Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5B6_LEIBR

TriTrypDb:

LbrM.08.0520 , LBRM2903_080011900 , LBRM2903_080012000

Length:

541

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5B6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5B6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	176	180	PF00656	0.576
CLV_NRD_NRD_1	113	115	PF00675	0.539
CLV_NRD_NRD_1	305	307	PF00675	0.530
CLV_NRD_NRD_1	357	359	PF00675	0.656
CLV_NRD_NRD_1	422	424	PF00675	0.550
CLV_NRD_NRD_1	515	517	PF00675	0.558
CLV_NRD_NRD_1	71	73	PF00675	0.574
CLV_NRD_NRD_1	78	80	PF00675	0.564
CLV_NRD_NRD_1	9	11	PF00675	0.544
CLV_NRD_NRD_1	97	99	PF00675	0.538
CLV_PCSK_FUR_1	420	424	PF00082	0.552
CLV_PCSK_KEX2_1	112	114	PF00082	0.535
CLV_PCSK_KEX2_1	304	306	PF00082	0.535
CLV_PCSK_KEX2_1	31	33	PF00082	0.549
CLV_PCSK_KEX2_1	359	361	PF00082	0.658
CLV_PCSK_KEX2_1	422	424	PF00082	0.550
CLV_PCSK_KEX2_1	515	517	PF00082	0.540
CLV_PCSK_KEX2_1	71	73	PF00082	0.574
CLV_PCSK_KEX2_1	78	80	PF00082	0.564
CLV_PCSK_KEX2_1	9	11	PF00082	0.544
CLV_PCSK_KEX2_1	95	97	PF00082	0.543
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.535
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.549
CLV_PCSK_PC1ET2_1	359	361	PF00082	0.658
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.579
CLV_PCSK_PC7_1	74	80	PF00082	0.576
DEG_Nend_Nbox_1	1	3	PF02207	0.550
DEG_SCF_FBW7_1	178	185	PF00400	0.606
DEG_SPOP_SBC_1	290	294	PF00917	0.542
DOC_CKS1_1	130	135	PF01111	0.569
DOC_CKS1_1	33	38	PF01111	0.568
DOC_CKS1_1	405	410	PF01111	0.535
DOC_PP1_RVXF_1	358	365	PF00149	0.516
DOC_PP2B_LxvP_1	223	226	PF13499	0.543
DOC_PP2B_LxvP_1	488	491	PF13499	0.642
DOC_PP4_FxxP_1	221	224	PF00568	0.551
DOC_PP4_FxxP_1	278	281	PF00568	0.574
DOC_USP7_MATH_1	137	141	PF00917	0.570
DOC_USP7_MATH_1	184	188	PF00917	0.675
DOC_USP7_MATH_1	196	200	PF00917	0.679
DOC_USP7_MATH_1	227	231	PF00917	0.644
DOC_USP7_MATH_1	390	394	PF00917	0.601
DOC_USP7_MATH_1	396	400	PF00917	0.604
DOC_USP7_MATH_1	401	405	PF00917	0.622
DOC_USP7_MATH_1	412	416	PF00917	0.556
DOC_USP7_MATH_1	457	461	PF00917	0.545
DOC_USP7_MATH_1	65	69	PF00917	0.621
DOC_WW_Pin1_4	124	129	PF00397	0.589
DOC_WW_Pin1_4	171	176	PF00397	0.708
DOC_WW_Pin1_4	178	183	PF00397	0.630
DOC_WW_Pin1_4	235	240	PF00397	0.526
DOC_WW_Pin1_4	317	322	PF00397	0.760
DOC_WW_Pin1_4	32	37	PF00397	0.565
DOC_WW_Pin1_4	324	329	PF00397	0.729
