Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5A8_LEIBR

TriTrypDb:

LbrM.08.0420 , LBRM2903_080009100 , LBRM2903_080009200

Length:

580

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5A8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5A8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.482
CLV_C14_Caspase3-7	472	476	PF00656	0.768
CLV_NRD_NRD_1	241	243	PF00675	0.597
CLV_NRD_NRD_1	480	482	PF00675	0.503
CLV_PCSK_KEX2_1	241	243	PF00082	0.597
CLV_PCSK_KEX2_1	330	332	PF00082	0.642
CLV_PCSK_PC1ET2_1	330	332	PF00082	0.642
CLV_Separin_Metazoa	177	181	PF03568	0.447
DEG_COP1_1	519	529	PF00400	0.516
DEG_SCF_FBW7_1	99	105	PF00400	0.660
DOC_CKS1_1	99	104	PF01111	0.657
DOC_CYCLIN_yCln2_LP_2	366	372	PF00134	0.519
DOC_MAPK_gen_1	566	572	PF00069	0.493
DOC_PP2B_LxvP_1	454	457	PF13499	0.744
DOC_PP2B_LxvP_1	486	489	PF13499	0.727
DOC_USP7_MATH_1	126	130	PF00917	0.737
DOC_USP7_MATH_1	307	311	PF00917	0.696
DOC_USP7_MATH_1	405	409	PF00917	0.521
DOC_USP7_MATH_1	416	420	PF00917	0.482
DOC_USP7_MATH_1	430	434	PF00917	0.514
DOC_USP7_MATH_1	460	464	PF00917	0.580
DOC_USP7_MATH_1	466	470	PF00917	0.561
DOC_USP7_MATH_1	496	500	PF00917	0.463
DOC_USP7_MATH_1	53	57	PF00917	0.550
DOC_WW_Pin1_4	129	134	PF00397	0.688
DOC_WW_Pin1_4	183	188	PF00397	0.528
DOC_WW_Pin1_4	203	208	PF00397	0.660
DOC_WW_Pin1_4	233	238	PF00397	0.464
DOC_WW_Pin1_4	266	271	PF00397	0.639
DOC_WW_Pin1_4	277	282	PF00397	0.722
DOC_WW_Pin1_4	338	343	PF00397	0.663
DOC_WW_Pin1_4	361	366	PF00397	0.754
DOC_WW_Pin1_4	368	373	PF00397	0.510
DOC_WW_Pin1_4	375	380	PF00397	0.626
DOC_WW_Pin1_4	462	467	PF00397	0.526
DOC_WW_Pin1_4	518	523	PF00397	0.704
DOC_WW_Pin1_4	98	103	PF00397	0.711
LIG_14-3-3_CanoR_1	135	145	PF00244	0.531
LIG_14-3-3_CanoR_1	169	178	PF00244	0.481
LIG_14-3-3_CanoR_1	50	58	PF00244	0.522
LIG_14-3-3_CanoR_1	84	93	PF00244	0.473
LIG_APCC_ABBA_1	141	146	PF00400	0.522
LIG_BRCT_BRCA1_1	284	288	PF00533	0.541
LIG_deltaCOP1_diTrp_1	208	216	PF00928	0.411
LIG_EH1_1	33	41	PF00400	0.540
LIG_FHA_1	150	156	PF00498	0.585
LIG_FHA_1	311	317	PF00498	0.580
LIG_FHA_1	338	344	PF00498	0.794
LIG_FHA_1	350	356	PF00498	0.662
LIG_FHA_1	358	364	PF00498	0.516
LIG_FHA_1	412	418	PF00498	0.588
LIG_FHA_1	529	535	PF00498	0.665
LIG_FHA_2	122	128	PF00498	0.600
LIG_FHA_2	25	31	PF00498	0.502
LIG_FHA_2	546	552	PF00498	0.415
LIG_Integrin_RGD_1	517	519	PF01839	0.606
LIG_LIR_Apic_2	399	405	PF02991	0.528
LIG_LIR_Gen_1	22	32	PF02991	0.739
LIG_LIR_Gen_1	323	334	PF02991	0.540
