Putative small ubiquitin protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

small ubiquitin protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H5B4_LEIBR

TriTrypDb:

LbrM.08.0500 , LBRM2903_080012200

Length:

117

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H5B4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5B4

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016925	protein sumoylation	7	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0031386	protein tag	1	1
GO:0044389	ubiquitin-like protein ligase binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.303
CLV_PCSK_KEX2_1	53	55	PF00082	0.418
CLV_PCSK_PC1ET2_1	53	55	PF00082	0.418
CLV_PCSK_SKI1_1	77	81	PF00082	0.326
DEG_Nend_UBRbox_2	1	3	PF02207	0.636
DOC_USP7_MATH_1	29	33	PF00917	0.669
DOC_WW_Pin1_4	87	92	PF00397	0.328
LIG_BRCT_BRCA1_1	74	78	PF00533	0.334
LIG_CtBP_PxDLS_1	91	95	PF00389	0.362
LIG_FHA_2	13	19	PF00498	0.599
LIG_FHA_2	88	94	PF00498	0.310
LIG_LIR_Nem_3	47	52	PF02991	0.303
LIG_Rb_pABgroove_1	74	82	PF01858	0.324
LIG_REV1ctd_RIR_1	47	58	PF16727	0.303
LIG_SH2_STAT5	65	68	PF00017	0.309
LIG_SH3_3	8	14	PF00018	0.533
LIG_UBA3_1	48	53	PF00899	0.303
MOD_CK1_1	72	78	PF00069	0.303
MOD_CK2_1	12	18	PF00069	0.585
MOD_GlcNHglycan	111	114	PF01048	0.542
MOD_GlcNHglycan	31	34	PF01048	0.590
MOD_PIKK_1	53	59	PF00454	0.327
MOD_PKA_1	53	59	PF00069	0.418
MOD_PKA_2	53	59	PF00069	0.434
MOD_PKA_2	72	78	PF00069	0.184
MOD_ProDKin_1	87	93	PF00069	0.328
MOD_SUMO_for_1	23	26	PF00179	0.623
MOD_SUMO_rev_2	81	91	PF00179	0.303
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.303

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P930	Leptomonas seymouri	87%	94%
A0A1X0NP22	Trypanosomatidae	83%	100%
A0A3R7N9J1	Trypanosoma rangeli	88%	100%
A0A3S5H652	Leishmania donovani	90%	100%
A4HTJ5	Leishmania infantum	90%	100%
B3H5R8	Arabidopsis thaliana	41%	100%
C9ZPI0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9AMC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
G2XKQ0	Homo sapiens	43%	100%
O13351	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	51%	100%
P55853	Caenorhabditis elegans	46%	100%
P55857	Oryza sativa subsp. japonica	54%	100%
Q12306	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	47%	100%
Q17QV3	Bos taurus	55%	100%
Q28H04	Xenopus tropicalis	55%	100%
Q3E8A8	Arabidopsis thaliana	34%	100%
Q4QIC2	Leishmania major	91%	100%
Q5XIF4	Rattus norvegicus	53%	100%
Q6DHL4	Danio rerio	51%	100%
Q6DI05	Danio rerio	55%	100%
Q6EEV6	Homo sapiens	43%	100%
Q6GPW2	Xenopus laevis	55%	100%
Q6NV25	Danio rerio	55%	100%
Q7SZR5	Danio rerio	49%	100%
Q7ZTK7	Xenopus laevis	55%	100%
Q8VZI7	Arabidopsis thaliana	44%	100%
Q9FKC5	Arabidopsis thaliana	40%	100%
Q9FLP5	Arabidopsis thaliana	39%	100%
Q9MZD5	Cervus nippon	50%	100%
Q9Z172	Mus musculus	54%	100%