DOC_WW_Pin1_4	373	378	PF00397	0.663
DOC_WW_Pin1_4	404	409	PF00397	0.533
DOC_WW_Pin1_4	50	55	PF00397	0.651
DOC_WW_Pin1_4	98	103	PF00397	0.567
LIG_14-3-3_CanoR_1	19	26	PF00244	0.495
LIG_14-3-3_CanoR_1	207	215	PF00244	0.671
LIG_14-3-3_CanoR_1	367	372	PF00244	0.542
LIG_14-3-3_CanoR_1	389	397	PF00244	0.540
LIG_14-3-3_CanoR_1	56	62	PF00244	0.565
LIG_14-3-3_CanoR_1	71	81	PF00244	0.539
LIG_BIR_III_2	195	199	PF00653	0.538
LIG_BIR_III_2	511	515	PF00653	0.537
LIG_BIR_III_4	500	504	PF00653	0.523
LIG_BRCT_BRCA1_1	186	190	PF00533	0.650
LIG_BRCT_BRCA1_1	479	483	PF00533	0.649
LIG_Clathr_ClatBox_1	330	334	PF01394	0.505
LIG_CSL_BTD_1	362	365	PF09270	0.514
LIG_EVH1_1	223	227	PF00568	0.542
LIG_FHA_1	19	25	PF00498	0.492
LIG_FHA_1	254	260	PF00498	0.495
LIG_FHA_1	292	298	PF00498	0.673
LIG_FHA_1	335	341	PF00498	0.532
LIG_FHA_1	368	374	PF00498	0.597
LIG_FHA_1	377	383	PF00498	0.683
LIG_FHA_1	471	477	PF00498	0.590
LIG_FHA_2	137	143	PF00498	0.691
LIG_FHA_2	148	154	PF00498	0.656
LIG_GSK3_LRP6_1	182	187	PF00069	0.598
LIG_LIR_Apic_2	402	408	PF02991	0.535
LIG_LIR_Gen_1	199	205	PF02991	0.547
LIG_LIR_Gen_1	311	321	PF02991	0.542
LIG_LIR_Gen_1	332	343	PF02991	0.628
LIG_LIR_Gen_1	480	491	PF02991	0.642
LIG_LIR_Nem_3	199	204	PF02991	0.549
LIG_LIR_Nem_3	266	270	PF02991	0.523
LIG_LIR_Nem_3	311	317	PF02991	0.544
LIG_LIR_Nem_3	332	338	PF02991	0.629
LIG_LIR_Nem_3	480	486	PF02991	0.643
LIG_NRBOX	241	247	PF00104	0.587
LIG_PDZ_Class_2	536	541	PF00595	0.628
LIG_Pex14_1	479	483	PF04695	0.649
LIG_RPA_C_Fungi	247	259	PF08784	0.526
LIG_SH2_CRK	3	7	PF00017	0.535
LIG_SH2_CRK	397	401	PF00017	0.533
LIG_SH2_NCK_1	397	401	PF00017	0.533
LIG_SH2_PTP2	201	204	PF00017	0.553
LIG_SH2_STAP1	26	30	PF00017	0.525
LIG_SH2_STAP1	397	401	PF00017	0.533
LIG_SH2_STAP1	57	61	PF00017	0.618
LIG_SH2_STAT5	201	204	PF00017	0.553
LIG_SH2_STAT5	26	29	PF00017	0.508
LIG_SH2_STAT5	335	338	PF00017	0.646
LIG_SH2_STAT5	425	428	PF00017	0.647
LIG_SH3_2	183	188	PF14604	0.664
LIG_SH3_3	180	186	PF00018	0.657
LIG_SH3_3	221	227	PF00018	0.560
LIG_SH3_3	322	328	PF00018	0.727
LIG_SH3_3	340	346	PF00018	0.646
LIG_SH3_3	400	406	PF00018	0.533
LIG_SH3_3	449	455	PF00018	0.545
LIG_SH3_3	496	502	PF00018	0.512
LIG_SUMO_SIM_anti_2	535	540	PF11976	0.624
LIG_SUMO_SIM_par_1	369	376	PF11976	0.526
LIG_TRAF2_1	150	153	PF00917	0.532
MOD_CDC14_SPxK_1	185	188	PF00782	0.671