LIG_LIR_Nem_3	22	28	PF02991	0.742
LIG_LIR_Nem_3	323	329	PF02991	0.539
LIG_PCNA_yPIPBox_3	502	510	PF02747	0.449
LIG_PDZ_Class_1	575	580	PF00595	0.407
LIG_PTB_Apo_2	504	511	PF02174	0.455
LIG_SH2_STAP1	8	12	PF00017	0.524
LIG_SH2_STAT3	420	423	PF00017	0.688
LIG_SH2_STAT5	247	250	PF00017	0.571
LIG_SH2_STAT5	25	28	PF00017	0.425
LIG_SH2_STAT5	420	423	PF00017	0.581
LIG_SH2_STAT5	8	11	PF00017	0.569
LIG_SH2_STAT5	92	95	PF00017	0.564
LIG_SH3_3	109	115	PF00018	0.691
LIG_SH3_3	139	145	PF00018	0.726
LIG_SH3_3	256	262	PF00018	0.532
LIG_SH3_3	280	286	PF00018	0.638
LIG_SH3_3	341	347	PF00018	0.542
LIG_SH3_3	366	372	PF00018	0.519
LIG_SH3_3	519	525	PF00018	0.605
LIG_SH3_3	96	102	PF00018	0.617
LIG_SUMO_SIM_anti_2	174	180	PF11976	0.408
LIG_SUMO_SIM_anti_2	254	260	PF11976	0.523
LIG_SUMO_SIM_anti_2	568	575	PF11976	0.496
LIG_SUMO_SIM_par_1	197	204	PF11976	0.417
LIG_SUMO_SIM_par_1	359	364	PF11976	0.526
LIG_TRAF2_1	172	175	PF00917	0.479
LIG_TRAF2_1	325	328	PF00917	0.543
LIG_UBA3_1	376	381	PF00899	0.737
LIG_WRC_WIRS_1	25	30	PF05994	0.685
MOD_CDC14_SPxK_1	186	189	PF00782	0.510
MOD_CDC14_SPxK_1	378	381	PF00782	0.631
MOD_CDK_SPK_2	233	238	PF00069	0.464
MOD_CDK_SPK_2	462	467	PF00069	0.526
MOD_CDK_SPxK_1	129	135	PF00069	0.531
MOD_CDK_SPxK_1	183	189	PF00069	0.502
MOD_CDK_SPxK_1	375	381	PF00069	0.628
MOD_CK1_1	100	106	PF00069	0.562
MOD_CK1_1	129	135	PF00069	0.678
MOD_CK1_1	203	209	PF00069	0.417
MOD_CK1_1	24	30	PF00069	0.576
MOD_CK1_1	254	260	PF00069	0.641
MOD_CK1_1	269	275	PF00069	0.660
MOD_CK1_1	310	316	PF00069	0.790
MOD_CK1_1	338	344	PF00069	0.752
MOD_CK1_1	408	414	PF00069	0.701
MOD_CK1_1	461	467	PF00069	0.635
MOD_CK1_1	520	526	PF00069	0.717
MOD_CK2_1	121	127	PF00069	0.529
MOD_CK2_1	169	175	PF00069	0.510
MOD_CK2_1	53	59	PF00069	0.614
MOD_GlcNHglycan	10	13	PF01048	0.563
MOD_GlcNHglycan	127	131	PF01048	0.654
MOD_GlcNHglycan	136	139	PF01048	0.614
MOD_GlcNHglycan	152	155	PF01048	0.623
MOD_GlcNHglycan	171	174	PF01048	0.421
MOD_GlcNHglycan	211	214	PF01048	0.573
MOD_GlcNHglycan	318	323	PF01048	0.810
MOD_GlcNHglycan	432	435	PF01048	0.581
MOD_GlcNHglycan	460	463	PF01048	0.768
MOD_GlcNHglycan	468	471	PF01048	0.675
MOD_GlcNHglycan	55	58	PF01048	0.625
MOD_GlcNHglycan	66	69	PF01048	0.698
MOD_GSK3_1	122	129	PF00069	0.663
MOD_GSK3_1	2	9	PF00069	0.581
MOD_GSK3_1	20	27	PF00069	0.665
MOD_GSK3_1	265	272	PF00069	0.756
MOD_GSK3_1	273	280	PF00069	0.711
MOD_GSK3_1	349	356	PF00069	0.633
MOD_GSK3_1	357	364	PF00069	0.672
