Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5B5_LEIBR

TriTrypDb:

LbrM.08.0510 , LBRM2903_080012100

Length:

276

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5B5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5B5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	139	143	PF00082	0.495
CLV_PCSK_SKI1_1	226	230	PF00082	0.684
CLV_PCSK_SKI1_1	240	244	PF00082	0.451
DEG_APCC_DBOX_1	217	225	PF00400	0.627
DOC_CKS1_1	20	25	PF01111	0.557
DOC_MAPK_MEF2A_6	139	148	PF00069	0.572
DOC_USP7_MATH_1	31	35	PF00917	0.602
DOC_WW_Pin1_4	19	24	PF00397	0.547
DOC_WW_Pin1_4	196	201	PF00397	0.683
DOC_WW_Pin1_4	211	216	PF00397	0.465
DOC_WW_Pin1_4	229	234	PF00397	0.697
DOC_WW_Pin1_4	259	264	PF00397	0.675
DOC_WW_Pin1_4	35	40	PF00397	0.458
LIG_14-3-3_CanoR_1	109	116	PF00244	0.461
LIG_14-3-3_CanoR_1	139	148	PF00244	0.511
LIG_Actin_WH2_2	112	128	PF00022	0.618
LIG_APCC_ABBA_1	129	134	PF00400	0.595
LIG_BIR_II_1	1	5	PF00653	0.586
LIG_FHA_1	135	141	PF00498	0.462
LIG_FHA_2	3	9	PF00498	0.586
LIG_FHA_2	36	42	PF00498	0.657
LIG_Integrin_isoDGR_2	264	266	PF01839	0.540
LIG_LIR_Gen_1	47	57	PF02991	0.397
LIG_LIR_Nem_3	47	52	PF02991	0.407
LIG_PCNA_yPIPBox_3	240	253	PF02747	0.640
LIG_SH2_NCK_1	49	53	PF00017	0.541
LIG_SH2_SRC	49	52	PF00017	0.545
LIG_SH2_STAP1	12	16	PF00017	0.572
LIG_SH2_STAT5	56	59	PF00017	0.556
LIG_SH3_3	230	236	PF00018	0.694
LIG_SUMO_SIM_anti_2	149	156	PF11976	0.339
LIG_TRAF2_1	90	93	PF00917	0.698
LIG_UBA3_1	16	21	PF00899	0.568
MOD_CDK_SPK_2	211	216	PF00069	0.561
MOD_CDK_SPxxK_3	196	203	PF00069	0.626
MOD_CDK_SPxxK_3	211	218	PF00069	0.482
MOD_CDK_SPxxK_3	259	266	PF00069	0.523
MOD_CK1_1	103	109	PF00069	0.673
MOD_CK1_1	150	156	PF00069	0.476
MOD_CK1_1	232	238	PF00069	0.616
MOD_CK1_1	70	76	PF00069	0.752
MOD_CK1_1	88	94	PF00069	0.478
MOD_CK2_1	2	8	PF00069	0.566
MOD_CK2_1	70	76	PF00069	0.638
MOD_CK2_1	87	93	PF00069	0.564
MOD_GlcNHglycan	168	171	PF01048	0.721
MOD_GlcNHglycan	69	72	PF01048	0.724
MOD_GlcNHglycan	82	85	PF01048	0.799
MOD_GlcNHglycan	87	90	PF01048	0.708
MOD_GSK3_1	108	115	PF00069	0.402
MOD_GSK3_1	232	239	PF00069	0.531
MOD_GSK3_1	31	38	PF00069	0.580
MOD_GSK3_1	80	87	PF00069	0.774
MOD_GSK3_1	88	95	PF00069	0.782
MOD_N-GLC_1	103	108	PF02516	0.705
MOD_N-GLC_1	166	171	PF02516	0.461
MOD_N-GLC_1	229	234	PF02516	0.726
MOD_NEK2_1	147	152	PF00069	0.450
MOD_NEK2_1	252	257	PF00069	0.541
MOD_PIKK_1	139	145	PF00454	0.426
MOD_PIKK_1	147	153	PF00454	0.456
MOD_PIKK_1	181	187	PF00454	0.733
MOD_PIKK_1	88	94	PF00454	0.763
MOD_PKA_2	108	114	PF00069	0.657
MOD_PKA_2	217	223	PF00069	0.637
MOD_Plk_1	103	109	PF00069	0.755
MOD_Plk_2-3	112	118	PF00069	0.437
MOD_Plk_4	150	156	PF00069	0.507
MOD_ProDKin_1	19	25	PF00069	0.542
MOD_ProDKin_1	196	202	PF00069	0.678
MOD_ProDKin_1	211	217	PF00069	0.458
MOD_ProDKin_1	229	235	PF00069	0.692
MOD_ProDKin_1	259	265	PF00069	0.677
MOD_ProDKin_1	35	41	PF00069	0.459
TRG_DiLeu_BaEn_1	136	141	PF01217	0.491
TRG_DiLeu_LyEn_5	136	141	PF01217	0.565
TRG_ENDOCYTIC_2	49	52	PF00928	0.530
TRG_NES_CRM1_1	96	108	PF08389	0.710
TRG_Pf-PMV_PEXEL_1	139	143	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMT4	Leptomonas seymouri	53%	97%
A0A0S4J3S7	Bodo saltans	24%	100%
A0A1X0NP32	Trypanosomatidae	30%	100%
A0A3S7WQ75	Leishmania donovani	75%	98%
A0A422NB91	Trypanosoma rangeli	28%	100%
A4HTJ6	Leishmania infantum	75%	98%
C9ZPH8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AMC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4QIC1	Leishmania major	74%	100%
V5BLF3	Trypanosoma cruzi	27%	100%