MOD_CDC14_SPxK_1	53	56	PF00782	0.559
MOD_CDK_SPK_2	124	129	PF00069	0.568
MOD_CDK_SPxK_1	182	188	PF00069	0.631
MOD_CDK_SPxK_1	50	56	PF00069	0.558
MOD_CK1_1	140	146	PF00069	0.569
MOD_CK1_1	162	168	PF00069	0.698
MOD_CK1_1	228	234	PF00069	0.705
MOD_CK1_1	271	277	PF00069	0.653
MOD_CK1_1	308	314	PF00069	0.595
MOD_CK1_1	320	326	PF00069	0.645
MOD_CK1_1	404	410	PF00069	0.591
MOD_CK1_1	441	447	PF00069	0.668
MOD_CK1_1	460	466	PF00069	0.505
MOD_CK1_1	467	473	PF00069	0.650
MOD_CK1_1	522	528	PF00069	0.591
MOD_CK2_1	136	142	PF00069	0.615
MOD_CK2_1	147	153	PF00069	0.577
MOD_CK2_1	309	315	PF00069	0.581
MOD_CK2_1	396	402	PF00069	0.533
MOD_CK2_1	80	86	PF00069	0.567
MOD_CMANNOS	363	366	PF00535	0.657
MOD_Cter_Amidation	76	79	PF01082	0.580
MOD_DYRK1A_RPxSP_1	98	102	PF00069	0.566
MOD_GlcNHglycan	114	117	PF01048	0.569
MOD_GlcNHglycan	197	201	PF01048	0.588
MOD_GlcNHglycan	261	264	PF01048	0.602
MOD_GlcNHglycan	273	276	PF01048	0.688
MOD_GlcNHglycan	347	350	PF01048	0.626
MOD_GlcNHglycan	392	395	PF01048	0.542
MOD_GlcNHglycan	426	429	PF01048	0.642
MOD_GlcNHglycan	445	448	PF01048	0.510
MOD_GlcNHglycan	479	482	PF01048	0.649
MOD_GlcNHglycan	57	60	PF01048	0.569
MOD_GlcNHglycan	67	70	PF01048	0.544
MOD_GlcNHglycan	75	78	PF01048	0.537
MOD_GlcNHglycan	82	85	PF01048	0.542
MOD_GSK3_1	120	127	PF00069	0.572
MOD_GSK3_1	132	139	PF00069	0.543
MOD_GSK3_1	173	180	PF00069	0.646
MOD_GSK3_1	182	189	PF00069	0.638
MOD_GSK3_1	196	203	PF00069	0.629
MOD_GSK3_1	259	266	PF00069	0.512
MOD_GSK3_1	280	287	PF00069	0.601
MOD_GSK3_1	289	296	PF00069	0.651
MOD_GSK3_1	305	312	PF00069	0.575
MOD_GSK3_1	313	320	PF00069	0.652
MOD_GSK3_1	32	39	PF00069	0.560
MOD_GSK3_1	369	376	PF00069	0.539
MOD_GSK3_1	384	391	PF00069	0.525
MOD_GSK3_1	437	444	PF00069	0.660
MOD_GSK3_1	457	464	PF00069	0.510
MOD_GSK3_1	466	473	PF00069	0.584
MOD_GSK3_1	87	94	PF00069	0.619
MOD_LATS_1	303	309	PF00433	0.535
MOD_LATS_1	38	44	PF00433	0.571
MOD_N-GLC_1	162	167	PF02516	0.698
MOD_N-GLC_1	235	240	PF02516	0.491
MOD_N-GLC_1	373	378	PF02516	0.537
MOD_N-GLC_1	87	92	PF02516	0.578
MOD_NEK2_1	1	6	PF00069	0.538
MOD_NEK2_1	18	23	PF00069	0.459
MOD_NEK2_1	24	29	PF00069	0.491
MOD_NEK2_1	284	289	PF00069	0.615
MOD_NEK2_1	313	318	PF00069	0.556
MOD_NEK2_1	424	429	PF00069	0.648
MOD_NEK2_1	443	448	PF00069	0.530
MOD_NEK2_1	477	482	PF00069	0.748
MOD_NEK2_2	412	417	PF00069	0.651
