Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5A9_LEIBR

TriTrypDb:

LbrM.08.0430 , LBRM2903_080009300

Length:

220

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4H5A9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5A9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	5	7	PF00675	0.475
CLV_PCSK_KEX2_1	193	195	PF00082	0.651
CLV_PCSK_KEX2_1	4	6	PF00082	0.474
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.651
CLV_PCSK_SKI1_1	214	218	PF00082	0.655
CLV_PCSK_SKI1_1	71	75	PF00082	0.444
DEG_MDM2_SWIB_1	124	131	PF02201	0.389
DEG_SPOP_SBC_1	14	18	PF00917	0.576
DOC_MAPK_FxFP_2	67	70	PF00069	0.646
DOC_MAPK_MEF2A_6	103	110	PF00069	0.621
DOC_MAPK_NFAT4_5	103	111	PF00069	0.622
DOC_PP4_FxxP_1	67	70	PF00568	0.646
DOC_USP7_MATH_1	15	19	PF00917	0.661
DOC_USP7_MATH_1	208	212	PF00917	0.518
DOC_USP7_UBL2_3	189	193	PF12436	0.449
LIG_14-3-3_CanoR_1	107	117	PF00244	0.598
LIG_14-3-3_CanoR_1	27	36	PF00244	0.642
LIG_14-3-3_CanoR_1	87	93	PF00244	0.602
LIG_APCC_ABBA_1	60	65	PF00400	0.641
LIG_BRCT_BRCA1_1	120	124	PF00533	0.289
LIG_BRCT_BRCA1_1	24	28	PF00533	0.602
LIG_deltaCOP1_diTrp_1	141	147	PF00928	0.415
LIG_deltaCOP1_diTrp_1	183	188	PF00928	0.458
LIG_FHA_1	14	20	PF00498	0.620
LIG_FHA_1	154	160	PF00498	0.459
LIG_FHA_1	198	204	PF00498	0.533
LIG_FHA_1	24	30	PF00498	0.571
LIG_FHA_2	79	85	PF00498	0.610
LIG_FHA_2	94	100	PF00498	0.577
LIG_KLC1_Yacidic_2	163	168	PF13176	0.423
LIG_LIR_Apic_2	168	173	PF02991	0.418
LIG_LIR_Apic_2	199	204	PF02991	0.460
LIG_LIR_Apic_2	65	70	PF02991	0.646
LIG_LIR_Gen_1	141	152	PF02991	0.418
LIG_LIR_Nem_3	127	131	PF02991	0.338
LIG_LIR_Nem_3	141	147	PF02991	0.378
LIG_LIR_Nem_3	177	182	PF02991	0.485
LIG_LIR_Nem_3	31	36	PF02991	0.726
LIG_LIR_Nem_3	65	69	PF02991	0.649
LIG_MYND_3	157	161	PF01753	0.423
LIG_Pex14_1	120	124	PF04695	0.399
LIG_Pex14_2	116	120	PF04695	0.378
LIG_Pex14_2	124	128	PF04695	0.378
LIG_Pex14_2	74	78	PF04695	0.720
LIG_SH2_STAP1	182	186	PF00017	0.456
LIG_SH2_STAT3	166	169	PF00017	0.430
LIG_SH2_STAT5	129	132	PF00017	0.354
LIG_SH2_STAT5	166	169	PF00017	0.416
LIG_SH2_STAT5	80	83	PF00017	0.627
LIG_SH3_3	152	158	PF00018	0.404
LIG_SH3_3	51	57	PF00018	0.682
LIG_SH3_3	73	79	PF00018	0.640
LIG_SH3_4	189	196	PF00018	0.447
LIG_TRAF2_1	81	84	PF00917	0.615
MOD_CK1_1	112	118	PF00069	0.562
MOD_CK1_1	127	133	PF00069	0.241
MOD_CK1_1	92	98	PF00069	0.603
MOD_CK2_1	47	53	PF00069	0.727
MOD_CK2_1	78	84	PF00069	0.615
MOD_CK2_1	93	99	PF00069	0.567
MOD_CMANNOS	117	120	PF00535	0.335
MOD_GlcNHglycan	39	42	PF01048	0.495
MOD_GSK3_1	108	115	PF00069	0.453
MOD_GSK3_1	192	199	PF00069	0.358
MOD_GSK3_1	6	13	PF00069	0.723
MOD_GSK3_1	78	85	PF00069	0.611
MOD_GSK3_1	89	96	PF00069	0.584
MOD_N-GLC_1	108	113	PF02516	0.393
MOD_NEK2_1	108	113	PF00069	0.607
MOD_NEK2_1	118	123	PF00069	0.355
MOD_NEK2_1	124	129	PF00069	0.355
MOD_NEK2_1	22	27	PF00069	0.659
MOD_PK_1	82	88	PF00069	0.615
MOD_PKA_2	86	92	PF00069	0.600
MOD_PKB_1	4	12	PF00069	0.581
MOD_Plk_1	82	88	PF00069	0.615
MOD_Plk_1	89	95	PF00069	0.602
MOD_Plk_4	112	118	PF00069	0.482
MOD_Plk_4	124	130	PF00069	0.335
MOD_Plk_4	6	12	PF00069	0.671
MOD_SUMO_rev_2	31	36	PF00179	0.679
MOD_SUMO_rev_2	72	79	PF00179	0.652
TRG_ENDOCYTIC_2	135	138	PF00928	0.388
TRG_ENDOCYTIC_2	182	185	PF00928	0.451
TRG_ER_diArg_1	3	6	PF00400	0.670

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P933	Leptomonas seymouri	81%	99%
A0A0S4IVJ7	Bodo saltans	67%	100%
A0A1X0NP20	Trypanosomatidae	73%	100%
A0A3S5H645	Leishmania donovani	90%	100%
A4HTI8	Leishmania infantum	90%	100%
C9ZPJ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	100%
E9AMB6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QID2	Leishmania major	89%	100%
V5DHY0	Trypanosoma cruzi	72%	100%