG_OCRL_FandH_1	126	138	PF00620	0.531
LIG_PCNA_yPIPBox_3	633	643	PF02747	0.510
LIG_REV1ctd_RIR_1	124	133	PF16727	0.491
LIG_SH2_CRK	185	189	PF00017	0.439
LIG_SH2_CRK	245	249	PF00017	0.373
LIG_SH2_CRK	686	690	PF00017	0.456
LIG_SH2_GRB2like	263	266	PF00017	0.635
LIG_SH2_NCK_1	686	690	PF00017	0.456
LIG_SH2_SRC	171	174	PF00017	0.470
LIG_SH2_SRC	589	592	PF00017	0.643
LIG_SH2_STAP1	223	227	PF00017	0.545
LIG_SH2_STAP1	253	257	PF00017	0.429
LIG_SH2_STAP1	395	399	PF00017	0.477
LIG_SH2_STAT5	134	137	PF00017	0.404
LIG_SH2_STAT5	140	143	PF00017	0.385
LIG_SH2_STAT5	171	174	PF00017	0.395
LIG_SH2_STAT5	176	179	PF00017	0.374
LIG_SH2_STAT5	31	34	PF00017	0.451
LIG_SH2_STAT5	392	395	PF00017	0.480
LIG_SH2_STAT5	447	450	PF00017	0.419
LIG_SH2_STAT5	589	592	PF00017	0.643
LIG_SH2_STAT5	59	62	PF00017	0.550
LIG_SH2_STAT5	625	628	PF00017	0.562
LIG_SH3_1	772	778	PF00018	0.477
LIG_SH3_3	224	230	PF00018	0.378
LIG_SH3_3	317	323	PF00018	0.542
LIG_SH3_3	461	467	PF00018	0.418
LIG_SH3_3	532	538	PF00018	0.630
LIG_SH3_3	547	553	PF00018	0.743
LIG_SH3_3	590	596	PF00018	0.641
LIG_SH3_3	613	619	PF00018	0.514
LIG_SH3_3	772	778	PF00018	0.477
LIG_SH3_3	88	94	PF00018	0.632
LIG_SH3_4	38	45	PF00018	0.419
LIG_SUMO_SIM_anti_2	207	213	PF11976	0.577
LIG_SUMO_SIM_anti_2	240	245	PF11976	0.518
LIG_SUMO_SIM_anti_2	370	375	PF11976	0.477
LIG_SUMO_SIM_anti_2	460	466	PF11976	0.532
LIG_SUMO_SIM_anti_2	605	614	PF11976	0.715
LIG_SUMO_SIM_anti_2	723	730	PF11976	0.477
LIG_SUMO_SIM_anti_2	744	751	PF11976	0.483
LIG_SUMO_SIM_par_1	353	360	PF11976	0.575
LIG_SUMO_SIM_par_1	416	421	PF11976	0.361
LIG_SUMO_SIM_par_1	723	730	PF11976	0.502
LIG_SUMO_SIM_par_1	748	755	PF11976	0.477
LIG_TRFH_1	35	39	PF08558	0.435
LIG_TYR_ITIM	243	248	PF00017	0.519
LIG_TYR_ITIM	32	37	PF00017	0.442
LIG_WRC_WIRS_1	155	160	PF05994	0.513
MOD_CK1_1	225	231	PF00069	0.505
MOD_CK1_1	496	502	PF00069	0.436
MOD_CK1_1	509	515	PF00069	0.645
MOD_CK1_1	570	576	PF00069	0.713
MOD_CK1_1	592	598	PF00069	0.695
MOD_CK1_1	627	633	PF00069	0.641
MOD_CK1_1	65	71	PF00069	0.700
MOD_CK1_1	652	658	PF00069	0.583
MOD_CK1_1	72	78	PF00069	0.785
MOD_CK1_1	789	795	PF00069	0.412
MOD_CK1_1	83	89	PF00069	0.548
MOD_CK2_1	148	154	PF00069	0.411
MOD_CK2_1	533	539	PF00069	0.727
MOD_CK2_1	72	78	PF00069	0.734
MOD_CK2_1	792	798	PF00069	0.420
MOD_GlcNHglycan	109	112	PF01048	0.424
MOD_GlcNHglycan	235	238	PF01048	0.549
MOD_GlcNHglycan	301	304	PF01048	0.375
MOD_GlcNHglycan	364	367	PF01048	0.241
MOD_GlcNHglycan	402	405	PF01048	0.465
MOD_GlcNHglycan	438	441	PF01048	0.353
MOD_GlcNHglycan	489	492	PF01048	0.621
MOD_GlcNHglycan	565	568	PF01048	0.636
MOD_GlcNHglycan	583	587	PF01048	0.447
MOD_GlcNHglycan	596	599	PF01048	0.688
MOD_GlcNHglycan	613	616	PF01048	0.516
MOD_GlcNHglycan	71	74	PF01048	0.570
MOD_GlcNHglycan	734	737	PF01048	0.308
MOD_GlcNHglycan	75	78	PF01048	0.547
MOD_GSK3_1	144	151	PF00069	0.299
MOD_GSK3_1	17	24	PF00069	0.522
MOD_GSK3_1	299	306	PF00069	0.459
MOD_GSK3_1	356	363	PF00069	0.532
MOD_GSK3_1	451	458	PF00069	0.555