MOD_PIKK_1	228	234	PF00454	0.731
MOD_PIKK_1	24	30	PF00454	0.506
MOD_PIKK_1	240	246	PF00454	0.480
MOD_PIKK_1	284	290	PF00454	0.662
MOD_PKA_1	112	118	PF00069	0.569
MOD_PKA_1	305	311	PF00069	0.534
MOD_PKA_2	106	112	PF00069	0.572
MOD_PKA_2	137	143	PF00069	0.610
MOD_PKA_2	147	153	PF00069	0.583
MOD_PKA_2	159	165	PF00069	0.638
MOD_PKA_2	170	176	PF00069	0.555
MOD_PKA_2	18	24	PF00069	0.494
MOD_PKA_2	305	311	PF00069	0.735
MOD_PKA_2	366	372	PF00069	0.522
MOD_PKA_2	388	394	PF00069	0.638
MOD_PKA_2	55	61	PF00069	0.568
MOD_PKA_2	65	71	PF00069	0.547
MOD_PKA_2	73	79	PF00069	0.541
MOD_Plk_1	162	168	PF00069	0.558
MOD_Plk_1	308	314	PF00069	0.584
MOD_Plk_1	401	407	PF00069	0.646
MOD_Plk_1	438	444	PF00069	0.537
MOD_Plk_2-3	309	315	PF00069	0.542
MOD_Plk_4	309	315	PF00069	0.542
MOD_Plk_4	457	463	PF00069	0.566
MOD_ProDKin_1	124	130	PF00069	0.589
MOD_ProDKin_1	171	177	PF00069	0.709
MOD_ProDKin_1	178	184	PF00069	0.628
MOD_ProDKin_1	235	241	PF00069	0.520
MOD_ProDKin_1	317	323	PF00069	0.759
MOD_ProDKin_1	32	38	PF00069	0.567
MOD_ProDKin_1	324	330	PF00069	0.730
MOD_ProDKin_1	373	379	PF00069	0.666
MOD_ProDKin_1	404	410	PF00069	0.535
MOD_ProDKin_1	50	56	PF00069	0.653
MOD_ProDKin_1	98	104	PF00069	0.569
TRG_DiLeu_BaEn_3	152	158	PF01217	0.521
TRG_DiLeu_BaEn_4	153	159	PF01217	0.520
TRG_DiLeu_BaLyEn_6	20	25	PF01217	0.489
TRG_DiLeu_BaLyEn_6	326	331	PF01217	0.517
TRG_ENDOCYTIC_2	201	204	PF00928	0.553
TRG_ENDOCYTIC_2	3	6	PF00928	0.535
TRG_ENDOCYTIC_2	314	317	PF00928	0.545
TRG_ENDOCYTIC_2	335	338	PF00928	0.646
TRG_ENDOCYTIC_2	397	400	PF00928	0.535
TRG_ER_diArg_1	304	306	PF00400	0.588
TRG_ER_diArg_1	357	360	PF00400	0.657
TRG_ER_diArg_1	419	422	PF00400	0.554
TRG_ER_diArg_1	514	516	PF00400	0.533
TRG_ER_diArg_1	64	67	PF00400	0.566
TRG_ER_diArg_1	71	74	PF00400	0.560
TRG_ER_diArg_1	78	80	PF00400	0.549
TRG_ER_diArg_1	9	12	PF00400	0.543
TRG_ER_diArg_1	96	98	PF00400	0.545
TRG_NES_CRM1_1	156	168	PF08389	0.544
TRG_NLS_Bipartite_1	78	99	PF00514	0.574
TRG_NLS_MonoCore_2	94	99	PF00514	0.575
TRG_NLS_MonoExtC_3	94	100	PF00514	0.578
TRG_NLS_MonoExtN_4	111	116	PF00514	0.572
TRG_NLS_MonoExtN_4	357	362	PF00514	0.657
TRG_Pf-PMV_PEXEL_1	23	28	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H653	Leishmania donovani	52%	100%
A4HTJ7	Leishmania infantum	52%	100%
E9AMC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
Q4QIC0	Leishmania major	55%	99%