MOD_GSK3_1	404	411	PF00069	0.705
MOD_GSK3_1	458	465	PF00069	0.623
MOD_GSK3_1	517	524	PF00069	0.732
MOD_GSK3_1	568	575	PF00069	0.448
MOD_GSK3_1	98	105	PF00069	0.806
MOD_N-GLC_1	395	400	PF02516	0.564
MOD_N-GLC_1	51	56	PF02516	0.519
MOD_N-GLC_1	545	550	PF02516	0.417
MOD_NEK2_1	1	6	PF00069	0.713
MOD_NEK2_1	200	205	PF00069	0.467
MOD_NEK2_1	21	26	PF00069	0.569
MOD_NEK2_1	336	341	PF00069	0.550
MOD_NEK2_1	409	414	PF00069	0.518
MOD_NEK2_1	44	49	PF00069	0.508
MOD_NEK2_1	505	510	PF00069	0.578
MOD_NEK2_1	572	577	PF00069	0.468
MOD_NEK2_2	405	410	PF00069	0.499
MOD_PIKK_1	3	9	PF00454	0.694
MOD_PIKK_1	310	316	PF00454	0.557
MOD_PKA_2	134	140	PF00069	0.537
MOD_PKA_2	240	246	PF00069	0.568
MOD_PKA_2	466	472	PF00069	0.731
MOD_Plk_1	21	27	PF00069	0.674
MOD_Plk_1	395	401	PF00069	0.563
MOD_Plk_1	405	411	PF00069	0.610
MOD_Plk_1	440	446	PF00069	0.461
MOD_Plk_1	545	551	PF00069	0.416
MOD_Plk_4	251	257	PF00069	0.553
MOD_Plk_4	284	290	PF00069	0.538
MOD_Plk_4	416	422	PF00069	0.485
MOD_Plk_4	505	511	PF00069	0.457
MOD_Plk_4	534	540	PF00069	0.629
MOD_Plk_4	568	574	PF00069	0.470
MOD_ProDKin_1	129	135	PF00069	0.690
MOD_ProDKin_1	183	189	PF00069	0.534
MOD_ProDKin_1	203	209	PF00069	0.660
MOD_ProDKin_1	233	239	PF00069	0.459
MOD_ProDKin_1	266	272	PF00069	0.643
MOD_ProDKin_1	277	283	PF00069	0.717
MOD_ProDKin_1	338	344	PF00069	0.660
MOD_ProDKin_1	361	367	PF00069	0.754
MOD_ProDKin_1	368	374	PF00069	0.512
MOD_ProDKin_1	375	381	PF00069	0.628
MOD_ProDKin_1	462	468	PF00069	0.525
MOD_ProDKin_1	518	524	PF00069	0.704
MOD_ProDKin_1	98	104	PF00069	0.716
MOD_SUMO_rev_2	177	186	PF00179	0.458
MOD_SUMO_rev_2	218	222	PF00179	0.473
MOD_SUMO_rev_2	323	332	PF00179	0.640
TRG_DiLeu_BaEn_1	174	179	PF01217	0.419
TRG_DiLeu_BaEn_1	35	40	PF01217	0.638
TRG_DiLeu_BaEn_4	174	180	PF01217	0.425
TRG_DiLeu_BaLyEn_6	68	73	PF01217	0.617
TRG_ENDOCYTIC_2	25	28	PF00928	0.700
TRG_ENDOCYTIC_2	41	44	PF00928	0.462
TRG_ENDOCYTIC_2	92	95	PF00928	0.564
TRG_ER_diArg_1	232	235	PF00400	0.616
TRG_ER_diArg_1	240	242	PF00400	0.599
TRG_ER_diArg_1	331	334	PF00400	0.640
TRG_ER_diArg_1	556	559	PF00400	0.613
TRG_NES_CRM1_1	291	302	PF08389	0.700
TRG_NLS_MonoExtC_3	329	334	PF00514	0.639
TRG_Pf-PMV_PEXEL_1	169	174	PF00026	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IML5	Leptomonas seymouri	41%	100%
A0A3S7WQ81	Leishmania donovani	66%	100%
A4HTI7	Leishmania infantum	66%	100%
E9AMB5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	82%
Q4QID3	Leishmania major	68%	100%