MOD_GSK3_1	489	496	PF00069	0.628
MOD_GSK3_1	559	566	PF00069	0.681
MOD_GSK3_1	567	574	PF00069	0.605
MOD_GSK3_1	62	69	PF00069	0.604
MOD_GSK3_1	624	631	PF00069	0.607
MOD_N-GLC_1	225	230	PF02516	0.539
MOD_N-GLC_1	264	269	PF02516	0.638
MOD_N-GLC_1	360	365	PF02516	0.375
MOD_N-GLC_1	460	465	PF02516	0.401
MOD_N-GLC_1	563	568	PF02516	0.699
MOD_N-GLC_1	628	633	PF02516	0.633
MOD_N-GLC_2	325	327	PF02516	0.341
MOD_NEK2_1	1	6	PF00069	0.700
MOD_NEK2_1	130	135	PF00069	0.392
MOD_NEK2_1	144	149	PF00069	0.388
MOD_NEK2_1	301	306	PF00069	0.542
MOD_NEK2_1	362	367	PF00069	0.441
MOD_NEK2_1	374	379	PF00069	0.524
MOD_NEK2_1	393	398	PF00069	0.477
MOD_NEK2_1	408	413	PF00069	0.411
MOD_NEK2_1	51	56	PF00069	0.576
MOD_NEK2_1	727	732	PF00069	0.487
MOD_NEK2_2	303	308	PF00069	0.477
MOD_PIKK_1	225	231	PF00454	0.544
MOD_PIKK_1	275	281	PF00454	0.634
MOD_PIKK_1	489	495	PF00454	0.571
MOD_PIKK_1	503	509	PF00454	0.599
MOD_PIKK_1	6	12	PF00454	0.648
MOD_PKA_2	249	255	PF00069	0.428
MOD_PKA_2	384	390	PF00069	0.477
MOD_PKA_2	57	63	PF00069	0.478
MOD_Plk_1	144	150	PF00069	0.302
MOD_Plk_1	24	30	PF00069	0.510
MOD_Plk_1	333	339	PF00069	0.502
MOD_Plk_1	460	466	PF00069	0.394
MOD_Plk_1	51	57	PF00069	0.591
MOD_Plk_1	789	795	PF00069	0.502
MOD_Plk_2-3	154	160	PF00069	0.470
MOD_Plk_2-3	455	461	PF00069	0.585
MOD_Plk_4	130	136	PF00069	0.400
MOD_Plk_4	144	150	PF00069	0.428
MOD_Plk_4	171	177	PF00069	0.496
MOD_Plk_4	244	250	PF00069	0.386
MOD_Plk_4	277	283	PF00069	0.556
MOD_Plk_4	30	36	PF00069	0.492
MOD_Plk_4	303	309	PF00069	0.477
MOD_Plk_4	350	356	PF00069	0.477
MOD_Plk_4	635	641	PF00069	0.536
MOD_Plk_4	699	705	PF00069	0.502
MOD_Plk_4	792	798	PF00069	0.502
MOD_Plk_4	83	89	PF00069	0.675
MOD_ProDKin_1	531	537	PF00069	0.527
MOD_ProDKin_1	559	565	PF00069	0.767
MOD_ProDKin_1	577	583	PF00069	0.431
MOD_ProDKin_1	589	595	PF00069	0.727
MOD_ProDKin_1	742	748	PF00069	0.502
MOD_ProDKin_1	90	96	PF00069	0.640
MOD_SUMO_for_1	142	145	PF00179	0.485
MOD_SUMO_for_1	177	180	PF00179	0.486
MOD_SUMO_rev_2	33	40	PF00179	0.525
MOD_SUMO_rev_2	98	108	PF00179	0.451
TRG_DiLeu_BaEn_1	370	375	PF01217	0.542
TRG_DiLeu_BaLyEn_6	217	222	PF01217	0.554
TRG_DiLeu_BaLyEn_6	775	780	PF01217	0.502
TRG_ENDOCYTIC_2	134	137	PF00928	0.485
TRG_ENDOCYTIC_2	176	179	PF00928	0.391
TRG_ENDOCYTIC_2	185	188	PF00928	0.408
TRG_ENDOCYTIC_2	245	248	PF00928	0.370
TRG_ENDOCYTIC_2	34	37	PF00928	0.441
TRG_ENDOCYTIC_2	442	445	PF00928	0.375
TRG_ENDOCYTIC_2	485	488	PF00928	0.417
TRG_ENDOCYTIC_2	686	689	PF00928	0.542
TRG_ER_diArg_1	501	503	PF00400	0.624
TRG_Pf-PMV_PEXEL_1	16	21	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	258	262	PF00026	0.354
TRG_Pf-PMV_PEXEL_1	715	719	PF00026	0.302

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDZ8	Leptomonas seymouri	61%	94%
A0A1X0NPK7	Trypanosomatidae	47%	100%
A0A3R7LSY3	Trypanosoma rangeli	46%	100%
A0A3S5H655	Leishmania donovani	78%	95%
A4HTJ9	Leishmania infantum	77%	95%
E9AMD0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	95%
Q4QIB8	Leishmania major	76%	99%