Isochorismatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Isochorismatase family, putative

Species:

Leishmania braziliensis

UniProt:

A4H5A1_LEIBR

TriTrypDb:

LbrM.08.0350 , LBRM2903_080008400

Length:

298

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 14
NetGPI	no	yes: 0, no: 16

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5A1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5A1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	221	225	PF00656	0.356
CLV_C14_Caspase3-7	281	285	PF00656	0.577
CLV_PCSK_KEX2_1	288	290	PF00082	0.506
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.506
CLV_PCSK_SKI1_1	226	230	PF00082	0.416
CLV_PCSK_SKI1_1	55	59	PF00082	0.385
DEG_COP1_1	130	137	PF00400	0.271
DEG_Nend_UBRbox_1	1	4	PF02207	0.519
DEG_SPOP_SBC_1	29	33	PF00917	0.463
DOC_MAPK_gen_1	226	234	PF00069	0.390
DOC_MAPK_MEF2A_6	226	234	PF00069	0.411
DOC_PP2B_PxIxI_1	229	235	PF00149	0.361
DOC_PP4_FxxP_1	227	230	PF00568	0.416
DOC_USP7_MATH_1	103	107	PF00917	0.535
DOC_USP7_MATH_1	30	34	PF00917	0.481
DOC_WW_Pin1_4	147	152	PF00397	0.292
DOC_WW_Pin1_4	271	276	PF00397	0.491
LIG_14-3-3_CanoR_1	37	44	PF00244	0.534
LIG_BRCT_BRCA1_1	32	36	PF00533	0.462
LIG_deltaCOP1_diTrp_1	94	98	PF00928	0.266
LIG_FHA_1	128	134	PF00498	0.383
LIG_FHA_1	186	192	PF00498	0.540
LIG_FHA_1	195	201	PF00498	0.503
LIG_FHA_1	243	249	PF00498	0.454
LIG_FHA_2	167	173	PF00498	0.629
LIG_FHA_2	219	225	PF00498	0.354
LIG_FHA_2	279	285	PF00498	0.577
LIG_LIR_Apic_2	224	230	PF02991	0.402
LIG_LIR_Gen_1	43	51	PF02991	0.311
LIG_LIR_Gen_1	94	103	PF02991	0.363
LIG_LIR_Nem_3	161	166	PF02991	0.407
LIG_LIR_Nem_3	203	208	PF02991	0.568
LIG_LIR_Nem_3	43	47	PF02991	0.360
LIG_LIR_Nem_3	94	98	PF02991	0.379
LIG_MYND_1	22	26	PF01753	0.492
LIG_Pex14_2	238	242	PF04695	0.383
LIG_Pex14_2	74	78	PF04695	0.311
LIG_SH2_CRK	163	167	PF00017	0.407
LIG_SH2_CRK	44	48	PF00017	0.328
LIG_SH2_STAP1	44	48	PF00017	0.326
LIG_SH2_STAT3	104	107	PF00017	0.430
LIG_SH2_STAT5	140	143	PF00017	0.495
LIG_SH3_3	113	119	PF00018	0.426
LIG_SH3_3	19	25	PF00018	0.578
LIG_SH3_4	229	236	PF00018	0.464
LIG_UBA3_1	231	236	PF00899	0.425
LIG_WRC_WIRS_1	235	240	PF05994	0.291
MOD_CK1_1	106	112	PF00069	0.481
MOD_CK1_1	16	22	PF00069	0.527
MOD_CK1_1	268	274	PF00069	0.503
MOD_CK1_1	277	283	PF00069	0.490
MOD_CK1_1	291	297	PF00069	0.469
MOD_CK1_1	31	37	PF00069	0.599
MOD_CK2_1	166	172	PF00069	0.568
MOD_GlcNHglycan	214	217	PF01048	0.389
MOD_GlcNHglycan	276	279	PF01048	0.536
MOD_GlcNHglycan	290	293	PF01048	0.561
MOD_GSK3_1	1	8	PF00069	0.492
MOD_GSK3_1	16	23	PF00069	0.561
MOD_GSK3_1	208	215	PF00069	0.486
MOD_GSK3_1	24	31	PF00069	0.552
MOD_GSK3_1	274	281	PF00069	0.555
MOD_GSK3_1	284	291	PF00069	0.519
MOD_GSK3_1	98	105	PF00069	0.365
MOD_NEK2_1	1	6	PF00069	0.481
MOD_NEK2_1	194	199	PF00069	0.536
MOD_NEK2_1	200	205	PF00069	0.602
MOD_NEK2_1	208	213	PF00069	0.508
MOD_NEK2_1	218	223	PF00069	0.431
MOD_NEK2_1	98	103	PF00069	0.313
MOD_NEK2_2	93	98	PF00069	0.335
MOD_PIKK_1	103	109	PF00454	0.433
MOD_PIKK_1	13	19	PF00454	0.505
MOD_PIKK_1	242	248	PF00454	0.420
MOD_PIKK_1	250	256	PF00454	0.543
MOD_PKA_1	288	294	PF00069	0.496
MOD_PKA_2	1	7	PF00069	0.482
MOD_PKA_2	288	294	PF00069	0.496
MOD_PKA_2	36	42	PF00069	0.432
MOD_Plk_1	42	48	PF00069	0.402
MOD_Plk_1	93	99	PF00069	0.362
MOD_Plk_4	128	134	PF00069	0.441
MOD_Plk_4	31	37	PF00069	0.460
MOD_ProDKin_1	147	153	PF00069	0.291
MOD_ProDKin_1	271	277	PF00069	0.491
TRG_DiLeu_BaEn_1	43	48	PF01217	0.351
TRG_DiLeu_BaEn_2	93	99	PF01217	0.344
TRG_DiLeu_LyEn_5	43	48	PF01217	0.351
TRG_ENDOCYTIC_2	163	166	PF00928	0.407
TRG_ENDOCYTIC_2	44	47	PF00928	0.349
TRG_NES_CRM1_1	172	185	PF08389	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I400	Leptomonas seymouri	59%	100%
A0A3S5H641	Leishmania donovani	37%	100%
A0A3S5H642	Leishmania donovani	47%	100%
A0A3S7WQ71	Leishmania donovani	67%	96%
A4H5A0	Leishmania braziliensis	39%	100%
A4H5A2	Leishmania braziliensis	49%	100%
A4HTI1	Leishmania infantum	37%	100%
A4HTI2	Leishmania infantum	67%	96%
A4HTI3	Leishmania infantum	47%	100%
E9AMA9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AMB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
E9AMB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
Q4QID7	Leishmania major	46%	100%
Q4QID8	Leishmania major	67%	100%
Q4QID9	Leishmania major	39%	100%